Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
Identifieur interne : 001867 ( Pmc/Corpus ); précédent : 001866; suivant : 001868Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function
Auteurs : Daniel I. Chasman ; Christian Fuchsberger ; Cristian Pattaro ; Alexander Teumer ; Carsten A. Böger ; Karlhans Endlich ; Matthias Olden ; Ming-Huei Chen ; Adrienne Tin ; Daniel Taliun ; Man Li ; Xiaoyi Gao ; Mathias Gorski ; Qiong Yang ; Claudia Hundertmark ; Meredith C. Foster ; Conall M. O'Seaghdha ; Nicole Glazer ; Aaron Isaacs ; Ching-Ti Liu ; Albert V. Smith ; Jeffrey R. O'Connell ; Maksim Struchalin ; Toshiko Tanaka ; Guo Li ; Andrew D. Johnson ; Hinco J. Gierman ; Mary F. Feitosa ; Shih-Jen Hwang ; Elizabeth J. Atkinson ; Kurt Lohman ; Marilyn C. Cornelis ; Sa Johansson ; Anke Tönjes ; Abbas Dehghan ; Jean-Charles Lambert ; Elizabeth G. Holliday ; Rossella Sorice ; Zoltan Kutalik ; Terho Lehtim Ki ; T Nu Esko ; Harshal Deshmukh ; Sheila Ulivi ; Audrey Y. Chu ; Federico Murgia ; Stella Trompet ; Medea Imboden ; Stefan Coassin ; Giorgio Pistis ; Tamara B. Harris ; Lenore J. Launer ; Thor Aspelund ; Gudny Eiriksdottir ; Braxton D. Mitchell ; Eric Boerwinkle ; Helena Schmidt ; Margherita Cavalieri ; Madhumathi Rao ; Frank Hu ; Ayse Demirkan ; Ben A. Oostra ; Mariza De Andrade ; Stephen T. Turner ; Jingzhong Ding ; Jeanette S. Andrews ; Barry I. Freedman ; Franco Giulianini ; Wolfgang Koenig ; Thomas Illig ; Christa Meisinger ; Christian Gieger ; Lina Zgaga ; Tatijana Zemunik ; Mladen Boban ; Cosetta Minelli ; Heather E. Wheeler ; Wilmar Igl ; Ghazal Zaboli ; Sarah H. Wild ; Alan F. Wright ; Harry Campbell ; David Ellinghaus ; Ute Nöthlings ; Gunnar Jacobs ; Reiner Biffar ; Florian Ernst ; Georg Homuth ; Heyo K. Kroemer ; Matthias Nauck ; Sylvia Stracke ; Uwe Völker ; Henry Völzke ; Peter Kovacs ; Michael Stumvoll ; Reedik M Gi ; Albert Hofman ; Andre G. Uitterlinden ; Fernando Rivadeneira ; Yurii S. Aulchenko ; Ozren Polasek ; Nick Hastie ; Veronique Vitart ; Catherine Helmer ; Jie Jin Wang ; Bénédicte Stengel ; Daniela Ruggiero ; Sven Bergmann ; Mika K Hönen ; Jorma Viikari ; Tiit Nikopensius ; Michael Province ; Shamika Ketkar ; Helen Colhoun ; Alex Doney ; Antonietta Robino ; Bernhard K. Kr Mer ; Laura Portas ; Ian Ford ; Brendan M. Buckley ; Martin Adam ; Gian-Andri Thun ; Bernhard Paulweber ; Margot Haun ; Cinzia Sala ; Paul Mitchell ; Marina Ciullo ; Stuart K. Kim ; Peter Vollenweider ; Olli Raitakari ; Andres Metspalu ; Colin Palmer ; Paolo Gasparini ; Mario Pirastu ; J. Wouter Jukema ; Nicole M. Probst-Hensch ; Florian Kronenberg ; Daniela Toniolo ; Vilmundur Gudnason ; Alan R. Shuldiner ; Josef Coresh ; Reinhold Schmidt ; Luigi Ferrucci ; David S. Siscovick ; Cornelia M. Van Duijn ; Ingrid B. Borecki ; Sharon L. R. Kardia ; Yongmei Liu ; Gary C. Curhan ; Igor Rudan ; Ulf Gyllensten ; James F. Wilson ; Andre Franke ; Peter P. Pramstaller ; Rainer Rettig ; Inga Prokopenko ; Jacqueline Witteman ; Caroline Hayward ; Paul M. Ridker ; Afshin Parsa ; Murielle Bochud ; Iris M. Heid ; W. H. Linda Kao ; Caroline S. Fox ; Anna KöttgenSource :
- Human Molecular Genetics [ 0964-6906 ] ; 2012.
Abstract
In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure of kidney function, we developed a strategy for integrating prior biological knowledge into the existing GWAS data for eGFR from the CKDGen Consortium. Our strategy focuses on single nucleotide polymorphism (SNPs) in genes that are connected by functional evidence, determined by literature mining and gene ontology (GO) hierarchies, to genes near previously validated eGFR associations. It then requires association thresholds consistent with multiple testing, and finally evaluates novel candidates by independent replication. Among the samples of European ancestry, we identified a genome-wide significant SNP in
Url:
DOI: 10.1093/hmg/dds369
PubMed: 22962313
PubMed Central: 3607468
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PMC:3607468Le document en format XML
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<author><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name>
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<author><name sortKey="Pattaro, Cristian" sort="Pattaro, Cristian" uniqKey="Pattaro C" first="Cristian" last="Pattaro">Cristian Pattaro</name>
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<author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name>
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<author><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A." last="Böger">Carsten A. Böger</name>
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<author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name>
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<author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
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<affiliation><nlm:aff id="af10"><addr-line>Department of Biostatistics</addr-line>
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<author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name>
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<author><name sortKey="Taliun, Daniel" sort="Taliun, Daniel" uniqKey="Taliun D" first="Daniel" last="Taliun">Daniel Taliun</name>
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<author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name>
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<author><name sortKey="Gao, Xiaoyi" sort="Gao, Xiaoyi" uniqKey="Gao X" first="Xiaoyi" last="Gao">Xiaoyi Gao</name>
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<author><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name>
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<author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
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<author><name sortKey="Hundertmark, Claudia" sort="Hundertmark, Claudia" uniqKey="Hundertmark C" first="Claudia" last="Hundertmark">Claudia Hundertmark</name>
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<author><name sortKey="Foster, Meredith C" sort="Foster, Meredith C" uniqKey="Foster M" first="Meredith C." last="Foster">Meredith C. Foster</name>
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<author><name sortKey="O Seaghdha, Conall M" sort="O Seaghdha, Conall M" uniqKey="O Seaghdha C" first="Conall M." last="O'Seaghdha">Conall M. O'Seaghdha</name>
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<affiliation><nlm:aff id="af16"><addr-line>Division of Nephrology</addr-line>
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<author><name sortKey="Glazer, Nicole" sort="Glazer, Nicole" uniqKey="Glazer N" first="Nicole" last="Glazer">Nicole Glazer</name>
<affiliation><nlm:aff id="af17"><addr-line>Section of Preventive Medicine and Epidemiology, Department of Medicine</addr-line>
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<author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name>
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<affiliation><nlm:aff id="af19"><addr-line>Centre for Medical Systems Biology</addr-line>
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,<addr-line>Leiden</addr-line>
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<author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name>
<affiliation><nlm:aff id="af20"><addr-line>Department of Biostatistics</addr-line>
,<institution>Boston University School of Public Health</institution>
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<author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
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<affiliation><nlm:aff id="af22"><institution>University of Iceland</institution>
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<author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Department of Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name>
<affiliation><nlm:aff id="af25"><addr-line>Departments of Epidemiology and Biostatistics, and Forensic Molecular Biology</addr-line>
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,<addr-line>Dr Molewaterplein 50-603015, Rotterdam, GE</addr-line>
,<country>The Netherlands</country>
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</affiliation>
</author>
<author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name>
<affiliation><nlm:aff id="af26"><institution>Clinical Research Branch, National Institute of Aging</institution>
,<addr-line>3001 S Hanover Street, Baltimore, MD 21225</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name>
<affiliation><nlm:aff id="af27"><institution>University of Washington</institution>
,<addr-line>1730 Minor Ave. Campus Box 358080, Seattle, WA 98101-1448</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name>
<affiliation><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gierman, Hinco J" sort="Gierman, Hinco J" uniqKey="Gierman H" first="Hinco J." last="Gierman">Hinco J. Gierman</name>
<affiliation><nlm:aff wicri:cut=" and" id="af28"><addr-line>Department of Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name>
<affiliation><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name>
<affiliation><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name>
<affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Division of Biomedical Statistics and Informatics</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name>
<affiliation><nlm:aff id="af32"><addr-line>Department of Epidemiology and Prevention, Public Health Sciences</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C." last="Cornelis">Marilyn C. Cornelis</name>
<affiliation><nlm:aff id="af35"><addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>665 Huntington Avenue, Building 2, Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name>
<affiliation><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name>
<affiliation><nlm:aff id="af37"><addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<affiliation><nlm:aff id="af38"><institution>INSERM UMR744, Institut Pasteur</institution>
,<addr-line>Lille</addr-line>
,<country>France</country>
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</affiliation>
</author>
<author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name>
<affiliation><nlm:aff id="af39"><addr-line>Centre for Information-based Medicine and School of Medicine and Public Health</addr-line>
,<institution>University of Newcastle, Hunter Medical Research Institute</institution>
,<addr-line>Newcastle, NSW</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name>
<affiliation><nlm:aff id="af40"><institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name>
<affiliation><nlm:aff id="af41"><addr-line>Department of Medical Genetics</addr-line>
,<institution>University of Lausanne</institution>
,<addr-line>Rue du Bugnon 27, CH, 1005 Lausanne</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af42"><institution>Swiss Institute of Bioinformatics</institution>
,<addr-line>Lausanne</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name>
<affiliation><nlm:aff id="af43"><addr-line>Department of Clinical Chemistry, Centre for Laboratory Medicine Tampere Finn</addr-line>
,<institution>University of Tampere and Tampere University Hospital</institution>
,<addr-line>Medi 2, 3th, floor, PO Box 2000, 33521 Tampere</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name>
<affiliation><nlm:aff id="af44"><institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af45"><addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Deshmukh, Harshal" sort="Deshmukh, Harshal" uniqKey="Deshmukh H" first="Harshal" last="Deshmukh">Harshal Deshmukh</name>
<affiliation><nlm:aff id="af46"><addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name>
<affiliation><nlm:aff id="af47"><institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name>
<affiliation><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name>
<affiliation><nlm:aff id="af48"><institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name>
<affiliation><nlm:aff id="af49"><addr-line>Deparment of Cardiology</addr-line>
,<institution>Leiden University Medical Center</institution>
,<addr-line>Postzone C2-R, PO Box 9600, 2300 RC Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name>
<affiliation><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af51"><institution>University of Basel</institution>
,<addr-line>Basel</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name>
<affiliation><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name>
<affiliation><nlm:aff id="af53"><addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<affiliation><nlm:aff id="af58"><institution>Laboratory of Epidemiology, Demography, and Biometry</institution>
,<addr-line>NIA-Gateway Building, 3C309, 7201 Wisconsin Ave., Bethesda, MD 20892-9205</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation><nlm:aff id="af58"><institution>Laboratory of Epidemiology, Demography, and Biometry</institution>
,<addr-line>NIA-Gateway Building, 3C309, 7201 Wisconsin Ave., Bethesda, MD 20892-9205</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name>
<affiliation><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af22"><institution>University of Iceland</institution>
,<addr-line>Sæmundargötu 2, 101 Reykjavik</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name>
<affiliation><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Department of Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<affiliation><nlm:aff id="af59"><addr-line>Human Genetics Center Houston</addr-line>
,<institution>University of Texas Health Science Center</institution>
,<addr-line>TX-1200 Herman Pressler Drive, Houston, TX 77030</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation><nlm:aff id="af60"><addr-line>Institute of Molecular Biology and Biochemistry and Department of Neurology</addr-line>
,<institution>Medical University Graz</institution>
,<addr-line>Harrachgasse 21 8010, Graz</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name>
<affiliation><nlm:aff id="af60"><addr-line>Institute of Molecular Biology and Biochemistry and Department of Neurology</addr-line>
,<institution>Medical University Graz</institution>
,<addr-line>Harrachgasse 21 8010, Graz</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rao, Madhumathi" sort="Rao, Madhumathi" uniqKey="Rao M" first="Madhumathi" last="Rao">Madhumathi Rao</name>
<affiliation><nlm:aff id="af61"><addr-line>Division of Nephrology/Tufts Evidence Practice Center</addr-line>
,<institution>Tufts University School of Medicine-Tufts Medical Center</institution>
,<addr-line>Boston, MA 02111</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hu, Frank" sort="Hu, Frank" uniqKey="Hu F" first="Frank" last="Hu">Frank Hu</name>
<affiliation><nlm:aff id="af35"><addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>665 Huntington Avenue, Building 2, Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af19"><addr-line>Centre for Medical Systems Biology</addr-line>
