Non-Enzymatic Glycation Impairs the Anti-Inflammatory Properties of Apolipoprotein A-I
Identifieur interne : 001350 ( Pmc/Curation ); précédent : 001349; suivant : 001351Non-Enzymatic Glycation Impairs the Anti-Inflammatory Properties of Apolipoprotein A-I
Auteurs : Estelle Nobécourt ; Fatiha Tabet ; Gilles Lambert [France] ; Rajesh Puranik [Australie] ; Shisan Bao [Australie] ; Ling Yan ; Michael J. Davies [Australie] ; Bronwyn E. Brown ; Alicia J. Jenkins [Australie] ; Gregory J. Dusting [Australie] ; David J. Bonnet ; Linda K. Curtiss ; Philip J. Barter [Australie] ; Kerry-Anne Rye [Australie]Source :
- Arteriosclerosis, thrombosis, and vascular biology [ 1079-5642 ] ; 2010.
Abstract
To investigate the effects of non-enzymatic glycation on the anti-inflammatory properties of apolipoprotein (apo) A-I.
Rabbits were infused with saline, lipid-free apoA-I from normal subjects (apoA-I
Non-enzymatic glycation impairs the anti-inflammatory properties of apoA-I.
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DOI: 10.1161/ATVBAHA.109.201715
PubMed: 20110571
PubMed Central: 3038672
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Estelle Nobécourt<affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Université de Nantes, Faculté de Médecine, Nantes, France, 44000</nlm:aff><orgName type="university">Université de Nantes</orgName><country>France</country><placeName><settlement type="city">Nantes</settlement><region type="region" nuts="2">Pays de la Loire</region></placeName></affiliation><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Department of Pathology, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation><nlm:aff id="A5">Free Radical Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation><nlm:aff id="A5">Free Radical Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation><nlm:aff id="A8">Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA, 92037</nlm:aff><wicri:noCountry code="subfield">92037</wicri:noCountry></affiliation><affiliation><nlm:aff id="A8">Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA, 92037</nlm:aff><wicri:noCountry code="subfield">92037</wicri:noCountry></affiliation><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A6">Department of Medicine, University of Melbourne, Victoria, Australia, 3010</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation>Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Non-Enzymatic Glycation Impairs the Anti-Inflammatory Properties of Apolipoprotein A-I</title><author><name sortKey="Nobecourt, Estelle" sort="Nobecourt, Estelle" uniqKey="Nobecourt E" first="Estelle" last="Nobécourt">Estelle Nobécourt</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation></author><author><name sortKey="Tabet, Fatiha" sort="Tabet, Fatiha" uniqKey="Tabet F" first="Fatiha" last="Tabet">Fatiha Tabet</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation></author><author><name sortKey="Lambert, Gilles" sort="Lambert, Gilles" uniqKey="Lambert G" first="Gilles" last="Lambert">Gilles Lambert</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Université de Nantes, Faculté de Médecine, Nantes, France, 44000</nlm:aff><orgName type="university">Université de Nantes</orgName><country>France</country><placeName><settlement type="city">Nantes</settlement><region type="region" nuts="2">Pays de la Loire</region></placeName></affiliation></author><author><name sortKey="Puranik, Rajesh" sort="Puranik, Rajesh" uniqKey="Puranik R" first="Rajesh" last="Puranik">Rajesh Puranik</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Bao, Shisan" sort="Bao, Shisan" uniqKey="Bao S" first="Shisan" last="Bao">Shisan Bao</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Department of Pathology, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Yan, Ling" sort="Yan, Ling" uniqKey="Yan L" first="Ling" last="Yan">Ling Yan</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation></author><author><name sortKey="Davies, Michael J" sort="Davies, Michael J" uniqKey="Davies M" first="Michael J." last="Davies">Michael J. Davies</name><affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation><nlm:aff id="A5">Free Radical Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation></author><author><name sortKey="Brown, Bronwyn E" sort="Brown, Bronwyn E" uniqKey="Brown B" first="Bronwyn E." last="Brown">Bronwyn E. Brown</name><affiliation><nlm:aff id="A5">Free Radical Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation></author><author><name sortKey="Jenkins, Alicia J" sort="Jenkins, Alicia J" uniqKey="Jenkins A" first="Alicia J" last="Jenkins">Alicia J. Jenkins</name><affiliation wicri:level="4"><nlm:aff id="A6">Department of Medicine, University of Melbourne, Victoria, Australia, 3010</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Dusting, Gregory J" sort="Dusting, Gregory