Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.
Identifieur interne : 002205 ( PubMed/Corpus ); précédent : 002204; suivant : 002206Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.
Auteurs : Lena Erlandsson ; Sa N V ; Annemarie Hennessy ; Daniel Vaiman ; Magnus Gram ; Bo Kerström ; Stefan R. HanssonSource :
- American journal of reproductive immunology (New York, N.Y. : 1989) [ 1600-0897 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- etiology : Pre-Eclampsia.
- immunology : Pre-Eclampsia.
- therapy : Pre-Eclampsia.
- Animals, Disease Models, Animal, Female, Humans, Pregnancy.
Abstract
Preeclampsia is a pregnancy-related disease afflicting 3-7% of pregnancies worldwide and leads to maternal and infant morbidity and mortality. The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four categories (i) spontaneous, (ii) surgically induced, (iii) pharmacologically/substance induced, and (iv) transgenic. This review aims at providing an inventory of novel models addressing etiology of the disease and or therapeutic/intervention opportunities.
DOI: 10.1111/aji.12460
PubMed: 26685057
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pubmed:26685057Le document en format XML
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Hansson</name><affiliation><nlm:affiliation>Obstetrics and Gynecology, Institution of Clinical Sciences, Lund University, Lund, Sweden.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26685057</idno><idno type="pmid">26685057</idno><idno type="doi">10.1111/aji.12460</idno><idno type="wicri:Area/PubMed/Corpus">002205</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002205</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.</title><author><name sortKey="Erlandsson, Lena" sort="Erlandsson, Lena" uniqKey="Erlandsson L" first="Lena" last="Erlandsson">Lena Erlandsson</name><affiliation><nlm:affiliation>Obstetrics and Gynecology, Institution of Clinical Sciences, Lund University, Lund, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="N V, Sa" sort="N V, Sa" uniqKey="N V " first=" Sa" last="N V"> Sa N V</name><affiliation><nlm:affiliation>Obstetrics and Gynecology, Institution of Clinical Sciences, Lund University, Lund, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Hennessy, Annemarie" sort="Hennessy, Annemarie" uniqKey="Hennessy A" first="Annemarie" last="Hennessy">Annemarie Hennessy</name><affiliation><nlm:affiliation>School of Medicine, Western Sydney University, Campbelltown, NSW, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Vaiman, Daniel" sort="Vaiman, Daniel" uniqKey="Vaiman D" first="Daniel" last="Vaiman">Daniel Vaiman</name><affiliation><nlm:affiliation>INSERM U1016, CNRS UMR8104, Faculté de Médecine, Institut Cochin, Paris, France.</nlm:affiliation></affiliation></author><author><name sortKey="Gram, Magnus" sort="Gram, Magnus" uniqKey="Gram M" first="Magnus" last="Gram">Magnus Gram</name><affiliation><nlm:affiliation>Infection Medicine, Institution of Clinical Sciences, Lund University, Lund, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey=" Kerstrom, Bo" sort=" Kerstrom, Bo" uniqKey=" Kerstrom B" first="Bo" last=" Kerström">Bo Kerström</name><affiliation><nlm:affiliation>Infection Medicine, Institution of Clinical Sciences, Lund University, Lund, Sweden.</nlm:affiliation></affiliation></author><author><name sortKey="Hansson, Stefan R" sort="Hansson, Stefan R" uniqKey="Hansson S" first="Stefan R" last="Hansson">Stefan R. Hansson</name><affiliation><nlm:affiliation>Obstetrics and Gynecology, Institution of Clinical Sciences, Lund University, Lund, Sweden.</nlm:affiliation></affiliation></author></analytic><series><title level="j">American journal of reproductive immunology (New York, N.Y. : 1989)</title><idno type="eISSN">1600-0897</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Pre-Eclampsia (etiology)</term><term>Pre-Eclampsia (immunology)</term><term>Pre-Eclampsia (therapy)</term><term>Pregnancy</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Pre-Eclampsia</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Pre-Eclampsia</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Pre-Eclampsia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Disease Models, Animal</term><term>Female</term><term>Humans</term><term>Pregnancy</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Preeclampsia is a pregnancy-related disease afflicting 3-7% of pregnancies worldwide and leads to maternal and infant morbidity and mortality. The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four categories (i) spontaneous, (ii) surgically induced, (iii) pharmacologically/substance induced, and (iv) transgenic. This review aims at providing an inventory of novel models addressing etiology of the disease and or therapeutic/intervention opportunities.