AustralieFrV1, Main, Curation, bibRecord, 005D83

Common variants at 12ql4 and 12q24 are associated with hippocampal volume

Identifieur interne : 005D83 ( Main/Curation ); précédent : 005D82; suivant : 005D84

Common variants at 12ql4 and 12q24 are associated with hippocampal volume

Auteurs : Joshua C. Bis [États-Unis] ; Charles Decarli [États-Unis] ; Albert Vernon Smith [Islande] ; Fedde Van Der Lijn [Pays-Bas] ; Fabrice Crivello [France] ; Myriam Fornage [États-Unis] ; Stephanie Debette [France, États-Unis] ; Joshua M. Shulman [États-Unis] ; Helena Schmidt [Autriche] ; Velandai Srikanth [Australie] ; Maaike Schuur [Pays-Bas] ; LEI YU [États-Unis] ; Seung-Hoan Choi [États-Unis] ; Sigurdur Sigurdsson [Islande] ; Benjamin F. J. Verhaaren [Pays-Bas] ; Anita L. Destefano [États-Unis] ; Jean-Charles Lambert ; Clifford R. Jr Jack ; Maksim Struchalin [Pays-Bas] ; Jim Stankovich [Australie] ; Carla A. Ibrahim-Verbaas [Pays-Bas] ; Debra Fleischman [États-Unis] ; Alex Zijdenbos ; Tom Den Heijer [Pays-Bas] ; Bernard Mazoyer [France] ; Laura H. Coker ; Christian Enzinger ; Patrick Danoy ; Najaf Amin [Pays-Bas] ; Konstantinos Arfanakis [États-Unis] ; Mark A. Van Buchem ; Renée F. A G. De Bruijn [Pays-Bas] ; Alexa Beiser [États-Unis] ; Carole Dufouil [France] ; JUEBIN HUANG ; Margherita Cavalieri ; Russell Thomson [Australie] ; Wiro J. Niessen [Pays-Bas] ; Lori B. Chibnik [États-Unis] ; Gauti K. Gislason [Islande] ; Albert Hofman [Pays-Bas] ; Aleksandra Pikula [États-Unis] ; Philippe Amouyel ; Kevin B. Freeman ; Thanh G. Phan [Australie] ; Ben A. Oostra [Pays-Bas] ; Jason L. Stein ; Sarah E. Medland ; Alejandro Arias Vasquez ; Derrek P. Hibar ; Margaret J. Wright ; Barbara Franke ; Nicholas G. Martin ; Paul M. Thompson ; Michael A. Nalls ; Andre G. Uitterlinden ; Rhoda Au [États-Unis] ; Alexis Elbaz [France] ; Richard J. Beare [Australie] ; John C. Van Swieten [Pays-Bas]

Source :

Nature genetics [ 1061-4036 ] ; 2012.

RBID : Pascal:12-0224070

Descripteurs français

Pascal (Inist)
- Variant.

English descriptors

KwdEn :
- Variant.

Abstract

Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 x 10^-7. In two additional samples (n = 2,318), associations were replicated at 12q14 within MSR83-WIF1 (discovery and replication; rs17178006; P = 5.3 × 10^-11) and at 12q24 near HRK-FBXW8 (rs7294919; P = 2.9 x 10^-11). Remaining associations included one SNP at 2q24 within DPP4 (rs6741949; P = 2.9 × 10^-7) and nine SNPs at 9p33 within ASTN2 (rs7852872; P = 1.0 × 10^-7); along with the chromosome 12 associations, these loci were also associated with hippocampal volume (P < 0.05) in a third younger, more heterogeneous sample (n = 7,794). The SNP in ASTN2 also showed suggestive association with decline in cognition in a largely independent sample (n =1,563). These associations implicate genes related to apoptosis (HRK), development (WIF1), oxidative stress (MSR3B), ubiquitination (FBXWB) and neuronal migration (ASTN2), as well as enzymes targeted by new diabetes medications (DPP4), indicating new genetic influences on hippocampal size and possibly the risk of cognitive decline and dementia.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427729

