AustralieFrV1, Istex, Curation, bibRecord, 001485

A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering

Identifieur interne : 001485 ( Istex/Curation ); précédent : 001484; suivant : 001486

A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering

Auteurs : Hui Hong [Royaume-Uni] ; Tim Stinear [Australie] ; Jessica Porter [Australie] ; Caroline Demangel [France] ; Peter F. Leadlay [Royaume-Uni]

Source :

ChemBioChem [ 1439-4227 ] ; 2007-11-23.

RBID : ISTEX:6F4B4D72721C18C07B394654390FF6306070B668

English descriptors

Abstract

A novel structural variant of the mycobacterial polyketide toxin mycolactone has been obtained by cloning a P450 hydroxylase gene from a related strain. This technique increases the range of available mycolactones for studies on the mode of action of the toxin.

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https://api.istex.fr/document/6F4B4D72721C18C07B394654390FF6306070B668/fulltext/pdf

DOI: 10.1002/cbic.200700411

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Le document en format XML

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<term>Culture supernatants</term>
<term>Cytochrome</term>
<term>Fish pathogen</term>
<term>Fragment ions</term>
<term>Frog pathogen</term>
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<term>Ulcerans</term>
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<front><div type="abstract">A novel structural variant of the mycobacterial polyketide toxin mycolactone has been obtained by cloning a P450 hydroxylase gene from a related strain. This technique increases the range of available mycolactones for studies on the mode of action of the toxin.</div>
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A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering

A Novel Mycolactone Toxin Obtained by Biosynthetic Engineering

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English descriptors

Abstract

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Links to Exploration step

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