Genetic variation at 16q24.2 is associated with small vessel stroke.
Identifieur interne : 000B72 ( Main/Exploration ); précédent : 000B71; suivant : 000B73Genetic variation at 16q24.2 is associated with small vessel stroke.
Auteurs : Matthew Traylor [Royaume-Uni] ; Rainer Malik [Allemagne] ; Mike A. Nalls [États-Unis] ; Ioana Cotlarciuc [Royaume-Uni] ; Farid Radmanesh [États-Unis] ; Gudmar Thorleifsson [Islande] ; Ken B. Hanscombe [Royaume-Uni] ; Carl Langefeld [États-Unis] ; Danish Saleheen [États-Unis] ; Natalia S. Rost [États-Unis] ; Idil Yet [Royaume-Uni] ; Tim D. Spector [Royaume-Uni] ; Jordana T. Bell [Royaume-Uni] ; Eilis Hannon [Royaume-Uni] ; Jonathan Mill [Royaume-Uni] ; Ganesh Chauhan [France] ; Stephanie Debette [France] ; Joshua C. Bis [États-Unis] ; W T Longstreth [États-Unis] ; M Arfan Ikram [Pays-Bas] ; Lenore J. Launer [États-Unis] ; Sudha Seshadri [États-Unis] ; Monica Anne Hamilton-Bruce [Australie] ; Jordi Jimenez-Conde [Espagne] ; John W. Cole [États-Unis] ; Reinhold Schmidt [Autriche] ; Agnieszka Słowik [Pologne] ; Robin Lemmens [Belgique] ; Arne Lindgren [Suède] ; Olle Melander [Suède] ; Raji P. Grewal [États-Unis] ; Ralph L. Sacco [États-Unis] ; Tatjana Rundek [États-Unis] ; Kathryn Rexrode [États-Unis] ; Donna K. Arnett [États-Unis] ; Julie A. Johnson [États-Unis] ; Oscar R. Benavente [Canada] ; Sylvia Wasssertheil-Smoller [États-Unis] ; Jin-Moo Lee [États-Unis] ; Sara L. Pulit [Pays-Bas] ; Quenna Wong [États-Unis] ; Stephen S. Rich [États-Unis] ; Paul I W. De Bakker [Pays-Bas] ; Patrick F. Mcardle [États-Unis] ; Daniel Woo [États-Unis] ; Christopher D. Anderson [États-Unis] ; Huichun Xu [États-Unis] ; Laura Heitsch [États-Unis] ; Myriam Fornage [États-Unis] ; Christina Jern [Suède] ; Kari Stefansson [Islande] ; Unnur Thorsteinsdottir [Islande] ; Solveig Gretarsdottir [États-Unis] ; Cathryn M. Lewis [Royaume-Uni] ; Pankaj Sharma [Royaume-Uni] ; Cathie L M. Sudlow [Royaume-Uni] ; Peter M. Rothwell [Royaume-Uni] ; Giorgio B. Boncoraglio [Italie] ; Vincent Thijs [États-Unis] ; Chris Levi [Australie] ; James F. Meschia [États-Unis] ; Jonathan Rosand [États-Unis] ; Steven J. Kittner [États-Unis] ; Braxton D. Mitchell [États-Unis] ; Martin Dichgans [Allemagne] ; Bradford B. Worrall [États-Unis] ; Hugh S. Markus [Royaume-Uni]Source :
- Annals of neurology [ 1531-8249 ] ; 2017.
Descripteurs français
- KwdFr :
- Accident vasculaire cérébral (génétique), Accident vasculaire cérébral lacunaire (génétique), Adulte, Adulte d'âge moyen, Chromosomes humains de la paire 16 (génétique), Doigts de zinc (génétique), Femelle, Humains, Locus génétiques, Maladies des petits vaisseaux cérébraux (génétique), Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Variation génétique, Étude d'association pangénomique.
- MESH :
- génétique : Accident vasculaire cérébral, Accident vasculaire cérébral lacunaire, Chromosomes humains de la paire 16, Doigts de zinc, Maladies des petits vaisseaux cérébraux.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Locus génétiques, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Variation génétique, Étude d'association pangénomique.
English descriptors
- KwdEn :
- MESH :
Abstract
Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises one quarter of all ischemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits have shown that younger-onset cases have an increased genetic burden. We leveraged this increased genetic burden by performing an age-at-onset informed GWAS meta-analysis, including a large younger-onset SVS population, to identify novel associations with stroke.
