AustralieFrV1, Main, Exploration, bibRecord, 003C58

A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Identifieur interne : 003C58 ( Main/Exploration ); précédent : 003C57; suivant : 003C59

A Unified Nomenclature and Amino Acid Numbering for Human PTEN

Auteurs : Rafael Pulido [Espagne] ; Suzanne J. Baker [États-Unis] ; Joao T. Barata [Portugal] ; Arkaitz Carracedo [Espagne] ; Victor J. Cid [Espagne] ; Ian D. Chin-Sang [Canada] ; Vrushank Davé [États-Unis] ; Jeroen Den Hertog [Pays-Bas] ; Peter Devreotes [États-Unis] ; Britta J. Eickholt ; Charis Eng [États-Unis] ; Frank B. Furnari [États-Unis] ; Maria-Magdalena Georgescu [États-Unis] ; Arne Gericke [États-Unis] ; Benjamin Hopkins [États-Unis] ; Xeujun Jiang [États-Unis] ; Seung-Rock Lee [Corée du Sud] ; Mathias Lösche [États-Unis] ; Prerna Malaney [États-Unis] ; Xavier Matias-Guiu [Espagne] ; María Molina [Espagne] ; Pier Paolo Pandolfi [États-Unis] ; Ramon Parsons [États-Unis] ; Paolo Pinton [Italie] ; Carmen Rivas [Espagne] ; Rafael M. Rocha [Brésil] ; Manuel S. Rodríguez [Espagne] ; Alonzo H. Ross [États-Unis] ; Manuel Serrano [Espagne] ; Vuk Stambolic [Canada] ; Bangyan Stiles [États-Unis] ; Akira Suzuki [Japon] ; Seong-Seng Tan [Australie] ; Nicholas K. Tonks [États-Unis] ; Lloyd C. Trotman [États-Unis] ; Nicolas Wolff [France] ; Rudiger Woscholski [Royaume-Uni] ; Hong Wu [République populaire de Chine] ; Nicholas R. Leslie [Royaume-Uni]

Source :

Science signaling [ 1937-9145 ] ; 2014.

RBID : PMC:4367864

Descripteurs français

KwdFr :
- Acides aminés (), Bases de données de protéines, Codon d'initiation, Humains, Phosphohydrolase PTEN (), Phosphohydrolase PTEN (génétique), Séquence d'acides aminés, Terminologie comme sujet.
MESH :
- génétique : Phosphohydrolase PTEN.
- Acides aminés, Bases de données de protéines, Codon d'initiation, Humains, Phosphohydrolase PTEN, Séquence d'acides aminés, Terminologie comme sujet.

English descriptors

KwdEn :
- Amino Acid Sequence, Amino Acids (chemistry), Codon, Initiator, Databases, Protein, Humans, PTEN Phosphohydrolase (chemistry), PTEN Phosphohydrolase (genetics), Terminology as Topic.
MESH :
- chemical , chemistry : Amino Acids, PTEN Phosphohydrolase.
- chemical , genetics : PTEN Phosphohydrolase.
- Amino Acid Sequence, Codon, Initiator, Databases, Protein, Humans, Terminology as Topic.

Abstract

The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P₃] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367864

DOI: 10.1126/scisignal.2005560
PubMed: 24985344
PubMed Central: 4367864

Affiliations:

