AustralieFrV1, Main, Exploration, bibRecord, 009221

A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering

Identifieur interne : 009221 ( Main/Exploration ); précédent : 009220; suivant : 009222

A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering

Auteurs : Hui Hong [Royaume-Uni] ; Tim Stinear [Australie] ; Jessica Porter [Australie] ; Caroline Demangel [France] ; Peter F. Leadlay [Royaume-Uni]

Source :

ChemBioChem [ 1439-4227 ] ; 2007-11-23.

RBID : ISTEX:6F4B4D72721C18C07B394654390FF6306070B668

English descriptors

Abstract

A novel structural variant of the mycobacterial polyketide toxin mycolactone has been obtained by cloning a P450 hydroxylase gene from a related strain. This technique increases the range of available mycolactones for studies on the mode of action of the toxin.

Url:

DOI: 10.1002/cbic.200700411

Affiliations:

Le document en format XML

<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering</title>
<author><name sortKey="Hong, Hui" sort="Hong, Hui" uniqKey="Hong H" first="Hui" last="Hong">Hui Hong</name>
</author>
<author><name sortKey="Stinear, Tim" sort="Stinear, Tim" uniqKey="Stinear T" first="Tim" last="Stinear">Tim Stinear</name>
</author>
<author><name sortKey="Porter, Jessica" sort="Porter, Jessica" uniqKey="Porter J" first="Jessica" last="Porter">Jessica Porter</name>
</author>
<author><name sortKey="Demangel, Caroline" sort="Demangel, Caroline" uniqKey="Demangel C" first="Caroline" last="Demangel">Caroline Demangel</name>
</author>
<author><name sortKey="Leadlay, Peter F" sort="Leadlay, Peter F" uniqKey="Leadlay P" first="Peter F." last="Leadlay">Peter F. Leadlay</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:6F4B4D72721C18C07B394654390FF6306070B668</idno>
<date when="2007" year="2007">2007</date>
<idno type="doi">10.1002/cbic.200700411</idno>
<idno type="url">https://api.istex.fr/document/6F4B4D72721C18C07B394654390FF6306070B668/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001485</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001485</idno>
<idno type="wicri:Area/Istex/Curation">001485</idno>
<idno type="wicri:Area/Istex/Checkpoint">001470</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001470</idno>
<idno type="wicri:doubleKey">1439-4227:2007:Hong H:a:novel:mycolactone</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699038</idno>
<idno type="RBID">PMC:2699038</idno>
<idno type="wicri:Area/Pmc/Corpus">001338</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001338</idno>
<idno type="wicri:Area/Pmc/Curation">001198</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001198</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002B62</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002B62</idno>
<idno type="wicri:Area/Ncbi/Merge">000303</idno>
<idno type="wicri:Area/Ncbi/Curation">000303</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000303</idno>
<idno type="wicri:doubleKey">1439-4227:2007:Hong H:a:novel:mycolactone</idno>
<idno type="wicri:Area/Main/Merge">009B94</idno>
<idno type="wicri:Area/Main/Curation">009221</idno>
<idno type="wicri:Area/Main/Exploration">009221</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering</title>
<author><name sortKey="Hong, Hui" sort="Hong, Hui" uniqKey="Hong H" first="Hui" last="Hong">Hui Hong</name>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sanger Building, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1QW</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stinear, Tim" sort="Stinear, Tim" uniqKey="Stinear T" first="Tim" last="Stinear">Tim Stinear</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology, Monash University, Wellington Road, Clayton, 3800</wicri:regionArea>
<wicri:noRegion>3800</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Porter, Jessica" sort="Porter, Jessica" uniqKey="Porter J" first="Jessica" last="Porter">Jessica Porter</name>
<affiliation wicri:level="1"><country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Microbiology, Monash University, Wellington Road, Clayton, 3800</wicri:regionArea>
<wicri:noRegion>3800</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Demangel, Caroline" sort="Demangel, Caroline" uniqKey="Demangel C" first="Caroline" last="Demangel">Caroline Demangel</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leadlay, Peter F" sort="Leadlay, Peter F" uniqKey="Leadlay P" first="Peter F." last="Leadlay">Peter F. Leadlay</name>
<affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country>
