Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial.
Identifieur interne : 001A69 ( Main/Exploration ); précédent : 001A68; suivant : 001A70Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial.
Auteurs : Andrea Wang-Gillam [États-Unis] ; Chung-Pin Li [Taïwan] ; György Bodoky [Hongrie] ; Andrew Dean [Australie] ; Yan-Shen Shan [Taïwan] ; Gayle Jameson [États-Unis] ; Teresa Macarulla [Espagne] ; Kyung-Hun Lee [Corée du Sud] ; David Cunningham [Royaume-Uni] ; Jean F. Blanc [France] ; Richard A. Hubner [Royaume-Uni] ; Chang-Fang Chiu [Taïwan] ; Gilberto Schwartsmann [Brésil] ; Jens T. Siveke [Allemagne] ; Fadi Braiteh [États-Unis] ; Victor Moyo [États-Unis] ; Bruce Belanger [États-Unis] ; Navreet Dhindsa [États-Unis] ; Eliel Bayever [États-Unis] ; Daniel D. Von Hoff [États-Unis] ; Li-Tzong Chen [Taïwan]Source :
- Lancet (London, England) [ 1474-547X ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Camptothécine (administration et posologie), Camptothécine (analogues et dérivés), Camptothécine (effets indésirables), Carcinome du canal pancréatique (mortalité), Carcinome du canal pancréatique (traitement médicamenteux), Diarrhée (), Désoxycytidine (administration et posologie), Désoxycytidine (analogues et dérivés), Désoxycytidine (effets indésirables), Estimation de Kaplan-Meier, Fatigue (), Femelle, Fluorouracil (administration et posologie), Fluorouracil (effets indésirables), Humains, Leucovorine (administration et posologie), Leucovorine (effets indésirables), Liposomes, Mâle, Métastase tumorale, Neutropénie (), Protocoles de polychimiothérapie antinéoplasique (usage thérapeutique), Résultat thérapeutique, Sujet âgé, Tumeurs du pancréas (mortalité), Tumeurs du pancréas (traitement médicamenteux), Vomissement ().
- MESH :
- administration et posologie : Camptothécine, Désoxycytidine, Fluorouracil, Leucovorine.
- analogues et dérivés : Camptothécine, Désoxycytidine.
- effets indésirables : Camptothécine, Désoxycytidine, Fluorouracil, Leucovorine.
- mortalité : Carcinome du canal pancréatique, Tumeurs du pancréas.
- traitement médicamenteux : Carcinome du canal pancréatique, Tumeurs du pancréas.
- usage thérapeutique : Protocoles de polychimiothérapie antinéoplasique.
- Adulte d'âge moyen, Diarrhée, Estimation de Kaplan-Meier, Fatigue, Femelle, Humains, Liposomes, Mâle, Métastase tumorale, Neutropénie, Résultat thérapeutique, Sujet âgé, Vomissement.
English descriptors
- KwdEn :
- Aged, Antineoplastic Combined Chemotherapy Protocols (therapeutic use), Camptothecin (administration & dosage), Camptothecin (adverse effects), Camptothecin (analogs & derivatives), Carcinoma, Pancreatic Ductal (drug therapy), Carcinoma, Pancreatic Ductal (mortality), Deoxycytidine (administration & dosage), Deoxycytidine (adverse effects), Deoxycytidine (analogs & derivatives), Diarrhea (chemically induced), Fatigue (chemically induced), Female, Fluorouracil (administration & dosage), Fluorouracil (adverse effects), Humans, Kaplan-Meier Estimate, Leucovorin (administration & dosage), Leucovorin (adverse effects), Liposomes, Male, Middle Aged, Neoplasm Metastasis, Neutropenia (chemically induced), Pancreatic Neoplasms (drug therapy), Pancreatic Neoplasms (mortality), Treatment Outcome, Vomiting (chemically induced).
- MESH :
- chemical , administration & dosage : Camptothecin, Deoxycytidine, Fluorouracil, Leucovorin.
- chemical , adverse effects : Camptothecin, Deoxycytidine, Fluorouracil, Leucovorin.
- chemical , analogs & derivatives : Camptothecin, Deoxycytidine.
- chemically induced : Diarrhea, Fatigue, Neutropenia, Vomiting.
- drug therapy : Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms.
