The Treatment Effect of an ACE-Inhibitor Based Regimen with Perindopril in Relation to Beta-Blocker use in 29,463 Patients with Vascular Disease: a Combined Analysis of Individual Data of ADVANCE, EUROPA and PROGRESS Trials
Identifieur interne : 000251 ( Main/Exploration ); précédent : 000250; suivant : 000252The Treatment Effect of an ACE-Inhibitor Based Regimen with Perindopril in Relation to Beta-Blocker use in 29,463 Patients with Vascular Disease: a Combined Analysis of Individual Data of ADVANCE, EUROPA and PROGRESS Trials
Auteurs : J. J. Brugts [Pays-Bas] ; M. Bertrand [France] ; W. Remme [Pays-Bas] ; R. Ferrari ; K. Fox [Royaume-Uni] ; S. Macmahon ; J. Chalmers ; M. L. Simoons [Pays-Bas] ; E. Boersma [Pays-Bas]Source :
- Cardiovascular Drugs and Therapy [ 0920-3206 ] ; 2017.
Abstract
In everyday practice, angiotensin converting enzyme inhibitors and beta-blockers are cornerstone treatments in patients with (cardio-)vascular disease. Clear data that evaluate the effects of the combination of these agents on morbidity and mortality are lacking.
In this retrospective pooled analysis of three large perindopril outcome trials (ADVANCE, EUROPA, PROGRESS), clinical outcomes were evaluated in 29,463 patients with vascular disease. Multivariate Cox regression analyses were performed in patients randomized to a perindopril-based regimen or placebo (treatment effect), and data were stratified according to background beta-blocker treatment. The primary endpoint was a composite of cardiovascular mortality, non-fatal myocardial infarction, and stroke.
The cumulative incidence of the primary endpoint over mean follow-up of 4.0 years (Sd 1.0) was significantly lower in the beta-blocker/perindopril group (9.6%; 545/5700 patients) as compared to beta-blocker/placebo (11.8%; 676/5718 patients) (
These data suggest that the beneficial cardioprotective effects of perindopril treatment are additive to the background beta-blockers use.
Url:
DOI: 10.1007/s10557-017-6747-9
PubMed: 28856537
PubMed Central: 5607906
Affiliations:
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J." last="Brugts">J. J. Brugts</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">000000040459992X</institution-id><institution-id institution-id-type="GRID">grid.5645.2</institution-id><institution>Department of Cardiology,</institution><institution>Erasmus University Medical Center, Thoraxcenter,</institution></institution-wrap>‘s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>‘s-Gravendijkwal 230, 3015 CE Rotterdam</wicri:regionArea><wicri:noRegion>3015 CE Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Bertrand, M" sort="Bertrand, M" uniqKey="Bertrand M" first="M." last="Bertrand">M. Bertrand</name><affiliation wicri:level="3"><nlm:aff id="Aff2">Institut CŒUR Poumon, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut CŒUR Poumon, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Remme, W" sort="Remme, W" uniqKey="Remme W" first="W." last="Remme">W. Remme</name><affiliation wicri:level="1"><nlm:aff id="Aff3">STICARES Cardiovascular Research Institute, Rhoon, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>STICARES Cardiovascular Research Institute, Rhoon</wicri:regionArea><wicri:noRegion>Rhoon</wicri:noRegion></affiliation></author><author><name sortKey="Ferrari, R" sort="Ferrari, R" uniqKey="Ferrari R" first="R." last="Ferrari">R. Ferrari</name><affiliation><nlm:aff id="Aff4">Centro Cardiologico Universitario University of Ferrara, Italy and Maria Cecilia Hospital, GVM Care & Research, E.S. Health Science Foundation, Cotignola, Ravenna Italy</nlm:aff><wicri:noCountry code="subfield">Ravenna Italy</wicri:noCountry></affiliation></author><author><name sortKey="Fox, K" sort="Fox, K" uniqKey="Fox K" first="K." last="Fox">K. Fox</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.439338.6</institution-id><institution>NHLI, Imperial College and ICMS,</institution><institution>Royal Brompton