</affiliation>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Sanger Building, Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1QW</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country wicri:rule="url">Royaume-Uni</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">ChemBioChem</title>
<title level="j" type="alt">CHEMBIOCHEM</title>
<idno type="ISSN">1439-4227</idno>
<idno type="eISSN">1439-7633</idno>
<imprint><biblScope unit="vol">8</biblScope>
<biblScope unit="issue">17</biblScope>
<biblScope unit="page" from="2043">2043</biblScope>
<biblScope unit="page" to="2047">2047</biblScope>
<biblScope unit="page-count">5</biblScope>
<publisher>WILEY‐VCH Verlag</publisher>
<pubPlace>Weinheim</pubPlace>
<date type="published" when="2007-11-23">2007-11-23</date>
</imprint>
<idno type="ISSN">1439-4227</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1439-4227</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aldehyde group</term>
<term>Biosynthetic engineering</term>
<term>Cell extracts</term>
<term>Core lactone</term>
<term>Culture supernatants</term>
<term>Cytochrome</term>
<term>Fish pathogen</term>
<term>Fragment ions</term>
<term>Frog pathogen</term>
<term>Hydroxy group</term>
<term>Immunosuppressive activity</term>
<term>Marinum</term>
<term>Mass analysis</term>
<term>Mycolactone</term>
<term>Mycolactone analogues</term>
<term>Mycolactone variants</term>
<term>Mycolactones</term>
<term>Novel mycolactone</term>
<term>Pathogen</term>
<term>Position equivalent</term>
<term>Side chain</term>
<term>Stinear</term>
<term>Ulcerans</term>
<term>Unreacted mycolactone</term>
<term>Verlag gmbh</term>
<term>Weinheim chembiochem</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Aldehyde group</term>
<term>Biosynthetic engineering</term>
<term>Cell extracts</term>
<term>Core lactone</term>
<term>Culture supernatants</term>
<term>Cytochrome</term>
<term>Fish pathogen</term>
<term>Fragment ions</term>
<term>Frog pathogen</term>
<term>Hydroxy group</term>
<term>Immunosuppressive activity</term>
<term>Marinum</term>
<term>Mass analysis</term>
<term>Mycolactone</term>
<term>Mycolactone analogues</term>
<term>Mycolactone variants</term>
<term>Mycolactones</term>
<term>Novel mycolactone</term>
<term>Pathogen</term>
<term>Position equivalent</term>
<term>Side chain</term>
<term>Stinear</term>
<term>Ulcerans</term>
<term>Unreacted mycolactone</term>
<term>Verlag gmbh</term>
<term>Weinheim chembiochem</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">A novel structural variant of the mycobacterial polyketide toxin mycolactone has been obtained by cloning a P450 hydroxylase gene from a related strain. This technique increases the range of available mycolactones for studies on the mode of action of the toxin.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Royaume-Uni</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Île-de-France</li>
</region>
<settlement><li>Cambridge</li>
<li>Paris</li>
</settlement>
<orgName><li>Université de Cambridge</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hong, Hui" sort="Hong, Hui" uniqKey="Hong H" first="Hui" last="Hong">Hui Hong</name>
</region>
<name sortKey="Leadlay, Peter F" sort="Leadlay, Peter F" uniqKey="Leadlay P" first="Peter F." last="Leadlay">Peter F. Leadlay</name>
<name sortKey="Leadlay, Peter F" sort="Leadlay, Peter F" uniqKey="Leadlay P" first="Peter F." last="Leadlay">Peter F. Leadlay</name>
<name sortKey="Leadlay, Peter F" sort="Leadlay, Peter F" uniqKey="Leadlay P" first="Peter F." last="Leadlay">Peter F. Leadlay</name>
</country>
<country name="Australie"><noRegion><name sortKey="Stinear, Tim" sort="Stinear, Tim" uniqKey="Stinear T" first="Tim" last="Stinear">Tim Stinear</name>
</noRegion>
<name sortKey="Porter, Jessica" sort="Porter, Jessica" uniqKey="Porter J" first="Jessica" last="Porter">Jessica Porter</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Demangel, Caroline" sort="Demangel, Caroline" uniqKey="Demangel C" first="Caroline" last="Demangel">Caroline Demangel</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 009221 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 009221 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:6F4B4D72721C18C07B394654390FF6306070B668
   |texte=   A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

Serveur d'exploration sur les relations entre la France et l'Australie

A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering

A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.