A unified nomenclature and amino acid numbering for human PTEN.
Identifieur interne : 003497 ( PubMed/Curation ); précédent : 003496; suivant : 003498A unified nomenclature and amino acid numbering for human PTEN.
Auteurs : Rafael Pulido [Espagne] ; Suzanne J. Baker [États-Unis] ; Joao T. Barata [Portugal] ; Arkaitz Carracedo [Espagne] ; Victor J. Cid [Espagne] ; Ian D. Chin-Sang [Canada] ; Vrushank Davé [États-Unis] ; Jeroen Den Hertog [Pays-Bas] ; Peter Devreotes [États-Unis] ; Britta J. Eickholt ; Charis Eng [États-Unis] ; Frank B. Furnari [États-Unis] ; Maria-Magdalena Georgescu [États-Unis] ; Arne Gericke [États-Unis] ; Benjamin Hopkins [États-Unis] ; Xeujun Jiang [États-Unis] ; Seung-Rock Lee [Corée du Sud] ; Mathias Lösche [États-Unis] ; Prerna Malaney [États-Unis] ; Xavier Matias-Guiu [Espagne] ; María Molina [Espagne] ; Pier Paolo Pandolfi [États-Unis] ; Ramon Parsons [États-Unis] ; Paolo Pinton [Italie] ; Carmen Rivas [Espagne] ; Rafael M. Rocha [Brésil] ; Manuel S. Rodríguez [Espagne] ; Alonzo H. Ross [États-Unis] ; Manuel Serrano [Espagne] ; Vuk Stambolic [Canada] ; Bangyan Stiles [États-Unis] ; Akira Suzuki [Japon] ; Seong-Seng Tan [Australie] ; Nicholas K. Tonks [États-Unis] ; Lloyd C. Trotman [États-Unis] ; Nicolas Wolff [France] ; Rudiger Woscholski [Royaume-Uni] ; Hong Wu [République populaire de Chine] ; Nicholas R. Leslie [Royaume-Uni]Source :
- Science signaling [ 1937-9145 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Amino Acids, PTEN Phosphohydrolase.
- chemical , genetics : PTEN Phosphohydrolase.
- Amino Acid Sequence, Codon, Initiator, Databases, Protein, Humans, Terminology as Topic.
Abstract
The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.
DOI: 10.1126/scisignal.2005560
PubMed: 24985344
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Britta J. Eickholt<affiliation><nlm:affiliation>Charité-Universitätsmedizin Berlin, Institute of Biochemistry and Cluster of Excellence NeuroCure, Berlin, German.</nlm:affiliation><wicri:noCountry code="subField">German</wicri:noCountry></affiliation>Le document en format XML
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Baker</name><affiliation wicri:level="1"><nlm:affiliation>Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis</wicri:regionArea></affiliation></author><author><name sortKey="Barata, Joao T" sort="Barata, Joao T" uniqKey="Barata J" first="Joao T" last="Barata">Joao T. Barata</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Carracedo, Arkaitz" sort="Carracedo, Arkaitz" uniqKey="Carracedo A" first="Arkaitz" last="Carracedo">Arkaitz Carracedo</name><affiliation wicri:level="1"><nlm:affiliation>Ikerbasque, Basque Foundation for Science, Bilbao, Spain. CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Ikerbasque, Basque Foundation for Science, Bilbao, Spain. CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao</wicri:regionArea></affiliation></author><author><name sortKey="Cid, Victor J" sort="Cid, Victor J" uniqKey="Cid V" first="Victor J" last="Cid">Victor J. Cid</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Chin Sang, Ian D" sort="Chin Sang, Ian D" uniqKey="Chin Sang I" first="Ian D" last="Chin-Sang">Ian D. Chin-Sang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, Queen's University, Kingston, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biology, Queen's University, Kingston, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Dave, Vrushank" sort="Dave, Vrushank" uniqKey="Dave V" first="Vrushank" last="Davé">Vrushank Davé</name><affiliation wicri:level="1"><nlm:affiliation>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620</wicri:regionArea></affiliation></author><author><name sortKey="Den Hertog, Jeroen" sort="Den Hertog, Jeroen" uniqKey="Den Hertog J" first="Jeroen" last="Den Hertog">Jeroen Den Hertog</name><affiliation wicri:level="1"><nlm:affiliation>Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Devreotes, Peter" sort="Devreotes, Peter" uniqKey="Devreotes P" first="Peter" last="Devreotes">Peter Devreotes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205</wicri:regionArea></affiliation></author><author><name sortKey="Eickholt, Britta J" sort="Eickholt, Britta J" uniqKey="Eickholt B" first="Britta J" last="Eickholt">Britta J. Eickholt</name><affiliation><nlm:affiliation>Charité-Universitätsmedizin Berlin, Institute of Biochemistry and Cluster of Excellence NeuroCure, Berlin, German.