Association between osteocalcin and cognitive performance in healthy older adults
Identifieur interne : 002334 ( Main/Exploration ); précédent : 002333; suivant : 002335Association between osteocalcin and cognitive performance in healthy older adults
Auteurs : Steven Bradburn [Royaume-Uni] ; Jamie S. Mcphee [Royaume-Uni] ; Liam Bagley [Royaume-Uni] ; Sarianna Sipila [Finlande] ; Lauri Stenroth [Finlande] ; Marco Vincenzo Narici [Royaume-Uni] ; Mati P Suke [Estonie] ; Helena Gapeyeva [Estonie] ; Gabrielle Osborne [Royaume-Uni] ; Lorraine Sassano [Royaume-Uni] ; Carel G. M. Meskers [Pays-Bas] ; Andrea B. Maier [Pays-Bas, Australie] ; Jean-Yves Hogrel [France] ; Yoann Barnouin [France] ; Gillian Butler-Browne [France] ; Chris Murgatroyd [Royaume-Uni]Source :
- Age and Ageing [ 0002-0729 ] ; 2016.
Abstract
cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.
this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor 23), as well as serum calcium and 25-hydroxy vitamin D assays. A selection of cognitive domains (working memory capacity, episodic memory, executive functioning and global cognition) was assessed with a standardised neuropsychological test battery.
adjusting for covariates and multiple testing revealed that plasma OC levels were positively associated with measures of executive functioning (
these correlative results demonstrate a positive association between OC, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women. Further work should address possible mechanistic interpretations in humans.
Url:
DOI: 10.1093/ageing/afw137
PubMed: 27515675
PubMed Central: 5105824
Affiliations:
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<author><name sortKey="Stenroth, Lauri" sort="Stenroth, Lauri" uniqKey="Stenroth L" first="Lauri" last="Stenroth">Lauri Stenroth</name>
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<author><name sortKey="Narici, Marco Vincenzo" sort="Narici, Marco Vincenzo" uniqKey="Narici M" first="Marco Vincenzo" last="Narici">Marco Vincenzo Narici</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="P Suke, Mati" sort="P Suke, Mati" uniqKey="P Suke M" first="Mati" last="P Suke">Mati P Suke</name>
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<country xml:lang="fr">Estonie</country>
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<author><name sortKey="Gapeyeva, Helena" sort="Gapeyeva, Helena" uniqKey="Gapeyeva H" first="Helena" last="Gapeyeva">Helena Gapeyeva</name>
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</nlm:aff>
<country xml:lang="fr">Estonie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Osborne, Gabrielle" sort="Osborne, Gabrielle" uniqKey="Osborne G" first="Gabrielle" last="Osborne">Gabrielle Osborne</name>
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</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Sassano, Lorraine" sort="Sassano, Lorraine" uniqKey="Sassano L" first="Lorraine" last="Sassano">Lorraine Sassano</name>
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</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Meskers, Carel G M" sort="Meskers, Carel G M" uniqKey="Meskers C" first="Carel G. M." last="Meskers">Carel G. M. Meskers</name>
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,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Maier, Andrea B" sort="Maier, Andrea B" uniqKey="Maier A" first="Andrea B." last="Maier">Andrea B. Maier</name>
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,<addr-line>Faculty of Human Movement Sciences</addr-line>
,<addr-line>Amsterdam</addr-line>
,<country>The Netherlands</country>
</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="afw137af8"><addr-line>Royal Melbourne Hospital</addr-line>
,<institution>University of Melbourne</institution>
,<addr-line>Melbourne</addr-line>
,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Hogrel, Jean Yves" sort="Hogrel, Jean Yves" uniqKey="Hogrel J" first="Jean-Yves" last="Hogrel">Jean-Yves Hogrel</name>
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<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Barnouin, Yoann" sort="Barnouin, Yoann" uniqKey="Barnouin Y" first="Yoann" last="Barnouin">Yoann Barnouin</name>
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<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Butler Browne, Gillian" sort="Butler Browne, Gillian" uniqKey="Butler Browne G" first="Gillian" last="Butler-Browne">Gillian Butler-Browne</name>
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<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Murgatroyd, Chris" sort="Murgatroyd, Chris" uniqKey="Murgatroyd C" first="Chris" last="Murgatroyd">Chris Murgatroyd</name>
<affiliation wicri:level="1"><nlm:aff id="afw137af1"><institution>Manchester Metropolitan University,</institution>
