Cerebellar Nicotinic Cholinergic Receptors are Intrinsic to the Cerebellum: Implications for Diverse Functional Roles
Identifieur interne : 002385 ( Pmc/Checkpoint ); précédent : 002384; suivant : 002386Cerebellar Nicotinic Cholinergic Receptors are Intrinsic to the Cerebellum: Implications for Diverse Functional Roles
Auteurs : Jill R. Turner ; Pavel I. Ortinski ; Rachel M. Sherrard ; Kenneth J. KellarSource :
- Cerebellum (London, England) [ 1473-4222 ] ; 2011.
Abstract
Although recent studies have delineated the specific nicotinic subtypes present in the mammalian cerebellum, very little is known about their location or function within the cerebellum. This is of increased interest since nicotinic receptors (nAChRs) in the cerebellum have recently been implicated in the pathology of autism spectrum disorders. To begin to better understand the roles of these heteromeric nAChRs in the cerebellar circuitry and their therapeutic potential as targets for drug development, we used various chemical and stereotaxic lesion models in conjunction with slice electrophysiology to examine how specific heteromeric nAChR subtypes may influence the surrounding cerebellar circuitry. Using subunit-specific immunoprecipitation of radiolabeled nAChRs in the cerebella following
Url:
DOI: 10.1007/s12311-011-0285-y
PubMed: 21562921
PubMed Central: 5094176
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:5094176Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cerebellar Nicotinic Cholinergic Receptors are Intrinsic to the Cerebellum: Implications for Diverse Functional Roles</title>
<author><name sortKey="Turner, Jill R" sort="Turner, Jill R" uniqKey="Turner J" first="Jill R." last="Turner">Jill R. Turner</name>
</author>
<author><name sortKey="Ortinski, Pavel I" sort="Ortinski, Pavel I" uniqKey="Ortinski P" first="Pavel I." last="Ortinski">Pavel I. Ortinski</name>
</author>
<author><name sortKey="Sherrard, Rachel M" sort="Sherrard, Rachel M" uniqKey="Sherrard R" first="Rachel M." last="Sherrard">Rachel M. Sherrard</name>
</author>
<author><name sortKey="Kellar, Kenneth J" sort="Kellar, Kenneth J" uniqKey="Kellar K" first="Kenneth J." last="Kellar">Kenneth J. Kellar</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21562921</idno>
<idno type="pmc">5094176</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094176</idno>
<idno type="RBID">PMC:5094176</idno>
<idno type="doi">10.1007/s12311-011-0285-y</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">001D92</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001D92</idno>
<idno type="wicri:Area/Pmc/Curation">001C48</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001C48</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002385</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002385</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cerebellar Nicotinic Cholinergic Receptors are Intrinsic to the Cerebellum: Implications for Diverse Functional Roles</title>
<author><name sortKey="Turner, Jill R" sort="Turner, Jill R" uniqKey="Turner J" first="Jill R." last="Turner">Jill R. Turner</name>
</author>
<author><name sortKey="Ortinski, Pavel I" sort="Ortinski, Pavel I" uniqKey="Ortinski P" first="Pavel I." last="Ortinski">Pavel I. Ortinski</name>
</author>
<author><name sortKey="Sherrard, Rachel M" sort="Sherrard, Rachel M" uniqKey="Sherrard R" first="Rachel M." last="Sherrard">Rachel M. Sherrard</name>
</author>
<author><name sortKey="Kellar, Kenneth J" sort="Kellar, Kenneth J" uniqKey="Kellar K" first="Kenneth J." last="Kellar">Kenneth J. Kellar</name>
</author>
</analytic>
<series><title level="j">Cerebellum (London, England)</title>
<idno type="ISSN">1473-4222</idno>
<idno type="eISSN">1473-4230</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Although recent studies have delineated the specific nicotinic subtypes present in the mammalian cerebellum, very little is known about their location or function within the cerebellum. This is of increased interest since nicotinic receptors (nAChRs) in the cerebellum have recently been implicated in the pathology of autism spectrum disorders. To begin to better understand the roles of these heteromeric nAChRs in the cerebellar circuitry and their therapeutic potential as targets for drug development, we used various chemical and stereotaxic lesion models in conjunction with slice electrophysiology to examine how specific heteromeric nAChR subtypes may influence the surrounding cerebellar circuitry. Using subunit-specific immunoprecipitation of radiolabeled nAChRs in the cerebella following <italic>N</italic>
-(2-chloroethyl)-<italic>N</italic>
-ethyl-2-bromobenzylamine hydrochloride, <italic>p</italic>
-chloroamphetamine, and pendunculotomy lesions, we show that most, if not all, cerebellar nicotinic receptors are present in cells within the cerebellum itself and not in extracerebellar afferents. Furthermore, we demonstrate that the β4-containing, but not the β2-containing, nAChRs intrinsic to the cerebellum can regulate inhibitory synaptic efficacy at two major classes of cerebellar neurons. These tandem findings suggest that nAChRs may present a potential drug target for disorders involving the cerebellum.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">101089443</journal-id>