</nlm:affiliation><wicri:noCountry code="subField">German</wicri:noCountry></affiliation></author><author><name sortKey="Eng, Charis" sort="Eng, Charis" uniqKey="Eng C" first="Charis" last="Eng">Charis Eng</name><affiliation wicri:level="1"><nlm:affiliation>Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106</wicri:regionArea></affiliation></author><author><name sortKey="Furnari, Frank B" sort="Furnari, Frank B" uniqKey="Furnari F" first="Frank B" last="Furnari">Frank B. Furnari</name><affiliation wicri:level="1"><nlm:affiliation>Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093</wicri:regionArea></affiliation></author><author><name sortKey="Georgescu, Maria Magdalena" sort="Georgescu, Maria Magdalena" uniqKey="Georgescu M" first="Maria-Magdalena" last="Georgescu">Maria-Magdalena Georgescu</name><affiliation wicri:level="1"><nlm:affiliation>The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Texas Southwestern Medical Center, Dallas, TX 75235</wicri:regionArea></affiliation></author><author><name sortKey="Gericke, Arne" sort="Gericke, Arne" uniqKey="Gericke A" first="Arne" last="Gericke">Arne Gericke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609</wicri:regionArea></affiliation></author><author><name sortKey="Hopkins, Benjamin" sort="Hopkins, Benjamin" uniqKey="Hopkins B" first="Benjamin" last="Hopkins">Benjamin Hopkins</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Xeujun" sort="Jiang, Xeujun" uniqKey="Jiang X" first="Xeujun" last="Jiang">Xeujun Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Seung Rock" sort="Lee, Seung Rock" uniqKey="Lee S" first="Seung-Rock" last="Lee">Seung-Rock Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju</wicri:regionArea></affiliation></author><author><name sortKey="Losche, Mathias" sort="Losche, Mathias" uniqKey="Losche M" first="Mathias" last="Lösche">Mathias Lösche</name><affiliation wicri:level="1"><nlm:affiliation>Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899</wicri:regionArea></affiliation></author><author><name sortKey="Malaney, Prerna" sort="Malaney, Prerna" uniqKey="Malaney P" first="Prerna" last="Malaney">Prerna Malaney</name><affiliation wicri:level="1"><nlm:affiliation>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620</wicri:regionArea></affiliation></author><author><name sortKey="Matias Guiu, Xavier" sort="Matias Guiu, Xavier" uniqKey="Matias Guiu X" first="Xavier" last="Matias-Guiu">Xavier Matias-Guiu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida</wicri:regionArea></affiliation></author><author><name sortKey="Molina, Maria" sort="Molina, Maria" uniqKey="Molina M" first="María" last="Molina">María Molina</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Pandolfi, Pier Paolo" sort="Pandolfi, Pier Paolo" uniqKey="Pandolfi P" first="Pier Paolo" last="Pandolfi">Pier Paolo Pandolfi</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115</wicri:regionArea></affiliation></author><author><name sortKey="Parsons, Ramon" sort="Parsons, Ramon" uniqKey="Parsons R" first="Ramon" last="Parsons">Ramon Parsons</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea></affiliation></author><author><name sortKey="Pinton, Paolo" sort="Pinton, Paolo" uniqKey="Pinton P" first="Paolo" last="Pinton">Paolo Pinton</name><affiliation wicri:level="1"><nlm:affiliation>Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara</wicri:regionArea></affiliation></author><author><name sortKey="Rivas, Carmen" sort="Rivas, Carmen" uniqKey="Rivas C" first="Carmen" last="Rivas">Carmen Rivas</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain; Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain; Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela</wicri:regionArea></affiliation></author><author><name sortKey="Rocha, Rafael M" sort="Rocha, Rafael M" uniqKey="Rocha R" first="Rafael M" last="Rocha">Rafael M. Rocha</name><affiliation wicri:level="1"><nlm:affiliation>Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez, Manuel S" sort="Rodriguez, Manuel S" uniqKey="Rodriguez M" first="Manuel S" last="Rodríguez">Manuel S. Rodríguez</name><affiliation wicri:level="1"><nlm:affiliation>Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebastián, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebastián</wicri:regionArea></affiliation></author><author><name sortKey="Ross, Alonzo