Impact of a lifestyle program on vascular insulin resistance in metabolic syndrome subjects: the RESOLVE study.
Identifieur interne : 002C62 ( Main/Exploration ); précédent : 002C61; suivant : 002C63Impact of a lifestyle program on vascular insulin resistance in metabolic syndrome subjects: the RESOLVE study.
Auteurs : Agnes Vinet [France] ; Philippe Obert ; Frederic Dutheil ; Lamine Diagne ; Robert Chapier ; Bruno Lesourd ; Daniel Courteix ; Guillaume WaltherSource :
- The Journal of clinical endocrinology and metabolism [ 1945-7197 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Débit sanguin régional (physiologie), Femelle, Glycémie (métabolisme), Humains, Inhibiteur-1 d'activateur du plasminogène (sang), Insuline (sang), Insulinorésistance (physiologie), Interleukine-6 (sang), Mode de vie, Mâle, Promotion de la santé, Protéine C-réactive (métabolisme), Résistance vasculaire (physiologie), Sujet âgé, Syndrome métabolique X (), Syndrome métabolique X (physiopathologie), Syndrome métabolique X (sang).
- MESH :
- métabolisme : Glycémie, Protéine C-réactive.
- physiologie : Débit sanguin régional, Insulinorésistance, Résistance vasculaire.
- physiopathologie : Syndrome métabolique X.
- sang : Inhibiteur-1 d'activateur du plasminogène, Insuline, Interleukine-6, Syndrome métabolique X.
- Adulte d'âge moyen, Femelle, Humains, Mode de vie, Mâle, Promotion de la santé, Sujet âgé, Syndrome métabolique X.
English descriptors
- KwdEn :
- Aged, Blood Glucose (metabolism), C-Reactive Protein (metabolism), Female, Health Promotion, Humans, Insulin (blood), Insulin Resistance (physiology), Interleukin-6 (blood), Life Style, Male, Metabolic Syndrome X (blood), Metabolic Syndrome X (physiopathology), Metabolic Syndrome X (therapy), Middle Aged, Plasminogen Activator Inhibitor 1 (blood), Regional Blood Flow (physiology), Vascular Resistance (physiology).
- MESH :
- chemical , blood : Insulin, Interleukin-6, Plasminogen Activator Inhibitor 1.
- chemical , metabolism : Blood Glucose, C-Reactive Protein.
- blood : Metabolic Syndrome X.
- physiology : Insulin Resistance, Regional Blood Flow, Vascular Resistance.
- physiopathology : Metabolic Syndrome X.
- therapy : Metabolic Syndrome X.
- Aged, Female, Health Promotion, Humans, Life Style, Male, Middle Aged.
Abstract
Impaired insulin-dependent vasodilation might contribute to microvascular dysfunction of metabolic syndrome (MetS). The aims of this study were to assess the insulin vasoreactivity in MetS, and to evaluate the effects of a lifestyle program. DESIGN, SETTING, PARTICIPANTS, AND OUTCOME MEASURES: Laser Doppler measurements were used to assess cutaneous blood flux (CBF) and flowmotion in response to iontophoresis of insulin and acetylcholine (ACh) in 38 MetS and 18 controls. Anthropometric, plasma insulin, glycemia, and inflammatory markers were measured. MetS subjects (n = 24) underwent a 6-month lifestyle intervention (M6) with a 3-week residential program (D21).
DOI: 10.1210/jc.2014-2704
PubMed: 25353072
Affiliations:
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Syndrome X (blood)</term><term>Metabolic Syndrome X (physiopathology)</term><term>Metabolic Syndrome X (therapy)</term><term>Middle Aged</term><term>Plasminogen Activator Inhibitor 1 (blood)</term><term>Regional Blood Flow (physiology)</term><term>Vascular Resistance (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Débit sanguin régional (physiologie)</term><term>Femelle</term><term>Glycémie (métabolisme)</term><term>Humains</term><term>Inhibiteur-1 d'activateur du plasminogène (sang)</term><term>Insuline (sang)</term><term>Insulinorésistance (physiologie)</term><term>Interleukine-6 (sang)</term><term>Mode de vie</term><term>Mâle</term><term>Promotion de la santé</term><term>Protéine C-réactive (métabolisme)</term><term>Résistance vasculaire (physiologie)</term><term>Sujet âgé</term><term>Syndrome métabolique X ()</term><term>Syndrome métabolique X (physiopathologie)</term><term>Syndrome métabolique X 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métabolique X</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Inhibiteur-1 d'activateur du plasminogène</term><term>Insuline</term><term>Interleukine-6</term><term>Syndrome métabolique X</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Health Promotion</term><term>Humans</term><term>Life Style</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mode de vie</term><term>Mâle</term><term>Promotion de la santé</term><term>Sujet âgé</term><term>Syndrome métabolique X</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Impaired insulin-dependent vasodilation might contribute to microvascular dysfunction of metabolic syndrome (MetS). The aims of this study were to assess the insulin vasoreactivity in MetS, and to evaluate the effects of a lifestyle program. DESIGN, SETTING, PARTICIPANTS, AND OUTCOME MEASURES: Laser Doppler measurements were used to assess cutaneous blood flux (CBF) and flowmotion in response to iontophoresis of insulin and acetylcholine (ACh) in 38 MetS and 18 controls. Anthropometric, plasma insulin, glycemia, and inflammatory markers were measured. MetS subjects (n = 24) underwent a 6-month lifestyle intervention (M6) with a 3-week residential program (D21).</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne (région administrative)</li><li>Auvergne-Rhône-Alpes</li></region><settlement><li>Châtelguyon</li></settlement></list><tree><noCountry><name sortKey="Chapier, Robert" sort="Chapier, Robert" uniqKey="Chapier R" first="Robert" last="Chapier">Robert Chapier</name><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name><name sortKey="Diagne, Lamine" sort="Diagne, Lamine" uniqKey="Diagne L" first="Lamine" last="Diagne">Lamine Diagne</name><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frederic" last="Dutheil">Frederic Dutheil</name><name sortKey="Lesourd, Bruno" sort="Lesourd, Bruno" uniqKey="Lesourd B" first="Bruno" last="Lesourd">Bruno Lesourd</name><name sortKey="Obert, Philippe" sort="Obert, Philippe" uniqKey="Obert P" first="Philippe" last="Obert">Philippe Obert</name><name sortKey="Walther, Guillaume" sort="Walther, Guillaume" uniqKey="Walther G" first="Guillaume" last="Walther">Guillaume Walther</name></noCountry><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Vinet, Agnes" sort="Vinet, Agnes" uniqKey="Vinet A" first="Agnes" last="Vinet">Agnes Vinet</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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