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001369
to stream PascalFrancis, to step Curation: Pour aller vers cette notice dans l'étape Curation :004B45
to stream PascalFrancis, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001265
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :006100
to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002E13
to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :002C63
to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :002011
to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000D78
to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :000D78
to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000D78
to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :005688

Links to Exploration step

Pascal:12-0224070

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Common variants at 12ql4 and 12q24 are associated with hippocampal volume</title>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of California, Davis</s1>
<s2>Sacramento, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Center of Neuroscience, University of California, Davis</s1>
<s2>Sacramento, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1>
<s2>Kopavogur</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Icelandic Heart Association</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Faculty of Medicine, University of Iceland</s1>
<s2>Reykjavik</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Der Lijn, Fedde Van" sort="Der Lijn, Fedde Van" uniqKey="Der Lijn F" first="Fedde Van" last="Der Lijn">Fedde Van Der Lijn</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurofunctional Imaging Group, University of Bordeaux, Unité Mixte de Recherche (UMR) 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Neurofunctional Imaging Group, Centre National de la Recherche Scientifique (CNRS), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Neurofunctional Imaging Group, Commissariat à l'Energie Atomique (CEA), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Human Genetics Center, School of Public Health, The University of Texas Health Sciences Center at Houston</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Epidemiology, University of Versailles Saint-Quentin-en-Yvelines</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Institute of Molecular Biology and Biochemistry, Medical University Graz</s1>
<s2>Graz</s2>
<s3>AUT</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>59 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1>
<s2>Hobart, Tasmania</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Hobart, Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schuur, Maaike" sort="Schuur, Maaike" uniqKey="Schuur M" first="Maaike" last="Schuur">Maaike Schuur</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lei Yu" sort="Lei Yu" uniqKey="Lei Yu" last="Lei Yu">LEI YU</name>
<affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name>
<affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1>
<s2>Kopavogur</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Icelandic Heart Association</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Verhaaren, Benjamin F J" sort="Verhaaren, Benjamin F J" uniqKey="Verhaaren B" first="Benjamin F. J." last="Verhaaren">Benjamin F. J. Verhaaren</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
</author>
<author><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name>
</author>
<author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stankovich, Jim" sort="Stankovich, Jim" uniqKey="Stankovich J" first="Jim" last="Stankovich">Jim Stankovich</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1>
<s2>Hobart, Tasmania</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Hobart, Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name>
<affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name>
</author>
<author><name sortKey="Heijer, Tom Den" sort="Heijer, Tom Den" uniqKey="Heijer T" first="Tom Den" last="Heijer">Tom Den Heijer</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurofunctional Imaging Group, University of Bordeaux, Unité Mixte de Recherche (UMR) 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Neurofunctional Imaging Group, Centre National de la Recherche Scientifique (CNRS), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Neurofunctional Imaging Group, Commissariat à l'Energie Atomique (CEA), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name>
</author>
<author><name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name>
</author>
<author><name sortKey="Danoy, Patrick" sort="Danoy, Patrick" uniqKey="Danoy P" first="Patrick" last="Danoy">Patrick Danoy</name>
</author>
<author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name>
<affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buchem, Mark A Van" sort="Buchem, Mark A Van" uniqKey="Buchem M" first="Mark A. Van" last="Buchem">Mark A. Van Buchem</name>
</author>
<author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A G." last="De Bruijn">Renée F. A G. De Bruijn</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Juebin Huang" sort="Juebin Huang" uniqKey="Juebin Huang" last="Juebin Huang">JUEBIN HUANG</name>
</author>
<author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name>
</author>