H" sort="Ross, Alonzo H" uniqKey="Ross A" first="Alonzo H" last="Ross">Alonzo H. Ross</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655</wicri:regionArea></affiliation></author><author><name sortKey="Serrano, Manuel" sort="Serrano, Manuel" uniqKey="Serrano M" first="Manuel" last="Serrano">Manuel Serrano</name><affiliation wicri:level="1"><nlm:affiliation>Spanish National Cancer Research Center (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Spanish National Cancer Research Center (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Stambolic, Vuk" sort="Stambolic, Vuk" uniqKey="Stambolic V" first="Vuk" last="Stambolic">Vuk Stambolic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Stiles, Bangyan" sort="Stiles, Bangyan" uniqKey="Stiles B" first="Bangyan" last="Stiles">Bangyan Stiles</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089</wicri:regionArea></affiliation></author><author><name sortKey="Suzuki, Akira" sort="Suzuki, Akira" uniqKey="Suzuki A" first="Akira" last="Suzuki">Akira Suzuki</name><affiliation wicri:level="1"><nlm:affiliation>Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Seong Seng" sort="Tan, Seong Seng" uniqKey="Tan S" first="Seong-Seng" last="Tan">Seong-Seng Tan</name><affiliation wicri:level="1"><nlm:affiliation>Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Tonks, Nicholas K" sort="Tonks, Nicholas K" uniqKey="Tonks N" first="Nicholas K" last="Tonks">Nicholas K. Tonks</name><affiliation wicri:level="1"><nlm:affiliation>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724</wicri:regionArea></affiliation></author><author><name sortKey="Trotman, Lloyd C" sort="Trotman, Lloyd C" uniqKey="Trotman L" first="Lloyd C" last="Trotman">Lloyd C. Trotman</name><affiliation wicri:level="1"><nlm:affiliation>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724</wicri:regionArea></affiliation></author><author><name sortKey="Wolff, Nicolas" sort="Wolff, Nicolas" uniqKey="Wolff N" first="Nicolas" last="Wolff">Nicolas Wolff</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Woscholski, Rudiger" sort="Woscholski, Rudiger" uniqKey="Woscholski R" first="Rudiger" last="Woscholski">Rudiger Woscholski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry and Institute of Chemical Biology, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Chemistry and Institute of Chemical Biology, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Hong" sort="Wu, Hong" uniqKey="Wu H" first="Hong" last="Wu">Hong Wu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Leslie, Nicholas R" sort="Leslie, Nicholas R" uniqKey="Leslie N" first="Nicholas R" last="Leslie">Nicholas R. Leslie</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24985344</idno><idno type="pmid">24985344</idno><idno type="doi">10.1126/scisignal.2005560</idno><idno type="wicri:Area/PubMed/Corpus">003610</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003610</idno><idno type="wicri:Area/PubMed/Curation">003497</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003497</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A unified nomenclature and amino acid numbering for human PTEN.</title><author><name sortKey="Pulido, Rafael" sort="Pulido, Rafael" uniqKey="Pulido R" first="Rafael" last="Pulido">Rafael Pulido</name><affiliation wicri:level="1"><nlm:affiliation>Ikerbasque, Basque Foundation for Science, Bilbao, Spain. BioCruces Health Research Institute, Barakaldo, Spain. rpulidomurillo@gmail.com.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Ikerbasque, Basque Foundation for Science, Bilbao, Spain. BioCruces Health Research Institute, Barakaldo</wicri:regionArea></affiliation></author><author><name sortKey="Baker, Suzanne J" sort="Baker, Suzanne J" uniqKey="Baker S" first="Suzanne J" last="Baker">Suzanne J. Baker</name><affiliation wicri:level="1"><nlm:affiliation>Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis</wicri:regionArea></affiliation></author><author><name sortKey="Barata, Joao T" sort="Barata, Joao T" uniqKey="Barata J" first="Joao T" last="Barata">Joao T. Barata</name><affiliation wicri:level="1"><nlm:affiliation>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.