Intra-Aortic Clusters Undergo Endothelial to Hematopoietic Phenotypic Transition during Early Embryogenesis
Identifieur interne : 005338 ( Main/Exploration ); précédent : 005337; suivant : 005339Intra-Aortic Clusters Undergo Endothelial to Hematopoietic Phenotypic Transition during Early Embryogenesis
Auteurs : Chiyo Mizuochi [Japon] ; Stuart T. Fraser [Australie] ; Katia Biasch [France] ; Yuka Horio [Japon] ; Yoshikane Kikushige [Japon] ; Kenzaburo Tani [Japon] ; Koichi Akashi [Japon] ; Manuela Tavian [France] ; Daisuke Sugiyama [Japon]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Intra-aortic clusters (IACs) attach to floor of large arteries and are considered to have recently acquired hematopoietic stem cell (HSC)-potential in vertebrate early mid-gestation embryos. The formation and function of IACs is poorly understood. To address this issue, IACs were characterized by immunohistochemistry and flow cytometry in mouse embryos. Immunohistochemical analysis revealed that IACs simultaneously express the surface antigens CD31, CD34 and c-Kit. As embryos developed from 9.5 to 10.5 dpc, IACs up-regulate the hematopoietic markers CD41 and CD45 while down-regulating the endothelial surface antigen VE-cadherin/CD144, suggesting that IACs lose endothelial phenotype after 9.5 dpc. Analysis of the hematopoietic potential of IACs revealed a significant change in macrophage CFC activity from 9.5 to 10.5 dpc. To further characterize IACs, we isolated IACs based on CD45 expression. Correspondingly, the expression of hematopoietic transcription factors in the CD45(neg) fraction of IACs was significantly up-regulated. These results suggest that the transition from endothelial to hematopoietic phenotype of IACs occurs after 9.5 dpc.
Url:
DOI: 10.1371/journal.pone.0035763
PubMed: 22558218
PubMed Central: 3338791
Affiliations:
- Australie, France, Japon
- Alsace (région administrative), Grand Est, Kyūshū, Nouvelle-Galles du Sud, Préfecture de Fukuoka
- Fukuoka, Strasbourg, Sydney
- Université de Kyūshū, Université de Sydney
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last="Kikushige">Yoshikane Kikushige</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka</wicri:regionArea><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author><author><name sortKey="Tani, Kenzaburo" sort="Tani, Kenzaburo" uniqKey="Tani K" first="Kenzaburo" last="Tani">Kenzaburo Tani</name><affiliation wicri:level="4"><nlm:aff id="aff5"><addr-line>Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka</wicri:regionArea><orgName 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id="aff3"><addr-line>Unité 682 INSERM, Strasbourg, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité 682 INSERM, Strasbourg</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Alsace (région administrative)</region><settlement type="city">Strasbourg</settlement></placeName></affiliation></author><author><name sortKey="Sugiyama, Daisuke" sort="Sugiyama, Daisuke" uniqKey="Sugiyama D" first="Daisuke" last="Sugiyama">Daisuke Sugiyama</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Department of Hematopoietic Stem Cells, SSP Stem Cell Unit, Kyushu University Faculty of Medical Sciences, Fukuoka, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Hematopoietic Stem Cells, SSP Stem Cell Unit, Kyushu University Faculty of Medical Sciences, Fukuoka</wicri:regionArea><wicri:noRegion>Fukuoka</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Intra-aortic clusters (IACs) attach to floor of large arteries and are considered to have recently acquired hematopoietic stem cell (HSC)-potential in vertebrate early mid-gestation embryos. The formation and function of IACs is poorly understood. To address this issue, IACs were characterized by immunohistochemistry and flow cytometry in mouse embryos. Immunohistochemical analysis revealed that IACs simultaneously express the surface antigens CD31, CD34 and c-Kit. As embryos developed from 9.5 to 10.5 dpc, IACs up-regulate the hematopoietic markers CD41 and CD45 while down-regulating the endothelial surface antigen VE-cadherin/CD144, suggesting that IACs lose endothelial phenotype after 9.5 dpc. Analysis of the hematopoietic potential of IACs revealed a significant change in macrophage CFC activity from 9.5 to 10.5 dpc. To further characterize IACs, we isolated IACs based on CD45 expression. Correspondingly, the expression of hematopoietic transcription factors in the CD45(neg) fraction of IACs was significantly up-regulated. These results suggest that the transition from endothelial to hematopoietic phenotype of IACs occurs after 9.5 dpc.