Impact of a lifestyle program on vascular insulin resistance in metabolic syndrome subjects: the RESOLVE study.
Identifieur interne : 003031 ( PubMed/Corpus ); précédent : 003030; suivant : 003032Impact of a lifestyle program on vascular insulin resistance in metabolic syndrome subjects: the RESOLVE study.
Auteurs : Agnes Vinet ; Philippe Obert ; Frederic Dutheil ; Lamine Diagne ; Robert Chapier ; Bruno Lesourd ; Daniel Courteix ; Guillaume WaltherSource :
- The Journal of clinical endocrinology and metabolism [ 1945-7197 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Blood Glucose (metabolism), C-Reactive Protein (metabolism), Female, Health Promotion, Humans, Insulin (blood), Insulin Resistance (physiology), Interleukin-6 (blood), Life Style, Male, Metabolic Syndrome X (blood), Metabolic Syndrome X (physiopathology), Metabolic Syndrome X (therapy), Middle Aged, Plasminogen Activator Inhibitor 1 (blood), Regional Blood Flow (physiology), Vascular Resistance (physiology).
- MESH :
- chemical , blood : Insulin, Interleukin-6, Plasminogen Activator Inhibitor 1.
- chemical , metabolism : Blood Glucose, C-Reactive Protein.
- blood : Metabolic Syndrome X.
- physiology : Insulin Resistance, Regional Blood Flow, Vascular Resistance.
- physiopathology : Metabolic Syndrome X.
- therapy : Metabolic Syndrome X.
- Aged, Female, Health Promotion, Humans, Life Style, Male, Middle Aged.
Abstract
Impaired insulin-dependent vasodilation might contribute to microvascular dysfunction of metabolic syndrome (MetS). The aims of this study were to assess the insulin vasoreactivity in MetS, and to evaluate the effects of a lifestyle program. DESIGN, SETTING, PARTICIPANTS, AND OUTCOME MEASURES: Laser Doppler measurements were used to assess cutaneous blood flux (CBF) and flowmotion in response to iontophoresis of insulin and acetylcholine (ACh) in 38 MetS and 18 controls. Anthropometric, plasma insulin, glycemia, and inflammatory markers were measured. MetS subjects (n = 24) underwent a 6-month lifestyle intervention (M6) with a 3-week residential program (D21).
DOI: 10.1210/jc.2014-2704
PubMed: 25353072
Links to Exploration step
pubmed:25353072Le document en format XML
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Montpied, F-63000 Clermont-Ferrand, France; and Omental (R.C.)-Thermalia Center, F-63140 Châtelguyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Obert, Philippe" sort="Obert, Philippe" uniqKey="Obert P" first="Philippe" last="Obert">Philippe Obert</name></author><author><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frederic" last="Dutheil">Frederic Dutheil</name></author><author><name sortKey="Diagne, Lamine" sort="Diagne, Lamine" uniqKey="Diagne L" first="Lamine" last="Diagne">Lamine Diagne</name></author><author><name sortKey="Chapier, Robert" sort="Chapier, Robert" uniqKey="Chapier R" first="Robert" last="Chapier">Robert Chapier</name></author><author><name sortKey="Lesourd, Bruno" sort="Lesourd, Bruno" uniqKey="Lesourd B" first="Bruno" last="Lesourd">Bruno Lesourd</name></author><author><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name></author><author><name sortKey="Walther, Guillaume" sort="Walther, Guillaume" uniqKey="Walther G" first="Guillaume" last="Walther">Guillaume Walther</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25353072</idno><idno type="pmid">25353072</idno><idno type="doi">10.1210/jc.2014-2704</idno><idno type="wicri:Area/PubMed/Corpus">003031</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003031</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Impact of a lifestyle program on vascular insulin resistance in metabolic syndrome subjects: the RESOLVE study.</title><author><name sortKey="Vinet, Agnes" sort="Vinet, Agnes" uniqKey="Vinet A" first="Agnes" last="Vinet">Agnes Vinet</name><affiliation><nlm:affiliation>Avignon University (A.V., P.O., L.D., G.W.), LAPEC EA4278, F-84000 Avignon, France; School of Exercise Science (P.O., F.D., D.C.), Australian Catholic University, Melbourne, 3065 Australia; Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (F.D., B.L., D.C.), EA3533, F-63000 Clermont-Ferrand, France; University Hospital of Clermont-Ferrand (F.D., B.L.), CHU G. Montpied, F-63000 Clermont-Ferrand, France; and Omental (R.C.)-Thermalia Center, F-63140 Châtelguyon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Obert, Philippe" sort="Obert, Philippe" uniqKey="Obert P" first="Philippe" last="Obert">Philippe Obert</name></author><author><name sortKey="Dutheil, Frederic" sort="Dutheil, Frederic" uniqKey="Dutheil F" first="Frederic" last="Dutheil">Frederic Dutheil</name></author><author><name sortKey="Diagne, Lamine" sort="Diagne, Lamine" uniqKey="Diagne L" first="Lamine" last="Diagne">Lamine Diagne</name></author><author><name sortKey="Chapier, Robert" sort="Chapier, Robert" uniqKey="Chapier R" first="Robert" last="Chapier">Robert Chapier</name></author><author><name sortKey="Lesourd, Bruno" sort="Lesourd, Bruno" uniqKey="Lesourd B" first="Bruno" last="Lesourd">Bruno Lesourd</name></author><author><name sortKey="Courteix, Daniel" sort="Courteix, Daniel" uniqKey="Courteix D" first="Daniel" last="Courteix">Daniel Courteix</name></author><author><name sortKey="Walther, Guillaume" sort="Walther, Guillaume" uniqKey="Walther G" first="Guillaume" last="Walther">Guillaume Walther</name></author></analytic><series><title level="j">The Journal of clinical endocrinology and metabolism</title><idno type="eISSN">1945-7197</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blood Glucose (metabolism)</term><term>C-Reactive Protein (metabolism)</term><term>Female</term><term>Health Promotion</term><term>Humans</term><term>Insulin (blood)</term><term>Insulin Resistance (physiology)</term><term>Interleukin-6 (blood)</term><term>Life Style</term><term>Male</term><term>Metabolic Syndrome X (blood)</term><term>Metabolic Syndrome X (physiopathology)</term><term>Metabolic Syndrome X (therapy)</term><term>Middle Aged</term><term>Plasminogen Activator Inhibitor 1 (blood)</term><term>Regional Blood Flow (physiology)</term><term>Vascular Resistance (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Insulin</term><term>Interleukin-6</term><term>Plasminogen Activator Inhibitor 