<journal-id journal-id-type="pubmed-jr-id">30404</journal-id>
<journal-id journal-id-type="nlm-ta">Cerebellum</journal-id>
<journal-id journal-id-type="iso-abbrev">Cerebellum</journal-id>
<journal-title-group><journal-title>Cerebellum (London, England)</journal-title>
</journal-title-group>
<issn pub-type="ppub">1473-4222</issn>
<issn pub-type="epub">1473-4230</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21562921</article-id>
<article-id pub-id-type="pmc">5094176</article-id>
<article-id pub-id-type="doi">10.1007/s12311-011-0285-y</article-id>
<article-id pub-id-type="manuscript">NIHMS825692</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Cerebellar Nicotinic Cholinergic Receptors are Intrinsic to the Cerebellum: Implications for Diverse Functional Roles</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Turner</surname>
<given-names>Jill R.</given-names>
</name>
<aff id="A1">Department of Pharmacology, Georgetown University, Washington, DC 20057, USA. Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Ortinski</surname>
<given-names>Pavel I.</given-names>
</name>
<aff id="A2">Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC, USA. Department of Physiology and Biophysics, Georgetown University, Washington, DC, USA</aff>
</contrib>
<contrib contrib-type="author"><name><surname>Sherrard</surname>
<given-names>Rachel M.</given-names>
</name>
<aff id="A3">Developmental Neuroplasticity Laboratory, School of Anatomy and Human Biology, University of Western Australia, Crawley, Australia. UMR7102 Neurobiologie des Processus Adaptatifs, UPMC Univ Paris 6, Paris 75005, France</aff>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Kellar</surname>
<given-names>Kenneth J.</given-names>
</name>
<aff id="A4">Department of Pharmacology, Georgetown University, Washington, DC 20057, USA. Interdisciplinary Program in Neuroscience, Georgetown University, Washington, DC, USA</aff>
<email>kellark@georgetown.edu</email>
</contrib>
</contrib-group>
<author-notes><fn id="FN1" fn-type="present-address"><p><italic>Present Address:</italic>
P. I. Ortinski, Department of Psychiatry, University of Pennsylvania, 125 S. 31st St., Philadelphia, PA 19106, USA</p>
</fn>
<fn id="FN2" fn-type="equal"><p>Jill R. Turner and Pavel I. Ortinski contributed equally.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>28</day>
<month>10</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="ppub"><month>12</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>03</day>
<month>11</month>
<year>2016</year>
</pub-date>
<volume>10</volume>
<issue>4</issue>
<fpage>748</fpage>
<lpage>757</lpage>
<pmc-comment>elocation-id from pubmed: 10.1007/s12311-011-0285-y</pmc-comment>
<abstract><p id="P1">Although recent studies have delineated the specific nicotinic subtypes present in the mammalian cerebellum, very little is known about their location or function within the cerebellum. This is of increased interest since nicotinic receptors (nAChRs) in the cerebellum have recently been implicated in the pathology of autism spectrum disorders. To begin to better understand the roles of these heteromeric nAChRs in the cerebellar circuitry and their therapeutic potential as targets for drug development, we used various chemical and stereotaxic lesion models in conjunction with slice electrophysiology to examine how specific heteromeric nAChR subtypes may influence the surrounding cerebellar circuitry. Using subunit-specific immunoprecipitation of radiolabeled nAChRs in the cerebella following <italic>N</italic>
-(2-chloroethyl)-<italic>N</italic>
-ethyl-2-bromobenzylamine hydrochloride, <italic>p</italic>
-chloroamphetamine, and pendunculotomy lesions, we show that most, if not all, cerebellar nicotinic receptors are present in cells within the cerebellum itself and not in extracerebellar afferents. Furthermore, we demonstrate that the β4-containing, but not the β2-containing, nAChRs intrinsic to the cerebellum can regulate inhibitory synaptic efficacy at two major classes of cerebellar neurons. These tandem findings suggest that nAChRs may present a potential drug target for disorders involving the cerebellum.</p>
</abstract>
<kwd-group><kwd>Nicotinic receptor</kwd>
<kwd>Cerebellum</kwd>
<kwd>Lesion</kwd>
<kwd>Rat</kwd>
<kwd>Immunoprecipitation</kwd>
<kwd>Electrophysiology</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Kellar, Kenneth J" sort="Kellar, Kenneth J" uniqKey="Kellar K" first="Kenneth J." last="Kellar">Kenneth J. Kellar</name>
<name sortKey="Ortinski, Pavel I" sort="Ortinski, Pavel I" uniqKey="Ortinski P" first="Pavel I." last="Ortinski">Pavel I. Ortinski</name>
<name sortKey="Sherrard, Rachel M" sort="Sherrard, Rachel M" uniqKey="Sherrard R" first="Rachel M." last="Sherrard">Rachel M. Sherrard</name>
<name sortKey="Turner, Jill R" sort="Turner, Jill R" uniqKey="Turner J" first="Jill R." last="Turner">Jill R. Turner</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002385 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 002385 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:5094176 |texte= Cerebellar Nicotinic Cholinergic Receptors are Intrinsic to the Cerebellum: Implications for Diverse Functional Roles }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:21562921" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |