AustralieFrV1, Main, Curation, bibRecord, 00D414

Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep

Identifieur interne : 00D414 ( Main/Curation ); précédent : 00D413; suivant : 00D415

Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep

Auteurs : Deborah A. Witherden [Australie] ; Nevin J. Abernethy [France] ; Wayne G. Kimpton [Nouvelle-Zélande] ; Ross N. P. Cahill [Nouvelle-Zélande]

Source :

Developmental Immunology [ 1044-6672 ] ; 1995.

RBID : PMC:2275959

Abstract

We have compared the expression of CD2, CD11a/CD18, CD44, and CD58 on αβ and γδT cells emigrating from the fetal and postnatal thymus. We report that both γδ and the CD4⁺ CD8^- and CD4^-CD8⁺ subsets of αβ T cells express mature levels of the adhesion molecules CD11a/CD18, CD44, and CD58 upon emigration from the thymus. Whereas CD44 is up-regulated on γδ⁺ thymocytes prior to export, down-regulation of both CD11a/CD18 and CD58 occurs prior to emigration from the thymus, suggesting that down-regulation of these molecules may be a final maturational step taken by developing γδ T cells before their export from the thymus. In contrast, there is continued up-regulation of CD2 on αβ and γδ T cells upon emigration from the thymus and as they move into the mature peripheral T-cell pool. There was also a marked reduction in the number of CD2⁺γδ T cells exported during fetal development that was associated with a marked reduction in the percentage of CD2²⁺ γδ thymocytes exported. The postthymic maturation of CD2 and the other changes in adhesion-molecule expression appear to be independent of extrinsic antigen, as the same changes were observed in the antigen-free environment of the fetus as in the postnatal lamb, which has been exposed to extrinsic antigen. It thus appears that these changes in adhesion-molecule expression are as a result of the normal maturation pathway from a developing thymocyte to a mature peripheral T cell.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275959

DOI: 10.1155/1995/35075
PubMed: 8770559
PubMed Central: 2275959

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PMC:2275959

Le document en format XML

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<author><name sortKey="Witherden, Deborah A" sort="Witherden, Deborah A" uniqKey="Witherden D" first="Deborah A." last="Witherden">Deborah A. Witherden</name>
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<front><div type="abstract" xml:lang="en"><p>We have compared the expression of CD2, CD11a/CD18, CD44, and CD58 on <italic>αβ</italic>
 and <italic>γδ</italic>
T cells emigrating from the fetal and postnatal thymus. We report that both <italic>γδ</italic> and the
CD4<sup>+</sup>
 CD8<sup>-</sup>
 and CD4<sup>-</sup>
CD8<sup>+</sup>
 subsets of <italic>αβ</italic> T cells express mature levels of the adhesion
molecules CD11a/CD18, CD44, and CD58 upon emigration from the thymus. Whereas
CD44 is up-regulated on <italic>γδ</italic>
<sup>+</sup> thymocytes prior to export, down-regulation of both
CD11a/CD18 and CD58 occurs prior to emigration from the thymus, suggesting that
down-regulation of these molecules may be a final maturational step taken by developing
<italic>γδ</italic> T cells before their export from the thymus. In contrast, there is continued up-regulation
of CD2 on <italic>αβ</italic>
 and <italic>γδ</italic> T cells upon emigration from the thymus and as they move into the
mature peripheral T-cell pool. There was also a marked reduction in the number of CD2<sup>+</sup>
<italic>γδ</italic> T cells exported during fetal development that was associated with a marked reduction
in the percentage of CD2<sup>2+</sup>
 <italic>γδ</italic> thymocytes exported. The postthymic maturation of CD2 and
the other changes in adhesion-molecule expression appear to be independent of extrinsic
antigen, as the same changes were observed in the antigen-free environment of the fetus
as in the postnatal lamb, which has been exposed to extrinsic antigen. It thus appears that
these changes in adhesion-molecule expression are as a result of the normal maturation
pathway from a developing thymocyte to a mature peripheral T cell.</p>
</div>
</front>
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Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep

Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep

Source :

Abstract

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Links to Exploration step

Le document en format XML

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