Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
Identifieur interne : 005340 ( Main/Exploration ); précédent : 005339; suivant : 005341Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
Auteurs : Daniel I. Chasman [États-Unis] ; Christian Fuchsberger [États-Unis] ; Cristian Pattaro [Italie] ; Alexander Teumer [Allemagne] ; Carsten A. Böger ; Karlhans Endlich [Allemagne] ; Matthias Olden [Allemagne] ; Ming-Huei Chen [États-Unis] ; Adrienne Tin [États-Unis] ; Daniel Taliun [Italie] ; Man Li [États-Unis] ; Xiaoyi Gao [États-Unis] ; Mathias Gorski [Allemagne] ; Qiong Yang [États-Unis] ; Claudia Hundertmark [Allemagne] ; Meredith C. Foster [États-Unis] ; Conall M. O'Seaghdha [États-Unis] ; Nicole Glazer [États-Unis] ; Aaron Isaacs [Pays-Bas] ; Ching-Ti Liu [États-Unis] ; Albert V. Smith [Islande] ; Jeffrey R. O'Connell ; Maksim Struchalin [Pays-Bas] ; Toshiko Tanaka [États-Unis] ; Guo Li [États-Unis] ; Andrew D. Johnson [États-Unis] ; Hinco J. Gierman [États-Unis] ; Mary F. Feitosa [États-Unis] ; Shih-Jen Hwang [États-Unis] ; Elizabeth J. Atkinson [États-Unis] ; Kurt Lohman ; Marilyn C. Cornelis [États-Unis] ; Sa Johansson [Suède] ; Anke Tönjes [Allemagne] ; Abbas Dehghan [Pays-Bas] ; Jean-Charles Lambert [France] ; Elizabeth G. Holliday [Australie] ; Rossella Sorice [Italie] ; Zoltan Kutalik [Suisse] ; Terho Lehtim Ki [Finlande] ; T Nu Esko [Estonie] ; Harshal Deshmukh ; Sheila Ulivi [Italie] ; Audrey Y. Chu [États-Unis] ; Federico Murgia [Italie] ; Stella Trompet [Pays-Bas] ; Medea Imboden [Suisse] ; Stefan Coassin [Autriche] ; Giorgio Pistis [Italie] ; Tamara B. Harris [États-Unis] ; Lenore J. Launer [États-Unis] ; Thor Aspelund [Islande] ; Gudny Eiriksdottir [Islande] ; Braxton D. Mitchell ; Eric Boerwinkle [États-Unis] ; Helena Schmidt [Autriche] ; Margherita Cavalieri [Autriche] ; Madhumathi Rao [États-Unis] ; Frank Hu [États-Unis] ; Ayse Demirkan [Pays-Bas] ; Ben A. Oostra [Pays-Bas] ; Mariza De Andrade [États-Unis] ; Stephen T. Turner [États-Unis] ; Jingzhong Ding ; Jeanette S. Andrews [États-Unis] ; Barry I. Freedman ; Franco Giulianini [États-Unis] ; Wolfgang Koenig [Allemagne] ; Thomas Illig [Allemagne] ; Christa Meisinger [Allemagne] ; Christian Gieger [Allemagne] ; Lina Zgaga [Croatie] ; Tatijana Zemunik [Croatie] ; Mladen Boban [Croatie] ; Cosetta Minelli [Italie] ; Heather E. Wheeler [États-Unis] ; Wilmar Igl [Suède] ; Ghazal Zaboli [Suède] ; Sarah H. Wild ; Alan F. Wright ; Harry Campbell ; David Ellinghaus [Allemagne] ; Ute Nöthlings [Allemagne] ; Gunnar Jacobs [Allemagne] ; Reiner Biffar [Allemagne] ; Florian Ernst [Autriche] ; Georg Homuth [Allemagne] ; Heyo K. Kroemer [Allemagne] ; Matthias Nauck [Allemagne] ; Sylvia Stracke [Allemagne] ; Uwe Völker [Allemagne] ; Henry Völzke [Allemagne] ; Peter Kovacs [Allemagne] ; Michael Stumvoll [Allemagne] ; Reedik M Gi [Estonie, Royaume-Uni] ; Albert Hofman [Pays-Bas] ; Andre G. Uitterlinden [Pays-Bas] ; Fernando Rivadeneira [Pays-Bas] ; Yurii S. Aulchenko [Pays-Bas] ; Ozren Polasek [Croatie] ; Nick Hastie ; Veronique Vitart ; Catherine Helmer [France] ; Jie Jin Wang [Australie] ; Bénédicte Stengel [France] ; Daniela Ruggiero [Italie] ; Sven Bergmann [Suisse] ; Mika K Hönen [Finlande] ; Jorma Viikari [Finlande] ; Tiit Nikopensius [Estonie] ; Michael Province [États-Unis] ; Shamika Ketkar [États-Unis] ; Helen Colhoun ; Alex Doney ; Antonietta Robino [Italie] ; Bernhard K. Kr Mer [Allemagne] ; Laura Portas [Italie] ; Ian Ford ; Brendan M. Buckley [Irlande (pays)] ; Martin Adam [Suisse] ; Gian-Andri Thun [Suisse] ; Bernhard Paulweber [Autriche] ; Margot Haun [Autriche] ; Cinzia Sala [Italie] ; Paul Mitchell [Australie] ; Marina Ciullo [Italie] ; Stuart K. Kim [États-Unis] ; Peter Vollenweider [Suisse] ; Olli Raitakari [Finlande] ; Andres Metspalu [Estonie] ; Colin Palmer ; Paolo Gasparini [Italie] ; Mario Pirastu [Italie] ; J. Wouter Jukema [Pays-Bas] ; Nicole M. Probst-Hensch [Suisse] ; Florian Kronenberg [Autriche] ; Daniela Toniolo [Italie] ; Vilmundur Gudnason [Islande] ; Alan R. Shuldiner [États-Unis] ; Josef Coresh [États-Unis] ; Reinhold Schmidt [Autriche] ; Luigi Ferrucci [États-Unis] ; David S. Siscovick [États-Unis] ; Cornelia M. Van Duijn [Pays-Bas] ; Ingrid B. Borecki [États-Unis] ; Sharon L. R. Kardia [États-Unis] ; Yongmei Liu ; Gary C. Curhan [États-Unis] ; Igor Rudan ; Ulf Gyllensten [Suède] ; James F. Wilson ; Andre Franke [Allemagne] ; Peter P. Pramstaller [Italie] ; Rainer Rettig [Allemagne] ; Inga Prokopenko [Royaume-Uni] ; Jacqueline Witteman [Pays-Bas] ; Caroline Hayward ; Paul M. Ridker [États-Unis] ; Afshin Parsa [États-Unis] ; Murielle Bochud [Suisse] ; Iris M. Heid [Allemagne] ; W. H. Linda Kao [États-Unis] ; Caroline S. Fox [États-Unis] ; Anna Köttgen [Allemagne, États-Unis]Source :
- Human Molecular Genetics [ 0964-6906 ] ; 2012.