Hospital,</institution></institution-wrap>London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Macmahon, S" sort="Macmahon, S" uniqKey="Macmahon S" first="S." last="Macmahon">S. Macmahon</name><affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0385 0051</institution-id><institution-id institution-id-type="GRID">grid.413249.9</institution-id><institution>The George Institute for Global Health,</institution><institution>The Royal Prince Alfred Hospital and the University of Sydney,</institution></institution-wrap>Sydney, New South Wales Australia</nlm:aff><wicri:noCountry code="subfield">New South Wales Australia</wicri:noCountry></affiliation></author><author><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0385 0051</institution-id><institution-id institution-id-type="GRID">grid.413249.9</institution-id><institution>The George Institute for Global Health,</institution><institution>The Royal Prince Alfred Hospital and the University of Sydney,</institution></institution-wrap>Sydney, New South Wales Australia</nlm:aff><wicri:noCountry code="subfield">New South Wales Australia</wicri:noCountry></affiliation></author><author><name sortKey="Simoons, M L" sort="Simoons, M L" uniqKey="Simoons M" first="M. L." last="Simoons">M. L. Simoons</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">000000040459992X</institution-id><institution-id institution-id-type="GRID">grid.5645.2</institution-id><institution>Department of Cardiology,</institution><institution>Erasmus University Medical Center, Thoraxcenter,</institution></institution-wrap>‘s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>‘s-Gravendijkwal 230, 3015 CE Rotterdam</wicri:regionArea><wicri:noRegion>3015 CE Rotterdam</wicri:noRegion></affiliation></author><author><name sortKey="Boersma, E" sort="Boersma, E" uniqKey="Boersma E" first="E." last="Boersma">E. Boersma</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">000000040459992X</institution-id><institution-id institution-id-type="GRID">grid.5645.2</institution-id><institution>Department of Cardiology,</institution><institution>Erasmus University Medical Center, Thoraxcenter,</institution></institution-wrap>‘s-Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>‘s-Gravendijkwal 230, 3015 CE Rotterdam</wicri:regionArea><wicri:noRegion>3015 CE Rotterdam</wicri:noRegion></affiliation></author></analytic><series><title level="j">Cardiovascular Drugs and Therapy</title><idno type="ISSN">0920-3206</idno><idno type="eISSN">1573-7241</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction</title><p id="Par1">In everyday practice, angiotensin converting enzyme inhibitors and beta-blockers are cornerstone treatments in patients with (cardio-)vascular disease. Clear data that evaluate the effects of the combination of these agents on morbidity and mortality are lacking.</p></sec><sec><title>Methods</title><p id="Par2">In this retrospective pooled analysis of three large perindopril outcome trials (ADVANCE, EUROPA, PROGRESS), clinical outcomes were evaluated in 29,463 patients with vascular disease. Multivariate Cox regression analyses were performed in patients randomized to a perindopril-based regimen or placebo (treatment effect), and data were stratified according to background beta-blocker treatment. The primary endpoint was a composite of cardiovascular mortality, non-fatal myocardial infarction, and stroke.</p></sec><sec><title>Results</title><p id="Par3">The cumulative incidence of the primary endpoint over mean follow-up of 4.0 years (Sd 1.0) was significantly lower in the beta-blocker/perindopril group (9.6%; 545/5700 patients) as compared to beta-blocker/placebo (11.8%; 676/5718 patients) (<italic>p</italic> < 0.01). Adding perindopril to existing beta-blocker treatment reduced the relative risk of the primary endpoint by 20% (hazard ratio (HR) 0.80; 95% confidence interval (CI) 0.71–0.90), non-fatal myocardial infarction by 23% (HR 0.77; 95% CI 0.65–0.91), and all-cause mortality by 22% (HR 0.78; 95% CI 0.68–0.88) as compared to placebo. Significant treatment benefit was not observed for stroke (HR 0.93; 95% CI 0.75–1.15). Significance was maintained for the primary endpoint and cardiovascular endpoints when data were further stratified by baseline hypertension. However, the mortality benefit was only observed in patients with hypertension with background beta-blocker use.