Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.
Identifieur interne : 001C29 ( Main/Exploration ); précédent : 001C28; suivant : 001C30Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.
Auteurs : Lena Erlandsson [Suède] ; Sa N V [Suède] ; Annemarie Hennessy [Australie] ; Daniel Vaiman [France] ; Magnus Gram [Suède] ; Bo Kerström [Suède] ; Stefan R. Hansson [Suède]Source :
- American journal of reproductive immunology (New York, N.Y. : 1989) [ 1600-0897 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Prééclampsie.
- étiologie : Prééclampsie.
- Animaux, Femelle, Grossesse, Humains, Modèles animaux de maladie humaine, Prééclampsie.
English descriptors
- KwdEn :
- MESH :
- etiology : Pre-Eclampsia.
- immunology : Pre-Eclampsia.
- therapy : Pre-Eclampsia.
- Animals, Disease Models, Animal, Female, Humans, Pregnancy.
Abstract
Preeclampsia is a pregnancy-related disease afflicting 3-7% of pregnancies worldwide and leads to maternal and infant morbidity and mortality. The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four categories (i) spontaneous, (ii) surgically induced, (iii) pharmacologically/substance induced, and (iv) transgenic. This review aims at providing an inventory of novel models addressing etiology of the disease and or therapeutic/intervention opportunities.
DOI: 10.1111/aji.12460
PubMed: 26685057
Affiliations:
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The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four categories (i) spontaneous, (ii) surgically induced, (iii) pharmacologically/substance induced, and (iv) transgenic. This review aims at providing an inventory of novel models addressing etiology of the disease and or therapeutic/intervention opportunities.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Suède</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="Suède"><noRegion><name sortKey="Erlandsson, Lena" sort="Erlandsson, Lena" uniqKey="Erlandsson L" first="Lena" last="Erlandsson">Lena Erlandsson</name></noRegion><name sortKey=" Kerstrom, Bo" sort=" Kerstrom, Bo" uniqKey=" Kerstrom B" first="Bo" last=" Kerström">Bo Kerström</name><name sortKey="Gram, Magnus" sort="Gram, Magnus" uniqKey="Gram M" first="Magnus" last="Gram">Magnus Gram</name><name sortKey="Hansson, Stefan R" sort="Hansson, Stefan R" uniqKey="Hansson S" first="Stefan R" last="Hansson">Stefan R. Hansson</name><name sortKey="N V, Sa" sort="N V, Sa" uniqKey="N V " first=" Sa" last="N V"> Sa N V</name></country><country name="Australie"><noRegion><name sortKey="Hennessy, Annemarie" sort="Hennessy, Annemarie" uniqKey="Hennessy A" first="Annemarie" last="Hennessy">Annemarie Hennessy</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Vaiman, Daniel" sort="Vaiman, Daniel" uniqKey="Vaiman D" first="Daniel" last="Vaiman">Daniel Vaiman</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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