Le document en format XML

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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609</wicri:regionArea>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida</wicri:regionArea>
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<author><name sortKey="Molina, Maria" sort="Molina, Maria" uniqKey="Molina M" first="María" last="Molina">María Molina</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRY-CIS), Madrid</wicri:regionArea>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea>
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</placeName>
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<author><name sortKey="Pinton, Paolo" sort="Pinton, Paolo" uniqKey="Pinton P" first="Paolo" last="Pinton">Paolo Pinton</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara</wicri:regionArea>
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<author><name sortKey="Rivas, Carmen" sort="Rivas, Carmen" uniqKey="Rivas C" first="Carmen" last="Rivas">Carmen Rivas</name>
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<placeName><settlement type="city">Santiago de Compostela</settlement>
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<author><name sortKey="Rocha, Rafael M" sort="Rocha, Rafael M" uniqKey="Rocha R" first="Rafael M." last="Rocha">Rafael M. Rocha</name>
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<author><name sortKey="Rodriguez, Manuel S" sort="Rodriguez, Manuel S" uniqKey="Rodriguez M" first="Manuel S." last="Rodríguez">Manuel S. Rodríguez</name>
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<country xml:lang="fr">Espagne</country>
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<author><name sortKey="Ross, Alonzo H" sort="Ross, Alonzo H" uniqKey="Ross A" first="Alonzo H." last="Ross">Alonzo H. Ross</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
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<author><name sortKey="Serrano, Manuel" sort="Serrano, Manuel" uniqKey="Serrano M" first="Manuel" last="Serrano">Manuel Serrano</name>
<affiliation wicri:level="3"><nlm:aff id="A27">Spanish National Cancer Research Center (CNIO), Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish National Cancer Research Center (CNIO), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
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<author><name sortKey="Stambolic, Vuk" sort="Stambolic, Vuk" uniqKey="Stambolic V" first="Vuk" last="Stambolic">Vuk Stambolic</name>
<affiliation wicri:level="4"><nlm:aff id="A28">Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
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<author><name sortKey="Stiles, Bangyan" sort="Stiles, Bangyan" uniqKey="Stiles B" first="Bangyan" last="Stiles">Bangyan Stiles</name>
<affiliation wicri:level="4"><nlm:aff id="A29">Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
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<author><name sortKey="Suzuki, Akira" sort="Suzuki, Akira" uniqKey="Suzuki A" first="Akira" last="Suzuki">Akira Suzuki</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita, Japan</nlm:aff>
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<author><name sortKey="Tan, Seong Seng" sort="Tan, Seong Seng" uniqKey="Tan S" first="Seong-Seng" last="Tan">Seong-Seng Tan</name>
<affiliation wicri:level="4"><nlm:aff id="A31">Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia</nlm:aff>
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</placeName>
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<author><name sortKey="Tonks, Nicholas K" sort="Tonks, Nicholas K" uniqKey="Tonks N" first="Nicholas K." last="Tonks">Nicholas K. Tonks</name>
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<country xml:lang="fr">États-Unis</country>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
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<author><name sortKey="Woscholski, Rudiger" sort="Woscholski, Rudiger" uniqKey="Woscholski R" first="Rudiger" last="Woscholski">Rudiger Woscholski</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
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<author><name sortKey="Wu, Hong" sort="Wu, Hong" uniqKey="Wu H" first="Hong" last="Wu">Hong Wu</name>
<affiliation wicri:level="3"><nlm:aff id="A35">Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
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<author><name sortKey="Leslie, Nicholas R" sort="Leslie, Nicholas R" uniqKey="Leslie N" first="Nicholas R." last="Leslie">Nicholas R. Leslie</name>
<affiliation wicri:level="3"><nlm:aff id="A36">Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Unified Nomenclature and Amino Acid Numbering for Human PTEN</title>
<author><name sortKey="Pulido, Rafael" sort="Pulido, Rafael" uniqKey="Pulido R" first="Rafael" last="Pulido">Rafael Pulido</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Ikerbasque, Basque Foundation for Science, Bilbao</wicri:regionArea>
<wicri:noRegion>Bilbao</wicri:noRegion>
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<affiliation wicri:level="1"><nlm:aff id="A2">BioCruces Health Research Institute, Barakaldo, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>BioCruces Health Research Institute, Barakaldo</wicri:regionArea>