,<institution>Leiden University</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af19"><addr-line>Centre for Medical Systems Biology</addr-line>
,<institution>Leiden University</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name>
<affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Division of Biomedical Statistics and Informatics</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name>
<affiliation><nlm:aff id="af31"><addr-line>Department of Internal Medicine, Division of Nephrology and Hypertension</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name>
<affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Internal Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrews, Jeanette S" sort="Andrews, Jeanette S" uniqKey="Andrews J" first="Jeanette S." last="Andrews">Jeanette S. Andrews</name>
<affiliation><nlm:aff id="af34"><addr-line>Department of Biostatistical Sciences, Public Health Sciences</addr-line>
,<institution>Wake Forest School of Medicine</institution>
,<addr-line>Winston-Salem, NC 27157</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name>
<affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Internal Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giulianini, Franco" sort="Giulianini, Franco" uniqKey="Giulianini F" first="Franco" last="Giulianini">Franco Giulianini</name>
<affiliation><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<affiliation><nlm:aff id="af62"><addr-line>Abteilung Innere II</addr-line>
,<institution>Universitätsklinikum Ulm</institution>
,<addr-line>Albert-Einstein-Allee 23, Ulm 89081</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name>
<affiliation><nlm:aff id="af13"><institution>Institute of Medical Informatics, Biometry and Epidemiology, and Institute of Epidemiology, Ludwig-Maximilians-Universität</institution>
,<addr-line>Ingolstädter Landstr. 1, 85764 Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name>
<affiliation><nlm:aff id="af63"><addr-line>Helmholtz Zentrum München</addr-line>
,<institution>German Research Center for Environmental Health</institution>
,<addr-line>Institute of Epidemiology II, Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name>
<affiliation><nlm:aff id="af63"><addr-line>Helmholtz Zentrum München</addr-line>
,<institution>German Research Center for Environmental Health</institution>
,<addr-line>Institute of Epidemiology II, Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af65"><addr-line>Andrija Stampar School of Public Health, Medical School</addr-line>
,<institution>University of Zagreb</institution>
,<addr-line>Zagreb</addr-line>
,<country>Croatia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name>
<affiliation><nlm:aff id="af66"><addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name>
<affiliation><nlm:aff id="af66"><addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name>
<affiliation><nlm:aff id="af4"><addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wheeler, Heather E" sort="Wheeler, Heather E" uniqKey="Wheeler H" first="Heather E." last="Wheeler">Heather E. Wheeler</name>
<affiliation><nlm:aff wicri:cut=" and" id="af28"><addr-line>Department of Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af29"><addr-line>Departments of Genetics and Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name>
<affiliation><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zaboli, Ghazal" sort="Zaboli, Ghazal" uniqKey="Zaboli G" first="Ghazal" last="Zaboli">Ghazal Zaboli</name>
<affiliation><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name>
<affiliation><nlm:aff id="af68"><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University</institution>
,<addr-line>Schittenhelmstr.12, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nothlings, Ute" sort="Nothlings, Ute" uniqKey="Nothlings U" first="Ute" last="Nöthlings">Ute Nöthlings</name>
<affiliation><nlm:aff id="af69"><addr-line>Section for Epidemiology</addr-line>
,<institution>Institute for Experimental Medicine, Christian-Albrechts-University of Kiel and Popgen Biobank, University Hospital Schleswig-Holstein</institution>
,<addr-line>Niemannsweg 11, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jacobs, Gunnar" sort="Jacobs, Gunnar" uniqKey="Jacobs G" first="Gunnar" last="Jacobs">Gunnar Jacobs</name>
<affiliation><nlm:aff id="af69"><addr-line>Section for Epidemiology</addr-line>
,<institution>Institute for Experimental Medicine, Christian-Albrechts-University of Kiel and Popgen Biobank, University Hospital Schleswig-Holstein</institution>
,<addr-line>Niemannsweg 11, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name>
<affiliation><nlm:aff id="af70"><addr-line>Clinic for Prosthodontic Dentistry</addr-line>
,<institution>Gerostomatology and Material Science, University of Greifswald</institution>
,<addr-line>Rotgerberstr 8, Greifswald 17475</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name>
<affiliation><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name>
<affiliation><nlm:aff id="af5"><institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>
,<addr-line>Friedrich-Ludwig-Jahn-Str. 15a, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K." last="Kroemer">Heyo K. Kroemer</name>
<affiliation><nlm:aff id="af71"><institution>Institute of Pharmacology, University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str., 23d, Greifswald 17487</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name>
<affiliation><nlm:aff id="af72"><institution>Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz Arndt-University Greifswald</institution>
,<addr-line>Ferdinand-Sauerbruch-Str., Greifswald 17475</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name>
<affiliation><nlm:aff id="af73"><addr-line>Clinic for Internal Medicine A</addr-line>
,<institution>University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str. 23a, Greifswald 17475</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name>
<affiliation><nlm:aff id="af5"><institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>
,<addr-line>Friedrich-Ludwig-Jahn-Str. 15a, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<affiliation><nlm:aff id="af74"><addr-line>Institute for Community Medicine</addr-line>
,<institution>University of Greifswald</institution>
,<addr-line>Walther-Rathenau-Str. 48, Greifswald 17487</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name>
<affiliation><nlm:aff id="af37"><addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name>
<affiliation><nlm:aff id="af37"><addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name>
<affiliation><nlm:aff id="af45"><addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af75"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7LJ</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af76"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7BN</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation><nlm:aff id="af77"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>PO Box 1738, 3000 DR Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation><nlm:aff id="af77"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>PO Box 1738, 3000 DR Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation><nlm:aff id="af66"><addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hastie, Nick" sort="Hastie, Nick" uniqKey="Hastie N" first="Nick" last="Hastie">Nick Hastie</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name>
<affiliation><nlm:aff id="af78"><institution>INSERM U897, Université Victor Ségalen Bordeaux 2</institution>
,<addr-line>ISPED case 11, 146 Rue Léo Saignat, F-33076 Bordeaux</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
<affiliation><nlm:aff id="af79"><addr-line>Centre for Vision Research</addr-line>
,<institution>University of Sydney, Westmead Millennium Institute, Westmead Hospital</institution>
,<addr-line>Sydney NSW 2145</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af80"><addr-line>Centre for Eye Research Australia (CERA)</addr-line>
,<institution>University of Melbourne</institution>
,<addr-line>32 Gisborne Street, East Melbourne, Victoria 3002</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Bénédicte" last="Stengel">Bénédicte Stengel</name>
<affiliation><nlm:aff id="af81"><institution>INSERM UMRS 1018-CESP Team 10, Univ Paris Sud</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name>
<affiliation><nlm:aff id="af40"><institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name>
<affiliation><nlm:aff id="af42"><institution>Swiss Institute of Bioinformatics</institution>
,<addr-line>Lausanne</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name>
<affiliation><nlm:aff id="af82"><addr-line>Department of Clinical Physiology</addr-line>
,<institution>University of Tampere and Tampere University Hospital</institution>
,<addr-line>33521-PO Box 2000, Tampere 33521</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name>
<affiliation><nlm:aff id="af83"><addr-line>Department of Clinical Physiology</addr-line>
,<institution>Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, University of Turku</institution>
,<addr-line>PO Box 52, Turku 20521</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nikopensius, Tiit" sort="Nikopensius, Tiit" uniqKey="Nikopensius T" first="Tiit" last="Nikopensius">Tiit Nikopensius</name>
<affiliation><nlm:aff id="af44"><institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Province, Michael" sort="Province, Michael" uniqKey="Province M" first="Michael" last="Province">Michael Province</name>
<affiliation><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name>
<affiliation><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Colhoun, Helen" sort="Colhoun, Helen" uniqKey="Colhoun H" first="Helen" last="Colhoun">Helen Colhoun</name>
<affiliation><nlm:aff id="af46"><addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Doney, Alex" sort="Doney, Alex" uniqKey="Doney A" first="Alex" last="Doney">Alex Doney</name>
<affiliation><nlm:aff id="af46"><addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name>
<affiliation><nlm:aff id="af47"><institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af84"><institution>University of Trieste</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name>
<affiliation><nlm:aff id="af85"><addr-line>Department of Medicine</addr-line>
,<institution>University Medical Centre Mannheim</institution>
,<addr-line>Theodor Kutzer Ufer 1-3, Mannheim 68167</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name>
<affiliation><nlm:aff id="af48"><institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation><nlm:aff id="af86"><addr-line>Robertson Centre for Biostatistics</addr-line>
,<institution>University of Glasgow</institution>
,<addr-line>Glasgow</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name>
<affiliation><nlm:aff id="af87"><addr-line>Department of Pharmacology and Therapeutics</addr-line>
,<institution>University College Cork</institution>
,<addr-line>Cork</addr-line>
,<country>Ireland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Adam, Martin" sort="Adam, Martin" uniqKey="Adam M" first="Martin" last="Adam">Martin Adam</name>
<affiliation><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thun, Gian Andri" sort="Thun, Gian Andri" uniqKey="Thun G" first="Gian-Andri" last="Thun">Gian-Andri Thun</name>
<affiliation><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name>
<affiliation><nlm:aff id="af88"><addr-line>First Department of Internal Medicine</addr-line>
,<institution>Paracelsus Medical University</institution>
,<addr-line>Müllner Hauptstraße 48, Salzburg 5020</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name>
<affiliation><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name>
<affiliation><nlm:aff id="af53"><addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<affiliation><nlm:aff id="af79"><addr-line>Centre for Vision Research</addr-line>
,<institution>University of Sydney, Westmead Millennium Institute, Westmead Hospital</institution>
,<addr-line>Sydney NSW 2145</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name>
<affiliation><nlm:aff id="af40"><institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kim, Stuart K" sort="Kim, Stuart K" uniqKey="Kim S" first="Stuart K." last="Kim">Stuart K. Kim</name>
<affiliation><nlm:aff id="af29"><addr-line>Departments of Genetics and Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name>
<affiliation><nlm:aff id="af89"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Centre Hospitalier Universitaire Vaudois and University of Lausanne</institution>
,<addr-line>Rue du Bugnon 46, Lausanne 1011, CH</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name>
<affiliation><nlm:aff id="af83"><addr-line>Department of Clinical Physiology</addr-line>
,<institution>Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, University of Turku</institution>
,<addr-line>PO Box 52, Turku 20521</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name>
<affiliation><nlm:aff id="af44"><institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af45"><addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Palmer, Colin" sort="Palmer, Colin" uniqKey="Palmer C" first="Colin" last="Palmer">Colin Palmer</name>
<affiliation><nlm:aff id="af90"><institution>University of Dundee-Biomedical Research Institute</institution>
,<addr-line>Level 5, Ninewells Hospital Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name>
<affiliation><nlm:aff id="af47"><institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af84"><institution>University of Trieste</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name>
<affiliation><nlm:aff id="af48"><institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<affiliation><nlm:aff id="af91"><institution>Durrer Center for Cardiogenetic Research</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af92"><institution>Interuniversity Cardiology Institute of the Netherlands (ICIN)</institution>
,<addr-line>Utrecht</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af93"><institution>Einthoven Laboratory for Experimental Vascular Medicine</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M." last="Probst-Hensch">Nicole M. Probst-Hensch</name>
<affiliation><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af51"><institution>University of Basel</institution>
,<addr-line>Basel</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name>
<affiliation><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name>
<affiliation><nlm:aff id="af53"><addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af22"><institution>University of Iceland</institution>
,<addr-line>Sæmundargötu 2, 101 Reykjavik</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Department of Medicine</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af94"><institution>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name>
<affiliation><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af95"><addr-line>Welch Center for Prevention</addr-line>