- mortality : Carcinoma, Pancreatic Ductal, Pancreatic Neoplasms.
- therapeutic use : Antineoplastic Combined Chemotherapy Protocols.
- Aged, Female, Humans, Kaplan-Meier Estimate, Liposomes, Male, Middle Aged, Neoplasm Metastasis, Treatment Outcome.
Abstract
Nanoliposomal irinotecan showed activity in a phase 2 study in patients with metastatic pancreatic ductal adenocarcinoma previously treated with gemcitabine-based therapies. We assessed the effect of nanoliposomal irinotecan alone or combined with fluorouracil and folinic acid in a phase 3 trial in this population.
DOI: 10.1016/S0140-6736(15)00986-1
PubMed: 26615328
Affiliations:
- Allemagne, Australie, Brésil, Corée du Sud, Espagne, France, Hongrie, Royaume-Uni, Taïwan, États-Unis
- Angleterre, Aquitaine, Arizona, Bavière, Catalogne, District de Haute-Bavière, Grand Londres, Grand Manchester, Hongrie centrale, Massachusetts, Missouri (État), Nevada, Nouvelle-Aquitaine, Rio Grande do Sul, Région capitale de Séoul
- Barcelone, Bordeaux, Budapest, Londres, Manchester, Munich, Porto Alegre, Saint-Louis (Missouri), Séoul
- École de médecine (Université Washington de Saint-Louis)
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002263
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- to stream PubMed, to step Checkpoint: 002237
- to stream Ncbi, to step Merge: 002E08
- to stream Ncbi, to step Curation: 002E08
- to stream Ncbi, to step Checkpoint: 002E08
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Le document en format XML
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<author><name sortKey="Macarulla, Teresa" sort="Macarulla, Teresa" uniqKey="Macarulla T" first="Teresa" last="Macarulla">Teresa Macarulla</name>
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<author><name sortKey="Lee, Kyung Hun" sort="Lee, Kyung Hun" uniqKey="Lee K" first="Kyung-Hun" last="Lee">Kyung-Hun Lee</name>
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<author><name sortKey="Cunningham, David" sort="Cunningham, David" uniqKey="Cunningham D" first="David" last="Cunningham">David Cunningham</name>
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<author><name sortKey="Blanc, Jean F" sort="Blanc, Jean F" uniqKey="Blanc J" first="Jean F" last="Blanc">Jean F. Blanc</name>
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<author><name sortKey="Hubner, Richard A" sort="Hubner, Richard A" uniqKey="Hubner R" first="Richard A" last="Hubner">Richard A. Hubner</name>
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<author><name sortKey="Chiu, Chang Fang" sort="Chiu, Chang Fang" uniqKey="Chiu C" first="Chang-Fang" last="Chiu">Chang-Fang Chiu</name>
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<author><name sortKey="Moyo, Victor" sort="Moyo, Victor" uniqKey="Moyo V" first="Victor" last="Moyo">Victor Moyo</name>
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<author><name sortKey="Belanger, Bruce" sort="Belanger, Bruce" uniqKey="Belanger B" first="Bruce" last="Belanger">Bruce Belanger</name>
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<author><name sortKey="Dhindsa, Navreet" sort="Dhindsa, Navreet" uniqKey="Dhindsa N" first="Navreet" last="Dhindsa">Navreet Dhindsa</name>
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<author><name sortKey="Von Hoff, Daniel D" sort="Von Hoff, Daniel D" uniqKey="Von Hoff D" first="Daniel D" last="Von Hoff">Daniel D. Von Hoff</name>
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<author><name sortKey="Chen, Li Tzong" sort="Chen, Li Tzong" uniqKey="Chen L" first="Li-Tzong" last="Chen">Li-Tzong Chen</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial.</title>
<author><name sortKey="Wang Gillam, Andrea" sort="Wang Gillam, Andrea" uniqKey="Wang Gillam A" first="Andrea" last="Wang-Gillam">Andrea Wang-Gillam</name>
<affiliation wicri:level="4"><nlm:affiliation>Washington University School of Medicine, St Louis, MO, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Washington University School of Medicine, St Louis, MO</wicri:regionArea>
<placeName><region type="state">Missouri (État)</region>
<settlement type="city">Saint-Louis (Missouri)</settlement>
</placeName>
<orgName type="university">École de médecine (Université Washington de Saint-Louis)</orgName>
</affiliation>
</author>
<author><name sortKey="Li, Chung Pin" sort="Li, Chung Pin" uniqKey="Li C" first="Chung-Pin" last="Li">Chung-Pin Li</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Gastroenterology and Hepatology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>Division of Gastroenterology and Hepatology, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine, Taipei</wicri:regionArea>
<wicri:noRegion>Taipei</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bodoky, Gyorgy" sort="Bodoky, Gyorgy" uniqKey="Bodoky G" first="György" last="Bodoky">György Bodoky</name>
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<country xml:lang="fr">Hongrie</country>
<wicri:regionArea>St László Teaching Hospital, Budapest</wicri:regionArea>
<placeName><settlement type="city">Budapest</settlement>
<region nuts="2">Hongrie centrale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dean, Andrew" sort="Dean, Andrew" uniqKey="Dean A" first="Andrew" last="Dean">Andrew Dean</name>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea>St John of God Hospital, Subiaco, WA</wicri:regionArea>
<wicri:noRegion>WA</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shan, Yan Shen" sort="Shan, Yan Shen" uniqKey="Shan Y" first="Yan-Shen" last="Shan">Yan-Shen Shan</name>
<affiliation wicri:level="1"><nlm:affiliation>National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
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<wicri:noRegion>Tainan</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jameson, Gayle" sort="Jameson, Gayle" uniqKey="Jameson G" first="Gayle" last="Jameson">Gayle Jameson</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>TGen, Phoenix, and HonorHealth, Scottsdale, AZ</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Macarulla, Teresa" sort="Macarulla, Teresa" uniqKey="Macarulla T" first="Teresa" last="Macarulla">Teresa Macarulla</name>
<affiliation wicri:level="3"><nlm:affiliation>Vall d'Hebron University Hospital (HUVH) and Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Vall d'Hebron University Hospital (HUVH) and Vall d'Hebron Institute of Oncology (VHIO), Barcelona</wicri:regionArea>
<placeName><settlement type="city">Barcelone</settlement>
<region nuts="2" type="region">Catalogne</region>
</placeName>
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<author><name sortKey="Lee, Kyung Hun" sort="Lee, Kyung Hun" uniqKey="Lee K" first="Kyung-Hun" last="Lee">Kyung-Hun Lee</name>
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<wicri:regionArea>Seoul National University Hospital, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
</placeName>
</affiliation>
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<author><name sortKey="Cunningham, David" sort="Cunningham, David" uniqKey="Cunningham D" first="David" last="Cunningham">David Cunningham</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Royal Marsden Hospital, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blanc, Jean F" sort="Blanc, Jean F" uniqKey="Blanc J" first="Jean F" last="Blanc">Jean F. Blanc</name>
<affiliation wicri:level="3"><nlm:affiliation>Hôpital Saint-André, Bordeaux, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
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<author><name sortKey="Braiteh, Fadi" sort="Braiteh, Fadi" uniqKey="Braiteh F" first="Fadi" last="Braiteh">Fadi Braiteh</name>
<affiliation wicri:level="2"><nlm:affiliation>Comprehensive Cancer Centers of Nevada, Las Vegas, NV, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Comprehensive Cancer Centers of Nevada, Las Vegas, NV</wicri:regionArea>
<placeName><region type="state">Nevada</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Moyo, Victor" sort="Moyo, Victor" uniqKey="Moyo V" first="Victor" last="Moyo">Victor Moyo</name>
<affiliation wicri:level="2"><nlm:affiliation>Merrimack Pharmaceuticals, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merrimack Pharmaceuticals, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Belanger, Bruce" sort="Belanger, Bruce" uniqKey="Belanger B" first="Bruce" last="Belanger">Bruce Belanger</name>
<affiliation wicri:level="2"><nlm:affiliation>Merrimack Pharmaceuticals, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merrimack Pharmaceuticals, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dhindsa, Navreet" sort="Dhindsa, Navreet" uniqKey="Dhindsa N" first="Navreet" last="Dhindsa">Navreet Dhindsa</name>
<affiliation wicri:level="2"><nlm:affiliation>Merrimack Pharmaceuticals, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merrimack Pharmaceuticals, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bayever, Eliel" sort="Bayever, Eliel" uniqKey="Bayever E" first="Eliel" last="Bayever">Eliel Bayever</name>