DOI: 10.1002/ana.24840
PubMed: 27997041
Affiliations:
- Allemagne, Australie, Autriche, Belgique, Canada, Espagne, France, Islande, Italie, Pays-Bas, Pologne, Royaume-Uni, Suède, États-Unis
- Angleterre, Angleterre de l'Est, Aquitaine, Bavière, Caroline du Nord, Catalogne, District de Haute-Bavière, Floride, Grand Londres, Hollande-Méridionale, Kentucky, Maryland, Massachusetts, Missouri (État), New Jersey, Nouvelle-Aquitaine, Ohio, Oxfordshire, Pennsylvanie, Texas, Utrecht (province), Virginie, Washington (État), Écosse, État de New York
- Barcelone, Bordeaux, Cambridge, Londres, Munich, Oxford, Rotterdam, Utrecht, Édimbourg
- Université Louis-et-Maximilien de Munich, Université d'Oxford, Université d'Édimbourg, Université de Cambridge
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Le document en format XML
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Nalls</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Cotlarciuc, Ioana" sort="Cotlarciuc, Ioana" uniqKey="Cotlarciuc I" first="Ioana" last="Cotlarciuc">Ioana Cotlarciuc</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cardiovascular Research Royal Holloway University of London (ICR2UL), London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Research Royal Holloway University of London (ICR2UL), London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Radmanesh, Farid" sort="Radmanesh, Farid" uniqKey="Radmanesh F" first="Farid" last="Radmanesh">Farid Radmanesh</name><affiliation wicri:level="2"><nlm:affiliation>Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics/AMGEN, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics/AMGEN, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Hanscombe, Ken B" sort="Hanscombe, Ken B" uniqKey="Hanscombe K" first="Ken B" last="Hanscombe">Ken B. 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Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Yet, Idil" sort="Yet, Idil" uniqKey="Yet I" first="Idil" last="Yet">Idil Yet</name><affiliation wicri:level="3"><nlm:affiliation>Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research & Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. 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Bis</name><affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W T" last="Longstreth">W T Longstreth</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Epidemiology, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Neurology and Epidemiology, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Epidemiology and Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Epidemiology and Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><nlm:affiliation>Boston University School of Medicine, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University School of Medicine, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Hamilton Bruce, Monica Anne" sort="Hamilton Bruce, Monica Anne" uniqKey="Hamilton Bruce M" first="Monica Anne" last="Hamilton-Bruce">Monica Anne Hamilton-Bruce</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Jimenez Conde, Jordi" sort="Jimenez Conde, Jordi" uniqKey="Jimenez Conde J" first="Jordi" last="Jimenez-Conde">Jordi Jimenez-Conde</name><affiliation wicri:level="3"><nlm:affiliation>Neurovascular Research Group (NEUVAS), Neurology Department, Institut Hospital del Mar d'Investigació Mèdica, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurovascular Research Group (NEUVAS), Neurology Department, Institut Hospital del Mar d'Investigació Mèdica, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cole, John W" sort="Cole, John W" uniqKey="Cole J" first="John W" last="Cole">John W. Cole</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Slowik, Agnieszka" sort="Slowik, Agnieszka" uniqKey="Slowik A" first="Agnieszka" last="Słowik">Agnieszka Słowik</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Jagiellonian University, Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Jagiellonian University, Krakow</wicri:regionArea><wicri:noRegion>Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Lemmens, Robin" sort="Lemmens, Robin" uniqKey="Lemmens R" first="Robin" last="Lemmens">Robin Lemmens</name><affiliation wicri:level="1"><nlm:affiliation>KU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>KU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Lindgren, Arne" sort="Lindgren, Arne" uniqKey="Lindgren A" first="Arne" last="Lindgren">Arne Lindgren</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences Lund, Neurology, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, Lund University, Malmö, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Grewal, Raji P" sort="Grewal, Raji P" uniqKey="Grewal R" first="Raji P" last="Grewal">Raji P. Grewal</name><affiliation wicri:level="2"><nlm:affiliation>Neuroscience Institute, Saint Francis Medical Center, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Neuroscience Institute, Saint Francis Medical Center, School of Health and Medical Sciences, Seton Hall University, South Orange</wicri:cityArea></affiliation></author><author><name sortKey="Sacco, Ralph L" sort="Sacco, Ralph L" uniqKey="Sacco R" first="Ralph L" last="Sacco">Ralph L. Sacco</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Miller School of Medicine, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Rundek, Tatjana" sort="Rundek, Tatjana" uniqKey="Rundek T" first="Tatjana" last="Rundek">Tatjana Rundek</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Miller School of Medicine, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Rexrode, Kathryn" sort="Rexrode, Kathryn" uniqKey="Rexrode K" first="Kathryn" last="Rexrode">Kathryn Rexrode</name><affiliation wicri:level="2"><nlm:affiliation>Harvard Medical School, Boston, MA, Center for Faculty Development and Diversity, Brigham and Women's Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard Medical School, Boston, MA, Center for Faculty Development and Diversity, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Arnett, Donna K" sort="Arnett, Donna K" uniqKey="Arnett D" first="Donna K" last="Arnett">Donna K. Arnett</name><affiliation wicri:level="2"><nlm:affiliation>College of Public Health, University of Kentucky, Lexington, KY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>College of Public Health, University of Kentucky, Lexington</wicri:cityArea></affiliation></author><author><name sortKey="Johnson, Julie A" sort="Johnson, Julie A" uniqKey="Johnson J" first="Julie A" last="Johnson">Julie A. Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville, FL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Benavente, Oscar R" sort="Benavente, Oscar R" uniqKey="Benavente O" first="Oscar R" last="Benavente">Oscar R. Benavente</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Wasssertheil Smoller, Sylvia" sort="Wasssertheil Smoller, Sylvia" uniqKey="Wasssertheil Smoller S" first="Sylvia" last="Wasssertheil-Smoller">Sylvia Wasssertheil-Smoller</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Jin Moo" sort="Lee, Jin Moo" uniqKey="Lee J" first="Jin-Moo" last="Lee">Jin-Moo Lee</name><affiliation wicri:level="2"><nlm:affiliation>Stroke Center, Department of Neurology, Washington University School of Medicine, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Stroke Center, Department of Neurology, Washington University School of Medicine, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Pulit, Sara L" sort="Pulit, Sara L" uniqKey="Pulit S" first="Sara L" last="Pulit">Sara L. Pulit</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Wong, Quenna" sort="Wong, Quenna" uniqKey="Wong Q" first="Quenna" last="Wong">Quenna Wong</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Biostatistics, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Rich, Stephen S" sort="Rich, Stephen S" uniqKey="Rich S" first="Stephen S" last="Rich">Stephen S. Rich</name><affiliation wicri:level="2"><nlm:affiliation>Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I W" last="De Bakker">Paul I W. De Bakker</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Mcardle, Patrick F" sort="Mcardle, Patrick F" uniqKey="Mcardle P" first="Patrick F" last="Mcardle">Patrick F. Mcardle</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Medicine, University of Maryland School of Medicine</wicri:cityArea></affiliation></author><author><name sortKey="Woo, Daniel" sort="Woo, Daniel" uniqKey="Woo D" first="Daniel" last="Woo">Daniel Woo</name><affiliation wicri:level="2"><nlm:affiliation>University of Cincinnati College of Medicine, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>University of Cincinnati College of Medicine, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Anderson, Christopher D" sort="Anderson, Christopher D" uniqKey="Anderson C" first="Christopher D" last="Anderson">Christopher D. Anderson</name><affiliation wicri:level="2"><nlm:affiliation>Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Xu, Huichun" sort="Xu, Huichun" uniqKey="Xu H" first="Huichun" last="Xu">Huichun Xu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Heitsch, Laura" sort="Heitsch, Laura" uniqKey="Heitsch L" first="Laura" last="Heitsch">Laura Heitsch</name><affiliation wicri:level="2"><nlm:affiliation>Division of Emergency Medicine, Washington University School of Medicine, St Louis, MO.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Division of Emergency Medicine, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="2"><nlm:affiliation>The University of Texas Health Science Center at Houston, Houston, TX.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>The University of Texas Health Science Center at Houston, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Jern, Christina" sort="Jern, Christina" uniqKey="Jern C" first="Christina" last="Jern">Christina Jern</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics/AMGEN, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics/AMGEN, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics/AMGEN, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics/AMGEN, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation wicri:level="2"><nlm:affiliation>Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M" last="Lewis">Cathryn M. Lewis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical and Molecular Genetics, King's College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical and Molecular Genetics, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cardiovascular Research Royal Holloway University of London (ICR2UL), London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Research Royal Holloway University of London (ICR2UL), London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sudlow, Cathie L M" sort="Sudlow, Cathie L M" uniqKey="Sudlow C" first="Cathie L M" last="Sudlow">Cathie L M. Sudlow</name><affiliation wicri:level="4"><nlm:affiliation>Center for Clinical Brain Sciences & Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Clinical Brain Sciences & Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Rothwell, Peter M" sort="Rothwell, Peter M" uniqKey="Rothwell P" first="Peter M" last="Rothwell">Peter M. Rothwell</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B" last="Boncoraglio">Giorgio B. Boncoraglio</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Thijs, Vincent" sort="Thijs, Vincent" uniqKey="Thijs V" first="Vincent" last="Thijs">Vincent Thijs</name><affiliation wicri:level="2"><nlm:affiliation>Framingham Heart Study, Framingham, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham Heart Study, Framingham</wicri:cityArea></affiliation></author><author><name sortKey="Levi, Chris" sort="Levi, Chris" uniqKey="Levi C" first="Chris" last="Levi">Chris Levi</name><affiliation wicri:level="1"><nlm:affiliation>John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Meschia, James F" sort="Meschia, James F" uniqKey="Meschia J" first="James F" last="Meschia">James F. Meschia</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, FL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic Jacksonville, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation wicri:level="2"><nlm:affiliation>Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Kittner, Steven J" sort="Kittner, Steven J" uniqKey="Kittner S" first="Steven J" last="Kittner">Steven J. Kittner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Medicine, University of Maryland School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Worrall, Bradford B" sort="Worrall, Bradford B" uniqKey="Worrall B" first="Bradford B" last="Worrall">Bradford B. Worrall</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Departments