<author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1>
<s2>Hobart, Tasmania</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Hobart, Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gislason, Gauti K" sort="Gislason, Gauti K" uniqKey="Gislason G" first="Gauti K." last="Gislason">Gauti K. Gislason</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1>
<s2>Kopavogur</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Icelandic Heart Association</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pikula, Aleksandra" sort="Pikula, Aleksandra" uniqKey="Pikula A" first="Aleksandra" last="Pikula">Aleksandra Pikula</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
</author>
<author><name sortKey="Freeman, Kevin B" sort="Freeman, Kevin B" uniqKey="Freeman K" first="Kevin B." last="Freeman">Kevin B. Freeman</name>
</author>
<author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G." last="Phan">Thanh G. Phan</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>59 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stein, Jason L" sort="Stein, Jason L" uniqKey="Stein J" first="Jason L." last="Stein">Jason L. Stein</name>
</author>
<author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name>
</author>
<author><name sortKey="Arias Vasquez, Alejandro" sort="Arias Vasquez, Alejandro" uniqKey="Arias Vasquez A" first="Alejandro" last="Arias Vasquez">Alejandro Arias Vasquez</name>
</author>
<author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name>
</author>
<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name>
</author>
<author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
</author>
<author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
</author>
<author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J." last="Beare">Richard J. Beare</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>59 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Swieten, John C Van" sort="Swieten, John C Van" uniqKey="Swieten J" first="John C. Van" last="Swieten">John C. Van Swieten</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0224070</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0224070 INIST</idno>
<idno type="RBID">Pascal:12-0224070</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001369</idno>
<idno type="wicri:Area/PascalFrancis/Curation">004B45</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001265</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001265</idno>
<idno type="wicri:doubleKey">1061-4036:2012:Bis J:common:variants:at</idno>
<idno type="wicri:Area/Main/Merge">006100</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427729</idno>
<idno type="RBID">PMC:3427729</idno>
<idno type="wicri:Area/Pmc/Corpus">002E13</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E13</idno>
<idno type="wicri:Area/Pmc/Curation">002C63</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C63</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002011</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002011</idno>
<idno type="wicri:Area/Ncbi/Merge">000D78</idno>
<idno type="wicri:Area/Ncbi/Curation">000D78</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000D78</idno>
<idno type="wicri:doubleKey">1061-4036:2012:Bis J:common:variants:at</idno>
<idno type="wicri:Area/Main/Merge">005688</idno>
<idno type="wicri:Area/Main/Curation">005D83</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Common variants at 12ql4 and 12q24 are associated with hippocampal volume</title>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of California, Davis</s1>
<s2>Sacramento, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Center of Neuroscience, University of California, Davis</s1>
<s2>Sacramento, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1>
<s2>Kopavogur</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Icelandic Heart Association</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Faculty of Medicine, University of Iceland</s1>
<s2>Reykjavik</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Der Lijn, Fedde Van" sort="Der Lijn, Fedde Van" uniqKey="Der Lijn F" first="Fedde Van" last="Der Lijn">Fedde Van Der Lijn</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurofunctional Imaging Group, University of Bordeaux, Unité Mixte de Recherche (UMR) 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Neurofunctional Imaging Group, Centre National de la Recherche Scientifique (CNRS), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Neurofunctional Imaging Group, Commissariat à l'Energie Atomique (CEA), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Human Genetics Center, School of Public Health, The University of Texas Health Sciences Center at Houston</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Epidemiology, University of Versailles Saint-Quentin-en-Yvelines</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Institute of Molecular Biology and Biochemistry, Medical University Graz</s1>
<s2>Graz</s2>
<s3>AUT</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>59 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1>
<s2>Hobart, Tasmania</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Hobart, Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schuur, Maaike" sort="Schuur, Maaike" uniqKey="Schuur M" first="Maaike" last="Schuur">Maaike Schuur</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lei Yu" sort="Lei Yu" uniqKey="Lei Yu" last="Lei Yu">LEI YU</name>
<affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name>
<affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1>
<s2>Kopavogur</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Icelandic Heart Association</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Verhaaren, Benjamin F J" sort="Verhaaren, Benjamin F J" uniqKey="Verhaaren B" first="Benjamin F. J." last="Verhaaren">Benjamin F. J. Verhaaren</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
</author>
<author><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name>
</author>
<author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stankovich, Jim" sort="Stankovich, Jim" uniqKey="Stankovich J" first="Jim" last="Stankovich">Jim Stankovich</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1>
<s2>Hobart, Tasmania</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Hobart, Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name>
<affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name>
</author>
<author><name sortKey="Heijer, Tom Den" sort="Heijer, Tom Den" uniqKey="Heijer T" first="Tom Den" last="Heijer">Tom Den Heijer</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurofunctional Imaging Group, University of Bordeaux, Unité Mixte de Recherche (UMR) 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Neurofunctional Imaging Group, Centre National de la Recherche Scientifique (CNRS), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Neurofunctional Imaging Group, Commissariat à l'Energie Atomique (CEA), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name>
</author>
<author><name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name>
</author>
<author><name sortKey="Danoy, Patrick" sort="Danoy, Patrick" uniqKey="Danoy P" first="Patrick" last="Danoy">Patrick Danoy</name>
</author>
<author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name>
<affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buchem, Mark A Van" sort="Buchem, Mark A Van" uniqKey="Buchem M" first="Mark A. Van" last="Buchem">Mark A. Van Buchem</name>
</author>
<author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A G." last="De Bruijn">Renée F. A G. De Bruijn</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Juebin Huang" sort="Juebin Huang" uniqKey="Juebin Huang" last="Juebin Huang">JUEBIN HUANG</name>
</author>
<author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name>
</author>
<author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1>
<s2>Hobart, Tasmania</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Hobart, Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gislason, Gauti K" sort="Gislason, Gauti K" uniqKey="Gislason G" first="Gauti K." last="Gislason">Gauti K. Gislason</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1>
<s2>Kopavogur</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Icelandic Heart Association</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pikula, Aleksandra" sort="Pikula, Aleksandra" uniqKey="Pikula A" first="Aleksandra" last="Pikula">Aleksandra Pikula</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
</author>
<author><name sortKey="Freeman, Kevin B" sort="Freeman, Kevin B" uniqKey="Freeman K" first="Kevin B." last="Freeman">Kevin B. Freeman</name>
</author>
<author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G." last="Phan">Thanh G. Phan</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>59 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stein, Jason L" sort="Stein, Jason L" uniqKey="Stein J" first="Jason L." last="Stein">Jason L. Stein</name>
</author>
<author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name>
</author>
<author><name sortKey="Arias Vasquez, Alejandro" sort="Arias Vasquez, Alejandro" uniqKey="Arias Vasquez A" first="Alejandro" last="Arias Vasquez">Alejandro Arias Vasquez</name>
</author>
<author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name>
</author>
<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name>
</author>
<author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
</author>
<author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
</author>
<author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J." last="Beare">Richard J. Beare</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>59 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Swieten, John C Van" sort="Swieten, John C Van" uniqKey="Swieten J" first="John C. Van" last="Swieten">John C. Van Swieten</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Variant</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Variant</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 x 10<sup>-7</sup>
. In two additional samples (n = 2,318), associations were replicated at 12q14 within MSR83-WIF1 (discovery and replication; rs17178006; P = 5.3 × 10<sup>-11</sup>
) and at 12q24 near HRK-FBXW8 (rs7294919; P = 2.9 x 10<sup>-11</sup>
). Remaining associations included one SNP at 2q24 within DPP4 (rs6741949; P = 2.9 × 10<sup>-7</sup>
) and nine SNPs at 9p33 within ASTN2 (rs7852872; P = 1.0 × 10<sup>-7</sup>
