Adenosine-guided pulmonary vein isolation for the treatment of paroxysmal atrial fibrillation: an international, multicentre, randomised superiority trial.
Identifieur interne : 003207 ( Main/Exploration ); précédent : 003206; suivant : 003208Adenosine-guided pulmonary vein isolation for the treatment of paroxysmal atrial fibrillation: an international, multicentre, randomised superiority trial.
Auteurs : Laurent Macle [Canada] ; Paul Khairy [Canada] ; Rukshen Weerasooriya [Australie] ; Paul Novak [Canada] ; Atul Verma [Canada] ; Stephan Willems [Allemagne] ; Thomas Arentz [Allemagne] ; Isabel Deisenhofer [Allemagne] ; George Veenhuyzen [Canada] ; Christophe Scavée [Belgique] ; Pierre Jaïs [France] ; Helmut Puererfellner [Autriche] ; Sylvie Levesque [Canada] ; Jason G. Andrade [Canada] ; Lena Rivard [Canada] ; Peter G. Guerra [Canada] ; Marc Dubuc [Canada] ; Bernard Thibault [Canada] ; Mario Talajic [Canada] ; Denis Roy [Canada] ; Stanley Nattel [Canada]Source :
- Lancet (London, England) [ 1474-547X ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical : Adenosine, Anti-Arrhythmia Agents.
- drug effects : Pulmonary Veins.
- methods : Catheter Ablation.
- surgery : Atrial Fibrillation, Pulmonary Veins.
- Female, Humans, Male, Middle Aged, Operative Time, Proportional Hazards Models, Secondary Prevention, Treatment Outcome.
Abstract
Catheter ablation is increasingly used to manage atrial fibrillation, but arrhythmia recurrences are common. Adenosine might identify pulmonary veins at risk of reconnection by unmasking dormant conduction, and thereby guide additional ablation to improve arrhythmia-free survival. We assessed whether adenosine-guided pulmonary vein isolation could prevent arrhythmia recurrence in patients undergoing radiofrequency catheter ablation for paroxysmal atrial fibrillation.
DOI: 10.1016/S0140-6736(15)60026-5
PubMed: 26211828
Affiliations:
- Allemagne, Australie, Autriche, Belgique, Canada, France
- Aquitaine, Bavière, District de Haute-Bavière, Hambourg, Nouvelle-Aquitaine, Région de Bruxelles-Capitale
- Bordeaux, Bruxelles, Hambourg, Munich
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Le document en format XML
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Medicine, Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Roy, Denis" sort="Roy, Denis" uniqKey="Roy D" first="Denis" last="Roy">Denis Roy</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Nattel, Stanley" sort="Nattel, Stanley" 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Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC, Canada. Electronic address: lmacle@mac.com.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Khairy, Paul" sort="Khairy, Paul" uniqKey="Khairy P" first="Paul" last="Khairy">Paul Khairy</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Weerasooriya, Rukshen" sort="Weerasooriya, Rukshen" uniqKey="Weerasooriya R" first="Rukshen" last="Weerasooriya">Rukshen Weerasooriya</name><affiliation wicri:level="1"><nlm:affiliation>University of Western Australia and Hollywood Private Hospital, Perth, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>University of Western Australia and Hollywood Private Hospital, Perth, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Novak, Paul" sort="Novak, Paul" uniqKey="Novak P" first="Paul" last="Novak">Paul Novak</name><affiliation wicri:level="1"><nlm:affiliation>Royal Jubilee Hospital, Victoria, BC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Royal Jubilee Hospital, Victoria, BC</wicri:regionArea><wicri:noRegion>BC</wicri:noRegion></affiliation></author><author><name sortKey="Verma, Atul" sort="Verma, Atul" uniqKey="Verma A" first="Atul" last="Verma">Atul Verma</name><affiliation wicri:level="1"><nlm:affiliation>Southlake Regional Health Centre, Newmarket, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Southlake Regional Health Centre, Newmarket, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Willems, Stephan" sort="Willems, Stephan" uniqKey="Willems S" first="Stephan" last="Willems">Stephan Willems</name><affiliation wicri:level="3"><nlm:affiliation>University Hospital Eppendorf, Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Hospital Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Arentz, Thomas" sort="Arentz, Thomas" uniqKey="Arentz T" first="Thomas" last="Arentz">Thomas Arentz</name><affiliation wicri:level="1"><nlm:affiliation>Herz-Zentrum, Bad Krozingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Herz-Zentrum, Bad Krozingen</wicri:regionArea><wicri:noRegion>Bad