of Neurology and Public Health Sciences, University of Virginia School of Medicine, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S" last="Markus">Hugh S. Markus</name><affiliation wicri:level="4"><nlm:affiliation>Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27997041</idno><idno type="pmid">27997041</idno><idno type="doi">10.1002/ana.24840</idno><idno type="wicri:Area/PubMed/Corpus">000F59</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000F59</idno><idno type="wicri:Area/PubMed/Curation">000F56</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000F56</idno><idno type="wicri:Area/PubMed/Checkpoint">000F56</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000F56</idno><idno type="wicri:Area/Ncbi/Merge">004065</idno><idno type="wicri:Area/Ncbi/Curation">004065</idno><idno type="wicri:Area/Ncbi/Checkpoint">004065</idno><idno type="wicri:Area/Main/Merge">000B67</idno><idno type="wicri:Area/Main/Curation">000B72</idno><idno type="wicri:Area/Main/Exploration">000B72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genetic variation at 16q24.2 is associated with small vessel stroke.</title><author><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical and Molecular Genetics, King's College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical and Molecular Genetics, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Malik, Rainer" sort="Malik, Rainer" uniqKey="Malik R" first="Rainer" last="Malik">Rainer Malik</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Nalls, Mike A" sort="Nalls, Mike A" uniqKey="Nalls M" first="Mike A" last="Nalls">Mike A. Nalls</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Neurogenetics, National Institute on Aging, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Cotlarciuc, Ioana" sort="Cotlarciuc, Ioana" uniqKey="Cotlarciuc I" first="Ioana" last="Cotlarciuc">Ioana Cotlarciuc</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cardiovascular Research Royal Holloway University of London (ICR2UL), London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Research Royal Holloway University of London (ICR2UL), London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Radmanesh, Farid" sort="Radmanesh, Farid" uniqKey="Radmanesh F" first="Farid" last="Radmanesh">Farid Radmanesh</name><affiliation wicri:level="2"><nlm:affiliation>Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Thorleifsson, Gudmar" sort="Thorleifsson, Gudmar" uniqKey="Thorleifsson G" first="Gudmar" last="Thorleifsson">Gudmar Thorleifsson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics/AMGEN, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics/AMGEN, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Hanscombe, Ken B" sort="Hanscombe, Ken B" uniqKey="Hanscombe K" first="Ken B" last="Hanscombe">Ken B. Hanscombe</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical and Molecular Genetics, King's College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical and Molecular Genetics, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Langefeld, Carl" sort="Langefeld, Carl" uniqKey="Langefeld C" first="Carl" last="Langefeld">Carl Langefeld</name><affiliation wicri:level="2"><nlm:affiliation>Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Saleheen, Danish" sort="Saleheen, Danish" uniqKey="Saleheen D" first="Danish" last="Saleheen">Danish Saleheen</name><affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia</wicri:cityArea></affiliation></author><author><name sortKey="Rost, Natalia S" sort="Rost, Natalia S" uniqKey="Rost N" first="Natalia S" last="Rost">Natalia S. Rost</name><affiliation wicri:level="2"><nlm:affiliation>J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Yet, Idil" sort="Yet, Idil" uniqKey="Yet I" first="Idil" last="Yet">Idil Yet</name><affiliation wicri:level="3"><nlm:affiliation>Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research & Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><affiliation wicri:level="3"><nlm:affiliation>Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research & Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Bell, Jordana T" sort="Bell, Jordana T" uniqKey="Bell J" first="Jordana T" last="Bell">Jordana T. Bell</name><affiliation wicri:level="3"><nlm:affiliation>Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Twin Research & Genetic Epidemiology, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Hannon, Eilis" sort="Hannon, Eilis" uniqKey="Hannon E" first="Eilis" last="Hannon">Eilis Hannon</name><affiliation wicri:level="1"><nlm:affiliation>University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Exeter Medical School, University of Exeter, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Mill, Jonathan" sort="Mill, Jonathan" uniqKey="Mill J" first="Jonathan" last="Mill">Jonathan Mill</name><affiliation wicri:level="1"><nlm:affiliation>University of Exeter Medical School, University of Exeter, Exeter, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>University of Exeter Medical School, University of Exeter, Exeter</wicri:regionArea><wicri:noRegion>Exeter</wicri:noRegion></affiliation></author><author><name sortKey="Chauhan, Ganesh" sort="Chauhan, Ganesh" uniqKey="Chauhan G" first="Ganesh" last="Chauhan">Ganesh Chauhan</name><affiliation wicri:level="3"><nlm:affiliation>Inserm Research Center for Epidemiology and Biostatistics (U897)-Team Neuroepidemiology, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm Research Center for Epidemiology and Biostatistics (U897)-Team Neuroepidemiology, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><affiliation wicri:level="3"><nlm:affiliation>Inserm Research Center for Epidemiology and Biostatistics (U897)-Team Neuroepidemiology, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Inserm Research Center for Epidemiology and Biostatistics (U897)-Team Neuroepidemiology, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W T" last="Longstreth">W T Longstreth</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Epidemiology, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Departments of Neurology and Epidemiology, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Epidemiology and Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Epidemiology and Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><affiliation