AustralieFrV1, Ncbi, Merge, bibRecord, 005241

Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep

Identifieur interne : 005241 ( Ncbi/Merge ); précédent : 005240; suivant : 005242

Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep

Auteurs : Deborah A. Witherden [Australie] ; Nevin J. Abernethy [France] ; Wayne G. Kimpton [Nouvelle-Zélande] ; Ross N. P. Cahill [Nouvelle-Zélande]

Source :

Developmental Immunology [ 1044-6672 ] ; 1995.

RBID : PMC:2275959

Abstract

We have compared the expression of CD2, CD11a/CD18, CD44, and CD58 on αβ and γδT cells emigrating from the fetal and postnatal thymus. We report that both γδ and the CD4⁺ CD8^- and CD4^-CD8⁺ subsets of αβ T cells express mature levels of the adhesion molecules CD11a/CD18, CD44, and CD58 upon emigration from the thymus. Whereas CD44 is up-regulated on γδ⁺ thymocytes prior to export, down-regulation of both CD11a/CD18 and CD58 occurs prior to emigration from the thymus, suggesting that down-regulation of these molecules may be a final maturational step taken by developing γδ T cells before their export from the thymus. In contrast, there is continued up-regulation of CD2 on αβ and γδ T cells upon emigration from the thymus and as they move into the mature peripheral T-cell pool. There was also a marked reduction in the number of CD2⁺γδ T cells exported during fetal development that was associated with a marked reduction in the percentage of CD2²⁺ γδ thymocytes exported. The postthymic maturation of CD2 and the other changes in adhesion-molecule expression appear to be independent of extrinsic antigen, as the same changes were observed in the antigen-free environment of the fetus as in the postnatal lamb, which has been exposed to extrinsic antigen. It thus appears that these changes in adhesion-molecule expression are as a result of the normal maturation pathway from a developing thymocyte to a mature peripheral T cell.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275959

