Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules
Identifieur interne : 001B09 ( Istex/Corpus ); précédent : 001B08; suivant : 001B10Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules
Auteurs : Melissa K. M. Leung ; Georgina K. Such ; Angus P. R. Johnston ; Dhee P. Biswas ; Zhiyuan Zhu ; Yan Yan ; Jean-François Lutz ; Frank CarusoSource :
- Small [ 1613-6810 ] ; 2011-04-18.
English descriptors
- KwdEn :
- Adsorption, Alkyne, Assembly conditions, Atom transfer, Bilayers, Bisazide, Bisazide linker, Buildup, Capsule, Capsule population, Caruso, Ch2o, Chem, Click, Click chemistry, Column chromatography, Copper sulfate, Core dissolution, Crosslinked, Crosslinked capsules, Crude product, Cytometry, Deconstruction, Degradation, Drug delivery, Frequency change, Full papers, Glycol, Gmbh, Human serum, Infrared imaging, Kgaa, Lcst, Leung, Linker, Lutz, Macromolecule, Methacrylate, Mmol, Multilayer, Multilayer assembly, Multilayer films, Multilayers, Naoac, Nonlinear, Organic phase, Pegalk, Pegalk layers, Planar, Polym, Polymer, Pvpon, Room temperature, Scale bars, Silica particles, Sodium ascorbate, Thermoresponsive, Thermoresponsive behavior, Thrombus, Triethylene glycol, Uorescence, Uorescence intensity, Uorescence microscopy, Verlag, Verlag gmbh, Weinheim.
- Teeft :
- Adsorption, Alkyne, Assembly conditions, Atom transfer, Bilayers, Bisazide, Bisazide linker, Buildup, Capsule, Capsule population, Caruso, Ch2o, Chem, Click, Click chemistry, Column chromatography, Copper sulfate, Core dissolution, Crosslinked, Crosslinked capsules, Crude product, Cytometry, Deconstruction, Degradation, Drug delivery, Frequency change, Full papers, Glycol, Gmbh, Human serum, Infrared imaging, Kgaa, Lcst, Leung, Linker, Lutz, Macromolecule, Methacrylate, Mmol, Multilayer, Multilayer assembly, Multilayer films, Multilayers, Naoac, Nonlinear, Organic phase, Pegalk, Pegalk layers, Planar, Polym, Polymer, Pvpon, Room temperature, Scale bars, Silica particles, Sodium ascorbate, Thermoresponsive, Thermoresponsive behavior, Thrombus, Triethylene glycol, Uorescence, Uorescence intensity, Uorescence microscopy, Verlag, Verlag gmbh, Weinheim.
Abstract
Nano‐/micrometer‐scaled films and capsules made of low‐fouling materials such as poly(ethylene glycol) (PEG) are of interest for drug delivery and tissue engineering applications. Herein, the assembly and degradation of low‐fouling, alkyne‐functionalized PEG (PEGAlk) multilayer films and capsules, which are prepared by combining layer‐by‐layer (LbL) assembly and click chemistry, are reported. A nonlinear, temperature‐responsive PEGAlk is synthesized, and is then used to form hydrogen‐bonded multilayers with poly(methacrylic acid) (PMA) at pH 5. The thermoresponsive behavior of PEGAlk is exploited to tailor film buildup by adjusting the assembly conditions. Using alkyne–azide click chemistry, PEGAlk/PMA multilayers are crosslinked with a bisazide linker that contains a disulfide bond, rendering these films and capsules redox‐responsive. At pH 7, by disrupting the hydrogen bonding between the polymers, PEGAlk LbL films and PEGAlk‐based capsules are obtained. These films exhibit specific deconstruction properties under simulated intracellular reducing conditions, but remain stable at physiological pH, suggesting potential applications in controlled drug release. The low‐fouling properties of the PEG films are confirmed by incubation with human serum and a blood clot. Additionally, these capsules showed negligible toxicity to human cells.
Url:
DOI: 10.1002/smll.201002258
Links to Exploration step
ISTEX:8F8C8E132096B09EBB125ED03C5906F39914115DLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules</title><author><name sortKey="Leung, Melissa K M" sort="Leung, Melissa K M" uniqKey="Leung M" first="Melissa K. M." last="Leung">Melissa K. M. Leung</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation></author><author><name sortKey="Such, Georgina K" sort="Such, Georgina K" uniqKey="Such G" first="Georgina K." last="Such">Georgina K. Such</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation></author><author><name sortKey="Johnston, Angus P R" sort="Johnston, Angus P R" uniqKey="Johnston A" first="Angus P. R." last="Johnston">Angus P. R. Johnston</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation></author><author><name sortKey="Biswas, Dhee P" sort="Biswas, Dhee P" uniqKey="Biswas D" first="Dhee P." last="Biswas">Dhee P. Biswas</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation></author><author><name sortKey="Zhu, Zhiyuan" sort="Zhu, Zhiyuan" uniqKey="Zhu Z" first="Zhiyuan" last="Zhu">Zhiyuan Zhu</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation></author><author><name sortKey="Yan, Yan" sort="Yan, Yan" uniqKey="Yan Y" first="Yan" last="Yan">Yan Yan</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation></author><author><name sortKey="Lutz, Jean Rancois" sort="Lutz, Jean Rancois" uniqKey="Lutz J" first="Jean-François" last="Lutz">Jean-François Lutz</name><affiliation><mods:affiliation>Research Group Nanotechnology for Life Science, Fraunhofer Institute for Applied Polymer Research, Geiselbergstrasse 69, Potsdam 14476, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Current Address: Present address: Precision Macromolecular Chemistry Group, Institut Charles Sadron, UPR22‐CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2, France</mods:affiliation></affiliation></author><author><name sortKey="Caruso, Frank" sort="Caruso, Frank" uniqKey="Caruso F" first="Frank" last="Caruso">Frank Caruso</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: fcaruso@unimelb.edu.au</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia.</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8F8C8E132096B09EBB125ED03C5906F39914115D</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/smll.201002258</idno><idno type="url">https://api.istex.fr/document/8F8C8E132096B09EBB125ED03C5906F39914115D/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001B09</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001B09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules</title><author><name sortKey="Leung, Melissa K M" sort="Leung, Melissa K M" uniqKey="Leung M" first="Melissa K. M." last="Leung">Melissa K. M. Leung</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation></author><author><name sortKey="Such, Georgina K" sort="Such, Georgina K" uniqKey="Such G" first="Georgina K." last="Such">Georgina K. Such</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation></author><author><name sortKey="Johnston, Angus P R" sort="Johnston, Angus P R" uniqKey="Johnston A" first="Angus P. R." last="Johnston">Angus P. R. Johnston</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation></author><author><name sortKey="Biswas, Dhee P" sort="Biswas, Dhee P" uniqKey="Biswas D" first="Dhee P." last="Biswas">Dhee P. Biswas</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation></author><author><name sortKey="Zhu, Zhiyuan" sort="Zhu, Zhiyuan" uniqKey="Zhu Z" first="Zhiyuan" last="Zhu">Zhiyuan Zhu</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation></author><author><name sortKey="Yan, Yan" sort="Yan, Yan" uniqKey="Yan Y" first="Yan" last="Yan">Yan Yan</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation></author><author><name sortKey="Lutz, Jean Rancois" sort="Lutz, Jean Rancois" uniqKey="Lutz J" first="Jean-François" last="Lutz">Jean-François Lutz</name><affiliation><mods:affiliation>Research Group Nanotechnology for Life Science, Fraunhofer Institute for Applied Polymer Research, Geiselbergstrasse 69, Potsdam 14476, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Current Address: Present address: Precision Macromolecular Chemistry Group, Institut Charles Sadron, UPR22‐CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2, France</mods:affiliation></affiliation></author><author><name sortKey="Caruso, Frank" sort="Caruso, Frank" uniqKey="Caruso F" first="Frank" last="Caruso">Frank Caruso</name><affiliation><mods:affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: fcaruso@unimelb.edu.au</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Small</title><title level="j" type="alt">SMALL</title><idno type="ISSN">1613-6810</idno><idno type="eISSN">1613-6829</idno><imprint><biblScope unit="vol">7</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1075">1075</biblScope><biblScope unit="page" to="1085">1085</biblScope><biblScope unit="page-count">11</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2011-04-18">2011-04-18</date></imprint><idno type="ISSN">1613-6810</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1613-6810</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adsorption</term><term>Alkyne</term><term>Assembly conditions</term><term>Atom transfer</term><term>Bilayers</term><term>Bisazide</term><term>Bisazide linker</term><term>Buildup</term><term>Capsule</term><term>Capsule population</term><term>Caruso</term><term>Ch2o</term><term>Chem</term><term>Click</term><term>Click chemistry</term><term>Column chromatography</term><term>Copper sulfate</term><term>Core dissolution</term><term>Crosslinked</term><term>Crosslinked capsules</term><term>Crude product</term><term>Cytometry</term><term>Deconstruction</term><term>Degradation</term><term>Drug delivery</term><term>Frequency change</term><term>Full papers</term><term>Glycol</term><term>Gmbh</term><term>Human serum</term><term>Infrared imaging</term><term>Kgaa</term><term>Lcst</term><term>Leung</term><term>Linker</term><term>Lutz</term><term>Macromolecule</term><term>Methacrylate</term><term>Mmol</term><term>Multilayer</term><term>Multilayer assembly</term><term>Multilayer films</term><term>Multilayers</term><term>Naoac</term><term>Nonlinear</term><term>Organic phase</term><term>Pegalk</term><term>Pegalk layers</term><term>Planar</term><term>Polym</term><term>Polymer</term><term>Pvpon</term><term>Room temperature</term><term>Scale bars</term><term>Silica particles</term><term>Sodium ascorbate</term><term>Thermoresponsive</term><term>Thermoresponsive behavior</term><term>Thrombus</term><term>Triethylene glycol</term><term>Uorescence</term><term>Uorescence intensity</term><term>Uorescence microscopy</term><term>Verlag</term><term>Verlag gmbh</term><term>Weinheim</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Adsorption</term><term>Alkyne</term><term>Assembly conditions</term><term>Atom transfer</term><term>Bilayers</term><term>Bisazide</term><term>Bisazide linker</term><term>Buildup</term><term>Capsule</term><term>Capsule population</term><term>Caruso</term><term>Ch2o</term><term>Chem</term><term>Click</term><term>Click chemistry</term><term>Column chromatography</term><term>Copper sulfate</term><term>Core dissolution</term><term>Crosslinked</term><term>Crosslinked capsules</term><term>Crude product</term><term>Cytometry</term><term>Deconstruction</term><term>Degradation</term><term>Drug delivery</term><term>Frequency change</term><term>Full papers</term><term>Glycol</term><term>Gmbh</term><term>Human serum</term><term>Infrared imaging</term><term>Kgaa</term><term>Lcst</term><term>Leung</term><term>Linker</term><term>Lutz</term><term>Macromolecule</term><term>Methacrylate</term><term>Mmol</term><term>Multilayer</term><term>Multilayer assembly</term><term>Multilayer films</term><term>Multilayers</term><term>Naoac</term><term>Nonlinear</term><term>Organic phase</term><term>Pegalk</term><term>Pegalk layers</term><term>Planar</term><term>Polym</term><term>Polymer</term><term>Pvpon</term><term>Room temperature</term><term>Scale bars</term><term>Silica