J" uniqKey="Dusting G" first="Gregory J." last="Dusting">Gregory J. Dusting</name><affiliation wicri:level="4"><nlm:aff id="A7">O’Brien Institute and Department of Surgery, University of Melbourne, Victoria, Australia, 3010</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Bonnet, David J" sort="Bonnet, David J" uniqKey="Bonnet D" first="David J." last="Bonnet">David J. Bonnet</name><affiliation><nlm:aff id="A8">Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA, 92037</nlm:aff><wicri:noCountry code="subfield">92037</wicri:noCountry></affiliation></author><author><name sortKey="Curtiss, Linda K" sort="Curtiss, Linda K" uniqKey="Curtiss L" first="Linda K." last="Curtiss">Linda K. Curtiss</name><affiliation><nlm:aff id="A8">Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA, 92037</nlm:aff><wicri:noCountry code="subfield">92037</wicri:noCountry></affiliation></author><author><name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J." last="Barter">Philip J. Barter</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A6">Department of Medicine, University of Melbourne, Victoria, Australia, 3010</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20110571</idno><idno type="pmc">3038672</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038672</idno><idno type="RBID">PMC:3038672</idno><idno type="doi">10.1161/ATVBAHA.109.201715</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">001490</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001490</idno><idno type="wicri:Area/Pmc/Curation">001350</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001350</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Non-Enzymatic Glycation Impairs the Anti-Inflammatory Properties of Apolipoprotein A-I</title><author><name sortKey="Nobecourt, Estelle" sort="Nobecourt, Estelle" uniqKey="Nobecourt E" first="Estelle" last="Nobécourt">Estelle Nobécourt</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation></author><author><name sortKey="Tabet, Fatiha" sort="Tabet, Fatiha" uniqKey="Tabet F" first="Fatiha" last="Tabet">Fatiha Tabet</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation></author><author><name sortKey="Lambert, Gilles" sort="Lambert, Gilles" uniqKey="Lambert G" first="Gilles" last="Lambert">Gilles Lambert</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">Université de Nantes, Faculté de Médecine, Nantes, France, 44000</nlm:aff><orgName type="university">Université de Nantes</orgName><country>France</country><placeName><settlement type="city">Nantes</settlement><region type="region" nuts="2">Pays de la Loire</region></placeName></affiliation></author><author><name sortKey="Puranik, Rajesh" sort="Puranik, Rajesh" uniqKey="Puranik R" first="Rajesh" last="Puranik">Rajesh Puranik</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Bao, Shisan" sort="Bao, Shisan" uniqKey="Bao S" first="Shisan" last="Bao">Shisan Bao</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A4">Department of Pathology, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Yan, Ling" sort="Yan, Ling" uniqKey="Yan L" first="Ling" last="Yan">Ling Yan</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation></author><author><name sortKey="Davies, Michael J" sort="Davies, Michael J" uniqKey="Davies M" first="Michael J." last="Davies">Michael J. Davies</name><affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation><nlm:aff id="A5">Free Radical Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation></author><author><name sortKey="Brown, Bronwyn E" sort="Brown, Bronwyn E" uniqKey="Brown B" first="Bronwyn E." last="Brown">Bronwyn E. Brown</name><affiliation><nlm:aff id="A5">Free Radical Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation></author><author><name sortKey="Jenkins, Alicia J" sort="Jenkins, Alicia J" uniqKey="Jenkins A" first="Alicia J" last="Jenkins">Alicia J. Jenkins</name><affiliation wicri:level="4"><nlm:aff id="A6">Department of Medicine, University of Melbourne, Victoria, Australia, 3010</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Dusting, Gregory J" sort="Dusting, Gregory J" uniqKey="Dusting G" first="Gregory J." last="Dusting">Gregory J. Dusting</name><affiliation wicri:level="4"><nlm:aff id="A7">O’Brien Institute and Department of Surgery, University of Melbourne, Victoria, Australia, 3010</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Bonnet, David J" sort="Bonnet, David J" uniqKey="Bonnet D" first="David J." last="Bonnet">David J. Bonnet</name><affiliation><nlm:aff id="A8">Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA, 92037</nlm:aff><wicri:noCountry code="subfield">92037</wicri:noCountry></affiliation></author><author><name sortKey="Curtiss, Linda K" sort="Curtiss, Linda K" uniqKey="Curtiss L" first="Linda K." last="Curtiss">Linda K. Curtiss</name><affiliation><nlm:aff