<wicri:noRegion>Barakaldo</wicri:noRegion>
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<author><name sortKey="Baker, Suzanne J" sort="Baker, Suzanne J" uniqKey="Baker S" first="Suzanne J." last="Baker">Suzanne J. Baker</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Developmental Neurobiology, St. Jude Children’s Research Hospital, Memphis</wicri:regionArea>
<wicri:noRegion>Memphis</wicri:noRegion>
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<author><name sortKey="Barata, Joao T" sort="Barata, Joao T" uniqKey="Barata J" first="Joao T." last="Barata">Joao T. Barata</name>
<affiliation wicri:level="1"><nlm:aff id="A4">Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal</nlm:aff>
<country xml:lang="fr">Portugal</country>
<wicri:regionArea>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon</wicri:regionArea>
<wicri:noRegion>Lisbon</wicri:noRegion>
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<author><name sortKey="Carracedo, Arkaitz" sort="Carracedo, Arkaitz" uniqKey="Carracedo A" first="Arkaitz" last="Carracedo">Arkaitz Carracedo</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Ikerbasque, Basque Foundation for Science, Bilbao, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Ikerbasque, Basque Foundation for Science, Bilbao</wicri:regionArea>
<wicri:noRegion>Bilbao</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A5">CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao</wicri:regionArea>
<wicri:noRegion>Bilbao</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cid, Victor J" sort="Cid, Victor J" uniqKey="Cid V" first="Victor J." last="Cid">Victor J. Cid</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRY-CIS), Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRY-CIS), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université complutense de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Chin Sang, Ian D" sort="Chin Sang, Ian D" uniqKey="Chin Sang I" first="Ian D." last="Chin-Sang">Ian D. Chin-Sang</name>
<affiliation wicri:level="1"><nlm:aff id="A7">Department of Biology, Queen’s University, Kingston, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Biology, Queen’s University, Kingston, Ontario</wicri:regionArea>
<wicri:noRegion>Ontario</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dave, Vrushank" sort="Dave, Vrushank" uniqKey="Dave V" first="Vrushank" last="Davé">Vrushank Davé</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620</wicri:regionArea>
<placeName><region type="state">Floride</region>
<settlement type="city">Tampa</settlement>
</placeName>
<orgName type="university">Université de Floride du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Den Hertog, Jeroen" sort="Den Hertog, Jeroen" uniqKey="Den Hertog J" first="Jeroen" last="Den Hertog">Jeroen Den Hertog</name>
<affiliation wicri:level="3"><nlm:aff id="A9">Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
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<author><name sortKey="Devreotes, Peter" sort="Devreotes, Peter" uniqKey="Devreotes P" first="Peter" last="Devreotes">Peter Devreotes</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eickholt, Britta J" sort="Eickholt, Britta J" uniqKey="Eickholt B" first="Britta J." last="Eickholt">Britta J. Eickholt</name>
<affiliation><nlm:aff id="A11">Charité—Universitätsmedizin Berlin, Institute of Biochemistry and Cluster of Excellence NeuroCure, Berlin, German</nlm:aff>
<wicri:noCountry code="subfield">German</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Eng, Charis" sort="Eng, Charis" uniqKey="Eng C" first="Charis" last="Eng">Charis Eng</name>
<affiliation wicri:level="2"><nlm:aff id="A12">Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Furnari, Frank B" sort="Furnari, Frank B" uniqKey="Furnari F" first="Frank B." last="Furnari">Frank B. Furnari</name>
<affiliation wicri:level="2"><nlm:aff id="A13">Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Georgescu, Maria Magdalena" sort="Georgescu, Maria Magdalena" uniqKey="Georgescu M" first="Maria-Magdalena" last="Georgescu">Maria-Magdalena Georgescu</name>
<affiliation wicri:level="2"><nlm:aff id="A14">The University of Texas South-western Medical Center, Dallas, TX 75235, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The University of Texas South-western Medical Center, Dallas, TX 75235</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gericke, Arne" sort="Gericke, Arne" uniqKey="Gericke A" first="Arne" last="Gericke">Arne Gericke</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hopkins, Benjamin" sort="Hopkins, Benjamin" uniqKey="Hopkins B" first="Benjamin" last="Hopkins">Benjamin Hopkins</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jiang, Xeujun" sort="Jiang, Xeujun" uniqKey="Jiang X" first="Xeujun" last="Jiang">Xeujun Jiang</name>
<affiliation wicri:level="2"><nlm:aff id="A17">Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lee, Seung Rock" sort="Lee, Seung Rock" uniqKey="Lee S" first="Seung-Rock" last="Lee">Seung-Rock Lee</name>