particles</term><term>Sodium ascorbate</term><term>Thermoresponsive</term><term>Thermoresponsive behavior</term><term>Thrombus</term><term>Triethylene glycol</term><term>Uorescence</term><term>Uorescence intensity</term><term>Uorescence microscopy</term><term>Verlag</term><term>Verlag gmbh</term><term>Weinheim</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nano‐/micrometer‐scaled films and capsules made of low‐fouling materials such as poly(ethylene glycol) (PEG) are of interest for drug delivery and tissue engineering applications. Herein, the assembly and degradation of low‐fouling, alkyne‐functionalized PEG (PEGAlk) multilayer films and capsules, which are prepared by combining layer‐by‐layer (LbL) assembly and click chemistry, are reported. A nonlinear, temperature‐responsive PEGAlk is synthesized, and is then used to form hydrogen‐bonded multilayers with poly(methacrylic acid) (PMA) at pH 5. The thermoresponsive behavior of PEGAlk is exploited to tailor film buildup by adjusting the assembly conditions. Using alkyne–azide click chemistry, PEGAlk/PMA multilayers are crosslinked with a bisazide linker that contains a disulfide bond, rendering these films and capsules redox‐responsive. At pH 7, by disrupting the hydrogen bonding between the polymers, PEGAlk LbL films and PEGAlk‐based capsules are obtained. These films exhibit specific deconstruction properties under simulated intracellular reducing conditions, but remain stable at physiological pH, suggesting potential applications in controlled drug release. The low‐fouling properties of the PEG films are confirmed by incubation with human serum and a blood clot. Additionally, these capsules showed negligible toxicity to human cells.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>pegalk</json:string><json:string>naoac</json:string><json:string>multilayer</json:string><json:string>multilayers</json:string><json:string>uorescence</json:string><json:string>crosslinked</json:string><json:string>ch2o</json:string><json:string>thrombus</json:string><json:string>mmol</json:string><json:string>bisazide</json:string><json:string>polymer</json:string><json:string>chem</json:string><json:string>gmbh</json:string><json:string>linker</json:string><json:string>adsorption</json:string><json:string>click chemistry</json:string><json:string>bisazide linker</json:string><json:string>alkyne</json:string><json:string>verlag</json:string><json:string>verlag gmbh</json:string><json:string>kgaa</json:string><json:string>weinheim</json:string><json:string>macromolecule</json:string><json:string>pvpon</json:string><json:string>lutz</json:string><json:string>nonlinear</json:string><json:string>capsule</json:string><json:string>uorescence intensity</json:string><json:string>lcst</json:string><json:string>frequency change</json:string><json:string>polym</json:string><json:string>leung</json:string><json:string>room temperature</json:string><json:string>thermoresponsive</json:string><json:string>bilayers</json:string><json:string>deconstruction</json:string><json:string>cytometry</json:string><json:string>silica particles</json:string><json:string>multilayer films</json:string><json:string>copper sulfate</json:string><json:string>sodium ascorbate</json:string><json:string>crosslinked capsules</json:string><json:string>human serum</json:string><json:string>full papers</json:string><json:string>degradation</json:string><json:string>caruso</json:string><json:string>methacrylate</json:string><json:string>drug delivery</json:string><json:string>multilayer assembly</json:string><json:string>click</json:string><json:string>glycol</json:string><json:string>triethylene glycol</json:string><json:string>scale bars</json:string><json:string>infrared imaging</json:string><json:string>thermoresponsive behavior</json:string><json:string>atom transfer</json:string><json:string>assembly conditions</json:string><json:string>crude product</json:string><json:string>column chromatography</json:string><json:string>uorescence microscopy</json:string><json:string>organic phase</json:string><json:string>pegalk layers</json:string><json:string>capsule population</json:string><json:string>core dissolution</json:string><json:string>planar</json:string><json:string>buildup</json:string></teeft></keywords><author><json:item><name>Melissa K. M. Leung</name><affiliations><json:string>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</json:string></affiliations></json:item><json:item><name>Georgina K. Such</name><affiliations><json:string>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</json:string></affiliations></json:item><json:item><name>Angus P. R. Johnston</name><affiliations><json:string>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</json:string></affiliations></json:item><json:item><name>Dhee P. Biswas</name><affiliations><json:string>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</json:string></affiliations></json:item><json:item><name>Zhiyuan Zhu</name><affiliations><json:string>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</json:string></affiliations></json:item><json:item><name>Yan Yan</name><affiliations><json:string>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</json:string></affiliations></json:item><json:item><name>Jean‐François Lutz</name><affiliations><json:string>Research Group Nanotechnology for Life Science, Fraunhofer Institute for Applied Polymer Research, Geiselbergstrasse 69, Potsdam 14476, Germany</json:string><json:string>Current Address: Present address: Precision Macromolecular Chemistry Group, Institut Charles Sadron, UPR22‐CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2, France</json:string></affiliations></json:item><json:item><name>Frank Caruso</name><affiliations><json:string>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</json:string><json:string>E-mail: fcaruso@unimelb.edu.au</json:string><json:string>Correspondence address: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>poly(ethylene glycol)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>polymeric materials</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>drug delivery</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>click chemistry</value></json:item></subject><articleId><json:string>SMLL201002258</json:string></articleId><arkIstex>ark:/67375/WNG-FX3NZWW6-Q</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Nano‐/micrometer‐scaled films and capsules made of low‐fouling materials such as poly(ethylene glycol) (PEG) are of interest for drug delivery and tissue engineering applications. Herein, the assembly and degradation of low‐fouling, alkyne‐functionalized PEG (PEGAlk) multilayer films and capsules, which are prepared by combining layer‐by‐layer (LbL) assembly and click chemistry, are reported. A nonlinear, temperature‐responsive PEGAlk is synthesized, and is then used to form hydrogen‐bonded multilayers with poly(methacrylic acid) (PMA) at pH 5. The thermoresponsive behavior of PEGAlk is exploited to tailor film buildup by adjusting the assembly conditions. Using alkyne–azide click chemistry, PEGAlk/PMA multilayers are crosslinked with a bisazide linker that contains a disulfide bond, rendering these films and capsules redox‐responsive. At pH 7, by disrupting the hydrogen bonding between the polymers, PEGAlk LbL films and PEGAlk‐based capsules are obtained. These films exhibit specific deconstruction properties under simulated intracellular reducing conditions, but remain stable at physiological pH, suggesting potential applications in controlled drug release. The low‐fouling properties of the PEG films are confirmed by incubation with human serum and a blood clot. Additionally, these capsules showed negligible toxicity to human cells.</abstract><qualityIndicators><score>9.16</score><pdfWordCount>7776</pdfWordCount><pdfCharCount>48291</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>11</pdfPageCount><pdfPageSize>595.276 x 793.701 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>180</abstractWordCount><abstractCharCount>1356</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules</title><pmid><json:string>21425467</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Small</title><language><json:string>unknown</json:string></language><doi><json:string>10.1002/(ISSN)1613-6829</json:string></doi><issn><json:string>1613-6810</json:string></issn><eissn><json:string>1613-6829</json:string></eissn><publisherId><json:string>SMLL</json:string></publisherId><volume>7</volume><issue>8</issue><pages><first>1075</first><last>1085</last><total>11</total></pages><genre><json:string>journal</json:string></genre><subject><json:item><value>Full Paper</value></json:item></subject></host><namedEntities><unitex><date><json:string>2011</json:string><json:string>1084</json:string><json:string>1080</json:string></date><geogName></geogName><orgName><json:string>Siemens Healthcare Diagnostics</json:string><json:string>Biomolecular Engineering The University</json:string><json:string>Research Group Nanotechnology for Life Science Fraunhofer Institute for Applied Polymer Research Geiselbergstrasse</json:string><json:string>Fraunhofer Institute for Applied Polymer Research</json:string><json:string>United States Food and Drug</json:string><json:string>Diabetes Institute, Melbourne</json:string><json:string>France DOI</json:string><json:string>University of Melbourne</json:string><json:string>JPK Instruments, Berlin, Germany</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>Studies</json:string><json:string>Q. Li</json:string><json:string>C. T. Schwall</json:string><json:string>H. Mohwald</json:string><json:string>M. W. M. Fijten</json:string><json:string>H. Moehwald</json:string><json:string>V. Torchilin</json:string><json:string>O. Akdemir</json:string><json:string>L. Chi</json:string><json:string>Zoya Zarafshani</json:string><json:string>H. S. Yoo</json:string><json:string>K. Matyjaszewski</json:string><json:string>B. J. Bauer</json:string><json:string>R. Nassimbene</json:string><json:string>R. Cartier</json:string><json:string>J. Mater</json:string><json:string>R. B. Chess</json:string><json:string>E. Donath</json:string><json:string>S. Granick</json:string><json:string>G. Barratt</json:string><json:string>W. B. Stockton</json:string><json:string>H. P. Yap</json:string><json:string>J. Cheng</json:string><json:string>C. Cortez</json:string><json:string>M. Rovira-Bru</json:string><json:string>K. B. Sharpless</json:string><json:string>T. Ishizone</json:string><json:string>D. M. Haddleton</json:string><json:string>J. Sung</json:string><json:string>H. E. Canavan</json:string><json:string>L. Bes</json:string><json:string>K. Peter</json:string><json:string>W. Potman</json:string><json:string>Frank