Control of Metastasis by NK Cells.
Identifieur interne : 000F17 ( Main/Exploration ); précédent : 000F16; suivant : 000F18Control of Metastasis by NK Cells.
Auteurs : Alejandro L Pez-Soto [Espagne] ; Segundo Gonzalez [Espagne] ; Mark J. Smyth [Australie] ; Lorenzo Galluzzi [France]Source :
- Cancer cell [ 1878-3686 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Cellules tueuses naturelles (immunologie), Humains, Immunothérapie, Microenvironnement tumoral, Métastase tumorale (), Métastase tumorale (anatomopathologie), Métastase tumorale (immunologie), Surveillance immunologique, Tumeurs (), Tumeurs (anatomopathologie), Tumeurs (immunologie), Échappement de la tumeur à la surveillance immunitaire.
- MESH :
- anatomopathologie : Métastase tumorale, Tumeurs.
- immunologie : Cellules tueuses naturelles, Métastase tumorale, Tumeurs.
- Animaux, Humains, Immunothérapie, Microenvironnement tumoral, Métastase tumorale, Surveillance immunologique, Tumeurs, Échappement de la tumeur à la surveillance immunitaire.
English descriptors
- KwdEn :
- Animals, Humans, Immunologic Surveillance, Immunotherapy, Killer Cells, Natural (immunology), Neoplasm Metastasis (immunology), Neoplasm Metastasis (pathology), Neoplasm Metastasis (prevention & control), Neoplasms (immunology), Neoplasms (pathology), Neoplasms (prevention & control), Tumor Escape, Tumor Microenvironment.
- MESH :
- immunology : Killer Cells, Natural, Neoplasm Metastasis, Neoplasms.
- pathology : Neoplasm Metastasis, Neoplasms.
- prevention & control : Neoplasm Metastasis, Neoplasms.
- Animals, Humans, Immunologic Surveillance, Immunotherapy, Tumor Escape, Tumor Microenvironment.
Abstract
The metastatic spread of malignant cells to distant anatomical locations is a prominent cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms that enable neoplastic cells to invade the local microenvironment, reach the circulation, and colonize distant sites, including the so-called epithelial-to-mesenchymal transition. Moreover, metastasis is regulated by microenvironmental and systemic processes, such as immunosurveillance. Here, we outline the cancer-cell-intrinsic and -extrinsic factors that regulate metastasis, discuss the key role of natural killer (NK) cells in the control of metastatic dissemination, and present potential therapeutic approaches to prevent or target metastatic disease by harnessing NK cells.
DOI: 10.1016/j.ccell.2017.06.009
PubMed: 28810142
Affiliations:
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Le document en format XML
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Electronic address: lopezsalejandro@uniovi.es.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Biología Funcional, Área de Inmunología, Universidad de Oviedo, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), 33006 Oviedo, Asturias</wicri:regionArea><wicri:noRegion>Asturias</wicri:noRegion></affiliation></author><author><name sortKey="Gonzalez, Segundo" sort="Gonzalez, Segundo" uniqKey="Gonzalez S" first="Segundo" last="Gonzalez">Segundo Gonzalez</name><affiliation wicri:level="1"><nlm:affiliation>Departamento de Biología Funcional, Área de Inmunología, Universidad de Oviedo, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), 33006 Oviedo, Asturias, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Departamento de Biología Funcional, Área de Inmunología, Universidad de Oviedo, Instituto Universitario de Oncología del Principado de Asturias (IUOPA), 33006 Oviedo, Asturias</wicri:regionArea><wicri:noRegion>Asturias</wicri:noRegion></affiliation></author><author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. 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Electronic address: deadoc@vodafone.it.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Radiation Oncology, Weill Cornell Medical College, New York, NY 10065, USA; Sandra and Edward Meyer Cancer Center, New York, NY 10065, USA; Université Paris Descartes/Paris V, 75006 Paris</wicri:regionArea><wicri:noRegion>75006 Paris</wicri:noRegion><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author></analytic><series><title level="j">Cancer cell</title><idno type="eISSN">1878-3686</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Humans</term><term>Immunologic Surveillance</term><term>Immunotherapy</term><term>Killer Cells, Natural (immunology)</term><term>Neoplasm Metastasis (immunology)</term><term>Neoplasm Metastasis (pathology)</term><term>Neoplasm Metastasis (prevention & control)</term><term>Neoplasms (immunology)</term><term>Neoplasms (pathology)</term><term>Neoplasms (prevention & control)</term><term>Tumor Escape</term><term>Tumor Microenvironment</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules tueuses naturelles (immunologie)</term><term>Humains</term><term>Immunothérapie</term><term>Microenvironnement tumoral</term><term>Métastase tumorale ()</term><term>Métastase tumorale (anatomopathologie)</term><term>Métastase tumorale (immunologie)</term><term>Surveillance immunologique</term><term>Tumeurs ()</term><term>Tumeurs (anatomopathologie)</term><term>Tumeurs (immunologie)</term><term>Échappement de la tumeur à la surveillance immunitaire</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Métastase tumorale</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules tueuses naturelles</term><term>Métastase tumorale</term><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Killer Cells, Natural</term><term>Neoplasm Metastasis</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neoplasm Metastasis</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Neoplasm Metastasis</term><term>Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Immunologic Surveillance</term><term>Immunotherapy</term><term>Tumor Escape</term><term>Tumor Microenvironment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Immunothérapie</term><term>Microenvironnement tumoral</term><term>Métastase tumorale</term><term>Surveillance immunologique</term><term>Tumeurs</term><term>Échappement de la tumeur à la surveillance immunitaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The metastatic spread of malignant cells to distant anatomical locations is a prominent cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms that enable neoplastic cells to invade the local microenvironment, reach the circulation, and colonize distant sites, including the so-called epithelial-to-mesenchymal transition. Moreover, metastasis is regulated by microenvironmental and systemic processes, such as immunosurveillance. Here, we outline the cancer-cell-intrinsic and -extrinsic factors that regulate metastasis, discuss the key role of natural killer (NK) cells in the control of metastatic dissemination, and present potential therapeutic approaches to prevent or target metastatic disease by harnessing NK cells.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Espagne</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="Espagne"><noRegion><name sortKey="L Pez Soto, Alejandro" sort="L Pez Soto, Alejandro" uniqKey="L Pez Soto A" first="Alejandro" last="L Pez-Soto">Alejandro L Pez-Soto</name></noRegion><name sortKey="Gonzalez, Segundo" sort="Gonzalez, Segundo" uniqKey="Gonzalez S" first="Segundo" last="Gonzalez">Segundo Gonzalez</name></country><country name="Australie"><noRegion><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Galluzzi, Lorenzo" sort="Galluzzi, Lorenzo" uniqKey="Galluzzi L" first="Lorenzo" last="Galluzzi">Lorenzo Galluzzi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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