<addr-line> School of Healthcare Science, Manchester</addr-line>
,<country>UK</country>
</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
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<series><title level="j">Age and Ageing</title>
<idno type="ISSN">0002-0729</idno>
<idno type="eISSN">1468-2834</idno>
<imprint><date when="2016">2016</date>
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<front><div type="abstract" xml:lang="en"><sec id="afw137s1" sec-type="intro"><title>Introduction</title>
<p>cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive performance in healthy adults.</p>
</sec>
<sec id="afw137s2" sec-type="methods"><title>Methods</title>
<p>this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women, mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dual-energy X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin (OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor 23), as well as serum calcium and 25-hydroxy vitamin D assays. A selection of cognitive domains (working memory capacity, episodic memory, executive functioning and global cognition) was assessed with a standardised neuropsychological test battery.</p>
</sec>
<sec id="afw137s3" sec-type="results"><title>Results</title>
<p>adjusting for covariates and multiple testing revealed that plasma OC levels were positively associated with measures of executive functioning (<italic>β</italic>
= 0.444, <italic>P</italic>
< 0.001) and global cognition (<italic>β</italic>
= 0.381, <italic>P</italic>
= 0.001) in the older women.</p>
</sec>
<sec id="afw137s4" sec-type="discussion"><title>Discussion</title>
<p>these correlative results demonstrate a positive association between OC, a factor known to regulate bone remodelling, with cognitive performance in older non-demented women. Further work should address possible mechanistic interpretations in humans.</p>
</sec>
</div>
</front>
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</back>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Estonie</li>
<li>Finlande</li>
<li>France</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
</country>
</list>
<tree><country name="Royaume-Uni"><noRegion><name sortKey="Bradburn, Steven" sort="Bradburn, Steven" uniqKey="Bradburn S" first="Steven" last="Bradburn">Steven Bradburn</name>
</noRegion>
<name sortKey="Bagley, Liam" sort="Bagley, Liam" uniqKey="Bagley L" first="Liam" last="Bagley">Liam Bagley</name>
<name sortKey="Mcphee, Jamie S" sort="Mcphee, Jamie S" uniqKey="Mcphee J" first="Jamie S" last="Mcphee">Jamie S. Mcphee</name>
<name sortKey="Murgatroyd, Chris" sort="Murgatroyd, Chris" uniqKey="Murgatroyd C" first="Chris" last="Murgatroyd">Chris Murgatroyd</name>
<name sortKey="Narici, Marco Vincenzo" sort="Narici, Marco Vincenzo" uniqKey="Narici M" first="Marco Vincenzo" last="Narici">Marco Vincenzo Narici</name>
<name sortKey="Osborne, Gabrielle" sort="Osborne, Gabrielle" uniqKey="Osborne G" first="Gabrielle" last="Osborne">Gabrielle Osborne</name>
<name sortKey="Sassano, Lorraine" sort="Sassano, Lorraine" uniqKey="Sassano L" first="Lorraine" last="Sassano">Lorraine Sassano</name>
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<country name="Finlande"><noRegion><name sortKey="Sipila, Sarianna" sort="Sipila, Sarianna" uniqKey="Sipila S" first="Sarianna" last="Sipila">Sarianna Sipila</name>
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<country name="Estonie"><noRegion><name sortKey="P Suke, Mati" sort="P Suke, Mati" uniqKey="P Suke M" first="Mati" last="P Suke">Mati P Suke</name>
</noRegion>
<name sortKey="Gapeyeva, Helena" sort="Gapeyeva, Helena" uniqKey="Gapeyeva H" first="Helena" last="Gapeyeva">Helena Gapeyeva</name>
</country>
<country name="Pays-Bas"><noRegion><name sortKey="Meskers, Carel G M" sort="Meskers, Carel G M" uniqKey="Meskers C" first="Carel G. M." last="Meskers">Carel G. M. Meskers</name>
</noRegion>
<name sortKey="Maier, Andrea B" sort="Maier, Andrea B" uniqKey="Maier A" first="Andrea B." last="Maier">Andrea B. Maier</name>
</country>
<country name="Australie"><noRegion><name sortKey="Maier, Andrea B" sort="Maier, Andrea B" uniqKey="Maier A" first="Andrea B." last="Maier">Andrea B. Maier</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Hogrel, Jean Yves" sort="Hogrel, Jean Yves" uniqKey="Hogrel J" first="Jean-Yves" last="Hogrel">Jean-Yves Hogrel</name>
</noRegion>
<name sortKey="Barnouin, Yoann" sort="Barnouin, Yoann" uniqKey="Barnouin Y" first="Yoann" last="Barnouin">Yoann Barnouin</name>
<name sortKey="Butler Browne, Gillian" sort="Butler Browne, Gillian" uniqKey="Butler Browne G" first="Gillian" last="Butler-Browne">Gillian Butler-Browne</name>
</country>
</tree>
</affiliations>
</record>
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