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26685057</PMID><DateCreated><Year>2016</Year><Month>02</Month><Day>11</Day></DateCreated><DateCompleted><Year>2016</Year><Month>10</Month><Day>27</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1600-0897</ISSN><JournalIssue CitedMedium="Internet"><Volume>75</Volume><Issue>3</Issue><PubDate><Year>2016</Year><Month>Mar</Month></PubDate></JournalIssue><Title>American journal of reproductive immunology (New York, N.Y. : 1989)</Title><ISOAbbreviation>Am. J. Reprod. Immunol.</ISOAbbreviation></Journal><ArticleTitle>Inventory of Novel Animal Models Addressing Etiology of Preeclampsia in the Development of New Therapeutic/Intervention Opportunities.</ArticleTitle><Pagination><MedlinePgn>402-10</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/aji.12460</ELocationID><Abstract><AbstractText>Preeclampsia is a pregnancy-related disease afflicting 3-7% of pregnancies worldwide and leads to maternal and infant morbidity and mortality. The disease is of placental origin and is commonly described as a disease of two stages. A variety of preeclampsia animal models have been proposed, but all of them have limitations in fully recapitulating the human disease. Based on the research question at hand, different or multiple models might be suitable. Multiple animal models in combination with in vitro or ex vivo studies on human placenta together offer a synergistic platform to further our understanding of the etiology of preeclampsia and potential therapeutic interventions. The described animal models of preeclampsia divide into four categories (i) spontaneous, (ii) surgically induced, (iii) pharmacologically/substance induced, and (iv) transgenic. This review aims at providing an inventory of novel models addressing etiology of the disease and or therapeutic/intervention opportunities.</AbstractText><CopyrightInformation>© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Erlandsson</LastName><ForeName>Lena</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Obstetrics and Gynecology, Institution of Clinical Sciences, Lund University, Lund, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nääv</LastName><ForeName>Åsa</ForeName><Initials>Å</Initials><AffiliationInfo><Affiliation>Obstetrics and Gynecology, Institution of Clinical Sciences, Lund University, Lund, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hennessy</LastName><ForeName>Annemarie</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Medicine, Western Sydney University, Campbelltown, NSW, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vaiman</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>INSERM U1016, CNRS UMR8104, Faculté de Médecine, Institut Cochin, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gram</LastName><ForeName>Magnus</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Infection Medicine, Institution of Clinical Sciences, Lund University, Lund, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Åkerström</LastName><ForeName>Bo</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Infection Medicine, Institution of Clinical Sciences, Lund University, Lund, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hansson</LastName><ForeName>Stefan R</ForeName><Initials>SR</Initials><AffiliationInfo><Affiliation>Obstetrics and Gynecology, Institution of Clinical Sciences, Lund University, Lund, Sweden.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>12</Month><Day>18</Day></ArticleDate></Article><MedlineJournalInfo><Country>Denmark</Country><MedlineTA>Am J Reprod Immunol</MedlineTA><NlmUniqueID>8912860</NlmUniqueID><ISSNLinking>1046-7408</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004195" MajorTopicYN="Y">Disease Models, Animal</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011225" MajorTopicYN="Y">Pre-Eclampsia</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011247" MajorTopicYN="N">Pregnancy</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Hypertension</Keyword><Keyword MajorTopicYN="N">placenta</Keyword><Keyword MajorTopicYN="N">proteinuria</Keyword><Keyword MajorTopicYN="N">treatment opportunities</Keyword><Keyword MajorTopicYN="N">two-stage model</Keyword><Keyword MajorTopicYN="N">α1-microglobulin</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>09</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>11</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>12</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>12</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>11</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">26685057</ArticleId><ArticleId IdType="doi">10.1111/aji.12460</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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