Cerebellar Nicotinic Cholinergic Receptors are Intrinsic to the Cerebellum: Implications for Diverse Functional Roles
Identifieur interne : 006212 ( Main/Exploration ); précédent : 006211; suivant : 006213Cerebellar Nicotinic Cholinergic Receptors are Intrinsic to the Cerebellum: Implications for Diverse Functional Roles
Auteurs : Jill R. Turner ; Pavel I. Ortinski ; Rachel M. Sherrard ; Kenneth J. KellarSource :
- Cerebellum (London, England) [ 1473-4222 ] ; 2011.
Abstract
Although recent studies have delineated the specific nicotinic subtypes present in the mammalian cerebellum, very little is known about their location or function within the cerebellum. This is of increased interest since nicotinic receptors (nAChRs) in the cerebellum have recently been implicated in the pathology of autism spectrum disorders. To begin to better understand the roles of these heteromeric nAChRs in the cerebellar circuitry and their therapeutic potential as targets for drug development, we used various chemical and stereotaxic lesion models in conjunction with slice electrophysiology to examine how specific heteromeric nAChR subtypes may influence the surrounding cerebellar circuitry. Using subunit-specific immunoprecipitation of radiolabeled nAChRs in the cerebella following
Url:
DOI: 10.1007/s12311-011-0285-y
PubMed: 21562921
PubMed Central: 5094176
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001D92
- to stream Pmc, to step Curation: 001C48
- to stream Pmc, to step Checkpoint: 002385
- to stream Ncbi, to step Merge: 000A54
- to stream Ncbi, to step Curation: 000A54
- to stream Ncbi, to step Checkpoint: 000A54
- to stream Main, to step Merge: 006579
- to stream Main, to step Curation: 006212
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebellar Nicotinic Cholinergic Receptors are Intrinsic to the Cerebellum: Implications for Diverse Functional Roles</title>
<author><name sortKey="Turner, Jill R" sort="Turner, Jill R" uniqKey="Turner J" first="Jill R." last="Turner">Jill R. Turner</name>
</author>
<author><name sortKey="Ortinski, Pavel I" sort="Ortinski, Pavel I" uniqKey="Ortinski P" first="Pavel I." last="Ortinski">Pavel I. Ortinski</name>
</author>
<author><name sortKey="Sherrard, Rachel M" sort="Sherrard, Rachel M" uniqKey="Sherrard R" first="Rachel M." last="Sherrard">Rachel M. Sherrard</name>
</author>
<author><name sortKey="Kellar, Kenneth J" sort="Kellar, Kenneth J" uniqKey="Kellar K" first="Kenneth J." last="Kellar">Kenneth J. Kellar</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21562921</idno>
<idno type="pmc">5094176</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094176</idno>
<idno type="RBID">PMC:5094176</idno>
<idno type="doi">10.1007/s12311-011-0285-y</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">001D92</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D92</idno>
<idno type="wicri:Area/Pmc/Curation">001C48</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C48</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002385</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002385</idno>
<idno type="wicri:Area/Ncbi/Merge">000A54</idno>
<idno type="wicri:Area/Ncbi/Curation">000A54</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000A54</idno>
<idno type="wicri:doubleKey">1473-4222:2011:Turner J:cerebellar:nicotinic:cholinergic</idno>
<idno type="wicri:Area/Main/Merge">006579</idno>
<idno type="wicri:Area/Main/Curation">006212</idno>
<idno type="wicri:Area/Main/Exploration">006212</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cerebellar Nicotinic Cholinergic Receptors are Intrinsic to the Cerebellum: Implications for Diverse Functional Roles</title>
<author><name sortKey="Turner, Jill R" sort="Turner, Jill R" uniqKey="Turner J" first="Jill R." last="Turner">Jill R. Turner</name>
</author>
<author><name sortKey="Ortinski, Pavel I" sort="Ortinski, Pavel I" uniqKey="Ortinski P" first="Pavel I." last="Ortinski">Pavel I. Ortinski</name>
</author>
<author><name sortKey="Sherrard, Rachel M" sort="Sherrard, Rachel M" uniqKey="Sherrard R" first="Rachel M." last="Sherrard">Rachel M. Sherrard</name>
</author>
<author><name sortKey="Kellar, Kenneth J" sort="Kellar, Kenneth J" uniqKey="Kellar K" first="Kenneth J." last="Kellar">Kenneth J. Kellar</name>
</author>
</analytic>
<series><title level="j">Cerebellum (London, England)</title>
<idno type="ISSN">1473-4222</idno>
<idno type="eISSN">1473-4230</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Although recent studies have delineated the specific nicotinic subtypes present in the mammalian cerebellum, very little is known about their location or function within the cerebellum. This is of increased interest since nicotinic receptors (nAChRs) in the cerebellum have recently been implicated in the pathology of autism spectrum disorders. To begin to better understand the roles of these heteromeric nAChRs in the cerebellar circuitry and their therapeutic potential as targets for drug development, we used various chemical and stereotaxic lesion models in conjunction with slice electrophysiology to examine how specific heteromeric nAChR subtypes may influence the surrounding cerebellar circuitry. Using subunit-specific immunoprecipitation of radiolabeled nAChRs in the cerebella following <italic>N</italic>
-(2-chloroethyl)-<italic>N</italic>
-ethyl-2-bromobenzylamine hydrochloride, <italic>p</italic>
-chloroamphetamine, and pendunculotomy lesions, we show that most, if not all, cerebellar nicotinic receptors are present in cells within the cerebellum itself and not in extracerebellar afferents. Furthermore, we demonstrate that the β4-containing, but not the β2-containing, nAChRs intrinsic to the cerebellum can regulate inhibitory synaptic efficacy at two major classes of cerebellar neurons. These tandem findings suggest that nAChRs may present a potential drug target for disorders involving the cerebellum.</p>
</div>
</front>
</TEI>
<affiliations><list></list>
<tree><noCountry><name sortKey="Kellar, Kenneth J" sort="Kellar, Kenneth J" uniqKey="Kellar K" first="Kenneth J." last="Kellar">Kenneth J. Kellar</name>
<name sortKey="Ortinski, Pavel I" sort="Ortinski, Pavel I" uniqKey="Ortinski P" first="Pavel I." last="Ortinski">Pavel I. Ortinski</name>
<name sortKey="Sherrard, Rachel M" sort="Sherrard, Rachel M" uniqKey="Sherrard R" first="Rachel M." last="Sherrard">Rachel M. Sherrard</name>
<name sortKey="Turner, Jill R" sort="Turner, Jill R" uniqKey="Turner J" first="Jill R." last="Turner">Jill R. Turner</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 006212 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 006212 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Exploration |type= RBID |clé= PMC:5094176 |texte= Cerebellar Nicotinic Cholinergic Receptors are Intrinsic to the Cerebellum: Implications for Diverse Functional Roles }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:21562921" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |