Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules
Identifieur interne : 006491 ( Main/Exploration ); précédent : 006490; suivant : 006492Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules
Auteurs : Melissa K. M. Leung [Australie] ; Georgina K. Such [Australie] ; Angus P. R. Johnston [Australie] ; Dhee P. Biswas [Australie] ; Zhiyuan Zhu [Australie] ; Yan Yan [Australie] ; Jean-François Lutz [Allemagne, France] ; Frank Caruso [Australie]Source :
- Small [ 1613-6810 ] ; 2011-04-18.
Descripteurs français
- Wicri :
- topic : Polymère.
English descriptors
- KwdEn :
- Adsorption, Alkyne, Assembly conditions, Atom transfer, Bilayers, Bisazide, Bisazide linker, Buildup, Capsule, Capsule population, Caruso, Ch2o, Chem, Click, Click chemistry, Column chromatography, Copper sulfate, Core dissolution, Crosslinked, Crosslinked capsules, Crude product, Cytometry, Deconstruction, Degradation, Drug delivery, Frequency change, Full papers, Glycol, Gmbh, Human serum, Infrared imaging, Kgaa, Lcst, Leung, Linker, Lutz, Macromolecule, Methacrylate, Mmol, Multilayer, Multilayer assembly, Multilayer films, Multilayers, Naoac, Nonlinear, Organic phase, Pegalk, Pegalk layers, Planar, Polym, Polymer, Pvpon, Room temperature, Scale bars, Silica particles, Sodium ascorbate, Thermoresponsive, Thermoresponsive behavior, Thrombus, Triethylene glycol, Uorescence, Uorescence intensity, Uorescence microscopy, Verlag, Verlag gmbh, Weinheim.
- Teeft :
- Adsorption, Alkyne, Assembly conditions, Atom transfer, Bilayers, Bisazide, Bisazide linker, Buildup, Capsule, Capsule population, Caruso, Ch2o, Chem, Click, Click chemistry, Column chromatography, Copper sulfate, Core dissolution, Crosslinked, Crosslinked capsules, Crude product, Cytometry, Deconstruction, Degradation, Drug delivery, Frequency change, Full papers, Glycol, Gmbh, Human serum, Infrared imaging, Kgaa, Lcst, Leung, Linker, Lutz, Macromolecule, Methacrylate, Mmol, Multilayer, Multilayer assembly, Multilayer films, Multilayers, Naoac, Nonlinear, Organic phase, Pegalk, Pegalk layers, Planar, Polym, Polymer, Pvpon, Room temperature, Scale bars, Silica particles, Sodium ascorbate, Thermoresponsive, Thermoresponsive behavior, Thrombus, Triethylene glycol, Uorescence, Uorescence intensity, Uorescence microscopy, Verlag, Verlag gmbh, Weinheim.
Abstract
Nano‐/micrometer‐scaled films and capsules made of low‐fouling materials such as poly(ethylene glycol) (PEG) are of interest for drug delivery and tissue engineering applications. Herein, the assembly and degradation of low‐fouling, alkyne‐functionalized PEG (PEGAlk) multilayer films and capsules, which are prepared by combining layer‐by‐layer (LbL) assembly and click chemistry, are reported. A nonlinear, temperature‐responsive PEGAlk is synthesized, and is then used to form hydrogen‐bonded multilayers with poly(methacrylic acid) (PMA) at pH 5. The thermoresponsive behavior of PEGAlk is exploited to tailor film buildup by adjusting the assembly conditions. Using alkyne–azide click chemistry, PEGAlk/PMA multilayers are crosslinked with a bisazide linker that contains a disulfide bond, rendering these films and capsules redox‐responsive. At pH 7, by disrupting the hydrogen bonding between the polymers, PEGAlk LbL films and PEGAlk‐based capsules are obtained. These films exhibit specific deconstruction properties under simulated intracellular reducing conditions, but remain stable at physiological pH, suggesting potential applications in controlled drug release. The low‐fouling properties of the PEG films are confirmed by incubation with human serum and a blood clot. Additionally, these capsules showed negligible toxicity to human cells.