Abstract
In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure of kidney function, we developed a strategy for integrating prior biological knowledge into the existing GWAS data for eGFR from the CKDGen Consortium. Our strategy focuses on single nucleotide polymorphism (SNPs) in genes that are connected by functional evidence, determined by literature mining and gene ontology (GO) hierarchies, to genes near previously validated eGFR associations. It then requires association thresholds consistent with multiple testing, and finally evaluates novel candidates by independent replication. Among the samples of European ancestry, we identified a genome-wide significant SNP in
Url:
DOI: 10.1093/hmg/dds369
PubMed: 22962313
PubMed Central: 3607468
Affiliations:
- Allemagne, Australie, Autriche, Croatie, Estonie, Finlande, France, Irlande (pays), Islande, Italie, Pays-Bas, Royaume-Uni, Suisse, Suède, États-Unis
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Le document en format XML
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<author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
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<author><name sortKey="Hundertmark, Claudia" sort="Hundertmark, Claudia" uniqKey="Hundertmark C" first="Claudia" last="Hundertmark">Claudia Hundertmark</name>
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<author><name sortKey="Foster, Meredith C" sort="Foster, Meredith C" uniqKey="Foster M" first="Meredith C." last="Foster">Meredith C. Foster</name>
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<author><name sortKey="O Seaghdha, Conall M" sort="O Seaghdha, Conall M" uniqKey="O Seaghdha C" first="Conall M." last="O'Seaghdha">Conall M. O'Seaghdha</name>
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<country xml:lang="fr">États-Unis</country>
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<affiliation wicri:level="1"><nlm:aff id="af16"><addr-line>Division of Nephrology</addr-line>
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<author><name sortKey="Glazer, Nicole" sort="Glazer, Nicole" uniqKey="Glazer N" first="Nicole" last="Glazer">Nicole Glazer</name>
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<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name>
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<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Centre for Medical Systems Biology</addr-line>
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<author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name>
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<author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
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<country xml:lang="fr">Islande</country>
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<affiliation wicri:level="1"><nlm:aff id="af22"><institution>University of Iceland</institution>
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<country xml:lang="fr">Islande</country>
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<author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Department of Medicine</addr-line>
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<author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name>
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,<addr-line>Dr Molewaterplein 50-603015, Rotterdam, GE</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name>
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<author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name>
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<author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name>
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,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gierman, Hinco J" sort="Gierman, Hinco J" uniqKey="Gierman H" first="Hinco J." last="Gierman">Hinco J. Gierman</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af28"><addr-line>Department of Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name>
<affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af30"><addr-line>Division of Biomedical Statistics and Informatics</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name>
<affiliation><nlm:aff id="af32"><addr-line>Department of Epidemiology and Prevention, Public Health Sciences</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C." last="Cornelis">Marilyn C. Cornelis</name>
<affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>665 Huntington Avenue, Building 2, Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name>
<affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<affiliation wicri:level="1"><nlm:aff id="af38"><institution>INSERM UMR744, Institut Pasteur</institution>
,<addr-line>Lille</addr-line>
,<country>France</country>
,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name>
<affiliation wicri:level="1"><nlm:aff id="af39"><addr-line>Centre for Information-based Medicine and School of Medicine and Public Health</addr-line>
,<institution>University of Newcastle, Hunter Medical Research Institute</institution>
,<addr-line>Newcastle, NSW</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name>
<affiliation wicri:level="1"><nlm:aff id="af40"><institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name>
<affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Medical Genetics</addr-line>
,<institution>University of Lausanne</institution>
,<addr-line>Rue du Bugnon 27, CH, 1005 Lausanne</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af42"><institution>Swiss Institute of Bioinformatics</institution>
,<addr-line>Lausanne</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name>
<affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Clinical Chemistry, Centre for Laboratory Medicine Tampere Finn</addr-line>
,<institution>University of Tampere and Tampere University Hospital</institution>
,<addr-line>Medi 2, 3th, floor, PO Box 2000, 33521 Tampere</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name>
<affiliation wicri:level="1"><nlm:aff id="af44"><institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deshmukh, Harshal" sort="Deshmukh, Harshal" uniqKey="Deshmukh H" first="Harshal" last="Deshmukh">Harshal Deshmukh</name>
<affiliation><nlm:aff id="af46"><addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name>
<affiliation wicri:level="1"><nlm:aff id="af47"><institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name>
<affiliation wicri:level="1"><nlm:aff id="af48"><institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name>
<affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Deparment of Cardiology</addr-line>
,<institution>Leiden University Medical Center</institution>
,<addr-line>Postzone C2-R, PO Box 9600, 2300 RC Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af51"><institution>University of Basel</institution>
,<addr-line>Basel</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name>
<affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name>
<affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<affiliation wicri:level="1"><nlm:aff id="af58"><institution>Laboratory of Epidemiology, Demography, and Biometry</institution>
,<addr-line>NIA-Gateway Building, 3C309, 7201 Wisconsin Ave., Bethesda, MD 20892-9205</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="1"><nlm:aff id="af58"><institution>Laboratory of Epidemiology, Demography, and Biometry</institution>
,<addr-line>NIA-Gateway Building, 3C309, 7201 Wisconsin Ave., Bethesda, MD 20892-9205</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name>
<affiliation wicri:level="1"><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af22"><institution>University of Iceland</institution>
,<addr-line>Sæmundargötu 2, 101 Reykjavik</addr-line>
,<country>Iceland</country>
,</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name>
<affiliation wicri:level="1"><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Department of Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<affiliation wicri:level="1"><nlm:aff id="af59"><addr-line>Human Genetics Center Houston</addr-line>
,<institution>University of Texas Health Science Center</institution>
,<addr-line>TX-1200 Herman Pressler Drive, Houston, TX 77030</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Institute of Molecular Biology and Biochemistry and Department of Neurology</addr-line>
,<institution>Medical University Graz</institution>
,<addr-line>Harrachgasse 21 8010, Graz</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name>
<affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Institute of Molecular Biology and Biochemistry and Department of Neurology</addr-line>
,<institution>Medical University Graz</institution>
,<addr-line>Harrachgasse 21 8010, Graz</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rao, Madhumathi" sort="Rao, Madhumathi" uniqKey="Rao M" first="Madhumathi" last="Rao">Madhumathi Rao</name>
<affiliation wicri:level="1"><nlm:aff id="af61"><addr-line>Division of Nephrology/Tufts Evidence Practice Center</addr-line>
,<institution>Tufts University School of Medicine-Tufts Medical Center</institution>
,<addr-line>Boston, MA 02111</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hu, Frank" sort="Hu, Frank" uniqKey="Hu F" first="Frank" last="Hu">Frank Hu</name>
<affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>665 Huntington Avenue, Building 2, Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Centre for Medical Systems Biology</addr-line>
,<institution>Leiden University</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Centre for Medical Systems Biology</addr-line>
,<institution>Leiden University</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af30"><addr-line>Division of Biomedical Statistics and Informatics</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name>
<affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Internal Medicine, Division of Nephrology and Hypertension</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name>
<affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Internal Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrews, Jeanette S" sort="Andrews, Jeanette S" uniqKey="Andrews J" first="Jeanette S." last="Andrews">Jeanette S. Andrews</name>
<affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Department of Biostatistical Sciences, Public Health Sciences</addr-line>
,<institution>Wake Forest School of Medicine</institution>
,<addr-line>Winston-Salem, NC 27157</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name>
<affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Internal Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giulianini, Franco" sort="Giulianini, Franco" uniqKey="Giulianini F" first="Franco" last="Giulianini">Franco Giulianini</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<affiliation wicri:level="1"><nlm:aff id="af62"><addr-line>Abteilung Innere II</addr-line>
,<institution>Universitätsklinikum Ulm</institution>
,<addr-line>Albert-Einstein-Allee 23, Ulm 89081</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name>
<affiliation wicri:level="1"><nlm:aff id="af13"><institution>Institute of Medical Informatics, Biometry and Epidemiology, and Institute of Epidemiology, Ludwig-Maximilians-Universität</institution>
,<addr-line>Ingolstädter Landstr. 1, 85764 Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name>
<affiliation wicri:level="1"><nlm:aff id="af63"><addr-line>Helmholtz Zentrum München</addr-line>
,<institution>German Research Center for Environmental Health</institution>
,<addr-line>Institute of Epidemiology II, Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name>
<affiliation wicri:level="1"><nlm:aff id="af63"><addr-line>Helmholtz Zentrum München</addr-line>
,<institution>German Research Center for Environmental Health</institution>
,<addr-line>Institute of Epidemiology II, Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af65"><addr-line>Andrija Stampar School of Public Health, Medical School</addr-line>
,<institution>University of Zagreb</institution>
,<addr-line>Zagreb</addr-line>
,<country>Croatia</country>
,</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name>
<affiliation wicri:level="1"><nlm:aff id="af66"><addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name>
<affiliation wicri:level="1"><nlm:aff id="af66"><addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wheeler, Heather E" sort="Wheeler, Heather E" uniqKey="Wheeler H" first="Heather E." last="Wheeler">Heather E. Wheeler</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af28"><addr-line>Department of Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Departments of Genetics and Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zaboli, Ghazal" sort="Zaboli, Ghazal" uniqKey="Zaboli G" first="Ghazal" last="Zaboli">Ghazal Zaboli</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name>
<affiliation wicri:level="1"><nlm:aff id="af68"><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University</institution>
,<addr-line>Schittenhelmstr.12, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nothlings, Ute" sort="Nothlings, Ute" uniqKey="Nothlings U" first="Ute" last="Nöthlings">Ute Nöthlings</name>
<affiliation wicri:level="1"><nlm:aff id="af69"><addr-line>Section for Epidemiology</addr-line>
,<institution>Institute for Experimental Medicine, Christian-Albrechts-University of Kiel and Popgen Biobank, University Hospital Schleswig-Holstein</institution>
,<addr-line>Niemannsweg 11, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jacobs, Gunnar" sort="Jacobs, Gunnar" uniqKey="Jacobs G" first="Gunnar" last="Jacobs">Gunnar Jacobs</name>
<affiliation wicri:level="1"><nlm:aff id="af69"><addr-line>Section for Epidemiology</addr-line>
,<institution>Institute for Experimental Medicine, Christian-Albrechts-University of Kiel and Popgen Biobank, University Hospital Schleswig-Holstein</institution>
,<addr-line>Niemannsweg 11, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name>
<affiliation wicri:level="1"><nlm:aff id="af70"><addr-line>Clinic for Prosthodontic Dentistry</addr-line>
,<institution>Gerostomatology and Material Science, University of Greifswald</institution>
,<addr-line>Rotgerberstr 8, Greifswald 17475</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name>
<affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name>
<affiliation wicri:level="1"><nlm:aff id="af5"><institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>
,<addr-line>Friedrich-Ludwig-Jahn-Str. 15a, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K." last="Kroemer">Heyo K. Kroemer</name>
<affiliation wicri:level="1"><nlm:aff id="af71"><institution>Institute of Pharmacology, University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str., 23d, Greifswald 17487</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name>
<affiliation wicri:level="1"><nlm:aff id="af72"><institution>Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz Arndt-University Greifswald</institution>
,<addr-line>Ferdinand-Sauerbruch-Str., Greifswald 17475</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name>
<affiliation wicri:level="1"><nlm:aff id="af73"><addr-line>Clinic for Internal Medicine A</addr-line>
,<institution>University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str. 23a, Greifswald 17475</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name>
<affiliation wicri:level="1"><nlm:aff id="af5"><institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>
,<addr-line>Friedrich-Ludwig-Jahn-Str. 15a, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<affiliation wicri:level="1"><nlm:aff id="af74"><addr-line>Institute for Community Medicine</addr-line>
,<institution>University of Greifswald</institution>
,<addr-line>Walther-Rathenau-Str. 48, Greifswald 17487</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name>
<affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name>
<affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af75"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7LJ</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af76"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7BN</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="1"><nlm:aff id="af77"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>PO Box 1738, 3000 DR Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation wicri:level="1"><nlm:aff id="af77"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>PO Box 1738, 3000 DR Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation wicri:level="1"><nlm:aff id="af66"><addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hastie, Nick" sort="Hastie, Nick" uniqKey="Hastie N" first="Nick" last="Hastie">Nick Hastie</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name>
<affiliation wicri:level="1"><nlm:aff id="af78"><institution>INSERM U897, Université Victor Ségalen Bordeaux 2</institution>
,<addr-line>ISPED case 11, 146 Rue Léo Saignat, F-33076 Bordeaux</addr-line>
,<country>France</country>
,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
<affiliation wicri:level="1"><nlm:aff id="af79"><addr-line>Centre for Vision Research</addr-line>
,<institution>University of Sydney, Westmead Millennium Institute, Westmead Hospital</institution>
,<addr-line>Sydney NSW 2145</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af80"><addr-line>Centre for Eye Research Australia (CERA)</addr-line>
,<institution>University of Melbourne</institution>
,<addr-line>32 Gisborne Street, East Melbourne, Victoria 3002</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Bénédicte" last="Stengel">Bénédicte Stengel</name>
<affiliation wicri:level="1"><nlm:aff id="af81"><institution>INSERM UMRS 1018-CESP Team 10, Univ Paris Sud</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name>
<affiliation wicri:level="1"><nlm:aff id="af40"><institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name>
<affiliation wicri:level="1"><nlm:aff id="af42"><institution>Swiss Institute of Bioinformatics</institution>
,<addr-line>Lausanne</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name>
<affiliation wicri:level="1"><nlm:aff id="af82"><addr-line>Department of Clinical Physiology</addr-line>
,<institution>University of Tampere and Tampere University Hospital</institution>
,<addr-line>33521-PO Box 2000, Tampere 33521</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name>
<affiliation wicri:level="1"><nlm:aff id="af83"><addr-line>Department of Clinical Physiology</addr-line>
,<institution>Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, University of Turku</institution>
,<addr-line>PO Box 52, Turku 20521</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nikopensius, Tiit" sort="Nikopensius, Tiit" uniqKey="Nikopensius T" first="Tiit" last="Nikopensius">Tiit Nikopensius</name>
<affiliation wicri:level="1"><nlm:aff id="af44"><institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Province, Michael" sort="Province, Michael" uniqKey="Province M" first="Michael" last="Province">Michael Province</name>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Colhoun, Helen" sort="Colhoun, Helen" uniqKey="Colhoun H" first="Helen" last="Colhoun">Helen Colhoun</name>
<affiliation><nlm:aff id="af46"><addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Doney, Alex" sort="Doney, Alex" uniqKey="Doney A" first="Alex" last="Doney">Alex Doney</name>
<affiliation><nlm:aff id="af46"><addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name>
<affiliation wicri:level="1"><nlm:aff id="af47"><institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af84"><institution>University of Trieste</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name>
<affiliation wicri:level="1"><nlm:aff id="af85"><addr-line>Department of Medicine</addr-line>
,<institution>University Medical Centre Mannheim</institution>
,<addr-line>Theodor Kutzer Ufer 1-3, Mannheim 68167</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name>
<affiliation wicri:level="1"><nlm:aff id="af48"><institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation><nlm:aff id="af86"><addr-line>Robertson Centre for Biostatistics</addr-line>
,<institution>University of Glasgow</institution>
,<addr-line>Glasgow</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Pharmacology and Therapeutics</addr-line>
,<institution>University College Cork</institution>
,<addr-line>Cork</addr-line>
,<country>Ireland</country>