</p></sec><sec><title>Conclusions</title><p id="Par4">These data suggest that the beneficial cardioprotective effects of perindopril treatment are additive to the background beta-blockers use.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mancia, G" uniqKey="Mancia G">G Mancia</name></author><author><name sortKey="Fagard, R" uniqKey="Fagard R">R Fagard</name></author><author><name sortKey="Narkiewicz, K" uniqKey="Narkiewicz K">K Narkiewicz</name></author><author><name sortKey="Redon, J" uniqKey="Redon J">J Redon</name></author><author><name sortKey="Zanchetti, A" uniqKey="Zanchetti A">A Zanchetti</name></author><author><name sortKey="Bohm, M" uniqKey="Bohm M">M Bohm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosendorff, C" uniqKey="Rosendorff C">C Rosendorff</name></author><author><name sortKey="Lackland, Dt" uniqKey="Lackland D">DT Lackland</name></author><author><name sortKey="Allison, M" uniqKey="Allison M">M Allison</name></author><author><name sortKey="Aronow, Ws" uniqKey="Aronow W">WS Aronow</name></author><author><name sortKey="Black, Hr" uniqKey="Black H">HR Black</name></author><author><name sortKey="Blumenthal, Rs" uniqKey="Blumenthal R">RS Blumenthal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ponikowski, P" uniqKey="Ponikowski P">P Ponikowski</name></author><author><name sortKey="Voors, Aa" uniqKey="Voors A">AA Voors</name></author><author><name sortKey="Anker, Sd" uniqKey="Anker S">SD Anker</name></author><author><name sortKey="Bueno, H" uniqKey="Bueno H">H Bueno</name></author><author><name sortKey="Cleland, Jg" uniqKey="Cleland J">JG Cleland</name></author><author><name sortKey="Coats, Aj" uniqKey="Coats A">AJ Coats</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thoenes, M" uniqKey="Thoenes M">M Thoenes</name></author><author><name sortKey="Neuberger, Hr" uniqKey="Neuberger H">HR Neuberger</name></author><author><name sortKey="Volpe, M" uniqKey="Volpe M">M Volpe</name></author><author><name sortKey="Khan, Bv" uniqKey="Khan B">BV Khan</name></author><author><name sortKey="Kirch, W" uniqKey="Kirch W">W Kirch</name></author><author><name sortKey="Bohm, M" uniqKey="Bohm M">M Bohm</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kotseva, K" uniqKey="Kotseva K">K Kotseva</name></author><author><name sortKey="Wood, D" uniqKey="Wood D">D Wood</name></author><author><name sortKey="De Bacquer, D" uniqKey="De Bacquer D">D De Bacquer</name></author><author><name sortKey="De Backer, G" uniqKey="De Backer G">G De Backer</name></author><author><name sortKey="Ryden, L" uniqKey="Ryden L">L Ryden</name></author><author><name sortKey="Jennings, C" uniqKey="Jennings C">C Jennings</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maggioni, Ap" uniqKey="Maggioni A">AP Maggioni</name></author><author><name sortKey="Anker, Sd" uniqKey="Anker S">SD Anker</name></author><author><name sortKey="Dahlstrom, U" uniqKey="Dahlstrom U">U Dahlstrom</name></author><author><name sortKey="Filippatos, G" uniqKey="Filippatos G">G Filippatos</name></author><author><name sortKey="Ponikowski, P" uniqKey="Ponikowski P">P Ponikowski</name></author><author><name sortKey="Zannad, F" uniqKey="Zannad F">F Zannad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Pj" uniqKey="Anderson P">PJ Anderson</name></author><author><name sortKey="Critchley, Ja" uniqKey="Critchley J">JA Critchley</name></author><author><name sortKey="Tomlinson, B" uniqKey="Tomlinson B">B Tomlinson</name></author><author><name sortKey="Resplandy, G" uniqKey="Resplandy G">G Resplandy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nedogoda, Sv" uniqKey="Nedogoda S">SV Nedogoda</name></author><author><name sortKey="Ledyaeva, Aa" uniqKey="Ledyaeva A">AA Ledyaeva</name></author><author><name