</nlm:affiliation><country xml:lang="fr">Portugal</country><wicri:regionArea>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon</wicri:regionArea></affiliation></author><author><name sortKey="Carracedo, Arkaitz" sort="Carracedo, Arkaitz" uniqKey="Carracedo A" first="Arkaitz" last="Carracedo">Arkaitz Carracedo</name><affiliation wicri:level="1"><nlm:affiliation>Ikerbasque, Basque Foundation for Science, Bilbao, Spain. CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Ikerbasque, Basque Foundation for Science, Bilbao, Spain. CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao</wicri:regionArea></affiliation></author><author><name sortKey="Cid, Victor J" sort="Cid, Victor J" uniqKey="Cid V" first="Victor J" last="Cid">Victor J. Cid</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Chin Sang, Ian D" sort="Chin Sang, Ian D" uniqKey="Chin Sang I" first="Ian D" last="Chin-Sang">Ian D. Chin-Sang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, Queen's University, Kingston, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biology, Queen's University, Kingston, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Dave, Vrushank" sort="Dave, Vrushank" uniqKey="Dave V" first="Vrushank" last="Davé">Vrushank Davé</name><affiliation wicri:level="1"><nlm:affiliation>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620</wicri:regionArea></affiliation></author><author><name sortKey="Den Hertog, Jeroen" sort="Den Hertog, Jeroen" uniqKey="Den Hertog J" first="Jeroen" last="Den Hertog">Jeroen Den Hertog</name><affiliation wicri:level="1"><nlm:affiliation>Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Devreotes, Peter" sort="Devreotes, Peter" uniqKey="Devreotes P" first="Peter" last="Devreotes">Peter Devreotes</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205</wicri:regionArea></affiliation></author><author><name sortKey="Eickholt, Britta J" sort="Eickholt, Britta J" uniqKey="Eickholt B" first="Britta J" last="Eickholt">Britta J. Eickholt</name><affiliation><nlm:affiliation>Charité-Universitätsmedizin Berlin, Institute of Biochemistry and Cluster of Excellence NeuroCure, Berlin, German.</nlm:affiliation><wicri:noCountry code="subField">German</wicri:noCountry></affiliation></author><author><name sortKey="Eng, Charis" sort="Eng, Charis" uniqKey="Eng C" first="Charis" last="Eng">Charis Eng</name><affiliation wicri:level="1"><nlm:affiliation>Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106</wicri:regionArea></affiliation></author><author><name sortKey="Furnari, Frank B" sort="Furnari, Frank B" uniqKey="Furnari F" first="Frank B" last="Furnari">Frank B. Furnari</name><affiliation wicri:level="1"><nlm:affiliation>Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093</wicri:regionArea></affiliation></author><author><name sortKey="Georgescu, Maria Magdalena" sort="Georgescu, Maria Magdalena" uniqKey="Georgescu M" first="Maria-Magdalena" last="Georgescu">Maria-Magdalena Georgescu</name><affiliation wicri:level="1"><nlm:affiliation>The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Texas Southwestern Medical Center, Dallas, TX 75235</wicri:regionArea></affiliation></author><author><name sortKey="Gericke, Arne" sort="Gericke, Arne" uniqKey="Gericke A" first="Arne" last="Gericke">Arne Gericke</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609</wicri:regionArea></affiliation></author><author><name sortKey="Hopkins, Benjamin" sort="Hopkins, Benjamin" uniqKey="Hopkins B" first="Benjamin" last="Hopkins">Benjamin Hopkins</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea></affiliation></author><author><name sortKey="Jiang, Xeujun" sort="Jiang, Xeujun" uniqKey="Jiang X" first="Xeujun" last="Jiang">Xeujun Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065</wicri:regionArea></affiliation></author><author><name sortKey="Lee, Seung Rock" sort="Lee, Seung Rock" uniqKey="Lee S" first="Seung-Rock" last="Lee">Seung-Rock Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju</wicri:regionArea></affiliation></author><author><name sortKey="Losche, Mathias" sort="Losche, Mathias" uniqKey="Losche M" first="Mathias" last="Lösche">Mathias Lösche</name><affiliation wicri:level="1"><nlm:affiliation>Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899</wicri:regionArea></affiliation></author><author><name sortKey="Malaney, Prerna" sort="Malaney, Prerna" uniqKey="Malaney P" first="Prerna" last="Malaney">Prerna Malaney</name><affiliation wicri:level="1"><nlm:affiliation>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620</wicri:regionArea></affiliation></author><author><name sortKey="Matias