,<institution>Epidemiology and Clinical Research, Johns Hopkins University</institution>
,<addr-line>2024 E Monument St., Suite 2-600, Baltimore, MD 21287</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation><nlm:aff id="af96"><addr-line>Department of Special Neurology</addr-line>
,<institution>University Clinic of Neurology, Medical University Graz</institution>
,<addr-line>Auenbruggerplatz 22, 8036 Graz</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation><nlm:aff id="af26"><institution>Clinical Research Branch, National Institute of Aging</institution>
,<addr-line>3001 S Hanover Street, Baltimore, MD 21225</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name>
<affiliation><nlm:aff id="af27"><institution>University of Washington</institution>
,<addr-line>1730 Minor Ave. Campus Box 358080, Seattle, WA 98101-1448</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name>
<affiliation><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name>
<affiliation><nlm:aff id="af97"><addr-line>Department of Epidemiology and School of Public Health</addr-line>
,<institution>University of Medicine</institution>
,<addr-line>109 Observatory #4605, Ann Arbor, MI 48109-2029</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name>
<affiliation><nlm:aff id="af32"><addr-line>Department of Epidemiology and Prevention, Public Health Sciences</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name>
<affiliation><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af98"><institution>Channing Laboratory, Brigham and Women's Hospital</institution>
,<addr-line>181 Longwood Avenue, Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name>
<affiliation><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name>
<affiliation><nlm:aff id="af68"><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University</institution>
,<addr-line>Schittenhelmstr.12, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
<affiliation><nlm:aff id="af4"><addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name>
<affiliation><nlm:aff id="af99"><institution>Institute of Physiology, University of Greifswald</institution>
,<addr-line>Greifswald 17487</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<affiliation><nlm:aff id="af75"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7LJ</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af76"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7BN</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Witteman, Jacqueline" sort="Witteman, Jacqueline" uniqKey="Witteman J" first="Jacqueline" last="Witteman">Jacqueline Witteman</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<affiliation><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name>
<affiliation><nlm:aff id="af24"><addr-line>Division of Nephrology</addr-line>
,<institution>University of Maryland Medical School</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name>
<affiliation><nlm:aff wicri:cut=" and" id="af100"><institution>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne</institution>
,<addr-line>Route de la Corniche 2, Epalinges 1066, CH</addr-line>
,<country>Switzerland</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Epidemiology and Preventive Medicine</addr-line>
,<institution>University Hospital Regensburg</institution>
,<addr-line>Franz-Josef-Strauss-Allee 11, 93042 Regensburg</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af13"><institution>Institute of Medical Informatics, Biometry and Epidemiology, and Institute of Epidemiology, Ludwig-Maximilians-Universität</institution>
,<addr-line>Ingolstädter Landstr. 1, 85764 Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W. H. Linda" last="Kao">W. H. Linda Kao</name>
<affiliation><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af95"><addr-line>Welch Center for Prevention</addr-line>
,<institution>Epidemiology and Clinical Research, Johns Hopkins University</institution>
,<addr-line>2024 E Monument St., Suite 2-600, Baltimore, MD 21287</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name>
<affiliation><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af101"><addr-line>Division of Endocrinology</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>75 Francis St., Boston, MA</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name>
<affiliation><nlm:aff id="af14"><addr-line>Renal Division</addr-line>
,<institution>Freiburg University Clinic</institution>
,<addr-line>Berliner Allee 29, 79110 Freiburg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22962313</idno>
<idno type="pmc">3607468</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607468</idno>
<idno type="RBID">PMC:3607468</idno>
<idno type="doi">10.1093/hmg/dds369</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">001867</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001867</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function</title>
<author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I." last="Chasman">Daniel I. Chasman</name>
<affiliation><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fuchsberger, Christian" sort="Fuchsberger, Christian" uniqKey="Fuchsberger C" first="Christian" last="Fuchsberger">Christian Fuchsberger</name>
<affiliation><nlm:aff id="af3"><addr-line>Department of Biostatistics, Center for Statistical Genetics</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pattaro, Cristian" sort="Pattaro, Cristian" uniqKey="Pattaro C" first="Cristian" last="Pattaro">Cristian Pattaro</name>
<affiliation><nlm:aff id="af4"><addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Teumer, Alexander" sort="Teumer, Alexander" uniqKey="Teumer A" first="Alexander" last="Teumer">Alexander Teumer</name>
<affiliation><nlm:aff id="af5"><institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>
,<addr-line>Friedrich-Ludwig-Jahn-Str. 15a, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boger, Carsten A" sort="Boger, Carsten A" uniqKey="Boger C" first="Carsten A." last="Böger">Carsten A. Böger</name>
<affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Internal Medicine II</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Endlich, Karlhans" sort="Endlich, Karlhans" uniqKey="Endlich K" first="Karlhans" last="Endlich">Karlhans Endlich</name>
<affiliation><nlm:aff id="af8"><institution>Institute of Anatomy and Cell Biology, University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str. 23c, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Olden, Matthias" sort="Olden, Matthias" uniqKey="Olden M" first="Matthias" last="Olden">Matthias Olden</name>
<affiliation><nlm:aff wicri:cut=" and" id="af6"><addr-line>Department of Internal Medicine II</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af7"><addr-line>Department of Epidemiology and Preventive Medicine</addr-line>
,<institution>University Hospital Regensburg</institution>
,<addr-line>Franz-Josef-Strauss-Allee 11, 93042 Regensburg</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chen, Ming Huei" sort="Chen, Ming Huei" uniqKey="Chen M" first="Ming-Huei" last="Chen">Ming-Huei Chen</name>
<affiliation><nlm:aff id="af9"><addr-line>Department of Neurology</addr-line>
,<institution>Boston University School of Medicine</institution>
,<addr-line>72 East Concord St. B603, Boston, MA 02118</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af10"><addr-line>Department of Biostatistics</addr-line>
,<institution>Boston University School of Public Health</institution>
,<addr-line>715 Albany St., Boston, MA 02118</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tin, Adrienne" sort="Tin, Adrienne" uniqKey="Tin A" first="Adrienne" last="Tin">Adrienne Tin</name>
<affiliation><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Taliun, Daniel" sort="Taliun, Daniel" uniqKey="Taliun D" first="Daniel" last="Taliun">Daniel Taliun</name>
<affiliation><nlm:aff id="af4"><addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Man" sort="Li, Man" uniqKey="Li M" first="Man" last="Li">Man Li</name>
<affiliation><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gao, Xiaoyi" sort="Gao, Xiaoyi" uniqKey="Gao X" first="Xiaoyi" last="Gao">Xiaoyi Gao</name>
<affiliation><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gorski, Mathias" sort="Gorski, Mathias" uniqKey="Gorski M" first="Mathias" last="Gorski">Mathias Gorski</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Epidemiology and Preventive Medicine</addr-line>
,<institution>University Hospital Regensburg</institution>
,<addr-line>Franz-Josef-Strauss-Allee 11, 93042 Regensburg</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af13"><institution>Institute of Medical Informatics, Biometry and Epidemiology, and Institute of Epidemiology, Ludwig-Maximilians-Universität</institution>
,<addr-line>Ingolstädter Landstr. 1, 85764 Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
<affiliation><nlm:aff id="af10"><addr-line>Department of Biostatistics</addr-line>
,<institution>Boston University School of Public Health</institution>
,<addr-line>715 Albany St., Boston, MA 02118</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hundertmark, Claudia" sort="Hundertmark, Claudia" uniqKey="Hundertmark C" first="Claudia" last="Hundertmark">Claudia Hundertmark</name>
<affiliation><nlm:aff id="af14"><addr-line>Renal Division</addr-line>
,<institution>Freiburg University Clinic</institution>
,<addr-line>Berliner Allee 29, 79110 Freiburg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Foster, Meredith C" sort="Foster, Meredith C" uniqKey="Foster M" first="Meredith C." last="Foster">Meredith C. Foster</name>
<affiliation><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="O Seaghdha, Conall M" sort="O Seaghdha, Conall M" uniqKey="O Seaghdha C" first="Conall M." last="O'Seaghdha">Conall M. O'Seaghdha</name>
<affiliation><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af16"><addr-line>Division of Nephrology</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>75 Francis St., Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Glazer, Nicole" sort="Glazer, Nicole" uniqKey="Glazer N" first="Nicole" last="Glazer">Nicole Glazer</name>
<affiliation><nlm:aff id="af17"><addr-line>Section of Preventive Medicine and Epidemiology, Department of Medicine</addr-line>
,<institution>Boston University School of Medicine</institution>
,<addr-line>761 Harrison Ave, Boston, MA 02118</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af19"><addr-line>Centre for Medical Systems Biology</addr-line>
,<institution>Leiden University</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liu, Ching Ti" sort="Liu, Ching Ti" uniqKey="Liu C" first="Ching-Ti" last="Liu">Ching-Ti Liu</name>
<affiliation><nlm:aff id="af20"><addr-line>Department of Biostatistics</addr-line>
,<institution>Boston University School of Public Health</institution>
,<addr-line>801 Massachusetts Ave, CT3, Boston, MA 02118</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Smith, Albert V" sort="Smith, Albert V" uniqKey="Smith A" first="Albert V." last="Smith">Albert V. Smith</name>
<affiliation><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af22"><institution>University of Iceland</institution>
,<addr-line>Sæmundargötu 2, 101 Reykjavik</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="O Connell, Jeffrey R" sort="O Connell, Jeffrey R" uniqKey="O Connell J" first="Jeffrey R." last="O'Connell">Jeffrey R. O'Connell</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Department of Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name>
<affiliation><nlm:aff id="af25"><addr-line>Departments of Epidemiology and Biostatistics, and Forensic Molecular Biology</addr-line>
,<institution>University of Rotterdam</institution>
,<addr-line>Dr Molewaterplein 50-603015, Rotterdam, GE</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tanaka, Toshiko" sort="Tanaka, Toshiko" uniqKey="Tanaka T" first="Toshiko" last="Tanaka">Toshiko Tanaka</name>
<affiliation><nlm:aff id="af26"><institution>Clinical Research Branch, National Institute of Aging</institution>
,<addr-line>3001 S Hanover Street, Baltimore, MD 21225</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Guo" sort="Li, Guo" uniqKey="Li G" first="Guo" last="Li">Guo Li</name>
<affiliation><nlm:aff id="af27"><institution>University of Washington</institution>
,<addr-line>1730 Minor Ave. Campus Box 358080, Seattle, WA 98101-1448</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D." last="Johnson">Andrew D. Johnson</name>
<affiliation><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gierman, Hinco J" sort="Gierman, Hinco J" uniqKey="Gierman H" first="Hinco J." last="Gierman">Hinco J. Gierman</name>
<affiliation><nlm:aff wicri:cut=" and" id="af28"><addr-line>Department of Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Feitosa, Mary F" sort="Feitosa, Mary F" uniqKey="Feitosa M" first="Mary F." last="Feitosa">Mary F. Feitosa</name>
<affiliation><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hwang, Shih Jen" sort="Hwang, Shih Jen" uniqKey="Hwang S" first="Shih-Jen" last="Hwang">Shih-Jen Hwang</name>
<affiliation><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Atkinson, Elizabeth J" sort="Atkinson, Elizabeth J" uniqKey="Atkinson E" first="Elizabeth J." last="Atkinson">Elizabeth J. Atkinson</name>
<affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Division of Biomedical Statistics and Informatics</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lohman, Kurt" sort="Lohman, Kurt" uniqKey="Lohman K" first="Kurt" last="Lohman">Kurt Lohman</name>
<affiliation><nlm:aff id="af32"><addr-line>Department of Epidemiology and Prevention, Public Health Sciences</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cornelis, Marilyn C" sort="Cornelis, Marilyn C" uniqKey="Cornelis M" first="Marilyn C." last="Cornelis">Marilyn C. Cornelis</name>
<affiliation><nlm:aff id="af35"><addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>665 Huntington Avenue, Building 2, Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Johansson, Sa" sort="Johansson, Sa" uniqKey="Johansson " first=" Sa" last="Johansson"> Sa Johansson</name>
<affiliation><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tonjes, Anke" sort="Tonjes, Anke" uniqKey="Tonjes A" first="Anke" last="Tönjes">Anke Tönjes</name>
<affiliation><nlm:aff id="af37"><addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Dehghan, Abbas" sort="Dehghan, Abbas" uniqKey="Dehghan A" first="Abbas" last="Dehghan">Abbas Dehghan</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<affiliation><nlm:aff id="af38"><institution>INSERM UMR744, Institut Pasteur</institution>
,<addr-line>Lille</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Holliday, Elizabeth G" sort="Holliday, Elizabeth G" uniqKey="Holliday E" first="Elizabeth G." last="Holliday">Elizabeth G. Holliday</name>
<affiliation><nlm:aff id="af39"><addr-line>Centre for Information-based Medicine and School of Medicine and Public Health</addr-line>