sortKey="Chumachok, Ev" uniqKey="Chumachok E">EV Chumachok</name></author><author><name sortKey="Tsoma, Vv" uniqKey="Tsoma V">VV Tsoma</name></author><author><name sortKey="Mazina, G" uniqKey="Mazina G">G Mazina</name></author><author><name sortKey="Salasyuk, As" uniqKey="Salasyuk A">AS Salasyuk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taddei, S" uniqKey="Taddei S">S Taddei</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fox, Km" uniqKey="Fox K">KM Fox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patel, A" uniqKey="Patel A">A Patel</name></author><author><name sortKey="Macmahon, S" uniqKey="Macmahon S">S MacMahon</name></author><author><name sortKey="Chalmers, J" uniqKey="Chalmers J">J Chalmers</name></author><author><name sortKey="Neal, B" uniqKey="Neal B">B Neal</name></author><author><name sortKey="Woodward, M" uniqKey="Woodward M">M Woodward</name></author><author><name sortKey="Billot, L" uniqKey="Billot L">L Billot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brugts, Jj" uniqKey="Brugts J">JJ Brugts</name></author><author><name sortKey="Ninomiya, T" uniqKey="Ninomiya T">T Ninomiya</name></author><author><name sortKey="Boersma, E" uniqKey="Boersma E">E Boersma</name></author><author><name sortKey="Remme, Wj" uniqKey="Remme W">WJ Remme</name></author><author><name sortKey="Bertrand, M" uniqKey="Bertrand M">M Bertrand</name></author><author><name sortKey="Ferrari, R" uniqKey="Ferrari R">R Ferrari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bertrand, Me" uniqKey="Bertrand M">ME Bertrand</name></author><author><name sortKey="Ferrari, R" uniqKey="Ferrari R">R Ferrari</name></author><author><name sortKey="Remme, Wj" uniqKey="Remme W">WJ Remme</name></author><author><name sortKey="Simoons, Ml" uniqKey="Simoons M">ML Simoons</name></author><author><name sortKey="Fox, Km" uniqKey="Fox K">KM Fox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raposeiras Roubin, S" uniqKey="Raposeiras Roubin S">S Raposeiras-Roubin</name></author><author><name sortKey="Abu Assi, E" uniqKey="Abu Assi E">E Abu-Assi</name></author><author><name sortKey="Redondo Dieguez, A" uniqKey="Redondo Dieguez A">A Redondo-Dieguez</name></author><author><name sortKey="Gonzalez Ferreiro, R" uniqKey="Gonzalez Ferreiro R">R Gonzalez-Ferreiro</name></author><author><name sortKey="Lopez Lopez, A" uniqKey="Lopez Lopez A">A Lopez-Lopez</name></author><author><name sortKey="Bouzas Cruz, N" uniqKey="Bouzas Cruz N">N Bouzas-Cruz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Law, Mr" uniqKey="Law M">MR Law</name></author><author><name sortKey="Morris, Jk" uniqKey="Morris J">JK Morris</name></author><author><name sortKey="Wald, Nj" uniqKey="Wald N">NJ Wald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Yuan, X" uniqKey="Yuan X">X Yuan</name></author><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Hua, K" uniqKey="Hua K">K Hua</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Choo, Eh" uniqKey="Choo E">EH Choo</name></author><author><name sortKey="Chang, K" uniqKey="Chang K">K Chang</name></author><author><name sortKey="Ahn, Y" uniqKey="Ahn Y">Y Ahn</name></author><author><name sortKey="Jeon, Ds" uniqKey="Jeon D">DS Jeon</name></author><author><name sortKey="Lee, Jm" uniqKey="Lee J">JM Lee</name></author><author><name sortKey="Kim, Db" uniqKey="Kim D">DB Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brugts, Jj" uniqKey="Brugts J">JJ Brugts</name></author><author><name sortKey="Den Uil, Ca" uniqKey="Den Uil C">CA den Uil</name></author><author><name sortKey="Danser, Ahj" uniqKey="Danser A">AHJ Danser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brugts, Jj" uniqKey="Brugts J">JJ Brugts</name></author><author><name sortKey="Van Vark, L" uniqKey="Van Vark L">L van Vark</name></author><author><name sortKey="Akkerhuis, M" uniqKey="Akkerhuis M">M Akkerhuis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kernis, Sj" uniqKey="Kernis S">SJ Kernis</name></author><author><name sortKey="Harjai, Kj" uniqKey="Harjai