<affiliation wicri:level="2"><nlm:affiliation>Merrimack Pharmaceuticals, Cambridge, MA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merrimack Pharmaceuticals, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Von Hoff, Daniel D" sort="Von Hoff, Daniel D" uniqKey="Von Hoff D" first="Daniel D" last="Von Hoff">Daniel D. Von Hoff</name>
<affiliation wicri:level="2"><nlm:affiliation>TGen, Phoenix, and HonorHealth, Scottsdale, AZ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>TGen, Phoenix, and HonorHealth, Scottsdale, AZ</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chen, Li Tzong" sort="Chen, Li Tzong" uniqKey="Chen L" first="Li-Tzong" last="Chen">Li-Tzong Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>National Institute of Cancer Research, National Health Research Institutes, Tainan, and Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan. Electronic address: leochen@nhri.org.tw.</nlm:affiliation>
<country xml:lang="fr">Taïwan</country>
<wicri:regionArea>National Institute of Cancer Research, National Health Research Institutes, Tainan, and Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; National Cheng Kung University Hospital, National Cheng Kung University, Tainan</wicri:regionArea>
<wicri:noRegion>Tainan</wicri:noRegion>
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<series><title level="j">Lancet (London, England)</title>
<idno type="eISSN">1474-547X</idno>
<imprint><date when="2016" type="published">2016</date>
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<term>Carcinoma, Pancreatic Ductal (mortality)</term>
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<term>Fatigue (chemically induced)</term>
<term>Female</term>
<term>Fluorouracil (administration & dosage)</term>
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<term>Humans</term>
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<term>Leucovorin (administration & dosage)</term>
<term>Leucovorin (adverse effects)</term>
<term>Liposomes</term>
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<term>Camptothécine (administration et posologie)</term>
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<front><div type="abstract" xml:lang="en">Nanoliposomal irinotecan showed activity in a phase 2 study in patients with metastatic pancreatic ductal adenocarcinoma previously treated with gemcitabine-based therapies. We assessed the effect of nanoliposomal irinotecan alone or combined with fluorouracil and folinic acid in a phase 3 trial in this population.</div>
</front>
</TEI>
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<li>Corée du Sud</li>
<li>Espagne</li>
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<li>Hongrie</li>
<li>Royaume-Uni</li>
<li>Taïwan</li>
<li>États-Unis</li>
</country>
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<tree><country name="États-Unis"><region name="Missouri (État)"><name sortKey="Wang Gillam, Andrea" sort="Wang Gillam, Andrea" uniqKey="Wang Gillam A" first="Andrea" last="Wang-Gillam">Andrea Wang-Gillam</name>
</region>
<name sortKey="Bayever, Eliel" sort="Bayever, Eliel" uniqKey="Bayever E" first="Eliel" last="Bayever">Eliel Bayever</name>
<name sortKey="Belanger, Bruce" sort="Belanger, Bruce" uniqKey="Belanger B" first="Bruce" last="Belanger">Bruce Belanger</name>
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<name sortKey="Dhindsa, Navreet" sort="Dhindsa, Navreet" uniqKey="Dhindsa N" first="Navreet" last="Dhindsa">Navreet Dhindsa</name>
<name sortKey="Jameson, Gayle" sort="Jameson, Gayle" uniqKey="Jameson G" first="Gayle" last="Jameson">Gayle Jameson</name>
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<name sortKey="Von Hoff, Daniel D" sort="Von Hoff, Daniel D" uniqKey="Von Hoff D" first="Daniel D" last="Von Hoff">Daniel D. Von Hoff</name>
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<name sortKey="Chiu, Chang Fang" sort="Chiu, Chang Fang" uniqKey="Chiu C" first="Chang-Fang" last="Chiu">Chang-Fang Chiu</name>
<name sortKey="Shan, Yan Shen" sort="Shan, Yan Shen" uniqKey="Shan Y" first="Yan-Shen" last="Shan">Yan-Shen Shan</name>
</country>
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</country>
<country name="Allemagne"><region name="Bavière"><name sortKey="Siveke, Jens T" sort="Siveke, Jens T" uniqKey="Siveke J" first="Jens T" last="Siveke">Jens T. Siveke</name>
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