<affiliation wicri:level="1"><nlm:aff id="A18">Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju</wicri:regionArea>
<wicri:noRegion>Gwangju</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Losche, Mathias" sort="Losche, Mathias" uniqKey="Losche M" first="Mathias" last="Lösche">Mathias Lösche</name>
<affiliation wicri:level="4"><nlm:aff id="A19">Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh. PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh. PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899</wicri:regionArea>
<placeName><region type="state">Maryland</region>
<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université Carnegie-Mellon</orgName>
</affiliation>
</author>
<author><name sortKey="Malaney, Prerna" sort="Malaney, Prerna" uniqKey="Malaney P" first="Prerna" last="Malaney">Prerna Malaney</name>
<affiliation wicri:level="4"><nlm:aff id="A8">Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620</wicri:regionArea>
<placeName><region type="state">Floride</region>
<settlement type="city">Tampa</settlement>
</placeName>
<orgName type="university">Université de Floride du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Matias Guiu, Xavier" sort="Matias Guiu, Xavier" uniqKey="Matias Guiu X" first="Xavier" last="Matias-Guiu">Xavier Matias-Guiu</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida</wicri:regionArea>
<wicri:noRegion>Lleida</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Molina, Maria" sort="Molina, Maria" uniqKey="Molina M" first="María" last="Molina">María Molina</name>
<affiliation wicri:level="4"><nlm:aff id="A6">Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRY-CIS), Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRY-CIS), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
<settlement type="city">Madrid</settlement>
</placeName>
<orgName type="university">Université complutense de Madrid</orgName>
</affiliation>
</author>
<author><name sortKey="Pandolfi, Pier Paolo" sort="Pandolfi, Pier Paolo" uniqKey="Pandolfi P" first="Pier Paolo" last="Pandolfi">Pier Paolo Pandolfi</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Parsons, Ramon" sort="Parsons, Ramon" uniqKey="Parsons R" first="Ramon" last="Parsons">Ramon Parsons</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pinton, Paolo" sort="Pinton, Paolo" uniqKey="Pinton P" first="Paolo" last="Pinton">Paolo Pinton</name>
<affiliation wicri:level="1"><nlm:aff id="A22">Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara</wicri:regionArea>
<wicri:noRegion>Ferrara</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rivas, Carmen" sort="Rivas, Carmen" uniqKey="Rivas C" first="Carmen" last="Rivas">Carmen Rivas</name>
<affiliation wicri:level="4"><nlm:aff id="A23">Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain; Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain; Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela</wicri:regionArea>
<orgName type="university">Université de Saint-Jacques-de-Compostelle</orgName>
<placeName><settlement type="city">Santiago de Compostela</settlement>
<region nuts="2" type="region">Galice</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rocha, Rafael M" sort="Rocha, Rafael M" uniqKey="Rocha R" first="Rafael M." last="Rocha">Rafael M. Rocha</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo</wicri:regionArea>
<placeName><settlement type="city">São Paulo</settlement>
<region type="state">État de São Paulo</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rodriguez, Manuel S" sort="Rodriguez, Manuel S" uniqKey="Rodriguez M" first="Manuel S." last="Rodríguez">Manuel S. Rodríguez</name>
<affiliation wicri:level="1"><nlm:aff id="A25">Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebastián, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebastián</wicri:regionArea>
<wicri:noRegion>San Sebastián</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ross, Alonzo H" sort="Ross, Alonzo H" uniqKey="Ross A" first="Alonzo H." last="Ross">Alonzo H. Ross</name>
<affiliation wicri:level="2"><nlm:aff id="A26">Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Serrano, Manuel" sort="Serrano, Manuel" uniqKey="Serrano M" first="Manuel" last="Serrano">Manuel Serrano</name>
<affiliation wicri:level="3"><nlm:aff id="A27">Spanish National Cancer Research Center (CNIO), Madrid, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Spanish National Cancer Research Center (CNIO), Madrid</wicri:regionArea>
<placeName><settlement type="city">Madrid</settlement>
<region nuts="2" type="region">Communauté de Madrid</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stambolic, Vuk" sort="Stambolic, Vuk" uniqKey="Stambolic V" first="Vuk" last="Stambolic">Vuk Stambolic</name>
<affiliation wicri:level="4"><nlm:aff id="A28">Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stiles, Bangyan" sort="Stiles, Bangyan" uniqKey="Stiles B" first="Bangyan" last="Stiles">Bangyan Stiles</name>
<affiliation wicri:level="4"><nlm:aff id="A29">Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089</wicri:regionArea>
<placeName><region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Suzuki, Akira" sort="Suzuki, Akira" uniqKey="Suzuki A" first="Akira" last="Suzuki">Akira Suzuki</name>