Url:
DOI: 10.1002/smll.201002258
Affiliations:
- Allemagne, Australie, France
- Brandebourg, Victoria (État)
- Melbourne, Potsdam
- Université de Melbourne
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Johnston</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Biswas, Dhee P" sort="Biswas, Dhee P" uniqKey="Biswas D" first="Dhee P." last="Biswas">Dhee P. Biswas</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Zhu, Zhiyuan" sort="Zhu, Zhiyuan" uniqKey="Zhu Z" first="Zhiyuan" last="Zhu">Zhiyuan Zhu</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Yan, Yan" sort="Yan, Yan" uniqKey="Yan Y" first="Yan" last="Yan">Yan Yan</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Lutz, Jean Rancois" sort="Lutz, Jean Rancois" uniqKey="Lutz J" first="Jean-François" last="Lutz">Jean-François Lutz</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Research Group Nanotechnology for Life Science, Fraunhofer Institute for Applied Polymer Research, Geiselbergstrasse 69, Potsdam 14476</wicri:regionArea><placeName><region type="land" nuts="2">Brandebourg</region><settlement type="city">Potsdam</settlement></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Current Address: Present address: Precision Macromolecular Chemistry Group, Institut Charles Sadron, UPR22‐CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2</wicri:regionArea><wicri:noRegion>67034 Strasbourg Cedex 2</wicri:noRegion><wicri:noRegion>67034 Strasbourg Cedex 2</wicri:noRegion></affiliation></author><author><name sortKey="Caruso, Frank" sort="Caruso, Frank" uniqKey="Caruso F" first="Frank" last="Caruso">Frank Caruso</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Australie</country></affiliation><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Correspondence address: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Small</title><title level="j" type="alt">SMALL</title><idno type="ISSN">1613-6810</idno><idno type="eISSN">1613-6829</idno><imprint><biblScope unit="vol">7</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1075">1075</biblScope><biblScope unit="page" to="1085">1085</biblScope><biblScope unit="page-count">11</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2011-04-18">2011-04-18</date></imprint><idno type="ISSN">1613-6810</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1613-6810</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adsorption</term><term>Alkyne</term><term>Assembly conditions</term><term>Atom transfer</term><term>Bilayers</term><term>Bisazide</term><term>Bisazide linker</term><term>Buildup</term><term>Capsule</term><term>Capsule population</term><term>Caruso</term><term>Ch2o</term><term>Chem</term><term>Click</term><term>Click chemistry</term><term>Column chromatography</term><term>Copper sulfate</term><term>Core dissolution</term><term>Crosslinked</term><term>Crosslinked capsules</term><term>Crude product</term><term>Cytometry</term><term>Deconstruction</term><term>Degradation</term><term>Drug delivery</term><term>Frequency change</term><term>Full papers</term><term>Glycol</term><term>Gmbh</term><term>Human serum</term><term>Infrared imaging</term><term>Kgaa</term><term>Lcst</term><term>Leung</term><term>Linker</term><term>Lutz</term><term>Macromolecule</term><term>Methacrylate</term><term>Mmol</term><term>Multilayer</term><term>Multilayer assembly</term><term>Multilayer films</term><term>Multilayers</term><term>Naoac</term><term>Nonlinear</term><term>Organic phase</term><term>Pegalk</term><term>Pegalk layers</term><term>Planar</term><term>Polym</term><term>Polymer</term><term>Pvpon</term><term>Room temperature</term><term>Scale bars</term><term>Silica particles</term><term>Sodium ascorbate</term><term>Thermoresponsive</term><term>Thermoresponsive behavior</term><term>Thrombus</term><term>Triethylene glycol</term><term>Uorescence</term><term>Uorescence intensity</term><term>Uorescence microscopy</term><term>Verlag</term><term>Verlag gmbh</term><term>Weinheim</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adsorption</term><term>Alkyne</term><term>Assembly conditions</term><term>Atom transfer</term><term>Bilayers</term><term>Bisazide</term><term>Bisazide linker</term><term>Buildup</term><term>Capsule</term><term>Capsule population</term><term>Caruso</term><term>Ch2o</term><term>Chem</term><term>Click</term><term>Click chemistry</term><term>Column chromatography</term><term>Copper sulfate</term><term>Core dissolution</term><term>Crosslinked</term><term>Crosslinked