K">KJ Harjai</name></author><author><name sortKey="Stone, Gw" uniqKey="Stone G">GW Stone</name></author><author><name sortKey="Grines, Ll" uniqKey="Grines L">LL Grines</name></author><author><name sortKey="Boura, Ja" uniqKey="Boura J">JA Boura</name></author><author><name sortKey="O Neill, Ww" uniqKey="O Neill W">WW O'Neill</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Vark, Lc" uniqKey="Van Vark L">LC van Vark</name></author><author><name sortKey="Bertrand, M" uniqKey="Bertrand M">M Bertrand</name></author><author><name sortKey="Akkerhuis, Km" uniqKey="Akkerhuis K">KM Akkerhuis</name></author><author><name sortKey="Brugts, Jj" uniqKey="Brugts J">JJ Brugts</name></author><author><name sortKey="Fox, K" uniqKey="Fox K">K Fox</name></author><author><name sortKey="Mourad, Jj" uniqKey="Mourad J">JJ Mourad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsoi, Kk" uniqKey="Tsoi K">KK Tsoi</name></author><author><name sortKey="Wong, Mc" uniqKey="Wong M">MC Wong</name></author><author><name sortKey="Tam, Ww" uniqKey="Tam W">WW Tam</name></author><author><name sortKey="Hirai, Hw" uniqKey="Hirai H">HW Hirai</name></author><author><name sortKey="Lao, Xq" uniqKey="Lao X">XQ Lao</name></author><author><name sortKey="Wang, Hh" uniqKey="Wang H">HH Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Savarese, G" uniqKey="Savarese G">G Savarese</name></author><author><name sortKey="Costanzo, P" uniqKey="Costanzo P">P Costanzo</name></author><author><name sortKey="Cleland, Jg" uniqKey="Cleland J">JG Cleland</name></author><author><name sortKey="Vassallo, E" uniqKey="Vassallo E">E Vassallo</name></author><author><name sortKey="Ruggiero, D" uniqKey="Ruggiero D">D Ruggiero</name></author><author><name sortKey="Rosano, G" uniqKey="Rosano G">G Rosano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gainer, Jv" uniqKey="Gainer J">JV Gainer</name></author><author><name sortKey="Morrow, Jd" uniqKey="Morrow J">JD Morrow</name></author><author><name sortKey="Loveland, A" uniqKey="Loveland A">A Loveland</name></author><author><name sortKey="King, Dj" uniqKey="King D">DJ King</name></author><author><name sortKey="Brown, Nj" uniqKey="Brown N">NJ Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ceconi, C" uniqKey="Ceconi C">C Ceconi</name></author><author><name sortKey="Francolini, G" uniqKey="Francolini G">G Francolini</name></author><author><name sortKey="Olivares, A" uniqKey="Olivares A">A Olivares</name></author><author><name sortKey="Comini, L" uniqKey="Comini L">L Comini</name></author><author><name sortKey="Bachetti, T" uniqKey="Bachetti T">T Bachetti</name></author><author><name sortKey="Ferrari, R" uniqKey="Ferrari R">R Ferrari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oeseburg, H" uniqKey="Oeseburg H">H Oeseburg</name></author><author><name sortKey="Iusuf, D" uniqKey="Iusuf D">D Iusuf</name></author><author><name sortKey="Van Der Harst, P" uniqKey="Van Der Harst P">P van der Harst</name></author><author><name sortKey="Van Gilst, Wh" uniqKey="Van Gilst W">WH van Gilst</name></author><author><name sortKey="Henning, Rh" uniqKey="Henning R">RH Henning</name></author><author><name sortKey="Roks, Aj" uniqKey="Roks A">AJ Roks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murphey, Lj" uniqKey="Murphey L">LJ Murphey</name></author><author><name sortKey="Malave, Ha" uniqKey="Malave H">HA Malave</name></author><author><name sortKey="Petro, J" uniqKey="Petro J">J Petro</name></author><author><name sortKey="Biaggioni, I" uniqKey="Biaggioni I">I Biaggioni</name></author><author><name sortKey="Byrne, Dw" uniqKey="Byrne D">DW Byrne</name></author><author><name sortKey="Vaughan, De" uniqKey="Vaughan D">DE Vaughan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chao, J" uniqKey="Chao J">J Chao</name></author><author><name sortKey="Li, Hj" uniqKey="Li H">HJ Li</name></author><author><name sortKey="Yao, Yy" uniqKey="Yao Y">YY Yao</name></author><author><name sortKey="Shen, B" uniqKey="Shen B">B Shen</name></author><author><name sortKey="Gao, L" uniqKey="Gao