,</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Adam, Martin" sort="Adam, Martin" uniqKey="Adam M" first="Martin" last="Adam">Martin Adam</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thun, Gian Andri" sort="Thun, Gian Andri" uniqKey="Thun G" first="Gian-Andri" last="Thun">Gian-Andri Thun</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name>
<affiliation wicri:level="1"><nlm:aff id="af88"><addr-line>First Department of Internal Medicine</addr-line>
,<institution>Paracelsus Medical University</institution>
,<addr-line>Müllner Hauptstraße 48, Salzburg 5020</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name>
<affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name>
<affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<affiliation wicri:level="1"><nlm:aff id="af79"><addr-line>Centre for Vision Research</addr-line>
,<institution>University of Sydney, Westmead Millennium Institute, Westmead Hospital</institution>
,<addr-line>Sydney NSW 2145</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name>
<affiliation wicri:level="1"><nlm:aff id="af40"><institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Stuart K" sort="Kim, Stuart K" uniqKey="Kim S" first="Stuart K." last="Kim">Stuart K. Kim</name>
<affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Departments of Genetics and Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name>
<affiliation wicri:level="1"><nlm:aff id="af89"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Centre Hospitalier Universitaire Vaudois and University of Lausanne</institution>
,<addr-line>Rue du Bugnon 46, Lausanne 1011, CH</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name>
<affiliation wicri:level="1"><nlm:aff id="af83"><addr-line>Department of Clinical Physiology</addr-line>
,<institution>Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, University of Turku</institution>
,<addr-line>PO Box 52, Turku 20521</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name>
<affiliation wicri:level="1"><nlm:aff id="af44"><institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Palmer, Colin" sort="Palmer, Colin" uniqKey="Palmer C" first="Colin" last="Palmer">Colin Palmer</name>
<affiliation><nlm:aff id="af90"><institution>University of Dundee-Biomedical Research Institute</institution>
,<addr-line>Level 5, Ninewells Hospital Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name>
<affiliation wicri:level="1"><nlm:aff id="af47"><institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af84"><institution>University of Trieste</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name>
<affiliation wicri:level="1"><nlm:aff id="af48"><institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<affiliation wicri:level="1"><nlm:aff id="af91"><institution>Durrer Center for Cardiogenetic Research</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af92"><institution>Interuniversity Cardiology Institute of the Netherlands (ICIN)</institution>
,<addr-line>Utrecht</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af93"><institution>Einthoven Laboratory for Experimental Vascular Medicine</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M." last="Probst-Hensch">Nicole M. Probst-Hensch</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af51"><institution>University of Basel</institution>
,<addr-line>Basel</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name>
<affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name>
<affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1"><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af22"><institution>University of Iceland</institution>
,<addr-line>Sæmundargötu 2, 101 Reykjavik</addr-line>
,<country>Iceland</country>
,</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Department of Medicine</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af94"><institution>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af95"><addr-line>Welch Center for Prevention</addr-line>
,<institution>Epidemiology and Clinical Research, Johns Hopkins University</institution>
,<addr-line>2024 E Monument St., Suite 2-600, Baltimore, MD 21287</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="af96"><addr-line>Department of Special Neurology</addr-line>
,<institution>University Clinic of Neurology, Medical University Graz</institution>
,<addr-line>Auenbruggerplatz 22, 8036 Graz</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation wicri:level="1"><nlm:aff id="af26"><institution>Clinical Research Branch, National Institute of Aging</institution>
,<addr-line>3001 S Hanover Street, Baltimore, MD 21225</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name>
<affiliation wicri:level="1"><nlm:aff id="af27"><institution>University of Washington</institution>
,<addr-line>1730 Minor Ave. Campus Box 358080, Seattle, WA 98101-1448</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name>
<affiliation wicri:level="1"><nlm:aff id="af97"><addr-line>Department of Epidemiology and School of Public Health</addr-line>
,<institution>University of Medicine</institution>
,<addr-line>109 Observatory #4605, Ann Arbor, MI 48109-2029</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name>
<affiliation><nlm:aff id="af32"><addr-line>Department of Epidemiology and Prevention, Public Health Sciences</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af98"><institution>Channing Laboratory, Brigham and Women's Hospital</institution>
,<addr-line>181 Longwood Avenue, Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name>
<affiliation wicri:level="1"><nlm:aff id="af68"><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University</institution>
,<addr-line>Schittenhelmstr.12, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name>
<affiliation wicri:level="1"><nlm:aff id="af99"><institution>Institute of Physiology, University of Greifswald</institution>
,<addr-line>Greifswald 17487</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<affiliation wicri:level="1"><nlm:aff id="af75"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7LJ</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af76"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7BN</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Witteman, Jacqueline" sort="Witteman, Jacqueline" uniqKey="Witteman J" first="Jacqueline" last="Witteman">Jacqueline Witteman</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name>
<affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Division of Nephrology</addr-line>
,<institution>University of Maryland Medical School</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af100"><institution>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne</institution>
,<addr-line>Route de la Corniche 2, Epalinges 1066, CH</addr-line>
,<country>Switzerland</country>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name>
<affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Epidemiology and Preventive Medicine</addr-line>
,<institution>University Hospital Regensburg</institution>
,<addr-line>Franz-Josef-Strauss-Allee 11, 93042 Regensburg</addr-line>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af13"><institution>Institute of Medical Informatics, Biometry and Epidemiology, and Institute of Epidemiology, Ludwig-Maximilians-Universität</institution>
,<addr-line>Ingolstädter Landstr. 1, 85764 Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W. H. Linda" last="Kao">W. H. Linda Kao</name>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af95"><addr-line>Welch Center for Prevention</addr-line>
,<institution>Epidemiology and Clinical Research, Johns Hopkins University</institution>
,<addr-line>2024 E Monument St., Suite 2-600, Baltimore, MD 21287</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af101"><addr-line>Division of Endocrinology</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>75 Francis St., Boston, MA</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name>
<affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Renal Division</addr-line>
,<institution>Freiburg University Clinic</institution>
,<addr-line>Berliner Allee 29, 79110 Freiburg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22962313</idno>
<idno type="pmc">3607468</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607468</idno>
<idno type="RBID">PMC:3607468</idno>
<idno type="doi">10.1093/hmg/dds369</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">001867</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001867</idno>
<idno type="wicri:Area/Pmc/Curation">001727</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001727</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001E80</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001E80</idno>
<idno type="wicri:Area/Ncbi/Merge">000F68</idno>
<idno type="wicri:Area/Ncbi/Curation">000F68</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000F68</idno>
<idno type="wicri:doubleKey">0964-6906:2012:Chasman D:integration:of:genome</idno>
<idno type="wicri:Area/Main/Merge">005566</idno>
<idno type="wicri:Area/Main/Curation">005340</idno>
<idno type="wicri:Area/Main/Exploration">005340</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function</title>
<author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name>
<affiliation wicri:level="1"><nlm:aff id="af3"><addr-line>Department of Biostatistics, Center for Statistical Genetics</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pattaro, Cristian" sort="Pattaro, Cristian" uniqKey="Pattaro C" first="Cristian" last="Pattaro">Cristian Pattaro</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name>
<affiliation wicri:level="1"><nlm:aff id="af5"><institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>
,<addr-line>Friedrich-Ludwig-Jahn-Str. 15a, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A." last="Böger">Carsten A. Böger</name>
<affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Internal Medicine II</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name>
<affiliation wicri:level="1"><nlm:aff id="af8"><institution>Institute of Anatomy and Cell Biology, University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str. 23c, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name>
<affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Internal Medicine II</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Epidemiology and Preventive Medicine</addr-line>
,<institution>University Hospital Regensburg</institution>
,<addr-line>Franz-Josef-Strauss-Allee 11, 93042 Regensburg</addr-line>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<affiliation wicri:level="1"><nlm:aff id="af9"><addr-line>Department of Neurology</addr-line>
,<institution>Boston University School of Medicine</institution>
,<addr-line>72 East Concord St. B603, Boston, MA 02118</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Department of Biostatistics</addr-line>
,<institution>Boston University School of Public Health</institution>
,<addr-line>715 Albany St., Boston, MA 02118</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Taliun, Daniel" sort="Taliun, Daniel" uniqKey="Taliun D" first="Daniel" last="Taliun">Daniel Taliun</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gao, Xiaoyi" sort="Gao, Xiaoyi" uniqKey="Gao X" first="Xiaoyi" last="Gao">Xiaoyi Gao</name>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name>
<affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Epidemiology and Preventive Medicine</addr-line>
,<institution>University Hospital Regensburg</institution>
,<addr-line>Franz-Josef-Strauss-Allee 11, 93042 Regensburg</addr-line>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af13"><institution>Institute of Medical Informatics, Biometry and Epidemiology, and Institute of Epidemiology, Ludwig-Maximilians-Universität</institution>
,<addr-line>Ingolstädter Landstr. 1, 85764 Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
<affiliation wicri:level="1"><nlm:aff id="af10"><addr-line>Department of Biostatistics</addr-line>
,<institution>Boston University School of Public Health</institution>
,<addr-line>715 Albany St., Boston, MA 02118</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hundertmark, Claudia" sort="Hundertmark, Claudia" uniqKey="Hundertmark C" first="Claudia" last="Hundertmark">Claudia Hundertmark</name>
<affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Renal Division</addr-line>
,<institution>Freiburg University Clinic</institution>
,<addr-line>Berliner Allee 29, 79110 Freiburg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Foster, Meredith C" sort="Foster, Meredith C" uniqKey="Foster M" first="Meredith C." last="Foster">Meredith C. Foster</name>
<affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="O Seaghdha, Conall M" sort="O Seaghdha, Conall M" uniqKey="O Seaghdha C" first="Conall M." last="O'Seaghdha">Conall M. O'Seaghdha</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af16"><addr-line>Division of Nephrology</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>75 Francis St., Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Glazer, Nicole" sort="Glazer, Nicole" uniqKey="Glazer N" first="Nicole" last="Glazer">Nicole Glazer</name>
<affiliation wicri:level="1"><nlm:aff id="af17"><addr-line>Section of Preventive Medicine and Epidemiology, Department of Medicine</addr-line>
,<institution>Boston University School of Medicine</institution>
,<addr-line>761 Harrison Ave, Boston, MA 02118</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Centre for Medical Systems Biology</addr-line>
,<institution>Leiden University</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name>
<affiliation wicri:level="1"><nlm:aff id="af20"><addr-line>Department of Biostatistics</addr-line>
,<institution>Boston University School of Public Health</institution>
,<addr-line>801 Massachusetts Ave, CT3, Boston, MA 02118</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
<affiliation wicri:level="1"><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af22"><institution>University of Iceland</institution>
,<addr-line>Sæmundargötu 2, 101 Reykjavik</addr-line>
,<country>Iceland</country>
,</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Department of Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name>
<affiliation wicri:level="1"><nlm:aff id="af25"><addr-line>Departments of Epidemiology and Biostatistics, and Forensic Molecular Biology</addr-line>
,<institution>University of Rotterdam</institution>
,<addr-line>Dr Molewaterplein 50-603015, Rotterdam, GE</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name>
<affiliation wicri:level="1"><nlm:aff id="af26"><institution>Clinical Research Branch, National Institute of Aging</institution>
,<addr-line>3001 S Hanover Street, Baltimore, MD 21225</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name>
<affiliation wicri:level="1"><nlm:aff id="af27"><institution>University of Washington</institution>
,<addr-line>1730 Minor Ave. Campus Box 358080, Seattle, WA 98101-1448</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name>
<affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gierman, Hinco J" sort="Gierman, Hinco J" uniqKey="Gierman H" first="Hinco J." last="Gierman">Hinco J. Gierman</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af28"><addr-line>Department of Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name>
<affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af30"><addr-line>Division of Biomedical Statistics and Informatics</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name>
<affiliation><nlm:aff id="af32"><addr-line>Department of Epidemiology and Prevention, Public Health Sciences</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C." last="Cornelis">Marilyn C. Cornelis</name>
<affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>665 Huntington Avenue, Building 2, Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name>
<affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<affiliation wicri:level="1"><nlm:aff id="af38"><institution>INSERM UMR744, Institut Pasteur</institution>
,<addr-line>Lille</addr-line>
,<country>France</country>
,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name>
<affiliation wicri:level="1"><nlm:aff id="af39"><addr-line>Centre for Information-based Medicine and School of Medicine and Public Health</addr-line>
,<institution>University of Newcastle, Hunter Medical Research Institute</institution>
,<addr-line>Newcastle, NSW</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name>
<affiliation wicri:level="1"><nlm:aff id="af40"><institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name>
<affiliation wicri:level="1"><nlm:aff id="af41"><addr-line>Department of Medical Genetics</addr-line>
,<institution>University of Lausanne</institution>
,<addr-line>Rue du Bugnon 27, CH, 1005 Lausanne</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af42"><institution>Swiss Institute of Bioinformatics</institution>
,<addr-line>Lausanne</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name>
<affiliation wicri:level="1"><nlm:aff id="af43"><addr-line>Department of Clinical Chemistry, Centre for Laboratory Medicine Tampere Finn</addr-line>
,<institution>University of Tampere and Tampere University Hospital</institution>
,<addr-line>Medi 2, 3th, floor, PO Box 2000, 33521 Tampere</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name>
<affiliation wicri:level="1"><nlm:aff id="af44"><institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Deshmukh, Harshal" sort="Deshmukh, Harshal" uniqKey="Deshmukh H" first="Harshal" last="Deshmukh">Harshal Deshmukh</name>
<affiliation><nlm:aff id="af46"><addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name>
<affiliation wicri:level="1"><nlm:aff id="af47"><institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name>
<affiliation wicri:level="1"><nlm:aff id="af48"><institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name>
<affiliation wicri:level="1"><nlm:aff id="af49"><addr-line>Deparment of Cardiology</addr-line>
,<institution>Leiden University Medical Center</institution>
,<addr-line>Postzone C2-R, PO Box 9600, 2300 RC Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af51"><institution>University of Basel</institution>
,<addr-line>Basel</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name>
<affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name>
<affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<affiliation wicri:level="1"><nlm:aff id="af58"><institution>Laboratory of Epidemiology, Demography, and Biometry</institution>
,<addr-line>NIA-Gateway Building, 3C309, 7201 Wisconsin Ave., Bethesda, MD 20892-9205</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="1"><nlm:aff id="af58"><institution>Laboratory of Epidemiology, Demography, and Biometry</institution>
,<addr-line>NIA-Gateway Building, 3C309, 7201 Wisconsin Ave., Bethesda, MD 20892-9205</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name>
<affiliation wicri:level="1"><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af22"><institution>University of Iceland</institution>
,<addr-line>Sæmundargötu 2, 101 Reykjavik</addr-line>
,<country>Iceland</country>
,</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name>
<affiliation wicri:level="1"><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Department of Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<affiliation wicri:level="1"><nlm:aff id="af59"><addr-line>Human Genetics Center Houston</addr-line>
,<institution>University of Texas Health Science Center</institution>
,<addr-line>TX-1200 Herman Pressler Drive, Houston, TX 77030</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Institute of Molecular Biology and Biochemistry and Department of Neurology</addr-line>
,<institution>Medical University Graz</institution>
,<addr-line>Harrachgasse 21 8010, Graz</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name>
<affiliation wicri:level="1"><nlm:aff id="af60"><addr-line>Institute of Molecular Biology and Biochemistry and Department of Neurology</addr-line>
,<institution>Medical University Graz</institution>
,<addr-line>Harrachgasse 21 8010, Graz</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rao, Madhumathi" sort="Rao, Madhumathi" uniqKey="Rao M" first="Madhumathi" last="Rao">Madhumathi Rao</name>
<affiliation wicri:level="1"><nlm:aff id="af61"><addr-line>Division of Nephrology/Tufts Evidence Practice Center</addr-line>
,<institution>Tufts University School of Medicine-Tufts Medical Center</institution>