capsules</term><term>Crude product</term><term>Cytometry</term><term>Deconstruction</term><term>Degradation</term><term>Drug delivery</term><term>Frequency change</term><term>Full papers</term><term>Glycol</term><term>Gmbh</term><term>Human serum</term><term>Infrared imaging</term><term>Kgaa</term><term>Lcst</term><term>Leung</term><term>Linker</term><term>Lutz</term><term>Macromolecule</term><term>Methacrylate</term><term>Mmol</term><term>Multilayer</term><term>Multilayer assembly</term><term>Multilayer films</term><term>Multilayers</term><term>Naoac</term><term>Nonlinear</term><term>Organic phase</term><term>Pegalk</term><term>Pegalk layers</term><term>Planar</term><term>Polym</term><term>Polymer</term><term>Pvpon</term><term>Room temperature</term><term>Scale bars</term><term>Silica particles</term><term>Sodium ascorbate</term><term>Thermoresponsive</term><term>Thermoresponsive behavior</term><term>Thrombus</term><term>Triethylene glycol</term><term>Uorescence</term><term>Uorescence intensity</term><term>Uorescence microscopy</term><term>Verlag</term><term>Verlag gmbh</term><term>Weinheim</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Polymère</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nano‐/micrometer‐scaled films and capsules made of low‐fouling materials such as poly(ethylene glycol) (PEG) are of interest for drug delivery and tissue engineering applications. Herein, the assembly and degradation of low‐fouling, alkyne‐functionalized PEG (PEGAlk) multilayer films and capsules, which are prepared by combining layer‐by‐layer (LbL) assembly and click chemistry, are reported. A nonlinear, temperature‐responsive PEGAlk is synthesized, and is then used to form hydrogen‐bonded multilayers with poly(methacrylic acid) (PMA) at pH 5. The thermoresponsive behavior of PEGAlk is exploited to tailor film buildup by adjusting the assembly conditions. Using alkyne–azide click chemistry, PEGAlk/PMA multilayers are crosslinked with a bisazide linker that contains a disulfide bond, rendering these films and capsules redox‐responsive. At pH 7, by disrupting the hydrogen bonding between the polymers, PEGAlk LbL films and PEGAlk‐based capsules are obtained. These films exhibit specific deconstruction properties under simulated intracellular reducing conditions, but remain stable at physiological pH, suggesting potential applications in controlled drug release. The low‐fouling properties of the PEG films are confirmed by incubation with human serum and a blood clot. Additionally, these capsules showed negligible toxicity to human cells.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li></country><region><li>Brandebourg</li><li>Victoria (État)</li></region><settlement><li>Melbourne</li><li>Potsdam</li></settlement><orgName><li>Université de Melbourne</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Leung, Melissa K M" sort="Leung, Melissa K M" uniqKey="Leung M" first="Melissa K. M." last="Leung">Melissa K. M. Leung</name></region><name sortKey="Biswas, Dhee P" sort="Biswas, Dhee P" uniqKey="Biswas D" first="Dhee P." last="Biswas">Dhee P. Biswas</name><name sortKey="Caruso, Frank" sort="Caruso, Frank" uniqKey="Caruso F" first="Frank" last="Caruso">Frank Caruso</name><name sortKey="Caruso, Frank" sort="Caruso, Frank" uniqKey="Caruso F" first="Frank" last="Caruso">Frank Caruso</name><name sortKey="Caruso, Frank" sort="Caruso, Frank" uniqKey="Caruso F" first="Frank" last="Caruso">Frank Caruso</name><name sortKey="Johnston, Angus P R" sort="Johnston, Angus P R" uniqKey="Johnston A" first="Angus P. R." last="Johnston">Angus P. R. Johnston</name><name sortKey="Such, Georgina K" sort="Such, Georgina K" uniqKey="Such G" first="Georgina K." last="Such">Georgina K. Such</name><name sortKey="Yan, Yan" sort="Yan, Yan" uniqKey="Yan Y" first="Yan" last="Yan">Yan Yan</name><name sortKey="Zhu, Zhiyuan" sort="Zhu, Zhiyuan" uniqKey="Zhu Z" first="Zhiyuan" last="Zhu">Zhiyuan Zhu</name></country><country name="Allemagne"><region name="Brandebourg"><name sortKey="Lutz, Jean Rancois" sort="Lutz, Jean Rancois" uniqKey="Lutz J" first="Jean-François" last="Lutz">Jean-François Lutz</name></region></country><country name="France"><noRegion><name sortKey="Lutz, Jean Rancois" sort="Lutz, Jean Rancois" uniqKey="Lutz J" first="Jean-François" last="Lutz">Jean-François Lutz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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