L">L Gao</name></author><author><name sortKey="Bledsoe, G" uniqKey="Bledsoe G">G Bledsoe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ceconi, C" uniqKey="Ceconi C">C Ceconi</name></author><author><name sortKey="Fox, Km" uniqKey="Fox K">KM Fox</name></author><author><name sortKey="Remme, Wj" uniqKey="Remme W">WJ Remme</name></author><author><name sortKey="Simoons, Ml" uniqKey="Simoons M">ML Simoons</name></author><author><name sortKey="Bertrand, M" uniqKey="Bertrand M">M Bertrand</name></author><author><name sortKey="Parrinello, G" uniqKey="Parrinello G">G Parrinello</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ceconi, C" uniqKey="Ceconi C">C Ceconi</name></author><author><name sortKey="Francolini, G" uniqKey="Francolini G">G Francolini</name></author><author><name sortKey="Bastianon, D" uniqKey="Bastianon D">D Bastianon</name></author><author><name sortKey="Gitti, Gl" uniqKey="Gitti G">GL Gitti</name></author><author><name sortKey="Comini, L" uniqKey="Comini L">L Comini</name></author><author><name sortKey="Ferrari, R" uniqKey="Ferrari R">R Ferrari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Madej, A" uniqKey="Madej A">A Madej</name></author><author><name sortKey="Buldak, L" uniqKey="Buldak L">L Buldak</name></author><author><name sortKey="Basiak, M" uniqKey="Basiak M">M Basiak</name></author><author><name sortKey="Szkrobka, W" uniqKey="Szkrobka W">W Szkrobka</name></author><author><name sortKey="Dulawa, A" uniqKey="Dulawa A">A Dulawa</name></author><author><name sortKey="Okopien, B" uniqKey="Okopien B">B Okopien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsoukas, G" uniqKey="Tsoukas G">G Tsoukas</name></author><author><name sortKey="Anand, S" uniqKey="Anand S">S Anand</name></author><author><name sortKey="Yang, K" uniqKey="Yang K">K Yang</name></author><author><name sortKey="Investigators, C" uniqKey="Investigators C">C Investigators</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ho, Pm" uniqKey="Ho P">PM Ho</name></author><author><name sortKey="Magid, Dj" uniqKey="Magid D">DJ Magid</name></author><author><name sortKey="Shetterly, Sm" uniqKey="Shetterly S">SM Shetterly</name></author><author><name sortKey="Olson, Kl" uniqKey="Olson K">KL Olson</name></author><author><name sortKey="Maddox, Tm" uniqKey="Maddox T">TM Maddox</name></author><author><name sortKey="Peterson, Pn" uniqKey="Peterson P">PN Peterson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chowdhury, R" uniqKey="Chowdhury R">R Chowdhury</name></author><author><name sortKey="Khan, H" uniqKey="Khan H">H Khan</name></author><author><name sortKey="Heydon, E" uniqKey="Heydon E">E Heydon</name></author><author><name sortKey="Shroufi, A" uniqKey="Shroufi A">A Shroufi</name></author><author><name sortKey="Fahimi, S" uniqKey="Fahimi S">S Fahimi</name></author><author><name sortKey="Moore, C" uniqKey="Moore C">C Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simpson, Sh" uniqKey="Simpson S">SH Simpson</name></author><author><name sortKey="Eurich, Dt" uniqKey="Eurich D">DT Eurich</name></author><author><name sortKey="Majumdar, Sr" uniqKey="Majumdar S">SR Majumdar</name></author><author><name sortKey="Padwal, Rs" uniqKey="Padwal R">RS Padwal</name></author><author><name sortKey="Tsuyuki, Rt" uniqKey="Tsuyuki R">RT Tsuyuki</name></author><author><name sortKey="Varney, J" uniqKey="Varney J">J Varney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piepoli, Mf" uniqKey="Piepoli M">MF Piepoli</name></author><author><name sortKey="Hoes, Aw" uniqKey="Hoes A">AW Hoes</name></author><author><name sortKey="Agewall, S" uniqKey="Agewall S">S Agewall</name></author><author><name sortKey="Albus, C" uniqKey="Albus C">C Albus</name></author><author><name sortKey="Brotons, C" uniqKey="Brotons C">C Brotons</name></author><author><name sortKey="Catapano, Al" uniqKey="Catapano A">AL Catapano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Egan, Bm" uniqKey="Egan B">BM Egan</name></author><author><name sortKey="Bandyopadhyay, D" uniqKey="Bandyopadhyay