wicri:level="2"><nlm:affiliation>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="2"><nlm:affiliation>Boston University School of Medicine, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Boston University School of Medicine, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Hamilton Bruce, Monica Anne" sort="Hamilton Bruce, Monica Anne" uniqKey="Hamilton Bruce M" first="Monica Anne" last="Hamilton-Bruce">Monica Anne Hamilton-Bruce</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia</wicri:regionArea><wicri:noRegion>South Australia</wicri:noRegion></affiliation></author><author><name sortKey="Jimenez Conde, Jordi" sort="Jimenez Conde, Jordi" uniqKey="Jimenez Conde J" first="Jordi" last="Jimenez-Conde">Jordi Jimenez-Conde</name><affiliation wicri:level="3"><nlm:affiliation>Neurovascular Research Group (NEUVAS), Neurology Department, Institut Hospital del Mar d'Investigació Mèdica, Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Neurovascular Research Group (NEUVAS), Neurology Department, Institut Hospital del Mar d'Investigació Mèdica, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Cole, John W" sort="Cole, John W" uniqKey="Cole J" first="John W" last="Cole">John W. Cole</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria.</nlm:affiliation><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz</wicri:regionArea><wicri:noRegion>Graz</wicri:noRegion></affiliation></author><author><name sortKey="Slowik, Agnieszka" sort="Slowik, Agnieszka" uniqKey="Slowik A" first="Agnieszka" last="Słowik">Agnieszka Słowik</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, Jagiellonian University, Krakow, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Neurology, Jagiellonian University, Krakow</wicri:regionArea><wicri:noRegion>Krakow</wicri:noRegion></affiliation></author><author><name sortKey="Lemmens, Robin" sort="Lemmens, Robin" uniqKey="Lemmens R" first="Robin" last="Lemmens">Robin Lemmens</name><affiliation wicri:level="1"><nlm:affiliation>KU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>KU Leuven-University of Leuven, Department of Neurosciences, Experimental Neurology and Leuven Research Institute for Neuroscience and Disease (LIND), Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Lindgren, Arne" sort="Lindgren, Arne" uniqKey="Lindgren A" first="Arne" last="Lindgren">Arne Lindgren</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences Lund, Neurology, Lund University, Lund, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences Lund, Neurology, Lund University, Lund</wicri:regionArea><wicri:noRegion>Lund</wicri:noRegion></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Sciences, Lund University, Malmö, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Clinical Sciences, Lund University, Malmö</wicri:regionArea><wicri:noRegion>Malmö</wicri:noRegion></affiliation></author><author><name sortKey="Grewal, Raji P" sort="Grewal, Raji P" uniqKey="Grewal R" first="Raji P" last="Grewal">Raji P. Grewal</name><affiliation wicri:level="2"><nlm:affiliation>Neuroscience Institute, Saint Francis Medical Center, School of Health and Medical Sciences, Seton Hall University, South Orange, NJ.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">New Jersey</region></placeName><wicri:cityArea>Neuroscience Institute, Saint Francis Medical Center, School of Health and Medical Sciences, Seton Hall University, South Orange</wicri:cityArea></affiliation></author><author><name sortKey="Sacco, Ralph L" sort="Sacco, Ralph L" uniqKey="Sacco R" first="Ralph L" last="Sacco">Ralph L. Sacco</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Miller School of Medicine, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Rundek, Tatjana" sort="Rundek, Tatjana" uniqKey="Rundek T" first="Tatjana" last="Rundek">Tatjana Rundek</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Miller School of Medicine, University of Miami, Miami</wicri:cityArea></affiliation></author><author><name sortKey="Rexrode, Kathryn" sort="Rexrode, Kathryn" uniqKey="Rexrode K" first="Kathryn" last="Rexrode">Kathryn Rexrode</name><affiliation wicri:level="2"><nlm:affiliation>Harvard Medical School, Boston, MA, Center for Faculty Development and Diversity, Brigham and Women's Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Harvard Medical School, Boston, MA, Center for Faculty Development and Diversity, Brigham and Women's Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Arnett, Donna K" sort="Arnett, Donna K" uniqKey="Arnett D" first="Donna K" last="Arnett">Donna K. Arnett</name><affiliation wicri:level="2"><nlm:affiliation>College of Public Health, University of Kentucky, Lexington, KY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>College of Public Health, University of Kentucky, Lexington</wicri:cityArea></affiliation></author><author><name sortKey="Johnson, Julie A" sort="Johnson, Julie A" uniqKey="Johnson J" first="Julie A" last="Johnson">Julie A. Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville, FL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, College of Pharmacy, Gainesville</wicri:cityArea></affiliation></author><author><name sortKey="Benavente, Oscar R" sort="Benavente, Oscar R" uniqKey="Benavente O" first="Oscar R" last="Benavente">Oscar R. Benavente</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology, University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Wasssertheil Smoller, Sylvia" sort="Wasssertheil Smoller, Sylvia" uniqKey="Wasssertheil Smoller S" first="Sylvia" last="Wasssertheil-Smoller">Sylvia Wasssertheil-Smoller</name><affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York</wicri:cityArea></affiliation></author><author><name sortKey="Lee, Jin Moo" sort="Lee, Jin Moo" uniqKey="Lee J" first="Jin-Moo" last="Lee">Jin-Moo Lee</name><affiliation wicri:level="2"><nlm:affiliation>Stroke Center, Department of Neurology, Washington University School of Medicine, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Stroke Center, Department of Neurology, Washington University School of Medicine, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Pulit, Sara L" sort="Pulit, Sara L" uniqKey="Pulit S" first="Sara L" last="Pulit">Sara L. Pulit</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Genetics, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Wong, Quenna" sort="Wong, Quenna" uniqKey="Wong