Critical review evaluating the pig as a model for human nutritional physiology.
Identifieur interne : 002147 ( Main/Exploration ); précédent : 002146; suivant : 002148Critical review evaluating the pig as a model for human nutritional physiology.
Auteurs : Eugeni Roura [Australie] ; Sietse-Jan Koopmans [Pays-Bas] ; Jean-Paul Lallès [France] ; Isabelle Le Huerou-Luron [France] ; Nadia De Jager [Australie] ; Teun Schuurman [Pays-Bas] ; David Val-Laillet [France]Source :
- Nutrition research reviews [ 1475-2700 ] ; 2016.
Abstract
The present review examines the pig as a model for physiological studies in human subjects related to nutrient sensing, appetite regulation, gut barrier function, intestinal microbiota and nutritional neuroscience. The nutrient-sensing mechanisms regarding acids (sour), carbohydrates (sweet), glutamic acid (umami) and fatty acids are conserved between humans and pigs. In contrast, pigs show limited perception of high-intensity sweeteners and NaCl and sense a wider array of amino acids than humans. Differences on bitter taste may reflect the adaptation to ecosystems. In relation to appetite regulation, plasma concentrations of cholecystokinin and glucagon-like peptide-1 are similar in pigs and humans, while peptide YY in pigs is ten to twenty times higher and ghrelin two to five times lower than in humans. Pigs are an excellent model for human studies for vagal nerve function related to the hormonal regulation of food intake. Similarly, the study of gut barrier functions reveals conserved defence mechanisms between the two species particularly in functional permeability. However, human data are scant for some of the defence systems and nutritional programming. The pig model has been valuable for studying the changes in human microbiota following nutritional interventions. In particular, the use of human flora-associated pigs is a useful model for infants, but the long-term stability of the implanted human microbiota in pigs remains to be investigated. The similarity of the pig and human brain anatomy and development is paradigmatic. Brain explorations and therapies described in pig, when compared with available human data, highlight their value in nutritional neuroscience, particularly regarding functional neuroimaging techniques.
DOI: 10.1017/S0954422416000020
PubMed: 27176552
Affiliations:
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Gilles</wicri:regionArea><wicri:noRegion>35590 St Gilles</wicri:noRegion><wicri:noRegion>35590 St Gilles</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nutrition research reviews</title><idno type="eISSN">1475-2700</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The present review examines the pig as a model for physiological studies in human subjects related to nutrient sensing, appetite regulation, gut barrier function, intestinal microbiota and nutritional neuroscience. The nutrient-sensing mechanisms regarding acids (sour), carbohydrates (sweet), glutamic acid (umami) and fatty acids are conserved between humans and pigs. In contrast, pigs show limited perception of high-intensity sweeteners and NaCl and sense a wider array of amino acids than humans. Differences on bitter taste may reflect the adaptation to ecosystems. In relation to appetite regulation, plasma concentrations of cholecystokinin and glucagon-like peptide-1 are similar in pigs and humans, while peptide YY in pigs is ten to twenty times higher and ghrelin two to five times lower than in humans. Pigs are an excellent model for human studies for vagal nerve function related to the hormonal regulation of food intake. Similarly, the study of gut barrier functions reveals conserved defence mechanisms between the two species particularly in functional permeability. However, human data are scant for some of the defence systems and nutritional programming. The pig model has been valuable for studying the changes in human microbiota following nutritional interventions. In particular, the use of human flora-associated pigs is a useful model for infants, but the long-term stability of the implanted human microbiota in pigs remains to be investigated. The similarity of the pig and human brain anatomy and development is paradigmatic. Brain explorations and therapies described in pig, when compared with available human data, highlight their value in nutritional neuroscience, particularly regarding functional neuroimaging techniques.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Pays-Bas</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Roura, Eugeni" sort="Roura, Eugeni" uniqKey="Roura E" first="Eugeni" last="Roura">Eugeni Roura</name></noRegion><name sortKey="De Jager, Nadia" sort="De Jager, Nadia" uniqKey="De Jager N" first="Nadia" last="De Jager">Nadia De Jager</name></country><country name="Pays-Bas"><noRegion><name sortKey="Koopmans, Sietse Jan" sort="Koopmans, Sietse Jan" uniqKey="Koopmans S" first="Sietse-Jan" last="Koopmans">Sietse-Jan Koopmans</name></noRegion><name sortKey="Schuurman, Teun" sort="Schuurman, Teun" uniqKey="Schuurman T" first="Teun" last="Schuurman">Teun Schuurman</name></country><country name="France"><noRegion><name sortKey="Lalles, Jean Paul" sort="Lalles, Jean Paul" uniqKey="Lalles J" first="Jean-Paul" last="Lallès">Jean-Paul Lallès</name></noRegion><name sortKey="Le Huerou Luron, Isabelle" sort="Le Huerou Luron, Isabelle" uniqKey="Le Huerou Luron I" first="Isabelle" last="Le Huerou-Luron">Isabelle Le Huerou-Luron</name><name sortKey="Val Laillet, David" sort="Val Laillet, David" uniqKey="Val Laillet D" first="David" last="Val-Laillet">David Val-Laillet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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