Caruso</json:string><json:string>C. J. Ochs</json:string><json:string>S. A. Sukhishvili</json:string><json:string>C. R. Becer</json:string><json:string>S. Garnier</json:string><json:string>E. S. Gil</json:string><json:string>C. Duschl</json:string><json:string>R. C. Hedden</json:string><json:string>M. F. Rubner</json:string><json:string>B. Zhao</json:string><json:string>J. Phys</json:string><json:string>H. M. L. Thijs</json:string><json:string>G. Antequera-Garcia</json:string><json:string>J. F. Quinn</json:string><json:string>L. Barner</json:string><json:string>K. Skrabania</json:string><json:string>T. G. Park</json:string><json:string>W. J. Parak</json:string><json:string>S. M. Hudson</json:string><json:string>C. Alexander</json:string><json:string>X. Cheng</json:string><json:string>G. Decher</json:string><json:string>S. Hahn</json:string><json:string>E. Millard</json:string><json:string>U. Pison</json:string><json:string>A. Z. Abbasi</json:string><json:string>E. Wischerhoff</json:string><json:string>G. B. Sukhorukov</json:string><json:string>A. Limer</json:string><json:string>G. Luther</json:string><json:string>M. M. Ali</json:string><json:string>C. H. Alarcón</json:string><json:string>B. D. Ratner</json:string><json:string>C. Menager</json:string><json:string>K. D. Lee</json:string><json:string>I. Sheri</json:string><json:string>J. Storsberg</json:string><json:string>F. Lutz</json:string><json:string>M. K. Ko</json:string><json:string>M. T. Peracchia</json:string><json:string>H. D. W. Roesink</json:string><json:string>P. R. Johnston</json:string><json:string>C. Gergely</json:string><json:string>J. A. Swanson</json:string><json:string>I. A. Banerjee</json:string><json:string>P. Lavalle</json:string><json:string>X. Zhang</json:string><json:string>P. Biswas</json:string><json:string>S. Angot</json:string><json:string>M. Marquez</json:string><json:string>M. K. M. Leung</json:string><json:string>P. Legrand</json:string><json:string>E. Tjipto</json:string><json:string>S. Agarwal</json:string><json:string>U. S. Schubert</json:string><json:string>H. Reiss</json:string><json:string>M. H. Stenzel</json:string><json:string>S. A. Davis</json:string><json:string>B. Radt</json:string><json:string>R. Gref</json:string><json:string>A. Gulik</json:string><json:string>A. Postma</json:string><json:string>G. Saito</json:string><json:string>J. C. Voegel</json:string><json:string>S. Gryc</json:string><json:string>E. Tomaskovic-Crook</json:string><json:string>C. Sönnichsen</json:string><json:string>Y. Minamitake</json:string><json:string>C. A. Smolders</json:string><json:string>R. A. Caruso</json:string><json:string>J. M. Harris</json:string><json:string>H. Fuchs</json:string><json:string>C. Wilhelm</json:string><json:string>A. Lankenau</json:string><json:string>Charles Sadron</json:string><json:string>P. Schaaf</json:string><json:string>M. A. M. Beerlage</json:string><json:string>B. A. Teply</json:string><json:string>S. Martina</json:string><json:string>H. G. Börner</json:string><json:string>A. H. E. Mueller</json:string><json:string>O. Bourdon</json:string><json:string>C. E. Hagemeyer</json:string><json:string>C. R. Kinnane</json:string><json:string>B. Städler</json:string><json:string>H. Bianco-Peled</json:string><json:string>G. Sauerbrey</json:string><json:string>S. Yamamoto</json:string><json:string>L. M. Liz-Marzan</json:string><json:string>L. Kaufner</json:string><json:string>C. Ganas</json:string><json:string>H. D. H. Stoever</json:string><json:string>B. Senger</json:string><json:string>J. Membr</json:string><json:string>K. Weichenhan</json:string><json:string>D. J. Graham</json:string><json:string>H. Lomas</json:string><json:string>P. Marko</json:string><json:string>Y. Cohen</json:string><json:string>H. C. Kolb</json:string><json:string>V. Nicolas</json:string><json:string>T. Cai</json:string><json:string>M. Titirici</json:string><json:string>A. P. R. Johnston</json:string><json:string>J. K. Heath</json:string><json:string>R. A. Petros</json:string><json:string>T. P. Davis</json:string><json:string>E. S. Read</json:string><json:string>T. Farhan</json:string><json:string>K. Uhlig</json:string><json:string>J. M. DeSimone</json:string><json:string>L. L. Mercato</json:string><json:string>R. A. Evans</json:string><json:string>C. Rudolph</json:string><json:string>K. Liang</json:string><json:string>K. Wark</json:string><json:string>R. Langer</json:string><json:string>D. Labarre</json:string><json:string>D. G. Castner</json:string><json:string>F. Giralt</json:string><json:string>D. P. Biswas</json:string><json:string>I. Tan</json:string><json:string>M. G. Finn</json:string><json:string>W. T. S. Huck</json:string><json:string>M. H. V. Mulder</json:string><json:string>F. Caruso</json:string><json:string>A. F. Radovic-Moreno</json:string><json:string>S. Sugihara</json:string><json:string>C. Picart</json:string><json:string>Z. Zarafshani</json:string><json:string>J. Mutterer</json:string><json:string>Y. Yan</json:string><json:string>Z. Hu</json:string><json:string>S. H. Cody</json:string><json:string>Y. J. Wang</json:string><json:string>D. Schmaljohann</json:string><json:string>Jean-François Lutz</json:string><json:string>V. C. Mosqueira</json:string><json:string>T. Obata</json:string><json:string>O. C. Farokhzad</json:string><json:string>I. Zins</json:string><json:string>R. De Rose</json:string><json:string>M. Symp</json:string><json:string>A. L. Becker</json:string><json:string>J. Pietrasik</json:string><json:string>A. N. Zelikin</json:string><json:string>T. Van Den Boomgaard</json:string><json:string>M. Hagiwara</json:string><json:string>L. Y. Wang</json:string><json:string>S. J. Dodds</json:string><json:string>A. Hoth</json:string><json:string>J. Andrieu</json:string><json:string>A. Laschewsky</json:string><json:string>Z. Q. Wang</json:string><json:string>R. Hoogenboom</json:string><json:string>D. Li</json:string><json:string>S. Han</json:string><json:string>J. J. Pellegrino</json:string><json:string>S. Lesieur</json:string><json:string>V. Trubetskoy</json:string><json:string>Z. Physik</json:string><json:string>S. Uezguen</json:string><json:string>P. Rivera-Gil</json:string><json:string>J. Polym</json:string><json:string>V. L. Osborne</json:string><json:string>E. Levy-Nissenbaum</json:string><json:string>D. R. Green</json:string><json:string>S. Stiller</json:string><json:string>C. Barner-Kowollik</json:string></persName><placeName><json:string>Aoshima</json:string><json:string>Potsdam</json:string><json:string>Germany</json:string><json:string>Australia</json:string><json:string>Nice</json:string><json:string>AZ</json:string><json:string>USA</json:string><json:string>Strasbourg</json:string><json:string>Eindhoven</json:string><json:string>NE</json:string><json:string>Sweden</json:string><json:string>Lincoln</json:string><json:string>Netherlands</json:string><json:string>Tucson</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>[2,3]</json:string><json:string>[22]</json:string><json:string>[36,37]</json:string><json:string>[54]</json:string><json:string>[20]</json:string><json:string>M. K. M. Leung et al.