Q" first="Quenna" last="Wong">Quenna Wong</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biostatistics, University of Washington, Seattle, WA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Washington (État)</region></placeName><wicri:cityArea>Department of Biostatistics, University of Washington, Seattle</wicri:cityArea></affiliation></author><author><name sortKey="Rich, Stephen S" sort="Rich, Stephen S" uniqKey="Rich S" first="Stephen S" last="Rich">Stephen S. Rich</name><affiliation wicri:level="2"><nlm:affiliation>Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I W" last="De Bakker">Paul I W. De Bakker</name><affiliation wicri:level="3"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht</wicri:regionArea><placeName><settlement type="city">Utrecht</settlement><region nuts="2" type="province">Utrecht (province)</region></placeName></affiliation></author><author><name sortKey="Mcardle, Patrick F" sort="Mcardle, Patrick F" uniqKey="Mcardle P" first="Patrick F" last="Mcardle">Patrick F. Mcardle</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Medicine, University of Maryland School of Medicine</wicri:cityArea></affiliation></author><author><name sortKey="Woo, Daniel" sort="Woo, Daniel" uniqKey="Woo D" first="Daniel" last="Woo">Daniel Woo</name><affiliation wicri:level="2"><nlm:affiliation>University of Cincinnati College of Medicine, Cincinnati, OH.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>University of Cincinnati College of Medicine, Cincinnati</wicri:cityArea></affiliation></author><author><name sortKey="Anderson, Christopher D" sort="Anderson, Christopher D" uniqKey="Anderson C" first="Christopher D" last="Anderson">Christopher D. Anderson</name><affiliation wicri:level="2"><nlm:affiliation>Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Xu, Huichun" sort="Xu, Huichun" uniqKey="Xu H" first="Huichun" last="Xu">Huichun Xu</name><affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Heitsch, Laura" sort="Heitsch, Laura" uniqKey="Heitsch L" first="Laura" last="Heitsch">Laura Heitsch</name><affiliation wicri:level="2"><nlm:affiliation>Division of Emergency Medicine, Washington University School of Medicine, St Louis, MO.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Missouri (État)</region></placeName><wicri:cityArea>Division of Emergency Medicine, Washington University School of Medicine, St Louis</wicri:cityArea></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="2"><nlm:affiliation>The University of Texas Health Science Center at Houston, Houston, TX.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>The University of Texas Health Science Center at Houston, Houston</wicri:cityArea></affiliation></author><author><name sortKey="Jern, Christina" sort="Jern, Christina" uniqKey="Jern C" first="Christina" last="Jern">Christina Jern</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics/AMGEN, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics/AMGEN, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Thorsteinsdottir, Unnur" sort="Thorsteinsdottir, Unnur" uniqKey="Thorsteinsdottir U" first="Unnur" last="Thorsteinsdottir">Unnur Thorsteinsdottir</name><affiliation wicri:level="1"><nlm:affiliation>deCODE genetics/AMGEN, Reykjavik, Iceland.</nlm:affiliation><country xml:lang="fr">Islande</country><wicri:regionArea>deCODE genetics/AMGEN, Reykjavik</wicri:regionArea><wicri:noRegion>Reykjavik</wicri:noRegion></affiliation></author><author><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><affiliation wicri:level="2"><nlm:affiliation>Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Caroline du Nord</region></placeName><wicri:cityArea>Center for Public Health Genomics and Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem</wicri:cityArea></affiliation></author><author><name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M" last="Lewis">Cathryn M. Lewis</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical and Molecular Genetics, King's College London, London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Medical and Molecular Genetics, King's College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Cardiovascular Research Royal Holloway University of London (ICR2UL), London, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Institute of Cardiovascular Research Royal Holloway University of London (ICR2UL), London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Sudlow, Cathie L M" sort="Sudlow, Cathie L M" uniqKey="Sudlow C" first="Cathie L M" last="Sudlow">Cathie L M. Sudlow</name><affiliation wicri:level="4"><nlm:affiliation>Center for Clinical Brain Sciences & Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Center for Clinical Brain Sciences & Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Rothwell, Peter M" sort="Rothwell, Peter M" uniqKey="Rothwell P" first="Peter M" last="Rothwell">Peter M. Rothwell</name><affiliation wicri:level="4"><nlm:affiliation>Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford</wicri:regionArea><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region><settlement type="city">Oxford</settlement></placeName><orgName type="university">Université d'Oxford</orgName></affiliation></author><author><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B" last="Boncoraglio">Giorgio B. Boncoraglio</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milano, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Cerebrovascular Diseases, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Thijs, Vincent" sort="Thijs, Vincent" uniqKey="Thijs V" first="Vincent" last="Thijs">Vincent Thijs</name><affiliation wicri:level="2"><nlm:affiliation>Framingham Heart Study, Framingham, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Framingham Heart Study, Framingham</wicri:cityArea></affiliation></author><author><name sortKey="Levi, Chris" sort="Levi, Chris" uniqKey="Levi C" first="Chris" last="Levi">Chris Levi</name><affiliation wicri:level="1"><nlm:affiliation>John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, Hunter Medical Research Institute and University of Newcastle, Newcastle, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Meschia, James F" sort="Meschia, James F" uniqKey="Meschia J" first="James F" last="Meschia">James F. Meschia</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, FL.