,<institution>University of Newcastle, Hunter Medical Research Institute</institution>
,<addr-line>Newcastle, NSW</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sorice, Rossella" sort="Sorice, Rossella" uniqKey="Sorice R" first="Rossella" last="Sorice">Rossella Sorice</name>
<affiliation><nlm:aff id="af40"><institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kutalik, Zoltan" sort="Kutalik, Zoltan" uniqKey="Kutalik Z" first="Zoltan" last="Kutalik">Zoltan Kutalik</name>
<affiliation><nlm:aff id="af41"><addr-line>Department of Medical Genetics</addr-line>
,<institution>University of Lausanne</institution>
,<addr-line>Rue du Bugnon 27, CH, 1005 Lausanne</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af42"><institution>Swiss Institute of Bioinformatics</institution>
,<addr-line>Lausanne</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lehtim Ki, Terho" sort="Lehtim Ki, Terho" uniqKey="Lehtim Ki T" first="Terho" last="Lehtim Ki">Terho Lehtim Ki</name>
<affiliation><nlm:aff id="af43"><addr-line>Department of Clinical Chemistry, Centre for Laboratory Medicine Tampere Finn</addr-line>
,<institution>University of Tampere and Tampere University Hospital</institution>
,<addr-line>Medi 2, 3th, floor, PO Box 2000, 33521 Tampere</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Esko, T Nu" sort="Esko, T Nu" uniqKey="Esko T" first="T Nu" last="Esko">T Nu Esko</name>
<affiliation><nlm:aff id="af44"><institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af45"><addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Deshmukh, Harshal" sort="Deshmukh, Harshal" uniqKey="Deshmukh H" first="Harshal" last="Deshmukh">Harshal Deshmukh</name>
<affiliation><nlm:aff id="af46"><addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ulivi, Sheila" sort="Ulivi, Sheila" uniqKey="Ulivi S" first="Sheila" last="Ulivi">Sheila Ulivi</name>
<affiliation><nlm:aff id="af47"><institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chu, Audrey Y" sort="Chu, Audrey Y" uniqKey="Chu A" first="Audrey Y." last="Chu">Audrey Y. Chu</name>
<affiliation><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Murgia, Federico" sort="Murgia, Federico" uniqKey="Murgia F" first="Federico" last="Murgia">Federico Murgia</name>
<affiliation><nlm:aff id="af48"><institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Trompet, Stella" sort="Trompet, Stella" uniqKey="Trompet S" first="Stella" last="Trompet">Stella Trompet</name>
<affiliation><nlm:aff id="af49"><addr-line>Deparment of Cardiology</addr-line>
,<institution>Leiden University Medical Center</institution>
,<addr-line>Postzone C2-R, PO Box 9600, 2300 RC Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Imboden, Medea" sort="Imboden, Medea" uniqKey="Imboden M" first="Medea" last="Imboden">Medea Imboden</name>
<affiliation><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af51"><institution>University of Basel</institution>
,<addr-line>Basel</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coassin, Stefan" sort="Coassin, Stefan" uniqKey="Coassin S" first="Stefan" last="Coassin">Stefan Coassin</name>
<affiliation><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pistis, Giorgio" sort="Pistis, Giorgio" uniqKey="Pistis G" first="Giorgio" last="Pistis">Giorgio Pistis</name>
<affiliation><nlm:aff id="af53"><addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<affiliation><nlm:aff id="af58"><institution>Laboratory of Epidemiology, Demography, and Biometry</institution>
,<addr-line>NIA-Gateway Building, 3C309, 7201 Wisconsin Ave., Bethesda, MD 20892-9205</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation><nlm:aff id="af58"><institution>Laboratory of Epidemiology, Demography, and Biometry</institution>
,<addr-line>NIA-Gateway Building, 3C309, 7201 Wisconsin Ave., Bethesda, MD 20892-9205</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aspelund, Thor" sort="Aspelund, Thor" uniqKey="Aspelund T" first="Thor" last="Aspelund">Thor Aspelund</name>
<affiliation><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af22"><institution>University of Iceland</institution>
,<addr-line>Sæmundargötu 2, 101 Reykjavik</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Eiriksdottir, Gudny" sort="Eiriksdottir, Gudny" uniqKey="Eiriksdottir G" first="Gudny" last="Eiriksdottir">Gudny Eiriksdottir</name>
<affiliation><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D." last="Mitchell">Braxton D. Mitchell</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Department of Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<affiliation><nlm:aff id="af59"><addr-line>Human Genetics Center Houston</addr-line>
,<institution>University of Texas Health Science Center</institution>
,<addr-line>TX-1200 Herman Pressler Drive, Houston, TX 77030</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation><nlm:aff id="af60"><addr-line>Institute of Molecular Biology and Biochemistry and Department of Neurology</addr-line>
,<institution>Medical University Graz</institution>
,<addr-line>Harrachgasse 21 8010, Graz</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name>
<affiliation><nlm:aff id="af60"><addr-line>Institute of Molecular Biology and Biochemistry and Department of Neurology</addr-line>
,<institution>Medical University Graz</institution>
,<addr-line>Harrachgasse 21 8010, Graz</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rao, Madhumathi" sort="Rao, Madhumathi" uniqKey="Rao M" first="Madhumathi" last="Rao">Madhumathi Rao</name>
<affiliation><nlm:aff id="af61"><addr-line>Division of Nephrology/Tufts Evidence Practice Center</addr-line>
,<institution>Tufts University School of Medicine-Tufts Medical Center</institution>
,<addr-line>Boston, MA 02111</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hu, Frank" sort="Hu, Frank" uniqKey="Hu F" first="Frank" last="Hu">Frank Hu</name>
<affiliation><nlm:aff id="af35"><addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>665 Huntington Avenue, Building 2, Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Demirkan, Ayse" sort="Demirkan, Ayse" uniqKey="Demirkan A" first="Ayse" last="Demirkan">Ayse Demirkan</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af19"><addr-line>Centre for Medical Systems Biology</addr-line>
,<institution>Leiden University</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af19"><addr-line>Centre for Medical Systems Biology</addr-line>
,<institution>Leiden University</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Andrade, Mariza" sort="De Andrade, Mariza" uniqKey="De Andrade M" first="Mariza" last="De Andrade">Mariza De Andrade</name>
<affiliation><nlm:aff wicri:cut=" and" id="af30"><addr-line>Division of Biomedical Statistics and Informatics</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name>
<affiliation><nlm:aff id="af31"><addr-line>Department of Internal Medicine, Division of Nephrology and Hypertension</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ding, Jingzhong" sort="Ding, Jingzhong" uniqKey="Ding J" first="Jingzhong" last="Ding">Jingzhong Ding</name>
<affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Internal Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Andrews, Jeanette S" sort="Andrews, Jeanette S" uniqKey="Andrews J" first="Jeanette S." last="Andrews">Jeanette S. Andrews</name>
<affiliation><nlm:aff id="af34"><addr-line>Department of Biostatistical Sciences, Public Health Sciences</addr-line>
,<institution>Wake Forest School of Medicine</institution>
,<addr-line>Winston-Salem, NC 27157</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Freedman, Barry I" sort="Freedman, Barry I" uniqKey="Freedman B" first="Barry I." last="Freedman">Barry I. Freedman</name>
<affiliation><nlm:aff wicri:cut=" and" id="af33"><addr-line>Department of Internal Medicine</addr-line>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giulianini, Franco" sort="Giulianini, Franco" uniqKey="Giulianini F" first="Franco" last="Giulianini">Franco Giulianini</name>
<affiliation><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<affiliation><nlm:aff id="af62"><addr-line>Abteilung Innere II</addr-line>
,<institution>Universitätsklinikum Ulm</institution>
,<addr-line>Albert-Einstein-Allee 23, Ulm 89081</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name>
<affiliation><nlm:aff id="af13"><institution>Institute of Medical Informatics, Biometry and Epidemiology, and Institute of Epidemiology, Ludwig-Maximilians-Universität</institution>
,<addr-line>Ingolstädter Landstr. 1, 85764 Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Meisinger, Christa" sort="Meisinger, Christa" uniqKey="Meisinger C" first="Christa" last="Meisinger">Christa Meisinger</name>
<affiliation><nlm:aff id="af63"><addr-line>Helmholtz Zentrum München</addr-line>
,<institution>German Research Center for Environmental Health</institution>
,<addr-line>Institute of Epidemiology II, Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name>
<affiliation><nlm:aff id="af63"><addr-line>Helmholtz Zentrum München</addr-line>
,<institution>German Research Center for Environmental Health</institution>
,<addr-line>Institute of Epidemiology II, Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zgaga, Lina" sort="Zgaga, Lina" uniqKey="Zgaga L" first="Lina" last="Zgaga">Lina Zgaga</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af65"><addr-line>Andrija Stampar School of Public Health, Medical School</addr-line>
,<institution>University of Zagreb</institution>
,<addr-line>Zagreb</addr-line>
,<country>Croatia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zemunik, Tatijana" sort="Zemunik, Tatijana" uniqKey="Zemunik T" first="Tatijana" last="Zemunik">Tatijana Zemunik</name>
<affiliation><nlm:aff id="af66"><addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Boban, Mladen" sort="Boban, Mladen" uniqKey="Boban M" first="Mladen" last="Boban">Mladen Boban</name>
<affiliation><nlm:aff id="af66"><addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Minelli, Cosetta" sort="Minelli, Cosetta" uniqKey="Minelli C" first="Cosetta" last="Minelli">Cosetta Minelli</name>
<affiliation><nlm:aff id="af4"><addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wheeler, Heather E" sort="Wheeler, Heather E" uniqKey="Wheeler H" first="Heather E." last="Wheeler">Heather E. Wheeler</name>
<affiliation><nlm:aff wicri:cut=" and" id="af28"><addr-line>Department of Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af29"><addr-line>Departments of Genetics and Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Igl, Wilmar" sort="Igl, Wilmar" uniqKey="Igl W" first="Wilmar" last="Igl">Wilmar Igl</name>
<affiliation><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Zaboli, Ghazal" sort="Zaboli, Ghazal" uniqKey="Zaboli G" first="Ghazal" last="Zaboli">Ghazal Zaboli</name>
<affiliation><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wild, Sarah H" sort="Wild, Sarah H" uniqKey="Wild S" first="Sarah H." last="Wild">Sarah H. Wild</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wright, Alan F" sort="Wright, Alan F" uniqKey="Wright A" first="Alan F." last="Wright">Alan F. Wright</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Campbell, Harry" sort="Campbell, Harry" uniqKey="Campbell H" first="Harry" last="Campbell">Harry Campbell</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ellinghaus, David" sort="Ellinghaus, David" uniqKey="Ellinghaus D" first="David" last="Ellinghaus">David Ellinghaus</name>
<affiliation><nlm:aff id="af68"><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University</institution>
,<addr-line>Schittenhelmstr.12, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nothlings, Ute" sort="Nothlings, Ute" uniqKey="Nothlings U" first="Ute" last="Nöthlings">Ute Nöthlings</name>
<affiliation><nlm:aff id="af69"><addr-line>Section for Epidemiology</addr-line>
,<institution>Institute for Experimental Medicine, Christian-Albrechts-University of Kiel and Popgen Biobank, University Hospital Schleswig-Holstein</institution>
,<addr-line>Niemannsweg 11, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jacobs, Gunnar" sort="Jacobs, Gunnar" uniqKey="Jacobs G" first="Gunnar" last="Jacobs">Gunnar Jacobs</name>
<affiliation><nlm:aff id="af69"><addr-line>Section for Epidemiology</addr-line>
,<institution>Institute for Experimental Medicine, Christian-Albrechts-University of Kiel and Popgen Biobank, University Hospital Schleswig-Holstein</institution>
,<addr-line>Niemannsweg 11, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Biffar, Reiner" sort="Biffar, Reiner" uniqKey="Biffar R" first="Reiner" last="Biffar">Reiner Biffar</name>
<affiliation><nlm:aff id="af70"><addr-line>Clinic for Prosthodontic Dentistry</addr-line>
,<institution>Gerostomatology and Material Science, University of Greifswald</institution>
,<addr-line>Rotgerberstr 8, Greifswald 17475</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ernst, Florian" sort="Ernst, Florian" uniqKey="Ernst F" first="Florian" last="Ernst">Florian Ernst</name>
<affiliation><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Homuth, Georg" sort="Homuth, Georg" uniqKey="Homuth G" first="Georg" last="Homuth">Georg Homuth</name>
<affiliation><nlm:aff id="af5"><institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>
,<addr-line>Friedrich-Ludwig-Jahn-Str. 15a, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kroemer, Heyo K" sort="Kroemer, Heyo K" uniqKey="Kroemer H" first="Heyo K." last="Kroemer">Heyo K. Kroemer</name>
<affiliation><nlm:aff id="af71"><institution>Institute of Pharmacology, University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str., 23d, Greifswald 17487</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nauck, Matthias" sort="Nauck, Matthias" uniqKey="Nauck M" first="Matthias" last="Nauck">Matthias Nauck</name>
<affiliation><nlm:aff id="af72"><institution>Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz Arndt-University Greifswald</institution>
,<addr-line>Ferdinand-Sauerbruch-Str., Greifswald 17475</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stracke, Sylvia" sort="Stracke, Sylvia" uniqKey="Stracke S" first="Sylvia" last="Stracke">Sylvia Stracke</name>
<affiliation><nlm:aff id="af73"><addr-line>Clinic for Internal Medicine A</addr-line>
,<institution>University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str. 23a, Greifswald 17475</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Volker, Uwe" sort="Volker, Uwe" uniqKey="Volker U" first="Uwe" last="Völker">Uwe Völker</name>
<affiliation><nlm:aff id="af5"><institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>
,<addr-line>Friedrich-Ludwig-Jahn-Str. 15a, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Volzke, Henry" sort="Volzke, Henry" uniqKey="Volzke H" first="Henry" last="Völzke">Henry Völzke</name>
<affiliation><nlm:aff id="af74"><addr-line>Institute for Community Medicine</addr-line>
,<institution>University of Greifswald</institution>
,<addr-line>Walther-Rathenau-Str. 48, Greifswald 17487</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kovacs, Peter" sort="Kovacs, Peter" uniqKey="Kovacs P" first="Peter" last="Kovacs">Peter Kovacs</name>