</json:string><json:string>[41]</json:string><json:string>[46]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-FX3NZWW6-Q</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - physics, condensed matter</json:string><json:string>2 - physics, applied</json:string><json:string>2 - nanoscience & nanotechnology</json:string><json:string>2 - materials science, multidisciplinary</json:string><json:string>2 - chemistry, physical</json:string><json:string>2 - chemistry, multidisciplinary</json:string></wos><scienceMetrix><json:string>1 - applied sciences</json:string><json:string>2 - enabling & strategic technologies</json:string><json:string>3 - nanoscience & nanotechnology</json:string></scienceMetrix><scopus><json:string>1 - Physical Sciences</json:string><json:string>2 - Engineering</json:string><json:string>3 - Engineering (miscellaneous)</json:string><json:string>1 - Physical Sciences</json:string><json:string>2 - Materials Science</json:string><json:string>3 - Biomaterials</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Biotechnology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string><json:string>4 - psychanalyse</json:string></inist></categories><publicationDate>2011</publicationDate><copyrightDate>2011</copyrightDate><doi><json:string>10.1002/smll.201002258</json:string></doi><id>8F8C8E132096B09EBB125ED03C5906F39914115D</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/8F8C8E132096B09EBB125ED03C5906F39914115D/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/8F8C8E132096B09EBB125ED03C5906F39914115D/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/8F8C8E132096B09EBB125ED03C5906F39914115D/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><availability><licence>Copyright © 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</licence></availability><date type="published" when="2011-04-18"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main" xml:lang="en">Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules</title><author xml:id="author-0000"><persName><forename type="first">Melissa K. M.</forename><surname>Leung</surname></persName><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Georgina K.</forename><surname>Such</surname></persName><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Angus P. R.</forename><surname>Johnston</surname></persName><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Dhee P.</forename><surname>Biswas</surname></persName><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Zhiyuan</forename><surname>Zhu</surname></persName><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Yan</forename><surname>Yan</surname></persName><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Jean‐François</forename><surname>Lutz</surname></persName><affiliation>Research Group Nanotechnology for Life Science, Fraunhofer Institute for Applied Polymer Research, Geiselbergstrasse 69, Potsdam 14476, Germany<address><country key="DE"></country></address></affiliation><affiliation>Current Address: Present address: Precision Macromolecular Chemistry Group, Institut Charles Sadron, UPR22‐CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0007" role="corresp"><persName><forename type="first">Frank</forename><surname>Caruso</surname></persName><email>fcaruso@unimelb.edu.au</email><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia<address><country key="AU"></country></address></affiliation><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia.</affiliation></author><idno type="istex">8F8C8E132096B09EBB125ED03C5906F39914115D</idno><idno type="ark">ark:/67375/WNG-FX3NZWW6-Q</idno><idno type="DOI">10.1002/smll.201002258</idno><idno type="unit">SMLL201002258</idno><idno type="toTypesetVersion">file:SMLL.SMLL201002258.pdf</idno></analytic><monogr><title level="j" type="main">Small</title><title level="j" type="alt">SMALL</title><idno type="pISSN">1613-6810</idno><idno type="eISSN">1613-6829</idno><idno type="book-DOI">10.1002/(ISSN)1613-6829</idno><idno type="book-part-DOI">10.1002/smll.v7.8</idno><idno type="product">SMLL</idno><imprint><biblScope unit="vol">7</biblScope><biblScope unit="issue">8</biblScope><biblScope unit="page" from="1075">1075</biblScope><biblScope unit="page" to="1085">1085</biblScope><biblScope unit="page-count">11</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2011-04-18"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>Nano‐/micrometer‐scaled films and capsules made of low‐fouling materials such as poly(ethylene glycol) (PEG) are of interest for drug delivery and tissue engineering applications. Herein, the assembly and degradation of low‐fouling, alkyne‐functionalized PEG (PEG<hi rend="subscript">Alk</hi>) multilayer films and capsules, which are prepared by combining layer‐by‐layer (LbL) assembly and click chemistry, are reported. A nonlinear, temperature‐responsive PEG<hi rend="subscript">Alk</hi> is synthesized, and is then used to form hydrogen‐bonded multilayers with poly(methacrylic acid) (PMA) at pH 5. The thermoresponsive behavior of PEG<hi rend="subscript">Alk</hi> is exploited to tailor film buildup by adjusting the assembly conditions. Using alkyne–azide click chemistry, PEG<hi rend="subscript">Alk</hi>/PMA multilayers are crosslinked with a bisazide linker that contains a disulfide bond, rendering these films and capsules redox‐responsive. At pH 7, by disrupting the hydrogen bonding between the polymers, PEG<hi rend="subscript">Alk</hi> LbL films and PEG<hi rend="subscript">Alk</hi>‐based capsules are obtained. These films exhibit specific deconstruction properties under simulated intracellular reducing conditions, but remain stable at physiological pH, suggesting potential applications in controlled drug release. The low‐fouling properties of the PEG films are confirmed by incubation with human serum and a blood clot. Additionally, these capsules showed negligible toxicity to human cells.</p></abstract><abstract xml:lang="en" style="graphical"><p><hi rend="bold">Multilayer degradable PEG‐based capsules</hi> are made of a nonlinear click‐ functionalized poly(ethylene glycol). These capsules exhibit excellent low‐fouling behavior against human thrombi (blood clots). Together with the specific degradation characteristics, these properties make the PEG‐based capsules promising for drug delivery applications. <figure type="box"><media mimeType="image" url="urn:x-wiley:16136810:media:SMLL201002258:content"></media><media mimeType="image/gif" url="" rendition="webLoRes"></media><media mimeType="image/jpeg" url="" rendition="webOriginal"></media><media mimeType="image/jpeg" url="" rendition="webHiRes"></media></figure></p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">poly(ethylene glycol)</term><term xml:id="kwd2">polymeric materials</term><term xml:id="kwd3">drug delivery</term><term xml:id="kwd4">click chemistry</term></keywords><keywords rend="articleCategory"><term>Full Paper</term></keywords><keywords rend="tocHeading1"><term>Full Papers</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/8F8C8E132096B09EBB125ED03C5906F39914115D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>WILEY‐VCH Verlag</publisherName><publisherLoc>Weinheim</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1613-6829</doi><issn type="print">1613-6810</issn><issn type="electronic">1613-6829</issn><idGroup><id type="product" value="SMLL"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="SMALL">Small</title><title type="short">Small</title></titleGroup></publicationMeta><publicationMeta level="part" position="80"><doi origin="wiley" registered="yes">10.1002/smll.v7.8</doi><numberingGroup><numbering type="journalVolume" number="7">7</numbering><numbering type="journalIssue">8</numbering></numberingGroup><coverDate startDate="2011-04-18">April 18, 2011</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="17" status="forIssue"><doi origin="wiley" registered="yes">10.1002/smll.201002258</doi><idGroup><id type="unit" value="SMLL201002258"></id></idGroup><countGroup><count type="pageTotal" number="11"></count></countGroup><titleGroup><title type="articleCategory">Full Paper</title><title type="tocHeading1">Full Papers</title></titleGroup><copyright ownership="publisher">Copyright © 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</copyright><eventGroup><event type="manuscriptReceived" date="2010-12-14"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.4.8 mode:FullText" date="2011-04-29"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-03-21"></event><event type="publishedOnlineFinalForm" date="2011-04-14"></event><event type="firstOnline" date="2011-03-21"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-08"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-11-03"></event></eventGroup><numberingGroup><numbering type="pageFirst">1075</numbering><numbering type="pageLast">1085</numbering></numberingGroup><correspondenceTo>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia.</correspondenceTo><objectNameGroup><objectName elementName="figure">Scheme</objectName></objectNameGroup><linkGroup><link type="toTypesetVersion" href="file:SMLL.SMLL201002258.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="8"></count><count type="referenceTotal" number="21"></count></countGroup><titleGroup><title type="main" xml:lang="en">Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Melissa K. M.</givenNames><familyName>Leung</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Georgina K.</givenNames><familyName>Such</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Angus P. R.</givenNames><familyName>Johnston</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Dhee P.</givenNames><familyName>Biswas</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Zhiyuan</givenNames><familyName>Zhu</familyName></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Yan</givenNames><familyName>Yan</familyName></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af2" currentRef="#add1"><personName><givenNames>Jean‐François</givenNames><familyName>Lutz</familyName></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Frank</givenNames><familyName>Caruso</familyName></personName><contactDetails><email>fcaruso@unimelb.edu.au</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="AU" type="organization"><unparsedAffiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="DE" type="organization"><unparsedAffiliation>Research Group Nanotechnology for Life Science, Fraunhofer Institute for Applied Polymer Research, Geiselbergstrasse 69, Potsdam 14476, Germany</unparsedAffiliation></affiliation><affiliation xml:id="add1" countryCode="FR"><unparsedAffiliation>Present address: Precision Macromolecular Chemistry Group, Institut Charles Sadron, UPR22‐CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">poly(ethylene glycol)</keyword><keyword xml:id="kwd2">polymeric materials</keyword><keyword xml:id="kwd3">drug delivery</keyword><keyword xml:id="kwd4">click chemistry</keyword></keywordGroup><supportingInformation><p>Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer‐reviewed, but not copy‐edited or typeset. They are made available as submitted by the authors.