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Floride</region></placeName><wicri:cityArea>Department of Neurology, Mayo Clinic Jacksonville, Jacksonville</wicri:cityArea></affiliation></author><author><name sortKey="Rosand, Jonathan" sort="Rosand, Jonathan" uniqKey="Rosand J" first="Jonathan" last="Rosand">Jonathan Rosand</name><affiliation wicri:level="2"><nlm:affiliation>Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston, MA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Kittner, Steven J" sort="Kittner, Steven J" uniqKey="Kittner S" first="Steven J" last="Kittner">Steven J. Kittner</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Neurology, University of Maryland School of Medicine and Baltimore VAMC, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. Mitchell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Maryland School of Medicine, Baltimore, MD.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Department of Medicine, University of Maryland School of Medicine, Baltimore</wicri:cityArea></affiliation></author><author><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University, Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians University, Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement><settlement type="city">Munich</settlement></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Worrall, Bradford B" sort="Worrall, Bradford B" uniqKey="Worrall B" first="Bradford B" last="Worrall">Bradford B. Worrall</name><affiliation wicri:level="2"><nlm:affiliation>Departments of Neurology and Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Virginie</region></placeName><wicri:cityArea>Departments of Neurology and Public Health Sciences, University of Virginia School of Medicine, Charlottesville</wicri:cityArea></affiliation></author><author><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S" last="Markus">Hugh S. Markus</name><affiliation wicri:level="4"><nlm:affiliation>Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Stroke Research Group, Division of Clinical Neurosciences, University of Cambridge, Cambridge</wicri:regionArea><orgName type="university">Université de Cambridge</orgName><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author></analytic><series><title level="j">Annals of neurology</title><idno type="eISSN">1531-8249</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cerebral Small Vessel Diseases (genetics)</term><term>Chromosomes, Human, Pair 16 (genetics)</term><term>Female</term><term>Genetic Loci</term><term>Genetic Variation</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Stroke (genetics)</term><term>Stroke, Lacunar (genetics)</term><term>Zinc Fingers (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Accident vasculaire cérébral (génétique)</term><term>Accident vasculaire cérébral lacunaire (génétique)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Chromosomes humains de la paire 16 (génétique)</term><term>Doigts de zinc (génétique)</term><term>Femelle</term><term>Humains</term><term>Locus génétiques</term><term>Maladies des petits vaisseaux cérébraux (génétique)</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Variation génétique</term><term>Étude d'association pangénomique</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Cerebral Small Vessel Diseases</term><term>Chromosomes, Human, Pair 16</term><term>Stroke</term><term>Stroke, Lacunar</term><term>Zinc Fingers</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Accident vasculaire cérébral</term><term>Accident vasculaire cérébral lacunaire</term><term>Chromosomes humains de la paire 16</term><term>Doigts de zinc</term><term>Maladies des petits vaisseaux cérébraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Genetic Loci</term><term>Genetic Variation</term><term>Genome-Wide Association Study</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Locus génétiques</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Variation génétique</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS comprises one quarter of all ischemic stroke and is a major manifestation of cerebral small vessel disease, the primary cause of vascular cognitive impairment. Studies across neurological traits have shown that younger-onset cases have an increased genetic burden. We leveraged this increased genetic burden by performing an age-at-onset informed GWAS meta-analysis, including a large younger-onset SVS population, to identify novel associations with stroke.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Autriche</li><li>Belgique</li><li>Canada</li><li>Espagne</li><li>France</li><li>Islande</li><li>Italie</li><li>Pays-Bas</li><li>Pologne</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Aquitaine</li><li>Bavière</li><li>Caroline du Nord</li><li>Catalogne</li><li>District de Haute-Bavière</li><li>Floride</li><li>Grand Londres</li><li>Hollande-Méridionale</li><li>Kentucky</li><li>Maryland</li><li>Massachusetts</li><li>Missouri (État)</li><li>New Jersey</li><li>Nouvelle-Aquitaine</li><li>Ohio</li><li>Oxfordshire</li><li>Pennsylvanie</li><li>Texas</li><li>Utrecht (province)</li><li>Virginie</li><li>Washington (État)</li><li>Écosse</li><li>État de New York</li></region><settlement><li>Barcelone</li><li>Bordeaux</li><li>Cambridge</li><li>Londres</li><li>Munich</li><li>Oxford</li><li>Rotterdam</li><li>Utrecht</li><li>Édimbourg</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li><li>Université d'Oxford</li><li>Université d'Édimbourg</li><li>Université de Cambridge</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Traylor, Matthew" sort="Traylor, Matthew" uniqKey="Traylor M" first="Matthew" last="Traylor">Matthew Traylor</name></region><name sortKey="Bell, Jordana T" sort="Bell, Jordana T" uniqKey="Bell J" first="Jordana T" last="Bell">Jordana T. Bell</name><name sortKey="Cotlarciuc, Ioana" sort="Cotlarciuc, Ioana" uniqKey="Cotlarciuc I" first="Ioana" last="Cotlarciuc">Ioana Cotlarciuc</name><name sortKey="Hannon, Eilis" sort="Hannon, Eilis" uniqKey="Hannon E" first="Eilis" last="Hannon">Eilis Hannon</name><name sortKey="Hanscombe, Ken B" sort="Hanscombe, Ken B" uniqKey="Hanscombe K" first="Ken B" last="Hanscombe">Ken B. Hanscombe</name><name sortKey="Lewis, Cathryn