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Dzierzak, E" uniqKey="Dzierzak E">E Dzierzak</name></author><author><name sortKey="Speck, Na" uniqKey="Speck N">NA Speck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mikkola, Hk" uniqKey="Mikkola H">HK Mikkola</name></author><author><name sortKey="Orkin, Sh" uniqKey="Orkin S">SH Orkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godin, I" uniqKey="Godin I">I Godin</name></author><author><name sortKey="Cumano, A" uniqKey="Cumano A">A Cumano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dieterlen Lievre, F" uniqKey="Dieterlen Lievre F">F Dieterlen-Lievre</name></author><author><name sortKey="Pouget, C" uniqKey="Pouget C">C Pouget</name></author><author><name 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uniqKey="Zeigler B">BM Zeigler</name></author><author><name sortKey="Dzierzak, E" uniqKey="Dzierzak E">E Dzierzak</name></author><author><name sortKey="Speck, Na" uniqKey="Speck N">NA Speck</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bertrand, Jy" uniqKey="Bertrand J">JY Bertrand</name></author><author><name sortKey="Chi, Nc" uniqKey="Chi N">NC Chi</name></author><author><name sortKey="Santoso, B" uniqKey="Santoso B">B Santoso</name></author><author><name sortKey="Teng, S" uniqKey="Teng S">S Teng</name></author><author><name sortKey="Stainier, Dy" uniqKey="Stainier D">DY Stainier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kissa, K" uniqKey="Kissa K">K Kissa</name></author><author><name sortKey="Herbomel, P" uniqKey="Herbomel P">P Herbomel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Boisset, Jc" uniqKey="Boisset J">JC Boisset</name></author><author><name sortKey="Van Cappellen, W" uniqKey="Van Cappellen W">W van Cappellen</name></author><author><name sortKey="Andrieu Soler, C" uniqKey="Andrieu Soler C">C Andrieu-Soler</name></author><author><name sortKey="Galjart, N" uniqKey="Galjart N">N Galjart</name></author><author><name sortKey="Dzierzak, E" uniqKey="Dzierzak E">E Dzierzak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sasaki, T" uniqKey="Sasaki T">T Sasaki</name></author><author><name sortKey="Mizuochi, C" uniqKey="Mizuochi C">C Mizuochi</name></author><author><name sortKey="Horio, Y" uniqKey="Horio Y">Y Horio</name></author><author><name sortKey="Nakao, K" uniqKey="Nakao K">K Nakao</name></author><author><name sortKey="Akashi, K" uniqKey="Akashi K">K Akashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mucenski, Ml" uniqKey="Mucenski M">ML Mucenski</name></author><author><name sortKey="Mclain, K" uniqKey="Mclain K">K McLain</name></author><author><name sortKey="Kier, Ab" uniqKey="Kier A">AB Kier</name></author><author><name sortKey="Swerdlow, Sh" uniqKey="Swerdlow S">SH Swerdlow</name></author><author><name sortKey="Schreiner, Cm" uniqKey="Schreiner C">CM Schreiner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okuda, T" uniqKey="Okuda T">T Okuda</name></author><author><name sortKey="Van Deursen, J" uniqKey="Van Deursen J">J van Deursen</name></author><author><name sortKey="Hiebert, Sw" uniqKey="Hiebert S">SW Hiebert</name></author><author><name sortKey="Grosveld, G" uniqKey="Grosveld G">G Grosveld</name></author><author><name sortKey="Downing, Jr" uniqKey="Downing J">JR Downing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Stacy, T" uniqKey="Stacy T">T Stacy</name></author><author><name sortKey="Binder, M" uniqKey="Binder M">M Binder</name></author><author><name sortKey="Marin Padilla, M" uniqKey="Marin 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Takakura</name></author><author><name sortKey="Huang, Xl" uniqKey="Huang X">XL Huang</name></author><author><name sortKey="Naruse, T" uniqKey="Naruse T">T Naruse</name></author><author><name sortKey="Hamaguchi, I" uniqKey="Hamaguchi I">I Hamaguchi</name></author><author><name sortKey="Dumont, Dj" uniqKey="Dumont D">DJ Dumont</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Theiler, K" uniqKey="Theiler K">K Theiler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kishihara, K" uniqKey="Kishihara K">K Kishihara</name></author><author><name sortKey="Penninger, J" uniqKey="Penninger J">J Penninger</name></author><author><name sortKey="Wallace, Va" uniqKey="Wallace V">VA Wallace</name></author><author><name sortKey="Kundig, Tm" uniqKey="Kundig T">TM Kundig</name></author><author><name sortKey="Kawai, K" uniqKey="Kawai K">K Kawai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Byth, Kf" uniqKey="Byth K">KF Byth</name></author><author><name sortKey="Conroy, La" uniqKey="Conroy L">LA Conroy</name></author><author><name sortKey="Howlett, S" uniqKey="Howlett S">S Howlett</name></author><author><name sortKey="Smith, Aj" uniqKey="Smith A">AJ Smith</name></author><author><name sortKey="May, J" uniqKey="May J">J May</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mee, Pj" uniqKey="Mee P">PJ Mee</name></author><author><name sortKey="Turner, M" uniqKey="Turner M">M Turner</name></author><author><name sortKey="Basson, Ma" uniqKey="Basson M">MA Basson</name></author><author><name sortKey="Costello, Ps" uniqKey="Costello P">PS Costello</name></author><author><name sortKey="Zamoyska, R" uniqKey="Zamoyska R">R Zamoyska</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="North, Te" uniqKey="North T">TE North</name></author><author><name sortKey="De Bruijn, Mf" uniqKey="De Bruijn M">MF de Bruijn</name></author><author><name sortKey="Stacy, T" uniqKey="Stacy T">T Stacy</name></author><author><name sortKey="Talebian, L" uniqKey="Talebian L">L Talebian</name></author><author><name sortKey="Lind, E" uniqKey="Lind E">E Lind</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Matsubara, A" uniqKey="Matsubara A">A Matsubara</name></author><author><name sortKey="Iwama, A" uniqKey="Iwama A">A Iwama</name></author><author><name sortKey="Yamazaki, S" uniqKey="Yamazaki S">S Yamazaki</name></author><author><name sortKey="Furuta, C" uniqKey="Furuta C">C Furuta</name></author><author><name sortKey="Hirasawa, R" uniqKey="Hirasawa R">R Hirasawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Ahilly, R" uniqKey="O Ahilly R">R O’Rahilly</name></author><author><name sortKey="Muller, F" uniqKey="Muller F">F Muller</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tavian, M" uniqKey="Tavian M">M Tavian</name></author><author><name sortKey="Peault, B" uniqKey="Peault B">B Peault</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Japon</li></country><region><li>Alsace (région administrative)</li><li>Grand Est</li><li>Kyūshū</li><li>Nouvelle-Galles du Sud</li><li>Préfecture de Fukuoka</li></region><settlement><li>Fukuoka</li><li>Strasbourg</li><li>Sydney</li></settlement><orgName><li>Université de Kyūshū</li><li>Université de Sydney</li></orgName></list><tree><country name="Japon"><noRegion><name sortKey="Mizuochi, Chiyo" sort="Mizuochi, Chiyo" uniqKey="Mizuochi C" first="Chiyo" last="Mizuochi">Chiyo Mizuochi</name></noRegion><name sortKey="Akashi, Koichi" sort="Akashi, Koichi" uniqKey="Akashi K" first="Koichi" last="Akashi">Koichi Akashi</name><name sortKey="Horio, Yuka" sort="Horio, Yuka" uniqKey="Horio Y" first="Yuka" last="Horio">Yuka Horio</name><name sortKey="Kikushige, Yoshikane" sort="Kikushige, Yoshikane" uniqKey="Kikushige Y" first="Yoshikane" last="Kikushige">Yoshikane Kikushige</name><name sortKey="Sugiyama, Daisuke" sort="Sugiyama, Daisuke" uniqKey="Sugiyama D" first="Daisuke" last="Sugiyama">Daisuke Sugiyama</name><name sortKey="Tani, Kenzaburo" sort="Tani, Kenzaburo" uniqKey="Tani K" first="Kenzaburo" last="Tani">Kenzaburo Tani</name></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Fraser, Stuart T" sort="Fraser, Stuart T" uniqKey="Fraser S" first="Stuart T." last="Fraser">Stuart T. Fraser</name></region></country><country name="France"><region name="Grand Est"><name sortKey="Biasch, Katia" sort="Biasch, Katia" uniqKey="Biasch K" first="Katia" last="Biasch">Katia Biasch</name></region><name sortKey="Tavian, Manuela" sort="Tavian, Manuela" uniqKey="Tavian M" first="Manuela" last="Tavian">Manuela Tavian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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