id="A8">Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA, 92037</nlm:aff><wicri:noCountry code="subfield">92037</wicri:noCountry></affiliation></author><author><name sortKey="Barter, Philip J" sort="Barter, Philip J" uniqKey="Barter P" first="Philip J." last="Barter">Philip J. Barter</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Rye, Kerry Anne" sort="Rye, Kerry Anne" uniqKey="Rye K" first="Kerry-Anne" last="Rye">Kerry-Anne Rye</name><affiliation><nlm:aff id="A1">Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</nlm:aff><wicri:noCountry code="subfield">2042</wicri:noCountry></affiliation><affiliation wicri:level="4"><nlm:aff id="A3">Faculty of Medicine, University of Sydney, NSW, Australia, 2006</nlm:aff><orgName type="university">Université de Sydney</orgName><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A6">Department of Medicine, University of Melbourne, Victoria, Australia, 3010</nlm:aff><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><series><title level="j">Arteriosclerosis, thrombosis, and vascular biology</title><idno type="ISSN">1079-5642</idno><idno type="eISSN">1524-4636</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objective</title><p id="P2">To investigate the effects of non-enzymatic glycation on the anti-inflammatory properties of apolipoprotein (apo) A-I.</p></sec><sec sec-type="methods" id="S2"><title>Methods and Results</title><p id="P3">Rabbits were infused with saline, lipid-free apoA-I from normal subjects (apoA-I<sub><italic>N</italic></sub>), lipid-free apoA-I non-enzymatically glycated by incubation with methylglyoxal (apoA-I<italic><sub>Glyc in vitro</sub></italic>), non-enzymatically glycated lipid-free apoA-I from subjects with diabetes (apoA-I<sub><italic>Glyc in vivo</italic></sub>), discoidal reconstituted HDL containing phosphatidylcholine and apoA-I<italic><sub>N</sub></italic>, (A-I<sub><italic>N</italic></sub>)rHDL, or apoA-I<sub><italic>Glyc in vitro</italic></sub>, (A-I<sub><italic>Glyc in vitro</italic></sub>)rHDL. At 24 h post-infusion, acute vascular inflammation was induced by inserting a non-occlusive, periarterial carotid collar. The animals were sacrificed 24 h post-collar insertion. The collars caused intima/media neutrophil infiltration and increased endothelial expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). ApoA-I<sub><italic>N</italic></sub> infusion decreased neutrophil infiltration and VCAM-1 and ICAM-1 expression by 89, 90 and 66%, respectively. The apoA-I<sub><italic>Glyc in vitro</italic></sub> infusion decreased neutrophil infiltration by 53%, but did not reduce VCAM-1 or ICAM-1 expression. ApoA-I<sub><italic>Glyc in vivo</italic></sub> did not inhibit neutrophil infiltration or adhesion molecule expression. (A-I<sub><italic>Glyc in vitro</italic></sub>)rHDL also inhibited vascular inflammation less effectively than (A-I<sub><italic>N</italic></sub>)rHDL. The reduced anti-inflammatory properties of non-enzymatically glycated apoA-I were attributed to a reduced ability to inhibit nuclear factor-κB activation and reactive oxygen species formation.</p></sec><sec id="S3"><title>Conclusion</title><p id="P4">Non-enzymatic glycation impairs the anti-inflammatory properties of apoA-I.</p></sec></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9505803</journal-id><journal-id journal-id-type="pubmed-jr-id">8623</journal-id><journal-id journal-id-type="nlm-ta">Arterioscler Thromb Vasc Biol</journal-id><journal-title>Arteriosclerosis, thrombosis, and vascular biology</journal-title><issn pub-type="ppub">1079-5642</issn><issn pub-type="epub">1524-4636</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20110571</article-id><article-id pub-id-type="pmc">3038672</article-id><article-id pub-id-type="doi">10.1161/ATVBAHA.109.201715</article-id><article-id pub-id-type="manuscript">NIHMS267616</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Non-Enzymatic Glycation Impairs the Anti-Inflammatory Properties of Apolipoprotein A-I</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Nobécourt</surname><given-names>Estelle</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Tabet</surname><given-names>Fatiha</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Lambert</surname><given-names>Gilles</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Puranik</surname><given-names>Rajesh</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Bao</surname><given-names>Shisan</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Yan</surname><given-names>Ling</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Davies</surname><given-names>Michael J.</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Bronwyn E.</given-names></name><xref ref-type="aff" rid="A5">5</xref></contrib><contrib contrib-type="author"><name><surname>Jenkins</surname><given-names>Alicia J</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Dusting</surname><given-names>Gregory J.