<affiliation><nlm:aff id="af37"><addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stumvoll, Michael" sort="Stumvoll, Michael" uniqKey="Stumvoll M" first="Michael" last="Stumvoll">Michael Stumvoll</name>
<affiliation><nlm:aff id="af37"><addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="M Gi, Reedik" sort="M Gi, Reedik" uniqKey="M Gi R" first="Reedik" last="M Gi">Reedik M Gi</name>
<affiliation><nlm:aff id="af45"><addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af75"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7LJ</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af76"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7BN</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation><nlm:aff id="af77"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>PO Box 1738, 3000 DR Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rivadeneira, Fernando" sort="Rivadeneira, Fernando" uniqKey="Rivadeneira F" first="Fernando" last="Rivadeneira">Fernando Rivadeneira</name>
<affiliation><nlm:aff id="af77"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>PO Box 1738, 3000 DR Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aulchenko, Yurii S" sort="Aulchenko, Yurii S" uniqKey="Aulchenko Y" first="Yurii S." last="Aulchenko">Yurii S. Aulchenko</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Polasek, Ozren" sort="Polasek, Ozren" uniqKey="Polasek O" first="Ozren" last="Polasek">Ozren Polasek</name>
<affiliation><nlm:aff id="af66"><addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hastie, Nick" sort="Hastie, Nick" uniqKey="Hastie N" first="Nick" last="Hastie">Nick Hastie</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vitart, Veronique" sort="Vitart, Veronique" uniqKey="Vitart V" first="Veronique" last="Vitart">Veronique Vitart</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Helmer, Catherine" sort="Helmer, Catherine" uniqKey="Helmer C" first="Catherine" last="Helmer">Catherine Helmer</name>
<affiliation><nlm:aff id="af78"><institution>INSERM U897, Université Victor Ségalen Bordeaux 2</institution>
,<addr-line>ISPED case 11, 146 Rue Léo Saignat, F-33076 Bordeaux</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Jie Jin" sort="Wang, Jie Jin" uniqKey="Wang J" first="Jie Jin" last="Wang">Jie Jin Wang</name>
<affiliation><nlm:aff id="af79"><addr-line>Centre for Vision Research</addr-line>
,<institution>University of Sydney, Westmead Millennium Institute, Westmead Hospital</institution>
,<addr-line>Sydney NSW 2145</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af80"><addr-line>Centre for Eye Research Australia (CERA)</addr-line>
,<institution>University of Melbourne</institution>
,<addr-line>32 Gisborne Street, East Melbourne, Victoria 3002</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Stengel, Benedicte" sort="Stengel, Benedicte" uniqKey="Stengel B" first="Bénédicte" last="Stengel">Bénédicte Stengel</name>
<affiliation><nlm:aff id="af81"><institution>INSERM UMRS 1018-CESP Team 10, Univ Paris Sud</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ruggiero, Daniela" sort="Ruggiero, Daniela" uniqKey="Ruggiero D" first="Daniela" last="Ruggiero">Daniela Ruggiero</name>
<affiliation><nlm:aff id="af40"><institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bergmann, Sven" sort="Bergmann, Sven" uniqKey="Bergmann S" first="Sven" last="Bergmann">Sven Bergmann</name>
<affiliation><nlm:aff id="af42"><institution>Swiss Institute of Bioinformatics</institution>
,<addr-line>Lausanne</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="K Honen, Mika" sort="K Honen, Mika" uniqKey="K Honen M" first="Mika" last="K Hönen">Mika K Hönen</name>
<affiliation><nlm:aff id="af82"><addr-line>Department of Clinical Physiology</addr-line>
,<institution>University of Tampere and Tampere University Hospital</institution>
,<addr-line>33521-PO Box 2000, Tampere 33521</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Viikari, Jorma" sort="Viikari, Jorma" uniqKey="Viikari J" first="Jorma" last="Viikari">Jorma Viikari</name>
<affiliation><nlm:aff id="af83"><addr-line>Department of Clinical Physiology</addr-line>
,<institution>Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, University of Turku</institution>
,<addr-line>PO Box 52, Turku 20521</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nikopensius, Tiit" sort="Nikopensius, Tiit" uniqKey="Nikopensius T" first="Tiit" last="Nikopensius">Tiit Nikopensius</name>
<affiliation><nlm:aff id="af44"><institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Province, Michael" sort="Province, Michael" uniqKey="Province M" first="Michael" last="Province">Michael Province</name>
<affiliation><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ketkar, Shamika" sort="Ketkar, Shamika" uniqKey="Ketkar S" first="Shamika" last="Ketkar">Shamika Ketkar</name>
<affiliation><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Colhoun, Helen" sort="Colhoun, Helen" uniqKey="Colhoun H" first="Helen" last="Colhoun">Helen Colhoun</name>
<affiliation><nlm:aff id="af46"><addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Doney, Alex" sort="Doney, Alex" uniqKey="Doney A" first="Alex" last="Doney">Alex Doney</name>
<affiliation><nlm:aff id="af46"><addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Robino, Antonietta" sort="Robino, Antonietta" uniqKey="Robino A" first="Antonietta" last="Robino">Antonietta Robino</name>
<affiliation><nlm:aff id="af47"><institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af84"><institution>University of Trieste</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kr Mer, Bernhard K" sort="Kr Mer, Bernhard K" uniqKey="Kr Mer B" first="Bernhard K." last="Kr Mer">Bernhard K. Kr Mer</name>
<affiliation><nlm:aff id="af85"><addr-line>Department of Medicine</addr-line>
,<institution>University Medical Centre Mannheim</institution>
,<addr-line>Theodor Kutzer Ufer 1-3, Mannheim 68167</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Portas, Laura" sort="Portas, Laura" uniqKey="Portas L" first="Laura" last="Portas">Laura Portas</name>
<affiliation><nlm:aff id="af48"><institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name>
<affiliation><nlm:aff id="af86"><addr-line>Robertson Centre for Biostatistics</addr-line>
,<institution>University of Glasgow</institution>
,<addr-line>Glasgow</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Buckley, Brendan M" sort="Buckley, Brendan M" uniqKey="Buckley B" first="Brendan M." last="Buckley">Brendan M. Buckley</name>
<affiliation><nlm:aff id="af87"><addr-line>Department of Pharmacology and Therapeutics</addr-line>
,<institution>University College Cork</institution>
,<addr-line>Cork</addr-line>
,<country>Ireland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Adam, Martin" sort="Adam, Martin" uniqKey="Adam M" first="Martin" last="Adam">Martin Adam</name>
<affiliation><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Thun, Gian Andri" sort="Thun, Gian Andri" uniqKey="Thun G" first="Gian-Andri" last="Thun">Gian-Andri Thun</name>
<affiliation><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Paulweber, Bernhard" sort="Paulweber, Bernhard" uniqKey="Paulweber B" first="Bernhard" last="Paulweber">Bernhard Paulweber</name>
<affiliation><nlm:aff id="af88"><addr-line>First Department of Internal Medicine</addr-line>
,<institution>Paracelsus Medical University</institution>
,<addr-line>Müllner Hauptstraße 48, Salzburg 5020</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Haun, Margot" sort="Haun, Margot" uniqKey="Haun M" first="Margot" last="Haun">Margot Haun</name>
<affiliation><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sala, Cinzia" sort="Sala, Cinzia" uniqKey="Sala C" first="Cinzia" last="Sala">Cinzia Sala</name>
<affiliation><nlm:aff id="af53"><addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mitchell, Paul" sort="Mitchell, Paul" uniqKey="Mitchell P" first="Paul" last="Mitchell">Paul Mitchell</name>
<affiliation><nlm:aff id="af79"><addr-line>Centre for Vision Research</addr-line>
,<institution>University of Sydney, Westmead Millennium Institute, Westmead Hospital</institution>
,<addr-line>Sydney NSW 2145</addr-line>
,<country>Australia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ciullo, Marina" sort="Ciullo, Marina" uniqKey="Ciullo M" first="Marina" last="Ciullo">Marina Ciullo</name>
<affiliation><nlm:aff id="af40"><institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kim, Stuart K" sort="Kim, Stuart K" uniqKey="Kim S" first="Stuart K." last="Kim">Stuart K. Kim</name>
<affiliation><nlm:aff id="af29"><addr-line>Departments of Genetics and Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vollenweider, Peter" sort="Vollenweider, Peter" uniqKey="Vollenweider P" first="Peter" last="Vollenweider">Peter Vollenweider</name>
<affiliation><nlm:aff id="af89"><addr-line>Department of Internal Medicine</addr-line>
,<institution>Centre Hospitalier Universitaire Vaudois and University of Lausanne</institution>
,<addr-line>Rue du Bugnon 46, Lausanne 1011, CH</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Raitakari, Olli" sort="Raitakari, Olli" uniqKey="Raitakari O" first="Olli" last="Raitakari">Olli Raitakari</name>
<affiliation><nlm:aff id="af83"><addr-line>Department of Clinical Physiology</addr-line>
,<institution>Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, University of Turku</institution>
,<addr-line>PO Box 52, Turku 20521</addr-line>
,<country>Finland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Metspalu, Andres" sort="Metspalu, Andres" uniqKey="Metspalu A" first="Andres" last="Metspalu">Andres Metspalu</name>
<affiliation><nlm:aff id="af44"><institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af45"><addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Palmer, Colin" sort="Palmer, Colin" uniqKey="Palmer C" first="Colin" last="Palmer">Colin Palmer</name>
<affiliation><nlm:aff id="af90"><institution>University of Dundee-Biomedical Research Institute</institution>
,<addr-line>Level 5, Ninewells Hospital Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gasparini, Paolo" sort="Gasparini, Paolo" uniqKey="Gasparini P" first="Paolo" last="Gasparini">Paolo Gasparini</name>
<affiliation><nlm:aff id="af47"><institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af84"><institution>University of Trieste</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pirastu, Mario" sort="Pirastu, Mario" uniqKey="Pirastu M" first="Mario" last="Pirastu">Mario Pirastu</name>
<affiliation><nlm:aff id="af48"><institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jukema, J Wouter" sort="Jukema, J Wouter" uniqKey="Jukema J" first="J. Wouter" last="Jukema">J. Wouter Jukema</name>
<affiliation><nlm:aff id="af91"><institution>Durrer Center for Cardiogenetic Research</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af92"><institution>Interuniversity Cardiology Institute of the Netherlands (ICIN)</institution>
,<addr-line>Utrecht</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af93"><institution>Einthoven Laboratory for Experimental Vascular Medicine</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Probst Hensch, Nicole M" sort="Probst Hensch, Nicole M" uniqKey="Probst Hensch N" first="Nicole M." last="Probst-Hensch">Nicole M. Probst-Hensch</name>
<affiliation><nlm:aff id="af50"><addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af51"><institution>University of Basel</institution>
,<addr-line>Basel</addr-line>
,<country>Switzerland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kronenberg, Florian" sort="Kronenberg, Florian" uniqKey="Kronenberg F" first="Florian" last="Kronenberg">Florian Kronenberg</name>
<affiliation><nlm:aff id="af52"><addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Toniolo, Daniela" sort="Toniolo, Daniela" uniqKey="Toniolo D" first="Daniela" last="Toniolo">Daniela Toniolo</name>
<affiliation><nlm:aff id="af53"><addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation><nlm:aff id="af21"><institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af22"><institution>University of Iceland</institution>
,<addr-line>Sæmundargötu 2, 101 Reykjavik</addr-line>
,<country>Iceland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Shuldiner, Alan R" sort="Shuldiner, Alan R" uniqKey="Shuldiner A" first="Alan R." last="Shuldiner">Alan R. Shuldiner</name>
<affiliation><nlm:aff wicri:cut=" and" id="af23"><addr-line>Department of Medicine</addr-line>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af94"><institution>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coresh, Josef" sort="Coresh, Josef" uniqKey="Coresh J" first="Josef" last="Coresh">Josef Coresh</name>
<affiliation><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af95"><addr-line>Welch Center for Prevention</addr-line>
,<institution>Epidemiology and Clinical Research, Johns Hopkins University</institution>
,<addr-line>2024 E Monument St., Suite 2-600, Baltimore, MD 21287</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation><nlm:aff id="af96"><addr-line>Department of Special Neurology</addr-line>
,<institution>University Clinic of Neurology, Medical University Graz</institution>
,<addr-line>Auenbruggerplatz 22, 8036 Graz</addr-line>
,<country>Austria</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ferrucci, Luigi" sort="Ferrucci, Luigi" uniqKey="Ferrucci L" first="Luigi" last="Ferrucci">Luigi Ferrucci</name>
<affiliation><nlm:aff id="af26"><institution>Clinical Research Branch, National Institute of Aging</institution>
,<addr-line>3001 S Hanover Street, Baltimore, MD 21225</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Siscovick, David S" sort="Siscovick, David S" uniqKey="Siscovick D" first="David S." last="Siscovick">David S. Siscovick</name>
<affiliation><nlm:aff id="af27"><institution>University of Washington</institution>
,<addr-line>1730 Minor Ave. Campus Box 358080, Seattle, WA 98101-1448</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Borecki, Ingrid B" sort="Borecki, Ingrid B" uniqKey="Borecki I" first="Ingrid B." last="Borecki">Ingrid B. Borecki</name>
<affiliation><nlm:aff id="af12"><addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kardia, Sharon L R" sort="Kardia, Sharon L R" uniqKey="Kardia S" first="Sharon L. R." last="Kardia">Sharon L. R. Kardia</name>
<affiliation><nlm:aff id="af97"><addr-line>Department of Epidemiology and School of Public Health</addr-line>
,<institution>University of Medicine</institution>
,<addr-line>109 Observatory #4605, Ann Arbor, MI 48109-2029</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Liu, Yongmei" sort="Liu, Yongmei" uniqKey="Liu Y" first="Yongmei" last="Liu">Yongmei Liu</name>
<affiliation><nlm:aff id="af32"><addr-line>Department of Epidemiology and Prevention, Public Health Sciences</addr-line>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Curhan, Gary C" sort="Curhan, Gary C" uniqKey="Curhan G" first="Gary C." last="Curhan">Gary C. Curhan</name>