Guiu, Xavier" sort="Matias Guiu, Xavier" uniqKey="Matias Guiu X" first="Xavier" last="Matias-Guiu">Xavier Matias-Guiu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida</wicri:regionArea></affiliation></author><author><name sortKey="Molina, Maria" sort="Molina, Maria" uniqKey="Molina M" first="María" last="Molina">María Molina</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Pandolfi, Pier Paolo" sort="Pandolfi, Pier Paolo" uniqKey="Pandolfi P" first="Pier Paolo" last="Pandolfi">Pier Paolo Pandolfi</name><affiliation wicri:level="1"><nlm:affiliation>Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115</wicri:regionArea></affiliation></author><author><name sortKey="Parsons, Ramon" sort="Parsons, Ramon" uniqKey="Parsons R" first="Ramon" last="Parsons">Ramon Parsons</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029</wicri:regionArea></affiliation></author><author><name sortKey="Pinton, Paolo" sort="Pinton, Paolo" uniqKey="Pinton P" first="Paolo" last="Pinton">Paolo Pinton</name><affiliation wicri:level="1"><nlm:affiliation>Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara</wicri:regionArea></affiliation></author><author><name sortKey="Rivas, Carmen" sort="Rivas, Carmen" uniqKey="Rivas C" first="Carmen" last="Rivas">Carmen Rivas</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain; Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain; Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela</wicri:regionArea></affiliation></author><author><name sortKey="Rocha, Rafael M" sort="Rocha, Rafael M" uniqKey="Rocha R" first="Rafael M" last="Rocha">Rafael M. Rocha</name><affiliation wicri:level="1"><nlm:affiliation>Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo</wicri:regionArea></affiliation></author><author><name sortKey="Rodriguez, Manuel S" sort="Rodriguez, Manuel S" uniqKey="Rodriguez M" first="Manuel S" last="Rodríguez">Manuel S. Rodríguez</name><affiliation wicri:level="1"><nlm:affiliation>Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebastián, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebastián</wicri:regionArea></affiliation></author><author><name sortKey="Ross, Alonzo H" sort="Ross, Alonzo H" uniqKey="Ross A" first="Alonzo H" last="Ross">Alonzo H. Ross</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655</wicri:regionArea></affiliation></author><author><name sortKey="Serrano, Manuel" sort="Serrano, Manuel" uniqKey="Serrano M" first="Manuel" last="Serrano">Manuel Serrano</name><affiliation wicri:level="1"><nlm:affiliation>Spanish National Cancer Research Center (CNIO), Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Spanish National Cancer Research Center (CNIO), Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Stambolic, Vuk" sort="Stambolic, Vuk" uniqKey="Stambolic V" first="Vuk" last="Stambolic">Vuk Stambolic</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario</wicri:regionArea></affiliation></author><author><name sortKey="Stiles, Bangyan" sort="Stiles, Bangyan" uniqKey="Stiles B" first="Bangyan" last="Stiles">Bangyan Stiles</name><affiliation wicri:level="1"><nlm:affiliation>Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089</wicri:regionArea></affiliation></author><author><name sortKey="Suzuki, Akira" sort="Suzuki, Akira" uniqKey="Suzuki A" first="Akira" last="Suzuki">Akira Suzuki</name><affiliation wicri:level="1"><nlm:affiliation>Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita</wicri:regionArea></affiliation></author><author><name sortKey="Tan, Seong Seng" sort="Tan, Seong Seng" uniqKey="Tan S" first="Seong-Seng" last="Tan">Seong-Seng Tan</name><affiliation wicri:level="1"><nlm:affiliation>Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Tonks, Nicholas K" sort="Tonks, Nicholas K" uniqKey="Tonks N" first="Nicholas K" last="Tonks">Nicholas K. Tonks</name><affiliation wicri:level="1"><nlm:affiliation>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724</wicri:regionArea></affiliation></author><author><name sortKey="Trotman, Lloyd C" sort="Trotman, Lloyd C" uniqKey="Trotman L" first="Lloyd C" last="Trotman">Lloyd C. Trotman</name><affiliation wicri:level="1"><nlm:affiliation>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724</wicri:regionArea></affiliation></author><author><name sortKey="Wolff, Nicolas" sort="Wolff, Nicolas" uniqKey="Wolff N" first="Nicolas" last="Wolff">Nicolas Wolff</name><affiliation