<affiliation wicri:level="1"><nlm:aff id="A30">Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita</wicri:regionArea>
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<author><name sortKey="Tan, Seong Seng" sort="Tan, Seong Seng" uniqKey="Tan S" first="Seong-Seng" last="Tan">Seong-Seng Tan</name>
<affiliation wicri:level="4"><nlm:aff id="A31">Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
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</affiliation>
</author>
<author><name sortKey="Tonks, Nicholas K" sort="Tonks, Nicholas K" uniqKey="Tonks N" first="Nicholas K." last="Tonks">Nicholas K. Tonks</name>
<affiliation wicri:level="2"><nlm:aff id="A32">Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724</wicri:regionArea>
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</placeName>
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<author><name sortKey="Trotman, Lloyd C" sort="Trotman, Lloyd C" uniqKey="Trotman L" first="Lloyd C." last="Trotman">Lloyd C. Trotman</name>
<affiliation wicri:level="2"><nlm:aff id="A32">Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wolff, Nicolas" sort="Wolff, Nicolas" uniqKey="Wolff N" first="Nicolas" last="Wolff">Nicolas Wolff</name>
<affiliation wicri:level="3"><nlm:aff id="A33">Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Woscholski, Rudiger" sort="Woscholski, Rudiger" uniqKey="Woscholski R" first="Rudiger" last="Woscholski">Rudiger Woscholski</name>
<affiliation wicri:level="3"><nlm:aff id="A34">Department of Chemistry and Institute of Chemical Biology, Imperial College London, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Chemistry and Institute of Chemical Biology, Imperial College London, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wu, Hong" sort="Wu, Hong" uniqKey="Wu H" first="Hong" last="Wu">Hong Wu</name>
<affiliation wicri:level="3"><nlm:aff id="A35">Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Leslie, Nicholas R" sort="Leslie, Nicholas R" uniqKey="Leslie N" first="Nicholas R." last="Leslie">Nicholas R. Leslie</name>
<affiliation wicri:level="3"><nlm:aff id="A36">Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh</wicri:regionArea>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Science signaling</title>
<idno type="eISSN">1937-9145</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Amino Acids (chemistry)</term>
<term>Codon, Initiator</term>
<term>Databases, Protein</term>
<term>Humans</term>
<term>PTEN Phosphohydrolase (chemistry)</term>
<term>PTEN Phosphohydrolase (genetics)</term>
<term>Terminology as Topic</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Acides aminés ()</term>
<term>Bases de données de protéines</term>
<term>Codon d'initiation</term>
<term>Humains</term>
<term>Phosphohydrolase PTEN ()</term>
<term>Phosphohydrolase PTEN (génétique)</term>
<term>Séquence d'acides aminés</term>
<term>Terminologie comme sujet</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Amino Acids</term>
<term>PTEN Phosphohydrolase</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>PTEN Phosphohydrolase</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Phosphohydrolase PTEN</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Codon, Initiator</term>
<term>Databases, Protein</term>
<term>Humans</term>
<term>Terminology as Topic</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Acides aminés</term>
<term>Bases de données de protéines</term>
<term>Codon d'initiation</term>
<term>Humains</term>
<term>Phosphohydrolase PTEN</term>
<term>Séquence d'acides aminés</term>
<term>Terminologie comme sujet</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P<sub>3</sub>
] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.</p>
</div>
</front>
</TEI>
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<orgName><li>Université Carnegie-Mellon</li>
<li>Université complutense de Madrid</li>
<li>Université de Californie du Sud</li>
<li>Université de Floride du Sud</li>
<li>Université de Melbourne</li>
<li>Université de Saint-Jacques-de-Compostelle</li>
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<name sortKey="Ross, Alonzo H" sort="Ross, Alonzo H" uniqKey="Ross A" first="Alonzo H." last="Ross">Alonzo H. Ross</name>
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<country name="Brésil"><region name="État de São Paulo"><name sortKey="Rocha, Rafael M" sort="Rocha, Rafael M" uniqKey="Rocha R" first="Rafael M." last="Rocha">Rafael M. Rocha</name>
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<country name="Australie"><region name="Victoria (État)"><name sortKey="Tan, Seong Seng" sort="Tan, Seong Seng" uniqKey="Tan S" first="Seong-Seng" last="Tan">Seong-Seng Tan</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Wolff, Nicolas" sort="Wolff, Nicolas" uniqKey="Wolff N" first="Nicolas" last="Wolff">Nicolas Wolff</name>
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Serveur d'exploration sur les relations entre la France et l'Australie

A Unified Nomenclature and Amino Acid Numbering for Human PTEN

A Unified Nomenclature and Amino Acid Numbering for Human PTEN

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