<affiliation><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af98"><institution>Channing Laboratory, Brigham and Women's Hospital</institution>
,<addr-line>181 Longwood Avenue, Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rudan, Igor" sort="Rudan, Igor" uniqKey="Rudan I" first="Igor" last="Rudan">Igor Rudan</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gyllensten, Ulf" sort="Gyllensten, Ulf" uniqKey="Gyllensten U" first="Ulf" last="Gyllensten">Ulf Gyllensten</name>
<affiliation><nlm:aff id="af36"><addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wilson, James F" sort="Wilson, James F" uniqKey="Wilson J" first="James F." last="Wilson">James F. Wilson</name>
<affiliation><nlm:aff id="af64"><addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Franke, Andre" sort="Franke, Andre" uniqKey="Franke A" first="Andre" last="Franke">Andre Franke</name>
<affiliation><nlm:aff id="af68"><institution>Institute of Clinical Molecular Biology, Christian-Albrechts University</institution>
,<addr-line>Schittenhelmstr.12, Kiel 24105</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pramstaller, Peter P" sort="Pramstaller, Peter P" uniqKey="Pramstaller P" first="Peter P." last="Pramstaller">Peter P. Pramstaller</name>
<affiliation><nlm:aff id="af4"><addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rettig, Rainer" sort="Rettig, Rainer" uniqKey="Rettig R" first="Rainer" last="Rettig">Rainer Rettig</name>
<affiliation><nlm:aff id="af99"><institution>Institute of Physiology, University of Greifswald</institution>
,<addr-line>Greifswald 17487</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Prokopenko, Inga" sort="Prokopenko, Inga" uniqKey="Prokopenko I" first="Inga" last="Prokopenko">Inga Prokopenko</name>
<affiliation><nlm:aff id="af75"><addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7LJ</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af76"><addr-line>Wellcome Trust Centre for Human Genetics</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7BN</addr-line>
,<country>UK</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Witteman, Jacqueline" sort="Witteman, Jacqueline" uniqKey="Witteman J" first="Jacqueline" last="Witteman">Jacqueline Witteman</name>
<affiliation><nlm:aff id="af18"><addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hayward, Caroline" sort="Hayward, Caroline" uniqKey="Hayward C" first="Caroline" last="Hayward">Caroline Hayward</name>
<affiliation><nlm:aff id="af67"><addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ridker, Paul M" sort="Ridker, Paul M" uniqKey="Ridker P" first="Paul M" last="Ridker">Paul M. Ridker</name>
<affiliation><nlm:aff id="af1"><addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name>
<affiliation><nlm:aff id="af24"><addr-line>Division of Nephrology</addr-line>
,<institution>University of Maryland Medical School</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bochud, Murielle" sort="Bochud, Murielle" uniqKey="Bochud M" first="Murielle" last="Bochud">Murielle Bochud</name>
<affiliation><nlm:aff wicri:cut=" and" id="af100"><institution>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne</institution>
,<addr-line>Route de la Corniche 2, Epalinges 1066, CH</addr-line>
,<country>Switzerland</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Heid, Iris M" sort="Heid, Iris M" uniqKey="Heid I" first="Iris M." last="Heid">Iris M. Heid</name>
<affiliation><nlm:aff id="af7"><addr-line>Department of Epidemiology and Preventive Medicine</addr-line>
,<institution>University Hospital Regensburg</institution>
,<addr-line>Franz-Josef-Strauss-Allee 11, 93042 Regensburg</addr-line>
,<country>Germany</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af13"><institution>Institute of Medical Informatics, Biometry and Epidemiology, and Institute of Epidemiology, Ludwig-Maximilians-Universität</institution>
,<addr-line>Ingolstädter Landstr. 1, 85764 Neuherberg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kao, W H Linda" sort="Kao, W H Linda" uniqKey="Kao W" first="W. H. Linda" last="Kao">W. H. Linda Kao</name>
<affiliation><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af95"><addr-line>Welch Center for Prevention</addr-line>
,<institution>Epidemiology and Clinical Research, Johns Hopkins University</institution>
,<addr-line>2024 E Monument St., Suite 2-600, Baltimore, MD 21287</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fox, Caroline S" sort="Fox, Caroline S" uniqKey="Fox C" first="Caroline S." last="Fox">Caroline S. Fox</name>
<affiliation><nlm:aff id="af2"><institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af15"><addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af101"><addr-line>Division of Endocrinology</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>75 Francis St., Boston, MA</addr-line>
,<country>USA</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Kottgen, Anna" sort="Kottgen, Anna" uniqKey="Kottgen A" first="Anna" last="Köttgen">Anna Köttgen</name>
<affiliation><nlm:aff id="af14"><addr-line>Renal Division</addr-line>
,<institution>Freiburg University Clinic</institution>
,<addr-line>Berliner Allee 29, 79110 Freiburg</addr-line>
,<country>Germany</country>
,</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af11"><addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Human Molecular Genetics</title>
<idno type="ISSN">0964-6906</idno>
<idno type="eISSN">1460-2083</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p>In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure of kidney function, we developed a strategy for integrating prior biological knowledge into the existing GWAS data for eGFR from the CKDGen Consortium. Our strategy focuses on single nucleotide polymorphism (SNPs) in genes that are connected by functional evidence, determined by literature mining and gene ontology (GO) hierarchies, to genes near previously validated eGFR associations. It then requires association thresholds consistent with multiple testing, and finally evaluates novel candidates by independent replication. Among the samples of European ancestry, we identified a genome-wide significant SNP in <italic>FBXL20</italic>
(<italic>P</italic>
= 5.6 × 10<sup>−9</sup>
) in meta-analysis of all available data, and additional SNPs at the <italic>INHBC</italic>
, <italic>LRP2</italic>
, <italic>PLEKHA1</italic>
, <italic>SLC3A2</italic>
and <italic>SLC7A6</italic>
genes meeting multiple-testing corrected significance for replication and overall <italic>P</italic>
-values of 4.5 × 10<sup>−4</sup>
–2.2 × 10<sup>−7</sup>
. Neither the novel <italic>PLEKHA1</italic>
nor <italic>FBXL20</italic>
associations, both further supported by association with eGFR among African Americans and with transcript abundance, would have been implicated by eGFR candidate gene approaches. <italic>LRP2</italic>
, encoding the megalin receptor, was identified through connection with the previously known eGFR gene <italic>DAB2</italic>
and extends understanding of the megalin system in kidney function. These findings highlight integration of existing genome-wide association data with independent biological knowledge to uncover novel candidate eGFR associations, including candidates lacking known connections to kidney-specific pathways. The strategy may also be applicable to other clinical phenotypes, although more testing will be needed to assess its potential for discovery in general.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Mol Genet</journal-id>
<journal-id journal-id-type="iso-abbrev">Hum. Mol. Genet</journal-id>
<journal-id journal-id-type="publisher-id">hmg</journal-id>
<journal-id journal-id-type="hwp">hmg</journal-id>
<journal-title-group><journal-title>Human Molecular Genetics</journal-title>
</journal-title-group>
<issn pub-type="ppub">0964-6906</issn>
<issn pub-type="epub">1460-2083</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22962313</article-id>
<article-id pub-id-type="pmc">3607468</article-id>
<article-id pub-id-type="doi">10.1093/hmg/dds369</article-id>
<article-id pub-id-type="publisher-id">dds369</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Association Studies Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Integration of genome-wide association studies with biological knowledge identifies six novel genes related to kidney function</article-title>
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<xref ref-type="aff" rid="af67">67</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vitart</surname>
<given-names>Veronique</given-names>
</name>
<xref ref-type="aff" rid="af67">67</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Helmer</surname>
<given-names>Catherine</given-names>
</name>
<xref ref-type="aff" rid="af78">78</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Jie Jin</given-names>
</name>
<xref ref-type="aff" rid="af79">79</xref>
<xref ref-type="aff" rid="af80">80</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Stengel</surname>
<given-names>Bénédicte</given-names>
</name>
<xref ref-type="aff" rid="af81">81</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ruggiero</surname>
<given-names>Daniela</given-names>
</name>
<xref ref-type="aff" rid="af40">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bergmann</surname>
<given-names>Sven</given-names>
</name>
<xref ref-type="aff" rid="af42">42</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kähönen</surname>
<given-names>Mika</given-names>
</name>
<xref ref-type="aff" rid="af82">82</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Viikari</surname>
<given-names>Jorma</given-names>
</name>
<xref ref-type="aff" rid="af83">83</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nikopensius</surname>
<given-names>Tiit</given-names>
</name>
<xref ref-type="aff" rid="af44">44</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Province</surname>
<given-names>Michael</given-names>
</name>
<xref ref-type="aff" rid="af12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ketkar</surname>
<given-names>Shamika</given-names>
</name>
<xref ref-type="aff" rid="af12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Colhoun</surname>
<given-names>Helen</given-names>
</name>
<xref ref-type="aff" rid="af46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Doney</surname>
<given-names>Alex</given-names>
</name>
<xref ref-type="aff" rid="af46">46</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Robino</surname>
<given-names>Antonietta</given-names>
</name>
<xref ref-type="aff" rid="af47">47</xref>
<xref ref-type="aff" rid="af84">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Krämer</surname>
<given-names>Bernhard K.</given-names>
</name>
<xref ref-type="aff" rid="af85">85</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Portas</surname>
<given-names>Laura</given-names>
</name>
<xref ref-type="aff" rid="af48">48</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ford</surname>
<given-names>Ian</given-names>
</name>
<xref ref-type="aff" rid="af86">86</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Buckley</surname>
<given-names>Brendan M.</given-names>
</name>
<xref ref-type="aff" rid="af87">87</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Adam</surname>
<given-names>Martin</given-names>
</name>
<xref ref-type="aff" rid="af50">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Thun</surname>
<given-names>Gian-Andri</given-names>
</name>
<xref ref-type="aff" rid="af50">50</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Paulweber</surname>
<given-names>Bernhard</given-names>
</name>
<xref ref-type="aff" rid="af88">88</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haun</surname>
<given-names>Margot</given-names>
</name>
<xref ref-type="aff" rid="af52">52</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sala</surname>
<given-names>Cinzia</given-names>
</name>
<xref ref-type="aff" rid="af53">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mitchell</surname>
<given-names>Paul</given-names>
</name>
<xref ref-type="aff" rid="af79">79</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ciullo</surname>
<given-names>Marina</given-names>
</name>
<xref ref-type="aff" rid="af40">40</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Stuart K.</given-names>
</name>
<xref ref-type="aff" rid="af29">29</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vollenweider</surname>
<given-names>Peter</given-names>
</name>
<xref ref-type="aff" rid="af89">89</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Raitakari</surname>
<given-names>Olli</given-names>
</name>
<xref ref-type="aff" rid="af83">83</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Metspalu</surname>
<given-names>Andres</given-names>
</name>
<xref ref-type="aff" rid="af44">44</xref>
<xref ref-type="aff" rid="af45">45</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Palmer</surname>
<given-names>Colin</given-names>
</name>
<xref ref-type="aff" rid="af90">90</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gasparini</surname>
<given-names>Paolo</given-names>
</name>
<xref ref-type="aff" rid="af47">47</xref>
<xref ref-type="aff" rid="af84">84</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pirastu</surname>
<given-names>Mario</given-names>
</name>
<xref ref-type="aff" rid="af48">48</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jukema</surname>
<given-names>J. Wouter</given-names>
</name>
<xref ref-type="aff" rid="af91">91</xref>
<xref ref-type="aff" rid="af92">92</xref>
<xref ref-type="aff" rid="af93">93</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Probst-Hensch</surname>
<given-names>Nicole M.</given-names>
</name>
<xref ref-type="aff" rid="af50">50</xref>
<xref ref-type="aff" rid="af51">51</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kronenberg</surname>
<given-names>Florian</given-names>
</name>
<xref ref-type="aff" rid="af52">52</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Toniolo</surname>
<given-names>Daniela</given-names>
</name>
<xref ref-type="aff" rid="af53">53</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gudnason</surname>
<given-names>Vilmundur</given-names>
</name>
<xref ref-type="aff" rid="af21">21</xref>
<xref ref-type="aff" rid="af22">22</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Shuldiner</surname>
<given-names>Alan R.</given-names>
</name>
<xref ref-type="aff" rid="af23">23</xref>
<xref ref-type="aff" rid="af94">94</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Coresh</surname>
<given-names>Josef</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
<xref ref-type="aff" rid="af95">95</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schmidt</surname>
<given-names>Reinhold</given-names>
</name>
<xref ref-type="aff" rid="af96">96</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ferrucci</surname>
<given-names>Luigi</given-names>
</name>
<xref ref-type="aff" rid="af26">26</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Siscovick</surname>