wicri:level="1"><nlm:affiliation>Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Woscholski, Rudiger" sort="Woscholski, Rudiger" uniqKey="Woscholski R" first="Rudiger" last="Woscholski">Rudiger Woscholski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Chemistry and Institute of Chemical Biology, Imperial College London, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Chemistry and Institute of Chemical Biology, Imperial College London, London</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Hong" sort="Wu, Hong" uniqKey="Wu H" first="Hong" last="Wu">Hong Wu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; School of Life Sciences and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing</wicri:regionArea></affiliation></author><author><name sortKey="Leslie, Nicholas R" sort="Leslie, Nicholas R" uniqKey="Leslie N" first="Nicholas R" last="Leslie">Nicholas R. Leslie</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Biological Chemistry, Biophysics and Bioengineering, School of Engineering and Physical Sciences, Heriot Watt University, Edinburgh</wicri:regionArea></affiliation></author></analytic><series><title level="j">Science signaling</title><idno type="eISSN">1937-9145</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Amino Acids (chemistry)</term><term>Codon, Initiator</term><term>Databases, Protein</term><term>Humans</term><term>PTEN Phosphohydrolase (chemistry)</term><term>PTEN Phosphohydrolase (genetics)</term><term>Terminology as Topic</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acides aminés ()</term><term>Bases de données de protéines</term><term>Codon d'initiation</term><term>Humains</term><term>Phosphohydrolase PTEN ()</term><term>Phosphohydrolase PTEN (génétique)</term><term>Séquence d'acides aminés</term><term>Terminologie comme sujet</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Amino Acids</term><term>PTEN Phosphohydrolase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>PTEN Phosphohydrolase</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Phosphohydrolase PTEN</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Codon, Initiator</term><term>Databases, Protein</term><term>Humans</term><term>Terminology as Topic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Acides aminés</term><term>Bases de données de protéines</term><term>Codon d'initiation</term><term>Humains</term><term>Phosphohydrolase PTEN</term><term>Séquence d'acides aminés</term><term>Terminologie comme sujet</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24985344</PMID><DateCreated><Year>2014</Year><Month>07</Month><Day>02</Day></DateCreated><DateCompleted><Year>2015</Year><Month>02</Month><Day>12</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1937-9145</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>332</Issue><PubDate><Year>2014</Year><Month>Jul</Month><Day>01</Day></PubDate></JournalIssue><Title>Science signaling</Title><ISOAbbreviation>Sci Signal</ISOAbbreviation></Journal><ArticleTitle>A unified nomenclature and amino acid numbering for human PTEN.</ArticleTitle><Pagination><MedlinePgn>pe15</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1126/scisignal.2005560</ELocationID><Abstract><AbstractText>The tumor suppressor PTEN is a major brake for cell transformation, mainly due to its phosphatidylinositol 3,4,5-trisphosphate [PI(3,4,5)P3] phosphatase activity that directly counteracts the oncogenicity of phosphoinositide 3-kinase (PI3K). PTEN mutations are frequent in tumors and in the germ line of patients with tumor predisposition or with neurological or cognitive disorders, which makes the PTEN gene and protein a major focus of interest in current biomedical research. After almost two decades of intense investigation on the 403-residue-long PTEN protein, a previously uncharacterized form of PTEN has been discovered that contains 173 amino-terminal extra amino acids, as a result of an alternate translation initiation site. To facilitate research in the field and to avoid ambiguities in the naming and identification of PTEN amino acids from publications and databases, we propose here a unifying nomenclature and amino acid numbering for this longer form of PTEN.</AbstractText><CopyrightInformation>Copyright © 2014, American Association for the Advancement of Science.