); along with the chromosome 12 associations, these loci were also associated with hippocampal volume (P < 0.05) in a third younger, more heterogeneous sample (n = 7,794). The SNP in ASTN2 also showed suggestive association with decline in cognition in a largely independent sample (n =1,563). These associations implicate genes related to apoptosis (HRK), development (WIF1), oxidative stress (MSR3B), ubiquitination (FBXWB) and neuronal migration (ASTN2), as well as enzymes targeted by new diabetes medications (DPP4), indicating new genetic influences on hippocampal size and possibly the risk of cognitive decline and dementia.</div>
</front>
</TEI>
<double idat="1061-4036:2012:Bis J:common:variants:at"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Common variants at 12ql4 and 12q24 are associated with hippocampal volume</title>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of California, Davis</s1>
<s2>Sacramento, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Center of Neuroscience, University of California, Davis</s1>
<s2>Sacramento, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1>
<s2>Kopavogur</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Icelandic Heart Association</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Faculty of Medicine, University of Iceland</s1>
<s2>Reykjavik</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Der Lijn, Fedde Van" sort="Der Lijn, Fedde Van" uniqKey="Der Lijn F" first="Fedde Van" last="Der Lijn">Fedde Van Der Lijn</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurofunctional Imaging Group, University of Bordeaux, Unité Mixte de Recherche (UMR) 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Neurofunctional Imaging Group, Centre National de la Recherche Scientifique (CNRS), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Neurofunctional Imaging Group, Commissariat à l'Energie Atomique (CEA), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Human Genetics Center, School of Public Health, The University of Texas Health Sciences Center at Houston</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Epidemiology, University of Versailles Saint-Quentin-en-Yvelines</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Institute of Molecular Biology and Biochemistry, Medical University Graz</s1>
<s2>Graz</s2>
<s3>AUT</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>59 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1>
<s2>Hobart, Tasmania</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Hobart, Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schuur, Maaike" sort="Schuur, Maaike" uniqKey="Schuur M" first="Maaike" last="Schuur">Maaike Schuur</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lei Yu" sort="Lei Yu" uniqKey="Lei Yu" last="Lei Yu">LEI YU</name>
<affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name>
<affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1>
<s2>Kopavogur</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Icelandic Heart Association</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Verhaaren, Benjamin F J" sort="Verhaaren, Benjamin F J" uniqKey="Verhaaren B" first="Benjamin F. J." last="Verhaaren">Benjamin F. J. Verhaaren</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
</author>
<author><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name>
</author>
<author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stankovich, Jim" sort="Stankovich, Jim" uniqKey="Stankovich J" first="Jim" last="Stankovich">Jim Stankovich</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1>
<s2>Hobart, Tasmania</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Hobart, Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name>
<affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name>
</author>
<author><name sortKey="Heijer, Tom Den" sort="Heijer, Tom Den" uniqKey="Heijer T" first="Tom Den" last="Heijer">Tom Den Heijer</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurofunctional Imaging Group, University of Bordeaux, Unité Mixte de Recherche (UMR) 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Neurofunctional Imaging Group, Centre National de la Recherche Scientifique (CNRS), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Neurofunctional Imaging Group, Commissariat à l'Energie Atomique (CEA), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name>
</author>
<author><name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name>
</author>
<author><name sortKey="Danoy, Patrick" sort="Danoy, Patrick" uniqKey="Danoy P" first="Patrick" last="Danoy">Patrick Danoy</name>
</author>
<author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name>
<affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buchem, Mark A Van" sort="Buchem, Mark A Van" uniqKey="Buchem M" first="Mark A. Van" last="Buchem">Mark A. Van Buchem</name>
</author>
<author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A G." last="De Bruijn">Renée F. A G. De Bruijn</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Juebin Huang" sort="Juebin Huang" uniqKey="Juebin Huang" last="Juebin Huang">JUEBIN HUANG</name>
</author>
<author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name>
</author>
<author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1>