<given-names>David S.</given-names>
</name>
<xref ref-type="aff" rid="af27">27</xref>
</contrib>
<contrib contrib-type="author"><name><surname>van Duijn</surname>
<given-names>Cornelia M.</given-names>
</name>
<xref ref-type="aff" rid="af18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Borecki</surname>
<given-names>Ingrid B.</given-names>
</name>
<xref ref-type="aff" rid="af12">12</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kardia</surname>
<given-names>Sharon L.R.</given-names>
</name>
<xref ref-type="aff" rid="af97">97</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Yongmei</given-names>
</name>
<xref ref-type="aff" rid="af32">32</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Curhan</surname>
<given-names>Gary C.</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
<xref ref-type="aff" rid="af98">98</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rudan</surname>
<given-names>Igor</given-names>
</name>
<xref ref-type="aff" rid="af64">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gyllensten</surname>
<given-names>Ulf</given-names>
</name>
<xref ref-type="aff" rid="af36">36</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wilson</surname>
<given-names>James F.</given-names>
</name>
<xref ref-type="aff" rid="af64">64</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Franke</surname>
<given-names>Andre</given-names>
</name>
<xref ref-type="aff" rid="af68">68</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pramstaller</surname>
<given-names>Peter P.</given-names>
</name>
<xref ref-type="aff" rid="af4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rettig</surname>
<given-names>Rainer</given-names>
</name>
<xref ref-type="aff" rid="af99">99</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Prokopenko</surname>
<given-names>Inga</given-names>
</name>
<xref ref-type="aff" rid="af75">75</xref>
<xref ref-type="aff" rid="af76">76</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Witteman</surname>
<given-names>Jacqueline</given-names>
</name>
<xref ref-type="aff" rid="af18">18</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hayward</surname>
<given-names>Caroline</given-names>
</name>
<xref ref-type="aff" rid="af67">67</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ridker</surname>
<given-names>Paul M</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Parsa</surname>
<given-names>Afshin</given-names>
</name>
<xref ref-type="aff" rid="af24">24</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bochud</surname>
<given-names>Murielle</given-names>
</name>
<xref ref-type="aff" rid="af100">100</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heid</surname>
<given-names>Iris M.</given-names>
</name>
<xref ref-type="aff" rid="af7">7</xref>
<xref ref-type="aff" rid="af13">13</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kao</surname>
<given-names>W.H. Linda</given-names>
</name>
<xref ref-type="aff" rid="af11">11</xref>
<xref ref-type="aff" rid="af95">95</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
<xref ref-type="author-notes" rid="AN3">§</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fox</surname>
<given-names>Caroline S.</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
<xref ref-type="aff" rid="af15">15</xref>
<xref ref-type="aff" rid="af101">101</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
<xref ref-type="author-notes" rid="AN3">§</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Köttgen</surname>
<given-names>Anna</given-names>
</name>
<xref ref-type="aff" rid="af14">14</xref>
<xref ref-type="aff" rid="af11">11</xref>
<xref ref-type="author-notes" rid="AN1">†</xref>
<xref ref-type="author-notes" rid="AN3">§</xref>
</contrib>
</contrib-group>
<aff id="af1"><label>1</label>
<addr-line>Division of Preventive Medicine</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>900 Commonwealth Avenue, Boston, MA 02215</addr-line>
,<country>USA</country>
,</aff>
<aff id="af2"><label>2</label>
<institution>Harvard Medical School</institution>
,<addr-line>Boston, MA 02115</addr-line>
,<country>USA</country>
,</aff>
<aff id="af3"><label>3</label>
<addr-line>Department of Biostatistics, Center for Statistical Genetics</addr-line>
,<institution>University of Michigan</institution>
,<addr-line>Ann Arbor, MI 48109</addr-line>
,<country>USA</country>
,</aff>
<aff id="af4"><label>4</label>
<addr-line>Center for Biomedicine, European Academy of Bozen/Bolzano</addr-line>
,<institution>Affiliated Institute of the University of Lübeck, Germany</institution>
,<addr-line>Viale Druso, 1-39100 Bolzano</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af5"><label>5</label>
<institution>Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald</institution>
,<addr-line>Friedrich-Ludwig-Jahn-Str. 15a, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af6"><label>6</label>
<addr-line>Department of Internal Medicine II</addr-line>
and</aff>
<aff id="af7"><label>7</label>
<addr-line>Department of Epidemiology and Preventive Medicine</addr-line>
,<institution>University Hospital Regensburg</institution>
,<addr-line>Franz-Josef-Strauss-Allee 11, 93042 Regensburg</addr-line>
,<country>Germany</country>
</aff>
<aff id="af8"><label>8</label>
<institution>Institute of Anatomy and Cell Biology, University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str. 23c, 17487 Greifswald</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af9"><label>9</label>
<addr-line>Department of Neurology</addr-line>
,<institution>Boston University School of Medicine</institution>
,<addr-line>72 East Concord St. B603, Boston, MA 02118</addr-line>
,<country>USA</country>
,</aff>
<aff id="af10"><label>10</label>
<addr-line>Department of Biostatistics</addr-line>
,<institution>Boston University School of Public Health</institution>
,<addr-line>715 Albany St., Boston, MA 02118</addr-line>
,<country>USA</country>
,</aff>
<aff id="af11"><label>11</label>
<addr-line>Department of Epidemiology</addr-line>
,<institution>Johns Hopkins Bloomberg School of Public Health</institution>
,<addr-line>615 N. Wolfe St., Baltimore, MD 21205</addr-line>
,<country>USA</country>
,</aff>
<aff id="af12"><label>12</label>
<addr-line>Division of Statistical Genomics</addr-line>
,<institution>Washington University School of Medicine</institution>
,<addr-line>4444 Forest Park Blvd. Box 8506, St Louis, MO 63108</addr-line>
,<country>USA</country>
,</aff>
<aff id="af13"><label>13</label>
<institution>Institute of Medical Informatics, Biometry and Epidemiology, and Institute of Epidemiology, Ludwig-Maximilians-Universität</institution>
,<addr-line>Ingolstädter Landstr. 1, 85764 Neuherberg</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af14"><label>14</label>
<addr-line>Renal Division</addr-line>
,<institution>Freiburg University Clinic</institution>
,<addr-line>Berliner Allee 29, 79110 Freiburg</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af15"><label>15</label>
<addr-line>Center for Population Studies</addr-line>
,<institution>NHLBI Framingham Heart Study</institution>
,<addr-line>73 Mt Wayte Ave Suite #2, Framingham, MA 01702</addr-line>
,<country>USA</country>
,</aff>
<aff id="af16"><label>16</label>
<addr-line>Division of Nephrology</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>75 Francis St., Boston, MA 02115</addr-line>
,<country>USA</country>
,</aff>
<aff id="af17"><label>17</label>
<addr-line>Section of Preventive Medicine and Epidemiology, Department of Medicine</addr-line>
,<institution>Boston University School of Medicine</institution>
,<addr-line>761 Harrison Ave, Boston, MA 02118</addr-line>
,<country>USA</country>
,</aff>
<aff id="af18"><label>18</label>
<addr-line>Department of Epidemiology</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>Dr. Molewaterplein 50, PO Box 2040, 3000CA Rotterdam</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af19"><label>19</label>
<addr-line>Centre for Medical Systems Biology</addr-line>
,<institution>Leiden University</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af20"><label>20</label>
<addr-line>Department of Biostatistics</addr-line>
,<institution>Boston University School of Public Health</institution>
,<addr-line>801 Massachusetts Ave, CT3, Boston, MA 02118</addr-line>
,<country>USA</country>
,</aff>
<aff id="af21"><label>21</label>
<institution>Icelandic Heart Association, Research Institute</institution>
,<addr-line>Holtasmari 1, 201 Kopavogur</addr-line>
,<country>Iceland</country>
,</aff>
<aff id="af22"><label>22</label>
<institution>University of Iceland</institution>
,<addr-line>Sæmundargötu 2, 101 Reykjavik</addr-line>
,<country>Iceland</country>
,</aff>
<aff id="af23"><label>23</label>
<addr-line>Department of Medicine</addr-line>
and</aff>
<aff id="af24"><label>24</label>
<addr-line>Division of Nephrology</addr-line>
,<institution>University of Maryland Medical School</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
</aff>
<aff id="af25"><label>25</label>
<addr-line>Departments of Epidemiology and Biostatistics, and Forensic Molecular Biology</addr-line>
,<institution>University of Rotterdam</institution>
,<addr-line>Dr Molewaterplein 50-603015, Rotterdam, GE</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af26"><label>26</label>
<institution>Clinical Research Branch, National Institute of Aging</institution>
,<addr-line>3001 S Hanover Street, Baltimore, MD 21225</addr-line>
,<country>USA</country>
,</aff>
<aff id="af27"><label>27</label>
<institution>University of Washington</institution>
,<addr-line>1730 Minor Ave. Campus Box 358080, Seattle, WA 98101-1448</addr-line>
,<country>USA</country>
,</aff>
<aff id="af28"><label>28</label>
<addr-line>Department of Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
and</aff>
<aff id="af29"><label>29</label>
<addr-line>Departments of Genetics and Developmental Biology</addr-line>
,<institution>Stanford University</institution>
,<addr-line>Stanford, CA 94305</addr-line>
,<country>USA</country>
</aff>
<aff id="af30"><label>30</label>
<addr-line>Division of Biomedical Statistics and Informatics</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
and</aff>
<aff id="af31"><label>31</label>
<addr-line>Department of Internal Medicine, Division of Nephrology and Hypertension</addr-line>
,<institution>Mayo Clinic</institution>
,<addr-line>200 First Street SW, Rochester, MN 55905</addr-line>
,<country>USA</country>
</aff>
<aff id="af32"><label>32</label>
<addr-line>Department of Epidemiology and Prevention, Public Health Sciences</addr-line>
,</aff>
<aff id="af33"><label>33</label>
<addr-line>Department of Internal Medicine</addr-line>
and</aff>
<aff id="af34"><label>34</label>
<addr-line>Department of Biostatistical Sciences, Public Health Sciences</addr-line>
,<institution>Wake Forest School of Medicine</institution>
,<addr-line>Winston-Salem, NC 27157</addr-line>
,<country>USA</country>
</aff>
<aff id="af35"><label>35</label>
<addr-line>Department of Nutrition</addr-line>
,<institution>Harvard School of Public Health</institution>
,<addr-line>665 Huntington Avenue, Building 2, Boston, MA 02115</addr-line>
,<country>USA</country>
,</aff>
<aff id="af36"><label>36</label>
<addr-line>Genetics and Pathology, Rudbeck Laboratory</addr-line>
,<institution>Uppsala University</institution>
,<addr-line>SE-751 85 Uppsala</addr-line>
,<country>Sweden</country>
,</aff>
<aff id="af37"><label>37</label>
<addr-line>IFB Adiposity Diseases and Department of Medicine</addr-line>
,<institution>University of Leipzig</institution>
,<addr-line>Liebigstr. 18, 04103 Leipzig</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af38"><label>38</label>
<institution>INSERM UMR744, Institut Pasteur</institution>
,<addr-line>Lille</addr-line>
,<country>France</country>
,</aff>
<aff id="af39"><label>39</label>
<addr-line>Centre for Information-based Medicine and School of Medicine and Public Health</addr-line>
,<institution>University of Newcastle, Hunter Medical Research Institute</institution>
,<addr-line>Newcastle, NSW</addr-line>
,<country>Australia</country>
,</aff>
<aff id="af40"><label>40</label>
<institution>Institute of Genetics and Biophysics ‘Adriano-Buzzati Traverso’</institution>
,<addr-line>CNR, Via P. Castellino 111, 80131 Napoli</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af41"><label>41</label>
<addr-line>Department of Medical Genetics</addr-line>
,<institution>University of Lausanne</institution>
,<addr-line>Rue du Bugnon 27, CH, 1005 Lausanne</addr-line>
,<country>Switzerland</country>
,</aff>
<aff id="af42"><label>42</label>
<institution>Swiss Institute of Bioinformatics</institution>
,<addr-line>Lausanne</addr-line>
,<country>Switzerland</country>
,</aff>
<aff id="af43"><label>43</label>
<addr-line>Department of Clinical Chemistry, Centre for Laboratory Medicine Tampere Finn</addr-line>
,<institution>University of Tampere and Tampere University Hospital</institution>
,<addr-line>Medi 2, 3th, floor, PO Box 2000, 33521 Tampere</addr-line>
,<country>Finland</country>
,</aff>
<aff id="af44"><label>44</label>
<institution>Institute of Molecular and Cell Biology, Estonian Biocenter, University of Tartu</institution>
,<addr-line>Riia 23, Tartu</addr-line>
,<country>Estonia</country>
,</aff>
<aff id="af45"><label>45</label>
<addr-line>Estonian Genome Center</addr-line>
,<institution>University of Tartu (EGCUT)</institution>
,<addr-line>Tiigi 61b, Tartu</addr-line>
,<country>Estonia</country>
,</aff>
<aff id="af46"><label>46</label>
<addr-line>Clinical Research Centre</addr-line>
,<institution>University of Dundee-Wellcome Trust Centre for Molecular Medicine</institution>
,<addr-line>Level 7, Ninewells Hospital, Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</aff>
<aff id="af47"><label>47</label>
<institution>Institute for Maternal and Child Health IRCCS ‘Burlo Garofolo’</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af48"><label>48</label>
<institution>Institute of Population Genetics</institution>
,<addr-line>CNR-Traversa La Crucca, 3 07040 Reg. Baldinca Li Punti, Sassari</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af49"><label>49</label>
<addr-line>Deparment of Cardiology</addr-line>
,<institution>Leiden University Medical Center</institution>
,<addr-line>Postzone C2-R, PO Box 9600, 2300 RC Leiden</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af50"><label>50</label>
<addr-line>Department of Epidemiology and Public Health</addr-line>
,<institution>Swiss Tropical and Public Health Institute</institution>
,<addr-line>Socinstrasse 57, PO Box, Basel 4002</addr-line>
,<country>Switzerland</country>
,</aff>
<aff id="af51"><label>51</label>
<institution>University of Basel</institution>
,<addr-line>Basel</addr-line>
,<country>Switzerland</country>
,</aff>
<aff id="af52"><label>52</label>
<addr-line>Division of Genetic Epidemiology</addr-line>
,<institution>Innsbruck Medical University</institution>
,<addr-line>Schoepfstraße 41, 6020 Innsbruck</addr-line>
,<country>Austria</country>
,</aff>
<aff id="af53"><label>53</label>