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pulido</LastName><ForeName>Rafael</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Ikerbasque, Basque Foundation for Science, Bilbao, Spain. BioCruces Health Research Institute, Barakaldo, Spain. rpulidomurillo@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Baker</LastName><ForeName>Suzanne J</ForeName><Initials>SJ</Initials><AffiliationInfo><Affiliation>Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barata</LastName><ForeName>Joao T</ForeName><Initials>JT</Initials><AffiliationInfo><Affiliation>Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carracedo</LastName><ForeName>Arkaitz</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Ikerbasque, Basque Foundation for Science, Bilbao, Spain. CIC bioGUNE, Bizkaia Technology Park, Derio, Spain; Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), Bilbao, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cid</LastName><ForeName>Victor J</ForeName><Initials>VJ</Initials><AffiliationInfo><Affiliation>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chin-Sang</LastName><ForeName>Ian D</ForeName><Initials>ID</Initials><AffiliationInfo><Affiliation>Department of Biology, Queen's University, Kingston, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Davé</LastName><ForeName>Vrushank</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>den Hertog</LastName><ForeName>Jeroen</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Hubrecht Institute-KNAW and University Medical Center Utrecht, Utrecht, Netherlands, and Institute of Biology, Leiden, Leiden, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Devreotes</LastName><ForeName>Peter</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eickholt</LastName><ForeName>Britta J</ForeName><Initials>BJ</Initials><AffiliationInfo><Affiliation>Charité-Universitätsmedizin Berlin, Institute of Biochemistry and Cluster of Excellence NeuroCure, Berlin, German.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Eng</LastName><ForeName>Charis</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Genomic Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA; Department of Genetics and Genome Sciences and CASE Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Furnari</LastName><ForeName>Frank B</ForeName><Initials>FB</Initials><AffiliationInfo><Affiliation>Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA 92093, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Georgescu</LastName><ForeName>Maria-Magdalena</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>The University of Texas Southwestern Medical Center, Dallas, TX 75235, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gericke</LastName><ForeName>Arne</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Biochemistry, Worcester Polytechnic Institute, Worcester, MA 01609, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hopkins</LastName><ForeName>Benjamin</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Xeujun</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Cell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Seung-Rock</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Department of Biochemistry, Research Center for Aging and Geriatrics, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, Republic of Korea.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lösche</LastName><ForeName>Mathias</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Physics Department and Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA; Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Malaney</LastName><ForeName>Prerna</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Morsani College of Medicine, Department of Pathology and Cell Biology, Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33620, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matias-Guiu</LastName><ForeName>Xavier</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Lleida, Spain; Biomedical Research Institute of Lleida (IRBLleida), Universitat de Lleida, Lleida, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Molina</LastName><ForeName>María</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Instituto Ramón y Cajal de Investigaciones Sanitarias (IRYCIS), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pandolfi</LastName><ForeName>Pier Paolo</ForeName><Initials>PP</Initials><AffiliationInfo><Affiliation>Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Harvard