Krozingen</wicri:noRegion><wicri:noRegion>Bad Krozingen</wicri:noRegion><wicri:noRegion>Bad Krozingen</wicri:noRegion></affiliation></author><author><name sortKey="Deisenhofer, Isabel" sort="Deisenhofer, Isabel" uniqKey="Deisenhofer I" first="Isabel" last="Deisenhofer">Isabel Deisenhofer</name><affiliation wicri:level="3"><nlm:affiliation>Deutsches Herz-Zentrum Munchën, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Deutsches Herz-Zentrum Munchën, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Veenhuyzen, George" sort="Veenhuyzen, George" uniqKey="Veenhuyzen G" first="George" last="Veenhuyzen">George Veenhuyzen</name><affiliation wicri:level="1"><nlm:affiliation>Libin Cardiovascular Institute, Calgary, AB, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Libin Cardiovascular Institute, Calgary, AB</wicri:regionArea><wicri:noRegion>AB</wicri:noRegion></affiliation></author><author><name sortKey="Scavee, Christophe" sort="Scavee, Christophe" uniqKey="Scavee C" first="Christophe" last="Scavée">Christophe Scavée</name><affiliation wicri:level="3"><nlm:affiliation>Cliniques Universitaires St-Luc, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Cliniques Universitaires St-Luc, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Jais, Pierre" sort="Jais, Pierre" uniqKey="Jais P" first="Pierre" last="Jaïs">Pierre Jaïs</name><affiliation wicri:level="3"><nlm:affiliation>Hôpital Haut-Lévèque, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital Haut-Lévèque, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Puererfellner, Helmut" sort="Puererfellner, Helmut" uniqKey="Puererfellner H" first="Helmut" last="Puererfellner">Helmut Puererfellner</name><affiliation wicri:level="1"><nlm:affiliation>KH der Elisabethinen, Linz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>KH der Elisabethinen, Linz</wicri:regionArea><wicri:noRegion>Linz</wicri:noRegion></affiliation></author><author><name sortKey="Levesque, Sylvie" sort="Levesque, Sylvie" uniqKey="Levesque S" first="Sylvie" last="Levesque">Sylvie Levesque</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Andrade, Jason G" sort="Andrade, Jason G" uniqKey="Andrade J" first="Jason G" last="Andrade">Jason G. Andrade</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Rivard, Lena" sort="Rivard, Lena" uniqKey="Rivard L" first="Lena" last="Rivard">Lena Rivard</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Guerra, Peter G" sort="Guerra, Peter G" uniqKey="Guerra P" first="Peter G" last="Guerra">Peter G. Guerra</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Dubuc, Marc" sort="Dubuc, Marc" uniqKey="Dubuc M" first="Marc" last="Dubuc">Marc Dubuc</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Thibault, Bernard" sort="Thibault, Bernard" uniqKey="Thibault B" first="Bernard" last="Thibault">Bernard Thibault</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Talajic, Mario" sort="Talajic, Mario" uniqKey="Talajic M" first="Mario" last="Talajic">Mario Talajic</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Roy, Denis" sort="Roy, Denis" uniqKey="Roy D" first="Denis" last="Roy">Denis Roy</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Nattel, Stanley" sort="Nattel, Stanley" uniqKey="Nattel S" first="Stanley" last="Nattel">Stanley Nattel</name><affiliation wicri:level="1"><nlm:affiliation>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal Heart Institute and Montreal Health Innovations Coordinating Centre, Department of Medicine, Université de Montréal, Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine</term><term>Anti-Arrhythmia Agents</term><term>Atrial Fibrillation (surgery)</term><term>Catheter Ablation (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Operative Time</term><term>Proportional Hazards Models</term><term>Pulmonary Veins (drug effects)</term><term>Pulmonary Veins (surgery)</term><term>Secondary Prevention</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Ablation par cathéter ()</term><term>Adulte d'âge moyen</term><term>Adénosine</term><term>Antiarythmiques</term><term>Durée opératoire</term><term>Femelle</term><term>Fibrillation auriculaire ()</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Prévention secondaire</term><term>Résultat thérapeutique</term><term>Veines pulmonaires ()</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Adenosine</term><term>Anti-Arrhythmia Agents</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Pulmonary Veins</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Catheter Ablation</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Atrial