DOI: 10.1155/1995/35075
PubMed: 8770559
PubMed Central: 2275959

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Le document en format XML

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<author><name sortKey="Witherden, Deborah A" sort="Witherden, Deborah A" uniqKey="Witherden D" first="Deborah A." last="Witherden">Deborah A. Witherden</name>
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<addr-line>The University of Melbourne</addr-line>
<addr-line>Cnr. Flemington Road and Park Drive</addr-line>
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<addr-line>3052</addr-line>
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<author><name sortKey="Abernethy, Nevin J" sort="Abernethy, Nevin J" uniqKey="Abernethy N" first="Nevin J." last="Abernethy">Nevin J. Abernethy</name>
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<author><name sortKey="Kimpton, Wayne G" sort="Kimpton, Wayne G" uniqKey="Kimpton W" first="Wayne G." last="Kimpton">Wayne G. Kimpton</name>
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<author><name sortKey="Witherden, Deborah A" sort="Witherden, Deborah A" uniqKey="Witherden D" first="Deborah A." last="Witherden">Deborah A. Witherden</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Laboratory for Foetal and Neonatal Immunology</addr-line>
<addr-line>The University of Melbourne</addr-line>
<addr-line>Cnr. Flemington Road and Park Drive</addr-line>
<addr-line>Parkville</addr-line>
<addr-line>Victoria</addr-line>
<addr-line>3052</addr-line>
<country>Australia</country>
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<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Abernethy, Nevin J" sort="Abernethy, Nevin J" uniqKey="Abernethy N" first="Nevin J." last="Abernethy">Nevin J. Abernethy</name>
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<addr-line>67404</addr-line>
<country>France</country>
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<country xml:lang="fr">France</country>
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<author><name sortKey="Kimpton, Wayne G" sort="Kimpton, Wayne G" uniqKey="Kimpton W" first="Wayne G." last="Kimpton">Wayne G. Kimpton</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Molecular Medicine</addr-line>
<addr-line>University of Auckland</addr-line>
<country>New Zealand</country>
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<country xml:lang="fr">Nouvelle-Zélande</country>
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<author><name sortKey="Cahill, Ross N P" sort="Cahill, Ross N P" uniqKey="Cahill R" first="Ross N. P." last="Cahill">Ross N. P. Cahill</name>
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<front><div type="abstract" xml:lang="en"><p>We have compared the expression of CD2, CD11a/CD18, CD44, and CD58 on <italic>αβ</italic>
 and <italic>γδ</italic>
T cells emigrating from the fetal and postnatal thymus. We report that both <italic>γδ</italic> and the
CD4<sup>+</sup>
 CD8<sup>-</sup>
 and CD4<sup>-</sup>
CD8<sup>+</sup>
 subsets of <italic>αβ</italic> T cells express mature levels of the adhesion
molecules CD11a/CD18, CD44, and CD58 upon emigration from the thymus. Whereas
CD44 is up-regulated on <italic>γδ</italic>
<sup>+</sup> thymocytes prior to export, down-regulation of both
CD11a/CD18 and CD58 occurs prior to emigration from the thymus, suggesting that
down-regulation of these molecules may be a final maturational step taken by developing
<italic>γδ</italic> T cells before their export from the thymus. In contrast, there is continued up-regulation
of CD2 on <italic>αβ</italic>
 and <italic>γδ</italic> T cells upon emigration from the thymus and as they move into the
mature peripheral T-cell pool. There was also a marked reduction in the number of CD2<sup>+</sup>
<italic>γδ</italic> T cells exported during fetal development that was associated with a marked reduction
in the percentage of CD2<sup>2+</sup>
 <italic>γδ</italic> thymocytes exported. The postthymic maturation of CD2 and
the other changes in adhesion-molecule expression appear to be independent of extrinsic
antigen, as the same changes were observed in the antigen-free environment of the fetus
as in the postnatal lamb, which has been exposed to extrinsic antigen. It thus appears that
these changes in adhesion-molecule expression are as a result of the normal maturation
pathway from a developing thymocyte to a mature peripheral T cell.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Dev Immunol</journal-id>
<journal-title>Developmental Immunology</journal-title>
<issn pub-type="ppub">1044-6672</issn>
<publisher><publisher-name>Hindawi Publishing Corporation</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">8770559</article-id>
<article-id pub-id-type="pmc">2275959</article-id>
<article-id pub-id-type="pii">S1740252295350755</article-id>
<article-id pub-id-type="doi">10.1155/1995/35075</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Witherden</surname>
<given-names>Deborah A.</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Abernethy</surname>
<given-names>Nevin J.</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kimpton</surname>
<given-names>Wayne G.</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Cahill</surname>
<given-names>Ross N. P.</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<addr-line>Laboratory for Foetal and Neonatal Immunology</addr-line>
<addr-line>The University of Melbourne</addr-line>
<addr-line>Cnr. Flemington Road and Park Drive</addr-line>
<addr-line>Parkville</addr-line>
<addr-line>Victoria</addr-line>
<addr-line>3052</addr-line>
<country>Australia</country>
</aff>
<aff id="aff2"><label>2</label>
<addr-line>IGBMC</addr-line>
<addr-line>BP163</addr-line>
<addr-line>Illkirch Cedex</addr-line>
<addr-line>C.U. de Strasbourg</addr-line>
<addr-line>67404</addr-line>
<country>France</country>
</aff>
<aff id="aff3"><label>3</label>
<addr-line>Department of Molecular Medicine</addr-line>
<addr-line>University of Auckland</addr-line>
<country>New Zealand</country>
</aff>
<pub-date pub-type="ppub"><year>1995</year>
</pub-date>
<volume>4</volume>
<issue>3</issue>
<fpage>199</fpage>
<lpage>209</lpage>
<history><date date-type="received"><day>20</day>
<month>10</month>
<year>1995</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 1995 Hindawi Publishing Corporation.</copyright-statement>
<copyright-year>1995</copyright-year>
<copyright-holder>Hindawi Publishing Corporation</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/"><p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p>
</license>
</permissions>
<abstract><p>We have compared the expression of CD2, CD11a/CD18, CD44, and CD58 on <italic>αβ</italic>
 and <italic>γδ</italic>
T cells emigrating from the fetal and postnatal thymus. We report that both <italic>γδ</italic> and the
CD4<sup>+</sup>
 CD8<sup>-</sup>
 and CD4<sup>-</sup>
CD8<sup>+</sup>
 subsets of <italic>αβ</italic> T cells express mature levels of the adhesion
molecules CD11a/CD18, CD44, and CD58 upon emigration from the thymus. Whereas
CD44 is up-regulated on <italic>γδ</italic>
<sup>+</sup> thymocytes prior to export, down-regulation of both
CD11a/CD18 and CD58 occurs prior to emigration from the thymus, suggesting that
down-regulation of these molecules may be a final maturational step taken by developing
<italic>γδ</italic> T cells before their export from the thymus. In contrast, there is continued up-regulation
of CD2 on <italic>αβ</italic>
 and <italic>γδ</italic> T cells upon emigration from the thymus and as they move into the
mature peripheral T-cell pool. There was also a marked reduction in the number of CD2<sup>+</sup>
<italic>γδ</italic> T cells exported during fetal development that was associated with a marked reduction
in the percentage of CD2<sup>2+</sup>
 <italic>γδ</italic> thymocytes exported. The postthymic maturation of CD2 and
the other changes in adhesion-molecule expression appear to be independent of extrinsic
antigen, as the same changes were observed in the antigen-free environment of the fetus
as in the postnatal lamb, which has been exposed to extrinsic antigen. It thus appears that
these changes in adhesion-molecule expression are as a result of the normal maturation
pathway from a developing thymocyte to a mature peripheral T cell.</p>
</abstract>
<kwd-group><kwd>Thymic emigrants</kwd>
<kwd>CD2</kwd>
<kwd>CD11a/18</kwd>
<kwd>CD44</kwd>
<kwd>CD58</kwd>
<kwd>fetal</kwd>
<kwd><italic>γδ</italic>
 T cells</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Australie</li>
<li>France</li>
<li>Nouvelle-Zélande</li>
</country>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Witherden, Deborah A" sort="Witherden, Deborah A" uniqKey="Witherden D" first="Deborah A." last="Witherden">Deborah A. Witherden</name>
</noRegion>
</country>
<country name="France"><noRegion><name sortKey="Abernethy, Nevin J" sort="Abernethy, Nevin J" uniqKey="Abernethy N" first="Nevin J." last="Abernethy">Nevin J. Abernethy</name>
</noRegion>
</country>
<country name="Nouvelle-Zélande"><noRegion><name sortKey="Kimpton, Wayne G" sort="Kimpton, Wayne G" uniqKey="Kimpton W" first="Wayne G." last="Kimpton">Wayne G. Kimpton</name>
</noRegion>
<name sortKey="Cahill, Ross N P" sort="Cahill, Ross N P" uniqKey="Cahill R" first="Ross N. P." last="Cahill">Ross N. P. Cahill</name>
</country>
</tree>
</affiliations>
</record>

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Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep

Antigen-Independent Maturation of CD2, CD11a/CD18, CD44, and CD58 Expression on Thymic Emigrants in Fetal and Postnatal Sheep

Source :

Abstract

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