D">D Bandyopadhyay</name></author><author><name sortKey="Shaftman, Sr" uniqKey="Shaftman S">SR Shaftman</name></author><author><name sortKey="Wagner, Cs" uniqKey="Wagner C">CS Wagner</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name></author><author><name sortKey="Yu Isenberg, Ks" uniqKey="Yu Isenberg K">KS Yu-Isenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belsey, Jd" uniqKey="Belsey J">JD Belsey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davidov, Me" uniqKey="Davidov M">ME Davidov</name></author><author><name sortKey="Singh, Sp" uniqKey="Singh S">SP Singh</name></author><author><name sortKey="Vlachakis, Nd" uniqKey="Vlachakis N">ND Vlachakis</name></author><author><name sortKey="Blumenthal, Jb" uniqKey="Blumenthal J">JB Blumenthal</name></author><author><name sortKey="Simon, Js" uniqKey="Simon J">JS Simon</name></author><author><name sortKey="Bryzinski, Bs" uniqKey="Bryzinski B">BS Bryzinski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nuttall, Sl" uniqKey="Nuttall S">SL Nuttall</name></author><author><name sortKey="Routledge, Hc" uniqKey="Routledge H">HC Routledge</name></author><author><name sortKey="Kendall, Mj" uniqKey="Kendall M">MJ Kendall</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Dahlof, B" uniqKey="Dahlof B">B Dahlöf</name></author><author><name sortKey="Sever, Ps" uniqKey="Sever P">PS Sever</name></author><author><name sortKey="Poulter, Nr" uniqKey="Poulter N">NR Poulter</name></author><author><name sortKey="Wedel, H" uniqKey="Wedel H">H Wedel</name></author><author><name sortKey="Beevers, Dg" uniqKey="Beevers D">DG Beevers</name></author><author><name sortKey="Caulfield, M" uniqKey="Caulfield M">M Caulfield</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brugts, Jj" uniqKey="Brugts J">JJ Brugts</name></author><author><name sortKey="De Maat, Mpm" uniqKey="De Maat M">MPM de Maat</name></author><author><name sortKey="Boersma, E" uniqKey="Boersma E">E Boersma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brugts, Jj" uniqKey="Brugts J">JJ Brugts</name></author><author><name sortKey="Hisatomi, A" uniqKey="Hisatomi A">A Hisatomi</name></author><author><name sortKey="Remme, W" uniqKey="Remme W">W Remme</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Holmer, Sr" uniqKey="Holmer S">SR Holmer</name></author><author><name sortKey="Hense, Hw" uniqKey="Hense H">HW Hense</name></author><author><name sortKey="Danser, Ah" uniqKey="Danser A">AH Danser</name></author><author><name sortKey="Mayer, B" uniqKey="Mayer B">B Mayer</name></author><author><name sortKey="Riegger, Ga" uniqKey="Riegger G">GA Riegger</name></author><author><name sortKey="Schunkert, H" uniqKey="Schunkert H">H Schunkert</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>Pays-Bas</li><li>Royaume-Uni</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement></list><tree><noCountry><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><name sortKey="Ferrari, R" sort="Ferrari, R" uniqKey="Ferrari R" first="R." last="Ferrari">R. Ferrari</name><name sortKey="Macmahon, S" sort="Macmahon, S" uniqKey="Macmahon S" first="S." last="Macmahon">S. Macmahon</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Brugts, J J" sort="Brugts, J J" uniqKey="Brugts J" first="J. J." last="Brugts">J. J. Brugts</name></noRegion><name sortKey="Boersma, E" sort="Boersma, E" uniqKey="Boersma E" first="E." last="Boersma">E. Boersma</name><name sortKey="Remme, W" sort="Remme, W" uniqKey="Remme W" first="W." last="Remme">W. Remme</name><name sortKey="Simoons, M L" sort="Simoons, M L" uniqKey="Simoons M" first="M. L." last="Simoons">M. L. Simoons</name></country><country name="France"><region name="Hauts-de-France"><name sortKey="Bertrand, M" sort="Bertrand, M" uniqKey="Bertrand M" first="M." last="Bertrand">M. Bertrand</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Fox, K" sort="Fox, K" uniqKey="Fox K" first="K." last="Fox">K. Fox</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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