</p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:16136810:media:smll201002258:smll_201002258_sm_suppl"></mediaResource><caption>suppl</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Nano‐/micrometer‐scaled films and capsules made of low‐fouling materials such as poly(ethylene glycol) (PEG) are of interest for drug delivery and tissue engineering applications. Herein, the assembly and degradation of low‐fouling, alkyne‐functionalized PEG (PEG<sub>Alk</sub>) multilayer films and capsules, which are prepared by combining layer‐by‐layer (LbL) assembly and click chemistry, are reported. A nonlinear, temperature‐responsive PEG<sub>Alk</sub> is synthesized, and is then used to form hydrogen‐bonded multilayers with poly(methacrylic acid) (PMA) at pH 5. The thermoresponsive behavior of PEG<sub>Alk</sub> is exploited to tailor film buildup by adjusting the assembly conditions. Using alkyne–azide click chemistry, PEG<sub>Alk</sub>/PMA multilayers are crosslinked with a bisazide linker that contains a disulfide bond, rendering these films and capsules redox‐responsive. At pH 7, by disrupting the hydrogen bonding between the polymers, PEG<sub>Alk</sub> LbL films and PEG<sub>Alk</sub>‐based capsules are obtained. These films exhibit specific deconstruction properties under simulated intracellular reducing conditions, but remain stable at physiological pH, suggesting potential applications in controlled drug release. The low‐fouling properties of the PEG films are confirmed by incubation with human serum and a blood clot. Additionally, these capsules showed negligible toxicity to human cells.</p></abstract><abstract type="graphical" xml:lang="en"><p><b>Multilayer degradable PEG‐based capsules</b> are made of a nonlinear click‐ functionalized poly(ethylene glycol). These capsules exhibit excellent low‐fouling behavior against human thrombi (blood clots). Together with the specific degradation characteristics, these properties make the PEG‐based capsules promising for drug delivery applications. <blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" eRights="yes" copyright="WILEY-VCH" href="urn:x-wiley:16136810:media:SMLL201002258:content"></mediaResource><mediaResource alt="thumbnail image" rendition="webLoRes" mimeType="image/gif" href=""></mediaResource><mediaResource alt="original image" rendition="webOriginal" mimeType="image/jpeg" href=""></mediaResource><mediaResource alt="magnified image" rendition="webHiRes" mimeType="image/jpeg" href=""></mediaResource></mediaResourceGroup></blockFixed></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules</title></titleInfo><name type="personal"><namePart type="given">Melissa K. M.</namePart><namePart type="family">Leung</namePart><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Georgina K.</namePart><namePart type="family">Such</namePart><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Angus P. R.</namePart><namePart type="family">Johnston</namePart><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dhee P.</namePart><namePart type="family">Biswas</namePart><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Zhiyuan</namePart><namePart type="family">Zhu</namePart><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yan</namePart><namePart type="family">Yan</namePart><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean‐François</namePart><namePart type="family">Lutz</namePart><affiliation>Research Group Nanotechnology for Life Science, Fraunhofer Institute for Applied Polymer Research, Geiselbergstrasse 69, Potsdam 14476, Germany</affiliation><affiliation>Current Address: Present address: Precision Macromolecular Chemistry Group, Institut Charles Sadron, UPR22‐CNRS, 23 rue du Loess, BP84047, 67034 Strasbourg Cedex 2, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frank</namePart><namePart type="family">Caruso</namePart><affiliation>Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia</affiliation><affiliation>E-mail: fcaruso@unimelb.edu.au</affiliation><affiliation>Correspondence address: Department of Chemical and Biomolecular Engineering, The University of Melbourne, Victoria 3010, Australia.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>WILEY‐VCH Verlag</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">2011-04-18</dateIssued><dateCaptured encoding="w3cdtf">2010-12-14</dateCaptured><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">8</extent><extent unit="references">21</extent></physicalDescription><abstract lang="en">Nano‐/micrometer‐scaled films and capsules made of low‐fouling materials such as poly(ethylene glycol) (PEG) are of interest for drug delivery and tissue engineering applications. Herein, the assembly and degradation of low‐fouling, alkyne‐functionalized PEG (PEGAlk) multilayer films and capsules, which are prepared by combining layer‐by‐layer (LbL) assembly and click chemistry, are reported. A nonlinear, temperature‐responsive PEGAlk is synthesized, and is then used to form hydrogen‐bonded multilayers with poly(methacrylic acid) (PMA) at pH 5. The thermoresponsive behavior of PEGAlk is exploited to tailor film buildup by adjusting the assembly conditions. Using alkyne–azide click chemistry, PEGAlk/PMA multilayers are crosslinked with a bisazide linker that contains a disulfide bond, rendering these films and capsules redox‐responsive. At pH 7, by disrupting the hydrogen bonding between the polymers, PEGAlk LbL films and PEGAlk‐based capsules are obtained. These films exhibit specific deconstruction properties under simulated intracellular reducing conditions, but remain stable at physiological pH, suggesting potential applications in controlled drug release. The low‐fouling properties of the PEG films are confirmed by incubation with human serum and a blood clot. Additionally, these capsules showed negligible toxicity to human cells.</abstract><abstract>Multilayer degradable PEG‐based capsules are made of a nonlinear click‐ functionalized poly(ethylene glycol). These capsules exhibit excellent low‐fouling behavior against human thrombi (blood clots). Together with the specific degradation characteristics, these properties make the PEG‐based capsules promising for drug delivery applications.</abstract><subject lang="en"><genre>keywords</genre><topic>poly(ethylene glycol)</topic><topic>polymeric materials</topic><topic>drug delivery</topic><topic>click chemistry</topic></subject><relatedItem type="host"><titleInfo><title>Small</title></titleInfo><titleInfo type="abbreviated"><title>Small</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><note type="content"> Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer‐reviewed, but not copy‐edited or typeset. They are made available as submitted by the authors.Supporting Info Item: suppl - </note><subject><genre>article-category</genre><topic>Full Paper</topic></subject><identifier type="ISSN">1613-6810</identifier><identifier type="eISSN">1613-6829</identifier><identifier type="DOI">10.1002/(ISSN)1613-6829</identifier><identifier type="PublisherID">SMLL</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>7</number></detail><detail type="issue"><caption>no.</caption><number>8</number></detail><extent unit="pages"><start>1075</start><end>1085</end><total>11</total></extent></part></relatedItem><identifier type="istex">8F8C8E132096B09EBB125ED03C5906F39914115D</identifier><identifier type="ark">ark:/67375/WNG-FX3NZWW6-Q</identifier><identifier type="DOI">10.1002/smll.201002258</identifier><identifier type="ArticleID">SMLL201002258</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>WILEY‐VCH Verlag</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/8F8C8E132096B09EBB125ED03C5906F39914115D/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B09 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 001B09 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:8F8C8E132096B09EBB125ED03C5906F39914115D
|texte= Assembly and Degradation of Low‐Fouling Click‐Functionalized Poly(ethylene glycol)‐Based Multilayer Films and Capsules
}}
| This area was generated with Dilib version V0.6.33. |  |