Medical School, Boston, MA 02115, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Parsons</LastName><ForeName>Ramon</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pinton</LastName><ForeName>Paolo</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Morphology, Surgery and Experimental Medicine, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rivas</LastName><ForeName>Carmen</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Departamento de Biología Molecular y Celular, Centro Nacional de Biotecnología-CSIC, Madrid, Spain; Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, CIMUS, Universidade de Santiago de Compostela (USC), Instituto de Investigaciones Sanitarias (IDIS), Santiago de Compostela, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rocha</LastName><ForeName>Rafael M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>Research Center, Antonio Prudente Foundation, Hospital A.C. Camargo; Department of Anatomic Pathology, Hospital A.C. Camargo, São Paulo, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rodríguez</LastName><ForeName>Manuel S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Ubiquitylation and Cancer Molecular Biology, Inbiomed, San Sebastián, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ross</LastName><ForeName>Alonzo H</ForeName><Initials>AH</Initials><AffiliationInfo><Affiliation>Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Serrano</LastName><ForeName>Manuel</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Spanish National Cancer Research Center (CNIO), Madrid, Spain.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stambolic</LastName><ForeName>Vuk</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Medical Biophysics, University of Toronto, Princess Margaret Cancer Center, University Health Network, Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stiles</LastName><ForeName>Bangyan</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Pharmacology and Pharmaceutical Sciences, USC School of Pharmacy, University of Southern California, Los Angeles, CA 90089, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suzuki</LastName><ForeName>Akira</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Global Centers of Excellence Program, Akita University Graduate School of Medicine, Akita, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Seong-Seng</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Brain Development and Regeneration Division, Florey Neuroscience Institutes, The University of Melbourne, Parkville, Victoria, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tonks</LastName><ForeName>Nicholas K</ForeName><Initials>NK</Initials><AffiliationInfo><Affiliation>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Trotman</LastName><ForeName>Lloyd C</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wolff</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Institut Pasteur, Unité de Résonance Magnétique Nucléaire des Biomolécules, Département de Biologie Structurale et Chimie, CNRS, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Woscholski</LastName><ForeName>Rudiger</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Chemistry and Institute 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GM055989</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA154986</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 CA053840</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>G0802289</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant><Grant><GrantID>G0801865</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>07</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Sci 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MajorTopicYN="N">Amino Acids</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018387" MajorTopicYN="Y">Codon, Initiator</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D030562" MajorTopicYN="Y">Databases, Protein</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051059" MajorTopicYN="N">PTEN Phosphohydrolase</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009626" MajorTopicYN="N">Terminology as Topic</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">NIHMS671399</OtherID><OtherID Source="NLM">PMC4367864</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate 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