M" sort="Lewis, Cathryn M" uniqKey="Lewis C" first="Cathryn M" last="Lewis">Cathryn M. Lewis</name><name sortKey="Markus, Hugh S" sort="Markus, Hugh S" uniqKey="Markus H" first="Hugh S" last="Markus">Hugh S. Markus</name><name sortKey="Mill, Jonathan" sort="Mill, Jonathan" uniqKey="Mill J" first="Jonathan" last="Mill">Jonathan Mill</name><name sortKey="Rothwell, Peter M" sort="Rothwell, Peter M" uniqKey="Rothwell P" first="Peter M" last="Rothwell">Peter M. Rothwell</name><name sortKey="Sharma, Pankaj" sort="Sharma, Pankaj" uniqKey="Sharma P" first="Pankaj" last="Sharma">Pankaj Sharma</name><name sortKey="Spector, Tim D" sort="Spector, Tim D" uniqKey="Spector T" first="Tim D" last="Spector">Tim D. Spector</name><name sortKey="Sudlow, Cathie L M" sort="Sudlow, Cathie L M" uniqKey="Sudlow C" first="Cathie L M" last="Sudlow">Cathie L M. Sudlow</name><name sortKey="Yet, Idil" sort="Yet, Idil" uniqKey="Yet I" first="Idil" last="Yet">Idil Yet</name></country><country name="Allemagne"><region name="Bavière"><name sortKey="Malik, Rainer" sort="Malik, Rainer" uniqKey="Malik R" first="Rainer" last="Malik">Rainer Malik</name></region><name sortKey="Dichgans, Martin" sort="Dichgans, Martin" uniqKey="Dichgans M" first="Martin" last="Dichgans">Martin Dichgans</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Nalls, Mike A" sort="Nalls, Mike A" uniqKey="Nalls M" first="Mike A" last="Nalls">Mike A. Nalls</name></region><name sortKey="Anderson, Christopher D" sort="Anderson, Christopher D" uniqKey="Anderson C" first="Christopher D" last="Anderson">Christopher D. Anderson</name><name sortKey="Arnett, Donna K" sort="Arnett, Donna K" uniqKey="Arnett D" first="Donna K" last="Arnett">Donna K. Arnett</name><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name><name sortKey="Cole, John W" sort="Cole, John W" uniqKey="Cole J" first="John W" last="Cole">John W. Cole</name><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><name sortKey="Gretarsdottir, Solveig" sort="Gretarsdottir, Solveig" uniqKey="Gretarsdottir S" first="Solveig" last="Gretarsdottir">Solveig Gretarsdottir</name><name sortKey="Grewal, Raji P" sort="Grewal, Raji P" uniqKey="Grewal R" first="Raji P" last="Grewal">Raji P. Grewal</name><name sortKey="Heitsch, Laura" sort="Heitsch, Laura" uniqKey="Heitsch L" first="Laura" last="Heitsch">Laura Heitsch</name><name sortKey="Johnson, Julie A" sort="Johnson, Julie A" uniqKey="Johnson J" first="Julie A" last="Johnson">Julie A. Johnson</name><name sortKey="Kittner, Steven J" sort="Kittner, Steven J" uniqKey="Kittner S" first="Steven J" last="Kittner">Steven J. Kittner</name><name sortKey="Langefeld, Carl" sort="Langefeld, Carl" uniqKey="Langefeld C" first="Carl" last="Langefeld">Carl Langefeld</name><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name><name sortKey="Lee, Jin Moo" sort="Lee, Jin Moo" uniqKey="Lee J" first="Jin-Moo" last="Lee">Jin-Moo Lee</name><name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W T" last="Longstreth">W T Longstreth</name><name sortKey="Mcardle, Patrick F" sort="Mcardle, Patrick F" uniqKey="Mcardle P" first="Patrick F" last="Mcardle">Patrick F. Mcardle</name><name sortKey="Meschia, James F" sort="Meschia, James F" uniqKey="Meschia J" first="James F" last="Meschia">James F. Meschia</name><name sortKey="Mitchell, Braxton D" sort="Mitchell, Braxton D" uniqKey="Mitchell B" first="Braxton D" last="Mitchell">Braxton D. 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Sacco</name><name sortKey="Saleheen, Danish" sort="Saleheen, Danish" uniqKey="Saleheen D" first="Danish" last="Saleheen">Danish Saleheen</name><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><name sortKey="Thijs, Vincent" sort="Thijs, Vincent" uniqKey="Thijs V" first="Vincent" last="Thijs">Vincent Thijs</name><name sortKey="Wasssertheil Smoller, Sylvia" sort="Wasssertheil Smoller, Sylvia" uniqKey="Wasssertheil Smoller S" first="Sylvia" last="Wasssertheil-Smoller">Sylvia Wasssertheil-Smoller</name><name sortKey="Wong, Quenna" sort="Wong, Quenna" uniqKey="Wong Q" first="Quenna" last="Wong">Quenna Wong</name><name sortKey="Woo, Daniel" sort="Woo, Daniel" uniqKey="Woo D" first="Daniel" last="Woo">Daniel Woo</name><name sortKey="Worrall, Bradford B" sort="Worrall, Bradford B" uniqKey="Worrall B" first="Bradford B" last="Worrall">Bradford B. 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De Bakker</name><name sortKey="Pulit, Sara L" sort="Pulit, Sara L" uniqKey="Pulit S" first="Sara L" last="Pulit">Sara L. Pulit</name></country><country name="Australie"><noRegion><name sortKey="Hamilton Bruce, Monica Anne" sort="Hamilton Bruce, Monica Anne" uniqKey="Hamilton Bruce M" first="Monica Anne" last="Hamilton-Bruce">Monica Anne Hamilton-Bruce</name></noRegion><name sortKey="Levi, Chris" sort="Levi, Chris" uniqKey="Levi C" first="Chris" last="Levi">Chris Levi</name></country><country name="Espagne"><region name="Catalogne"><name sortKey="Jimenez Conde, Jordi" sort="Jimenez Conde, Jordi" uniqKey="Jimenez Conde J" first="Jordi" last="Jimenez-Conde">Jordi Jimenez-Conde</name></region></country><country name="Autriche"><noRegion><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Slowik, Agnieszka" sort="Slowik, Agnieszka" uniqKey="Slowik A" first="Agnieszka" last="Słowik">Agnieszka Słowik</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Lemmens, Robin" sort="Lemmens, Robin" uniqKey="Lemmens R" first="Robin" last="Lemmens">Robin Lemmens</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Lindgren, Arne" sort="Lindgren, Arne" uniqKey="Lindgren A" first="Arne" last="Lindgren">Arne Lindgren</name></noRegion><name sortKey="Jern, Christina" sort="Jern, Christina" uniqKey="Jern C" first="Christina" last="Jern">Christina Jern</name><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name></country><country name="Canada"><noRegion><name sortKey="Benavente, Oscar R" sort="Benavente, Oscar R" uniqKey="Benavente O" first="Oscar R" last="Benavente">Oscar R. Benavente</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Boncoraglio, Giorgio B" sort="Boncoraglio, Giorgio B" uniqKey="Boncoraglio G" first="Giorgio B" last="Boncoraglio">Giorgio B. Boncoraglio</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Genetic variation at 16q24.2 is associated with small vessel stroke.
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