Fibrillation</term><term>Pulmonary Veins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Operative Time</term><term>Proportional Hazards Models</term><term>Secondary Prevention</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Ablation par cathéter</term><term>Adulte d'âge moyen</term><term>Adénosine</term><term>Antiarythmiques</term><term>Durée opératoire</term><term>Femelle</term><term>Fibrillation auriculaire</term><term>Humains</term><term>Modèles de hasards proportionnels</term><term>Mâle</term><term>Prévention secondaire</term><term>Résultat thérapeutique</term><term>Veines pulmonaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Catheter ablation is increasingly used to manage atrial fibrillation, but arrhythmia recurrences are common. Adenosine might identify pulmonary veins at risk of reconnection by unmasking dormant conduction, and thereby guide additional ablation to improve arrhythmia-free survival. We assessed whether adenosine-guided pulmonary vein isolation could prevent arrhythmia recurrence in patients undergoing radiofrequency catheter ablation for paroxysmal atrial fibrillation.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>France</li></country><region><li>Aquitaine</li><li>Bavière</li><li>District de Haute-Bavière</li><li>Hambourg</li><li>Nouvelle-Aquitaine</li><li>Région de Bruxelles-Capitale</li></region><settlement><li>Bordeaux</li><li>Bruxelles</li><li>Hambourg</li><li>Munich</li></settlement></list><tree><country name="Canada"><noRegion><name sortKey="Macle, Laurent" sort="Macle, Laurent" uniqKey="Macle L" first="Laurent" last="Macle">Laurent Macle</name></noRegion><name sortKey="Andrade, Jason G" sort="Andrade, Jason G" uniqKey="Andrade J" first="Jason G" last="Andrade">Jason G. Andrade</name><name sortKey="Dubuc, Marc" sort="Dubuc, Marc" uniqKey="Dubuc M" first="Marc" last="Dubuc">Marc Dubuc</name><name sortKey="Guerra, Peter G" sort="Guerra, Peter G" uniqKey="Guerra P" first="Peter G" last="Guerra">Peter G. Guerra</name><name sortKey="Khairy, Paul" sort="Khairy, Paul" uniqKey="Khairy P" first="Paul" last="Khairy">Paul Khairy</name><name sortKey="Levesque, Sylvie" sort="Levesque, Sylvie" uniqKey="Levesque S" first="Sylvie" last="Levesque">Sylvie Levesque</name><name sortKey="Nattel, Stanley" sort="Nattel, Stanley" uniqKey="Nattel S" first="Stanley" last="Nattel">Stanley Nattel</name><name sortKey="Novak, Paul" sort="Novak, Paul" uniqKey="Novak P" first="Paul" last="Novak">Paul Novak</name><name sortKey="Rivard, Lena" sort="Rivard, Lena" uniqKey="Rivard L" first="Lena" last="Rivard">Lena Rivard</name><name sortKey="Roy, Denis" sort="Roy, Denis" uniqKey="Roy D" first="Denis" last="Roy">Denis Roy</name><name sortKey="Talajic, Mario" sort="Talajic, Mario" uniqKey="Talajic M" first="Mario" last="Talajic">Mario Talajic</name><name sortKey="Thibault, Bernard" sort="Thibault, Bernard" uniqKey="Thibault B" first="Bernard" last="Thibault">Bernard Thibault</name><name sortKey="Veenhuyzen, George" sort="Veenhuyzen, George" uniqKey="Veenhuyzen G" first="George" last="Veenhuyzen">George Veenhuyzen</name><name sortKey="Verma, Atul" sort="Verma, Atul" uniqKey="Verma A" first="Atul" last="Verma">Atul Verma</name></country><country name="Australie"><noRegion><name sortKey="Weerasooriya, Rukshen" sort="Weerasooriya, Rukshen" uniqKey="Weerasooriya R" first="Rukshen" last="Weerasooriya">Rukshen Weerasooriya</name></noRegion></country><country name="Allemagne"><region name="Hambourg"><name sortKey="Willems, Stephan" sort="Willems, Stephan" uniqKey="Willems S" first="Stephan" last="Willems">Stephan Willems</name></region><name sortKey="Arentz, Thomas" sort="Arentz, Thomas" uniqKey="Arentz T" first="Thomas" last="Arentz">Thomas Arentz</name><name sortKey="Deisenhofer, Isabel" sort="Deisenhofer, Isabel" uniqKey="Deisenhofer I" first="Isabel" last="Deisenhofer">Isabel Deisenhofer</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Scavee, Christophe" sort="Scavee, Christophe" uniqKey="Scavee C" first="Christophe" last="Scavée">Christophe Scavée</name></region></country><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Jais, Pierre" sort="Jais, Pierre" uniqKey="Jais P" first="Pierre" last="Jaïs">Pierre Jaïs</name></region></country><country name="Autriche"><noRegion><name sortKey="Puererfellner, Helmut" sort="Puererfellner, Helmut" uniqKey="Puererfellner H" first="Helmut" last="Puererfellner">Helmut Puererfellner</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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