<addr-line>Division of Genetics and Cell Biology</addr-line>
,<institution>San Raffaele Scientific Institute</institution>
,<addr-line>Via Olgettina 58, 20132 Milano</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af54"><label>54</label>
<institution>Coronary ARtery DIsease Genome-wide Replication And Meta-Analysis (CARDIoGRAM) Consortium</institution>
,</aff>
<aff id="af55"><label>55</label>
<institution>International Consortium for Blood Pressure Genomewide Association Studies</institution>
,</aff>
<aff id="af56"><label>56</label>
<institution>Candidate Gene Association Resource (CARe) Consortium</institution>
,</aff>
<aff id="af57"><label>57</label>
<institution>Welcome Trust Case Control Consortium 2</institution>
,</aff>
<aff id="af58"><label>58</label>
<institution>Laboratory of Epidemiology, Demography, and Biometry</institution>
,<addr-line>NIA-Gateway Building, 3C309, 7201 Wisconsin Ave., Bethesda, MD 20892-9205</addr-line>
,<country>USA</country>
,</aff>
<aff id="af59"><label>59</label>
<addr-line>Human Genetics Center Houston</addr-line>
,<institution>University of Texas Health Science Center</institution>
,<addr-line>TX-1200 Herman Pressler Drive, Houston, TX 77030</addr-line>
,<country>USA</country>
,</aff>
<aff id="af60"><label>60</label>
<addr-line>Institute of Molecular Biology and Biochemistry and Department of Neurology</addr-line>
,<institution>Medical University Graz</institution>
,<addr-line>Harrachgasse 21 8010, Graz</addr-line>
,<country>Austria</country>
,</aff>
<aff id="af61"><label>61</label>
<addr-line>Division of Nephrology/Tufts Evidence Practice Center</addr-line>
,<institution>Tufts University School of Medicine-Tufts Medical Center</institution>
,<addr-line>Boston, MA 02111</addr-line>
,<country>USA</country>
,</aff>
<aff id="af62"><label>62</label>
<addr-line>Abteilung Innere II</addr-line>
,<institution>Universitätsklinikum Ulm</institution>
,<addr-line>Albert-Einstein-Allee 23, Ulm 89081</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af63"><label>63</label>
<addr-line>Helmholtz Zentrum München</addr-line>
,<institution>German Research Center for Environmental Health</institution>
,<addr-line>Institute of Epidemiology II, Neuherberg</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af64"><label>64</label>
<addr-line>Center for Population Health Sciences</addr-line>
,<institution>University of Edinburgh Medical School</institution>
,<addr-line>UK-Teviot Place, Edinburgh EH8 9AG</addr-line>
,<country>Scotland</country>
,</aff>
<aff id="af65"><label>65</label>
<addr-line>Andrija Stampar School of Public Health, Medical School</addr-line>
,<institution>University of Zagreb</institution>
,<addr-line>Zagreb</addr-line>
,<country>Croatia</country>
,</aff>
<aff id="af66"><label>66</label>
<addr-line>Croatian Centre for Global Health, Faculty of Medicine</addr-line>
,<institution>University of Split</institution>
,<addr-line>Soltanska 2, Split</addr-line>
,<country>Croatia</country>
,</aff>
<aff id="af67"><label>67</label>
<addr-line>MRC Human Genetics Unit</addr-line>
,<institution>Institute of Genetics and Molecular Medicine––Western General Hospital</institution>
,<addr-line>Crewe Road, Edinburgh EH4 2XU</addr-line>
,<country>Scotland</country>
,</aff>
<aff id="af68"><label>68</label>
<institution>Institute of Clinical Molecular Biology, Christian-Albrechts University</institution>
,<addr-line>Schittenhelmstr.12, Kiel 24105</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af69"><label>69</label>
<addr-line>Section for Epidemiology</addr-line>
,<institution>Institute for Experimental Medicine, Christian-Albrechts-University of Kiel and Popgen Biobank, University Hospital Schleswig-Holstein</institution>
,<addr-line>Niemannsweg 11, Kiel 24105</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af70"><label>70</label>
<addr-line>Clinic for Prosthodontic Dentistry</addr-line>
,<institution>Gerostomatology and Material Science, University of Greifswald</institution>
,<addr-line>Rotgerberstr 8, Greifswald 17475</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af71"><label>71</label>
<institution>Institute of Pharmacology, University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str., 23d, Greifswald 17487</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af72"><label>72</label>
<institution>Institute of Clinical Chemistry and Laboratory Medicine, Ernst-Moritz Arndt-University Greifswald</institution>
,<addr-line>Ferdinand-Sauerbruch-Str., Greifswald 17475</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af73"><label>73</label>
<addr-line>Clinic for Internal Medicine A</addr-line>
,<institution>University of Greifswald</institution>
,<addr-line>Friedrich-Loeffler-Str. 23a, Greifswald 17475</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af74"><label>74</label>
<addr-line>Institute for Community Medicine</addr-line>
,<institution>University of Greifswald</institution>
,<addr-line>Walther-Rathenau-Str. 48, Greifswald 17487</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af75"><label>75</label>
<addr-line>Oxford Centre for Diabetes, Endocrinology and Metabolism</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7LJ</addr-line>
,<country>UK</country>
,</aff>
<aff id="af76"><label>76</label>
<addr-line>Wellcome Trust Centre for Human Genetics</addr-line>
,<institution>University of Oxford</institution>
,<addr-line>Oxford OX3 7BN</addr-line>
,<country>UK</country>
,</aff>
<aff id="af77"><label>77</label>
<addr-line>Department of Internal Medicine</addr-line>
,<institution>Erasmus Medical Center</institution>
,<addr-line>PO Box 1738, 3000 DR Rotterdam</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af78"><label>78</label>
<institution>INSERM U897, Université Victor Ségalen Bordeaux 2</institution>
,<addr-line>ISPED case 11, 146 Rue Léo Saignat, F-33076 Bordeaux</addr-line>
,<country>France</country>
,</aff>
<aff id="af79"><label>79</label>
<addr-line>Centre for Vision Research</addr-line>
,<institution>University of Sydney, Westmead Millennium Institute, Westmead Hospital</institution>
,<addr-line>Sydney NSW 2145</addr-line>
,<country>Australia</country>
,</aff>
<aff id="af80"><label>80</label>
<addr-line>Centre for Eye Research Australia (CERA)</addr-line>
,<institution>University of Melbourne</institution>
,<addr-line>32 Gisborne Street, East Melbourne, Victoria 3002</addr-line>
,<country>Australia</country>
,</aff>
<aff id="af81"><label>81</label>
<institution>INSERM UMRS 1018-CESP Team 10, Univ Paris Sud</institution>
,<addr-line>Villejuif</addr-line>
,<country>France</country>
,</aff>
<aff id="af82"><label>82</label>
<addr-line>Department of Clinical Physiology</addr-line>
,<institution>University of Tampere and Tampere University Hospital</institution>
,<addr-line>33521-PO Box 2000, Tampere 33521</addr-line>
,<country>Finland</country>
,</aff>
<aff id="af83"><label>83</label>
<addr-line>Department of Clinical Physiology</addr-line>
,<institution>Research Centre of Applied and Preventive Cardiovascular Medicine, Turku University Hospital, University of Turku</institution>
,<addr-line>PO Box 52, Turku 20521</addr-line>
,<country>Finland</country>
,</aff>
<aff id="af84"><label>84</label>
<institution>University of Trieste</institution>
,<addr-line>Trieste</addr-line>
,<country>Italy</country>
,</aff>
<aff id="af85"><label>85</label>
<addr-line>Department of Medicine</addr-line>
,<institution>University Medical Centre Mannheim</institution>
,<addr-line>Theodor Kutzer Ufer 1-3, Mannheim 68167</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af86"><label>86</label>
<addr-line>Robertson Centre for Biostatistics</addr-line>
,<institution>University of Glasgow</institution>
,<addr-line>Glasgow</addr-line>
,<country>Scotland</country>
,</aff>
<aff id="af87"><label>87</label>
<addr-line>Department of Pharmacology and Therapeutics</addr-line>
,<institution>University College Cork</institution>
,<addr-line>Cork</addr-line>
,<country>Ireland</country>
,</aff>
<aff id="af88"><label>88</label>
<addr-line>First Department of Internal Medicine</addr-line>
,<institution>Paracelsus Medical University</institution>
,<addr-line>Müllner Hauptstraße 48, Salzburg 5020</addr-line>
,<country>Austria</country>
,</aff>
<aff id="af89"><label>89</label>
<addr-line>Department of Internal Medicine</addr-line>
,<institution>Centre Hospitalier Universitaire Vaudois and University of Lausanne</institution>
,<addr-line>Rue du Bugnon 46, Lausanne 1011, CH</addr-line>
,<country>Switzerland</country>
,</aff>
<aff id="af90"><label>90</label>
<institution>University of Dundee-Biomedical Research Institute</institution>
,<addr-line>Level 5, Ninewells Hospital Dundee DD1 9SY</addr-line>
,<country>Scotland</country>
,</aff>
<aff id="af91"><label>91</label>
<institution>Durrer Center for Cardiogenetic Research</institution>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af92"><label>92</label>
<institution>Interuniversity Cardiology Institute of the Netherlands (ICIN)</institution>
,<addr-line>Utrecht</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af93"><label>93</label>
<institution>Einthoven Laboratory for Experimental Vascular Medicine</institution>
,<addr-line>Leiden</addr-line>
,<country>The Netherlands</country>
,</aff>
<aff id="af94"><label>94</label>
<institution>Geriatric Research and Education Clinical Center, Veterans Administration Medical Center</institution>
,<addr-line>Baltimore, MD</addr-line>
,<country>USA</country>
,</aff>
<aff id="af95"><label>95</label>
<addr-line>Welch Center for Prevention</addr-line>
,<institution>Epidemiology and Clinical Research, Johns Hopkins University</institution>
,<addr-line>2024 E Monument St., Suite 2-600, Baltimore, MD 21287</addr-line>
,<country>USA</country>
,</aff>
<aff id="af96"><label>96</label>
<addr-line>Department of Special Neurology</addr-line>
,<institution>University Clinic of Neurology, Medical University Graz</institution>
,<addr-line>Auenbruggerplatz 22, 8036 Graz</addr-line>
,<country>Austria</country>
,</aff>
<aff id="af97"><label>97</label>
<addr-line>Department of Epidemiology and School of Public Health</addr-line>
,<institution>University of Medicine</institution>
,<addr-line>109 Observatory #4605, Ann Arbor, MI 48109-2029</addr-line>
,<country>USA</country>
,</aff>
<aff id="af98"><label>98</label>
<institution>Channing Laboratory, Brigham and Women's Hospital</institution>
,<addr-line>181 Longwood Avenue, Boston, MA 02115</addr-line>
,<country>USA</country>
,</aff>
<aff id="af99"><label>99</label>
<institution>Institute of Physiology, University of Greifswald</institution>
,<addr-line>Greifswald 17487</addr-line>
,<country>Germany</country>
,</aff>
<aff id="af100"><label>100</label>
<institution>University Institute of Social and Preventive Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne</institution>
,<addr-line>Route de la Corniche 2, Epalinges 1066, CH</addr-line>
,<country>Switzerland</country>
and</aff>
<aff id="af101"><label>101</label>
<addr-line>Division of Endocrinology</addr-line>
,<institution>Brigham and Women's Hospital</institution>
,<addr-line>75 Francis St., Boston, MA</addr-line>
,<country>USA</country>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
To whom correspondence should be addressed at: Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave East, Boston, MA 02215, USA. Tel: +1 6172780821; Email: <email>dchasman@rics.bwh.harvard.edu</email>
(Daniel I. Chasman); Department of Biostatistics, University of Michigan School of Public Health, 1420 Washington Heights, Ann Arbor, MI 48109-2029, USA. Tel: +1 7346156833; Email: <email>cfuchsb@umich.edu</email>
(Christian Fuchsberger); Universitätsklinikum Freiburg, Medizin IV, Nephrologie, Berliner Allee 29, 79110 Freiburg im Breisgau, Germany. Tel: +49 76127078050; Email: <email>anna.koettgen@uniklinik-freiburg.de</email>
(Anna Köttgen)</corresp>
<fn id="AN1"><label>†</label>
<p>Writing group.</p>
</fn>
<fn id="AN2"><label>‡</label>
<p>These authors jointly contributed.</p>
</fn>
<fn id="AN3"><label>§</label>
<p>These authors jointly oversaw the work.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>15</day>
<month>12</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>8</day>
<month>9</month>
<year>2012</year>
</pub-date>
<volume>21</volume>
<issue>24</issue>
<fpage>5329</fpage>
<lpage>5343</lpage>
<history><date date-type="received"><day>29</day>
<month>6</month>
<year>2012</year>
</date>
<date date-type="rev-recd"><day>16</day>
<month>8</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>28</day>
<month>8</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>© The Author 2012. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="dds369.pdf"></self-uri>
<abstract><p>In conducting genome-wide association studies (GWAS), analytical approaches leveraging biological information may further understanding of the pathophysiology of clinical traits. To discover novel associations with estimated glomerular filtration rate (eGFR), a measure of kidney function, we developed a strategy for integrating prior biological knowledge into the existing GWAS data for eGFR from the CKDGen Consortium. Our strategy focuses on single nucleotide polymorphism (SNPs) in genes that are connected by functional evidence, determined by literature mining and gene ontology (GO) hierarchies, to genes near previously validated eGFR associations. It then requires association thresholds consistent with multiple testing, and finally evaluates novel candidates by independent replication. Among the samples of European ancestry, we identified a genome-wide significant SNP in <italic>FBXL20</italic>
(<italic>P</italic>
= 5.6 × 10<sup>−9</sup>
) in meta-analysis of all available data, and additional SNPs at the <italic>INHBC</italic>
, <italic>LRP2</italic>
, <italic>PLEKHA1</italic>
, <italic>SLC3A2</italic>
and <italic>SLC7A6</italic>
genes meeting multiple-testing corrected significance for replication and overall <italic>P</italic>
-values of 4.5 × 10<sup>−4</sup>
–2.2 × 10<sup>−7</sup>
. Neither the novel <italic>PLEKHA1</italic>
nor <italic>FBXL20</italic>
associations, both further supported by association with eGFR among African Americans and with transcript abundance, would have been implicated by eGFR candidate gene approaches. <italic>LRP2</italic>
, encoding the megalin receptor, was identified through connection with the previously known eGFR gene <italic>DAB2</italic>
and extends understanding of the megalin system in kidney function. These findings highlight integration of existing genome-wide association data with independent biological knowledge to uncover novel candidate eGFR associations, including candidates lacking known connections to kidney-specific pathways. The strategy may also be applicable to other clinical phenotypes, although more testing will be needed to assess its potential for discovery in general.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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