</given-names></name><xref ref-type="aff" rid="A7">7</xref></contrib><contrib contrib-type="author"><name><surname>Bonnet</surname><given-names>David J.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Curtiss</surname><given-names>Linda K.</given-names></name><xref ref-type="aff" rid="A8">8</xref></contrib><contrib contrib-type="author"><name><surname>Barter</surname><given-names>Philip J.</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Rye</surname><given-names>Kerry-Anne</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A6">6</xref></contrib></contrib-group><aff id="A1"><label>1</label>Lipid Research Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</aff><aff id="A2"><label>2</label>Université de Nantes, Faculté de Médecine, Nantes, France, 44000</aff><aff id="A3"><label>3</label>Faculty of Medicine, University of Sydney, NSW, Australia, 2006</aff><aff id="A4"><label>4</label>Department of Pathology, University of Sydney, NSW, Australia, 2006</aff><aff id="A5"><label>5</label>Free Radical Group, The Heart Research Institute, Sydney, NSW, Australia, 2042</aff><aff id="A6"><label>6</label>Department of Medicine, University of Melbourne, Victoria, Australia, 3010</aff><aff id="A7"><label>7</label>O’Brien Institute and Department of Surgery, University of Melbourne, Victoria, Australia, 3010</aff><aff id="A8"><label>8</label>Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA, 92037</aff><author-notes><corresp id="cor1"><italic>Corresponding author:</italic> Kerry-Anne Rye, Lipid Research Group, The Heart Research Institute, 7 Eliza St, Newtown, NSW, Australia, 2042. Tel: +61 2 8208 8900; Fax: +61 2 9565 5584. <email>k.rye@hri.org.au</email> or <email>karye@ozemail.com.au</email></corresp><fn id="FN1" fn-type="equal"><label>*</label><p id="P1">both authors contributed equally to the work</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>4</day><month>2</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>28</day><month>1</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>4</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>4</month><year>2011</year></pub-date><volume>30</volume><issue>4</issue><fpage>766</fpage><lpage>772</lpage><abstract><sec id="S1"><title>Objective</title><p id="P2">To investigate the effects of non-enzymatic glycation on the anti-inflammatory properties of apolipoprotein (apo) A-I.</p></sec><sec sec-type="methods" id="S2"><title>Methods and Results</title><p id="P3">Rabbits were infused with saline, lipid-free apoA-I from normal subjects (apoA-I<sub><italic>N</italic></sub>), lipid-free apoA-I non-enzymatically glycated by incubation with methylglyoxal (apoA-I<italic><sub>Glyc in vitro</sub></italic>), non-enzymatically glycated lipid-free apoA-I from subjects with diabetes (apoA-I<sub><italic>Glyc in vivo</italic></sub>), discoidal reconstituted HDL containing phosphatidylcholine and apoA-I<italic><sub>N</sub></italic>, (A-I<sub><italic>N</italic></sub>)rHDL, or apoA-I<sub><italic>Glyc in vitro</italic></sub>, (A-I<sub><italic>Glyc in vitro</italic></sub>)rHDL. At 24 h post-infusion, acute vascular inflammation was induced by inserting a non-occlusive, periarterial carotid collar. The animals were sacrificed 24 h post-collar insertion. The collars caused intima/media neutrophil infiltration and increased endothelial expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). ApoA-I<sub><italic>N</italic></sub> infusion decreased neutrophil infiltration and VCAM-1 and ICAM-1 expression by 89, 90 and 66%, respectively. The apoA-I<sub><italic>Glyc in vitro</italic></sub> infusion decreased neutrophil infiltration by 53%, but did not reduce VCAM-1 or ICAM-1 expression. ApoA-I<sub><italic>Glyc in vivo</italic></sub> did not inhibit neutrophil infiltration or adhesion molecule expression. (A-I<sub><italic>Glyc in vitro</italic></sub>)rHDL also inhibited vascular inflammation less effectively than (A-I<sub><italic>N</italic></sub>)rHDL. The reduced anti-inflammatory properties of non-enzymatically glycated apoA-I were attributed to a reduced ability to inhibit nuclear factor-κB activation and reactive oxygen species formation.</p></sec><sec id="S3"><title>Conclusion</title><p id="P4">Non-enzymatic glycation impairs the anti-inflammatory properties of apoA-I.</p></sec></abstract><kwd-group><kwd>apoA-I</kwd><kwd>inflammation</kwd><kwd>HDL</kwd><kwd>adhesion molecules</kwd><kwd>neutrophils</kwd><kwd>NF-κB</kwd><kwd>reactive oxygen species</kwd></kwd-group><contract-num rid="HL1">P01 HL088093-01A1
||HL</contract-num><contract-sponsor id="HL1">National Heart, Lung, and Blood Institute : NHLBI</contract-sponsor></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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