1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Blood Glucose</term><term>C-Reactive Protein</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Insulin Resistance</term><term>Regional Blood Flow</term><term>Vascular Resistance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Metabolic Syndrome X</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Health Promotion</term><term>Humans</term><term>Life Style</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Impaired insulin-dependent vasodilation might contribute to microvascular dysfunction of metabolic syndrome (MetS). The aims of this study were to assess the insulin vasoreactivity in MetS, and to evaluate the effects of a lifestyle program. DESIGN, SETTING, PARTICIPANTS, AND OUTCOME MEASURES: Laser Doppler measurements were used to assess cutaneous blood flux (CBF) and flowmotion in response to iontophoresis of insulin and acetylcholine (ACh) in 38 MetS and 18 controls. Anthropometric, plasma insulin, glycemia, and inflammatory markers were measured. MetS subjects (n = 24) underwent a 6-month lifestyle intervention (M6) with a 3-week residential program (D21).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25353072</PMID><DateCreated><Year>2015</Year><Month>02</Month><Day>09</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>14</Day></DateCompleted><DateRevised><Year>2017</Year><Month>11</Month><Day>16</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1945-7197</ISSN><JournalIssue CitedMedium="Internet"><Volume>100</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Feb</Month></PubDate></JournalIssue><Title>The Journal of clinical endocrinology and metabolism</Title><ISOAbbreviation>J. Clin. Endocrinol. Metab.</ISOAbbreviation></Journal><ArticleTitle>Impact of a lifestyle program on vascular insulin resistance in metabolic syndrome subjects: the RESOLVE study.</ArticleTitle><Pagination><MedlinePgn>442-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1210/jc.2014-2704</ELocationID><Abstract><AbstractText Label="CONTEXT AND OBJECTIVE" NlmCategory="OBJECTIVE">Impaired insulin-dependent vasodilation might contribute to microvascular dysfunction of metabolic syndrome (MetS). The aims of this study were to assess the insulin vasoreactivity in MetS, and to evaluate the effects of a lifestyle program. DESIGN, SETTING, PARTICIPANTS, AND OUTCOME MEASURES: Laser Doppler measurements were used to assess cutaneous blood flux (CBF) and flowmotion in response to iontophoresis of insulin and acetylcholine (ACh) in 38 MetS and 18 controls. Anthropometric, plasma insulin, glycemia, and inflammatory markers were measured. MetS subjects (n = 24) underwent a 6-month lifestyle intervention (M6) with a 3-week residential program (D21).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The absolute and relative peak insulin and ACh CBF were significantly higher in controls than in MetS subjects. Significant inverse correlations were found between peak insulin CBF and glycemia, insulin and glycated hemoglobin, active plasminogen activator inhibitor-1 (PAI-1), C-reactive protein (CRP), and IL-6. With respect to flowmotion, MetS subjects showed lower values in total spectrum CBF and in all its components (except respiratory one). At D21 and M6, peak insulin CBF increased and was no longer different from control values whereas peak ACh CBF did not change. From D21, all the different components and the total CBF spectrum became similar to the control values. The changes in peak insulin CBF and in endothelial component between M6 and baseline were inversely correlated with the change in CRP and PAI-1.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The local vasodilatory effects to insulin and its overall flowmotion are impaired in MetS subjects in relation to inflammation. The lifestyle intervention reversed this insulin-induced vascular dysfunction in parallel to decreased inflammation level.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Vinet</LastName><ForeName>Agnes</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Avignon University (A.V., P.O., L.D., G.W.), LAPEC EA4278, F-84000 Avignon, France; School of Exercise Science (P.O., F.D., D.C.), Australian Catholic University, Melbourne, 3065 Australia; Laboratory of Metabolic Adaptations to Exercise in Physiological and Pathological Conditions (F.D., B.L., D.C.), EA3533, F-63000 Clermont-Ferrand, France; University Hospital of Clermont-Ferrand (F.D., B.L.), CHU G. Montpied, F-63000 Clermont-Ferrand, France; and Omental (R.C.)-Thermalia Center, F-63140 Châtelguyon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Obert</LastName><ForeName>Philippe</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Dutheil</LastName><ForeName>Frederic</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Diagne</LastName><ForeName>Lamine</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Chapier</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Lesourd</LastName><ForeName>Bruno</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Courteix</LastName><ForeName>Daniel</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Walther</LastName><ForeName>Guillaume</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><DataBankList 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MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006293" MajorTopicYN="Y">Health Promotion</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007328" MajorTopicYN="N">Insulin</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007333" MajorTopicYN="N">Insulin Resistance</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015850" MajorTopicYN="N">Interleukin-6</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008019" MajorTopicYN="Y">Life Style</DescriptorName></MeshHeading><MeshHeading><DescriptorName 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MajorTopicYN="N">physiology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>10</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>10</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25353072</ArticleId><ArticleId IdType="doi">10.1210/jc.2014-2704</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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