,<addr-line>Boston, MA 02111</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hu, Frank" sort="Hu, Frank" uniqKey="Hu F" first="Frank" last="Hu">Frank Hu</name>
<affiliation wicri:level="1"><nlm:aff id="af35"><addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>665 Huntington Avenue, Building 2, Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Centre for Medical Systems Biology</addr-line>
,<institution>Leiden University</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af19"><addr-line>Centre for Medical Systems Biology</addr-line>
,<institution>Leiden University</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af30"><addr-line>Division of Biomedical Statistics and Informatics</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name>
<affiliation wicri:level="1"><nlm:aff id="af31"><addr-line>Department of Internal Medicine, Division of Nephrology and Hypertension</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name>
<affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Internal Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrews, Jeanette S" sort="Andrews, Jeanette S" uniqKey="Andrews J" first="Jeanette S." last="Andrews">Jeanette S. Andrews</name>
<affiliation wicri:level="1"><nlm:aff id="af34"><addr-line>Department of Biostatistical Sciences, Public Health Sciences</addr-line>
,<institution>Wake Forest School of Medicine</institution>
,<addr-line>Winston-Salem, NC 27157</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name>
<affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Internal Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giulianini, Franco" sort="Giulianini, Franco" uniqKey="Giulianini F" first="Franco" last="Giulianini">Franco Giulianini</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<affiliation wicri:level="1"><nlm:aff id="af62"><addr-line>Abteilung Innere II</addr-line>
,<institution>Universitätsklinikum Ulm</institution>
,<addr-line>Albert-Einstein-Allee 23, Ulm 89081</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name>
<affiliation wicri:level="1"><nlm:aff id="af13"><institution>Institute of Medical Informatics, Biometry and Epidemiology, and Institute of Epidemiology, Ludwig-Maximilians-Universität</institution>
,<addr-line>Ingolstädter Landstr. 1, 85764 Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name>
<affiliation wicri:level="1"><nlm:aff id="af63"><addr-line>Helmholtz Zentrum München</addr-line>
,<institution>German Research Center for Environmental Health</institution>
,<addr-line>Institute of Epidemiology II, Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name>
<affiliation wicri:level="1"><nlm:aff id="af63"><addr-line>Helmholtz Zentrum München</addr-line>
,<institution>German Research Center for Environmental Health</institution>
,<addr-line>Institute of Epidemiology II, Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af65"><addr-line>Andrija Stampar School of Public Health, Medical School</addr-line>
,<institution>University of Zagreb</institution>
,<addr-line>Zagreb</addr-line>
,<country>Croatia</country>
,</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name>
<affiliation wicri:level="1"><nlm:aff id="af66"><addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name>
<affiliation wicri:level="1"><nlm:aff id="af66"><addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wheeler, Heather E" sort="Wheeler, Heather E" uniqKey="Wheeler H" first="Heather E." last="Wheeler">Heather E. Wheeler</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af28"><addr-line>Department of Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Departments of Genetics and Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zaboli, Ghazal" sort="Zaboli, Ghazal" uniqKey="Zaboli G" first="Ghazal" last="Zaboli">Ghazal Zaboli</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name>
<affiliation wicri:level="1"><nlm:aff id="af68"><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University</institution>
,<addr-line>Schittenhelmstr.12, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nothlings, Ute" sort="Nothlings, Ute" uniqKey="Nothlings U" first="Ute" last="Nöthlings">Ute Nöthlings</name>
<affiliation wicri:level="1"><nlm:aff id="af69"><addr-line>Section for Epidemiology</addr-line>
,<institution>Institute for Experimental Medicine, Christian-Albrechts-University of Kiel and Popgen Biobank, University Hospital Schleswig-Holstein</institution>
,<addr-line>Niemannsweg 11, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jacobs, Gunnar" sort="Jacobs, Gunnar" uniqKey="Jacobs G" first="Gunnar" last="Jacobs">Gunnar Jacobs</name>
<affiliation wicri:level="1"><nlm:aff id="af69"><addr-line>Section for Epidemiology</addr-line>
,<institution>Institute for Experimental Medicine, Christian-Albrechts-University of Kiel and Popgen Biobank, University Hospital Schleswig-Holstein</institution>
,<addr-line>Niemannsweg 11, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name>
<affiliation wicri:level="1"><nlm:aff id="af70"><addr-line>Clinic for Prosthodontic Dentistry</addr-line>
,<institution>Gerostomatology and Material Science, University of Greifswald</institution>
,<addr-line>Rotgerberstr 8, Greifswald 17475</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name>
<affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name>
<affiliation wicri:level="1"><nlm:aff id="af5"><institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>
,<addr-line>Friedrich-Ludwig-Jahn-Str. 15a, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K." last="Kroemer">Heyo K. Kroemer</name>
<affiliation wicri:level="1"><nlm:aff id="af71"><institution>Institute of Pharmacology, University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str., 23d, Greifswald 17487</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name>
<affiliation wicri:level="1"><nlm:aff id="af72"><institution>Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz Arndt-University Greifswald</institution>
,<addr-line>Ferdinand-Sauerbruch-Str., Greifswald 17475</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name>
<affiliation wicri:level="1"><nlm:aff id="af73"><addr-line>Clinic for Internal Medicine A</addr-line>
,<institution>University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str. 23a, Greifswald 17475</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name>
<affiliation wicri:level="1"><nlm:aff id="af5"><institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>
,<addr-line>Friedrich-Ludwig-Jahn-Str. 15a, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<affiliation wicri:level="1"><nlm:aff id="af74"><addr-line>Institute for Community Medicine</addr-line>
,<institution>University of Greifswald</institution>
,<addr-line>Walther-Rathenau-Str. 48, Greifswald 17487</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name>
<affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name>
<affiliation wicri:level="1"><nlm:aff id="af37"><addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af75"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7LJ</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af76"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7BN</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="1"><nlm:aff id="af77"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>PO Box 1738, 3000 DR Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation wicri:level="1"><nlm:aff id="af77"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>PO Box 1738, 3000 DR Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation wicri:level="1"><nlm:aff id="af66"><addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</nlm:aff>
<country xml:lang="fr">Croatie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hastie, Nick" sort="Hastie, Nick" uniqKey="Hastie N" first="Nick" last="Hastie">Nick Hastie</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name>
<affiliation wicri:level="1"><nlm:aff id="af78"><institution>INSERM U897, Université Victor Ségalen Bordeaux 2</institution>
,<addr-line>ISPED case 11, 146 Rue Léo Saignat, F-33076 Bordeaux</addr-line>
,<country>France</country>
,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
<affiliation wicri:level="1"><nlm:aff id="af79"><addr-line>Centre for Vision Research</addr-line>
,<institution>University of Sydney, Westmead Millennium Institute, Westmead Hospital</institution>
,<addr-line>Sydney NSW 2145</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af80"><addr-line>Centre for Eye Research Australia (CERA)</addr-line>
,<institution>University of Melbourne</institution>
,<addr-line>32 Gisborne Street, East Melbourne, Victoria 3002</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Bénédicte" last="Stengel">Bénédicte Stengel</name>
<affiliation wicri:level="1"><nlm:aff id="af81"><institution>INSERM UMRS 1018-CESP Team 10, Univ Paris Sud</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name>
<affiliation wicri:level="1"><nlm:aff id="af40"><institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name>
<affiliation wicri:level="1"><nlm:aff id="af42"><institution>Swiss Institute of Bioinformatics</institution>
,<addr-line>Lausanne</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name>
<affiliation wicri:level="1"><nlm:aff id="af82"><addr-line>Department of Clinical Physiology</addr-line>
,<institution>University of Tampere and Tampere University Hospital</institution>
,<addr-line>33521-PO Box 2000, Tampere 33521</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name>
<affiliation wicri:level="1"><nlm:aff id="af83"><addr-line>Department of Clinical Physiology</addr-line>
,<institution>Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, University of Turku</institution>
,<addr-line>PO Box 52, Turku 20521</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nikopensius, Tiit" sort="Nikopensius, Tiit" uniqKey="Nikopensius T" first="Tiit" last="Nikopensius">Tiit Nikopensius</name>
<affiliation wicri:level="1"><nlm:aff id="af44"><institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Province, Michael" sort="Province, Michael" uniqKey="Province M" first="Michael" last="Province">Michael Province</name>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Colhoun, Helen" sort="Colhoun, Helen" uniqKey="Colhoun H" first="Helen" last="Colhoun">Helen Colhoun</name>
<affiliation><nlm:aff id="af46"><addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Doney, Alex" sort="Doney, Alex" uniqKey="Doney A" first="Alex" last="Doney">Alex Doney</name>
<affiliation><nlm:aff id="af46"><addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name>
<affiliation wicri:level="1"><nlm:aff id="af47"><institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af84"><institution>University of Trieste</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name>
<affiliation wicri:level="1"><nlm:aff id="af85"><addr-line>Department of Medicine</addr-line>
,<institution>University Medical Centre Mannheim</institution>
,<addr-line>Theodor Kutzer Ufer 1-3, Mannheim 68167</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name>
<affiliation wicri:level="1"><nlm:aff id="af48"><institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation><nlm:aff id="af86"><addr-line>Robertson Centre for Biostatistics</addr-line>
,<institution>University of Glasgow</institution>
,<addr-line>Glasgow</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name>
<affiliation wicri:level="1"><nlm:aff id="af87"><addr-line>Department of Pharmacology and Therapeutics</addr-line>
,<institution>University College Cork</institution>
,<addr-line>Cork</addr-line>
,<country>Ireland</country>
,</nlm:aff>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Adam, Martin" sort="Adam, Martin" uniqKey="Adam M" first="Martin" last="Adam">Martin Adam</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thun, Gian Andri" sort="Thun, Gian Andri" uniqKey="Thun G" first="Gian-Andri" last="Thun">Gian-Andri Thun</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name>
<affiliation wicri:level="1"><nlm:aff id="af88"><addr-line>First Department of Internal Medicine</addr-line>
,<institution>Paracelsus Medical University</institution>
,<addr-line>Müllner Hauptstraße 48, Salzburg 5020</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name>
<affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name>
<affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<affiliation wicri:level="1"><nlm:aff id="af79"><addr-line>Centre for Vision Research</addr-line>
,<institution>University of Sydney, Westmead Millennium Institute, Westmead Hospital</institution>
,<addr-line>Sydney NSW 2145</addr-line>
,<country>Australia</country>
,</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name>
<affiliation wicri:level="1"><nlm:aff id="af40"><institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kim, Stuart K" sort="Kim, Stuart K" uniqKey="Kim S" first="Stuart K." last="Kim">Stuart K. Kim</name>
<affiliation wicri:level="1"><nlm:aff id="af29"><addr-line>Departments of Genetics and Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name>
<affiliation wicri:level="1"><nlm:aff id="af89"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Centre Hospitalier Universitaire Vaudois and University of Lausanne</institution>
,<addr-line>Rue du Bugnon 46, Lausanne 1011, CH</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name>
<affiliation wicri:level="1"><nlm:aff id="af83"><addr-line>Department of Clinical Physiology</addr-line>
,<institution>Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, University of Turku</institution>
,<addr-line>PO Box 52, Turku 20521</addr-line>
,<country>Finland</country>
,</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name>
<affiliation wicri:level="1"><nlm:aff id="af44"><institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af45"><addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Palmer, Colin" sort="Palmer, Colin" uniqKey="Palmer C" first="Colin" last="Palmer">Colin Palmer</name>
<affiliation><nlm:aff id="af90"><institution>University of Dundee-Biomedical Research Institute</institution>
,<addr-line>Level 5, Ninewells Hospital Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name>
<affiliation wicri:level="1"><nlm:aff id="af47"><institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af84"><institution>University of Trieste</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name>
<affiliation wicri:level="1"><nlm:aff id="af48"><institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<affiliation wicri:level="1"><nlm:aff id="af91"><institution>Durrer Center for Cardiogenetic Research</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af92"><institution>Interuniversity Cardiology Institute of the Netherlands (ICIN)</institution>
,<addr-line>Utrecht</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af93"><institution>Einthoven Laboratory for Experimental Vascular Medicine</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M." last="Probst-Hensch">Nicole M. Probst-Hensch</name>
<affiliation wicri:level="1"><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af51"><institution>University of Basel</institution>
,<addr-line>Basel</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name>
<affiliation wicri:level="1"><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name>
<affiliation wicri:level="1"><nlm:aff id="af53"><addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1"><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af22"><institution>University of Iceland</institution>
,<addr-line>Sæmundargötu 2, 101 Reykjavik</addr-line>
,<country>Iceland</country>
,</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Department of Medicine</addr-line>
</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af94"><institution>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af95"><addr-line>Welch Center for Prevention</addr-line>
,<institution>Epidemiology and Clinical Research, Johns Hopkins University</institution>
,<addr-line>2024 E Monument St., Suite 2-600, Baltimore, MD 21287</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="af96"><addr-line>Department of Special Neurology</addr-line>
,<institution>University Clinic of Neurology, Medical University Graz</institution>
,<addr-line>Auenbruggerplatz 22, 8036 Graz</addr-line>
,<country>Austria</country>
,</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation wicri:level="1"><nlm:aff id="af26"><institution>Clinical Research Branch, National Institute of Aging</institution>
,<addr-line>3001 S Hanover Street, Baltimore, MD 21225</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name>
<affiliation wicri:level="1"><nlm:aff id="af27"><institution>University of Washington</institution>
,<addr-line>1730 Minor Ave. Campus Box 358080, Seattle, WA 98101-1448</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name>
<affiliation wicri:level="1"><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name>
<affiliation wicri:level="1"><nlm:aff id="af97"><addr-line>Department of Epidemiology and School of Public Health</addr-line>
,<institution>University of Medicine</institution>
,<addr-line>109 Observatory #4605, Ann Arbor, MI 48109-2029</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name>
<affiliation><nlm:aff id="af32"><addr-line>Department of Epidemiology and Prevention, Public Health Sciences</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af98"><institution>Channing Laboratory, Brigham and Women's Hospital</institution>
,<addr-line>181 Longwood Avenue, Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name>
<affiliation wicri:level="1"><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name>
<affiliation wicri:level="1"><nlm:aff id="af68"><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University</institution>
,<addr-line>Schittenhelmstr.12, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
<affiliation wicri:level="1"><nlm:aff id="af4"><addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name>
<affiliation wicri:level="1"><nlm:aff id="af99"><institution>Institute of Physiology, University of Greifswald</institution>
,<addr-line>Greifswald 17487</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<affiliation wicri:level="1"><nlm:aff id="af75"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7LJ</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af76"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7BN</addr-line>
,<country>UK</country>
,</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Witteman, Jacqueline" sort="Witteman, Jacqueline" uniqKey="Witteman J" first="Jacqueline" last="Witteman">Jacqueline Witteman</name>
<affiliation wicri:level="1"><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
<wicri:noCountry code="nlm country">Scotland</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<affiliation wicri:level="1"><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name>
<affiliation wicri:level="1"><nlm:aff id="af24"><addr-line>Division of Nephrology</addr-line>
,<institution>University of Maryland Medical School</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name>
<affiliation wicri:level="1"><nlm:aff wicri:cut=" and" id="af100"><institution>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne</institution>
,<addr-line>Route de la Corniche 2, Epalinges 1066, CH</addr-line>
,<country>Switzerland</country>
</nlm:aff>
<country xml:lang="fr">Suisse</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name>
<affiliation wicri:level="1"><nlm:aff id="af7"><addr-line>Department of Epidemiology and Preventive Medicine</addr-line>
,<institution>University Hospital Regensburg</institution>
,<addr-line>Franz-Josef-Strauss-Allee 11, 93042 Regensburg</addr-line>
,<country>Germany</country>
</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af13"><institution>Institute of Medical Informatics, Biometry and Epidemiology, and Institute of Epidemiology, Ludwig-Maximilians-Universität</institution>
,<addr-line>Ingolstädter Landstr. 1, 85764 Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W. H. Linda" last="Kao">W. H. Linda Kao</name>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af95"><addr-line>Welch Center for Prevention</addr-line>
,<institution>Epidemiology and Clinical Research, Johns Hopkins University</institution>
,<addr-line>2024 E Monument St., Suite 2-600, Baltimore, MD 21287</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name>
<affiliation wicri:level="1"><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af101"><addr-line>Division of Endocrinology</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>75 Francis St., Boston, MA</addr-line>
,<country>USA</country>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name>
<affiliation wicri:level="1"><nlm:aff id="af14"><addr-line>Renal Division</addr-line>
,<institution>Freiburg University Clinic</institution>
,<addr-line>Berliner Allee 29, 79110 Freiburg</addr-line>
,<country>Germany</country>
,</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Human Molecular Genetics</title>
<idno type="ISSN">0964-6906</idno>
<idno type="eISSN">1460-2083</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure of kidney function, we developed a strategy for integrating prior biological knowledge into the existing GWAS data for eGFR from the CKDGen Consortium. Our strategy focuses on single nucleotide polymorphism (SNPs) in genes that are connected by functional evidence, determined by literature mining and gene ontology (GO) hierarchies, to genes near previously validated eGFR associations. It then requires association thresholds consistent with multiple testing, and finally evaluates novel candidates by independent replication. Among the samples of European ancestry, we identified a genome-wide significant SNP in <italic>FBXL20</italic>
(<italic>P</italic>
= 5.6 × 10<sup>−9</sup>
) in meta-analysis of all available data, and additional SNPs at the <italic>INHBC</italic>
, <italic>LRP2</italic>
, <italic>PLEKHA1</italic>
, <italic>SLC3A2</italic>
and <italic>SLC7A6</italic>
genes meeting multiple-testing corrected significance for replication and overall <italic>P</italic>
-values of 4.5 × 10<sup>−4</sup>
–2.2 × 10<sup>−7</sup>
. Neither the novel <italic>PLEKHA1</italic>
nor <italic>FBXL20</italic>
associations, both further supported by association with eGFR among African Americans and with transcript abundance, would have been implicated by eGFR candidate gene approaches. <italic>LRP2</italic>
, encoding the megalin receptor, was identified through connection with the previously known eGFR gene <italic>DAB2</italic>
and extends understanding of the megalin system in kidney function. These findings highlight integration of existing genome-wide association data with independent biological knowledge to uncover novel candidate eGFR associations, including candidates lacking known connections to kidney-specific pathways. The strategy may also be applicable to other clinical phenotypes, although more testing will be needed to assess its potential for discovery in general.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Autriche</li>
<li>Croatie</li>
<li>Estonie</li>
<li>Finlande</li>
<li>France</li>
<li>Irlande (pays)</li>
<li>Islande</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
</list>
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<name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<name sortKey="Colhoun, Helen" sort="Colhoun, Helen" uniqKey="Colhoun H" first="Helen" last="Colhoun">Helen Colhoun</name>
<name sortKey="Deshmukh, Harshal" sort="Deshmukh, Harshal" uniqKey="Deshmukh H" first="Harshal" last="Deshmukh">Harshal Deshmukh</name>
<name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name>
<name sortKey="Doney, Alex" sort="Doney, Alex" uniqKey="Doney A" first="Alex" last="Doney">Alex Doney</name>
<name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name>
<name sortKey="Hastie, Nick" sort="Hastie, Nick" uniqKey="Hastie N" first="Nick" last="Hastie">Nick Hastie</name>
<name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name>
<name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name>
<name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name>
<name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name>
<name sortKey="Palmer, Colin" sort="Palmer, Colin" uniqKey="Palmer C" first="Colin" last="Palmer">Colin Palmer</name>
<name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name>
<name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name>
<name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name>
<name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name>
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<country name="États-Unis"><noRegion><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
</noRegion>
<name sortKey="Andrews, Jeanette S" sort="Andrews, Jeanette S" uniqKey="Andrews J" first="Jeanette S." last="Andrews">Jeanette S. Andrews</name>
<name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name>
<name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name>
<name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
<name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name>
<name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name>
<name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name>
<name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C." last="Cornelis">Marilyn C. Cornelis</name>
<name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name>
<name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name>
<name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name>
<name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name>
<name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<name sortKey="Foster, Meredith C" sort="Foster, Meredith C" uniqKey="Foster M" first="Meredith C." last="Foster">Meredith C. Foster</name>
<name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name>
<name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name>
<name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name>
<name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name>
<name sortKey="Gao, Xiaoyi" sort="Gao, Xiaoyi" uniqKey="Gao X" first="Xiaoyi" last="Gao">Xiaoyi Gao</name>
<name sortKey="Gierman, Hinco J" sort="Gierman, Hinco J" uniqKey="Gierman H" first="Hinco J." last="Gierman">Hinco J. Gierman</name>
<name sortKey="Giulianini, Franco" sort="Giulianini, Franco" uniqKey="Giulianini F" first="Franco" last="Giulianini">Franco Giulianini</name>
<name sortKey="Glazer, Nicole" sort="Glazer, Nicole" uniqKey="Glazer N" first="Nicole" last="Glazer">Nicole Glazer</name>
<name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<name sortKey="Hu, Frank" sort="Hu, Frank" uniqKey="Hu F" first="Frank" last="Hu">Frank Hu</name>
<name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name>
<name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name>
<name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W. H. Linda" last="Kao">W. H. Linda Kao</name>
<name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W. H. Linda" last="Kao">W. H. Linda Kao</name>
<name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name>
<name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name>
<name sortKey="Kim, Stuart K" sort="Kim, Stuart K" uniqKey="Kim S" first="Stuart K." last="Kim">Stuart K. Kim</name>
<name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name>
<name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name>
<name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name>
<name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name>
<name sortKey="O Seaghdha, Conall M" sort="O Seaghdha, Conall M" uniqKey="O Seaghdha C" first="Conall M." last="O'Seaghdha">Conall M. O'Seaghdha</name>
<name sortKey="O Seaghdha, Conall M" sort="O Seaghdha, Conall M" uniqKey="O Seaghdha C" first="Conall M." last="O'Seaghdha">Conall M. O'Seaghdha</name>
<name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name>
<name sortKey="Province, Michael" sort="Province, Michael" uniqKey="Province M" first="Michael" last="Province">Michael Province</name>
<name sortKey="Rao, Madhumathi" sort="Rao, Madhumathi" uniqKey="Rao M" first="Madhumathi" last="Rao">Madhumathi Rao</name>
<name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name>
<name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name>
<name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name>
<name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name>
<name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name>
<name sortKey="Wheeler, Heather E" sort="Wheeler, Heather E" uniqKey="Wheeler H" first="Heather E." last="Wheeler">Heather E. Wheeler</name>
<name sortKey="Wheeler, Heather E" sort="Wheeler, Heather E" uniqKey="Wheeler H" first="Heather E." last="Wheeler">Heather E. Wheeler</name>
<name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
</country>
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</noRegion>
<name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name>
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<name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name>
<name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name>
<name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name>
<name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name>
<name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name>
<name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name>
<name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
<name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name>
<name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name>
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<name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name>
</country>
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</noRegion>
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<name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name>
<name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name>
<name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name>
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<name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name>
<name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name>
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<name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
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<name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name>
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<name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
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