<s2>Hobart, Tasmania</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Hobart, Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gislason, Gauti K" sort="Gislason, Gauti K" uniqKey="Gislason G" first="Gauti K." last="Gislason">Gauti K. Gislason</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1>
<s2>Kopavogur</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Icelandic Heart Association</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pikula, Aleksandra" sort="Pikula, Aleksandra" uniqKey="Pikula A" first="Aleksandra" last="Pikula">Aleksandra Pikula</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
</author>
<author><name sortKey="Freeman, Kevin B" sort="Freeman, Kevin B" uniqKey="Freeman K" first="Kevin B." last="Freeman">Kevin B. Freeman</name>
</author>
<author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G." last="Phan">Thanh G. Phan</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>59 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stein, Jason L" sort="Stein, Jason L" uniqKey="Stein J" first="Jason L." last="Stein">Jason L. Stein</name>
</author>
<author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name>
</author>
<author><name sortKey="Arias Vasquez, Alejandro" sort="Arias Vasquez, Alejandro" uniqKey="Arias Vasquez A" first="Alejandro" last="Arias Vasquez">Alejandro Arias Vasquez</name>
</author>
<author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name>
</author>
<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name>
</author>
<author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
</author>
<author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
</author>
<author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J." last="Beare">Richard J. Beare</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>59 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Swieten, John C Van" sort="Swieten, John C Van" uniqKey="Swieten J" first="John C. Van" last="Swieten">John C. Van Swieten</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">12-0224070</idno>
<date when="2012">2012</date>
<idno type="stanalyst">PASCAL 12-0224070 INIST</idno>
<idno type="RBID">Pascal:12-0224070</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">001369</idno>
<idno type="wicri:Area/PascalFrancis/Curation">004B45</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">001265</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001265</idno>
<idno type="wicri:doubleKey">1061-4036:2012:Bis J:common:variants:at</idno>
<idno type="wicri:Area/Main/Merge">006100</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Common variants at 12ql4 and 12q24 are associated with hippocampal volume</title>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Cardiovascular Health Research Unit, Department of Medicine, University of Washington</s1>
<s2>Seattle, Washington</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Neurology, University of California, Davis</s1>
<s2>Sacramento, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>Center of Neuroscience, University of California, Davis</s1>
<s2>Sacramento, California</s2>
<s3>USA</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1>
<s2>Kopavogur</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Icelandic Heart Association</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Faculty of Medicine, University of Iceland</s1>
<s2>Reykjavik</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Der Lijn, Fedde Van" sort="Der Lijn, Fedde Van" uniqKey="Der Lijn F" first="Fedde Van" last="Der Lijn">Fedde Van Der Lijn</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurofunctional Imaging Group, University of Bordeaux, Unité Mixte de Recherche (UMR) 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Neurofunctional Imaging Group, Centre National de la Recherche Scientifique (CNRS), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Neurofunctional Imaging Group, Commissariat à l'Energie Atomique (CEA), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><inist:fA14 i1="11"><s1>Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Human Genetics Center, School of Public Health, The University of Texas Health Sciences Center at Houston</s1>
<s2>Houston, Texas</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="14"><s1>Department of Epidemiology, University of Versailles Saint-Quentin-en-Yvelines</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1"><inist:fA14 i1="18"><s1>Institute of Molecular Biology and Biochemistry, Medical University Graz</s1>
<s2>Graz</s2>
<s3>AUT</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Autriche</country>
<wicri:noRegion>Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>59 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1>
<s2>Hobart, Tasmania</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Hobart, Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schuur, Maaike" sort="Schuur, Maaike" uniqKey="Schuur M" first="Maaike" last="Schuur">Maaike Schuur</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lei Yu" sort="Lei Yu" uniqKey="Lei Yu" last="Lei Yu">LEI YU</name>
<affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name>
<affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1>
<s2>Kopavogur</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Icelandic Heart Association</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Verhaaren, Benjamin F J" sort="Verhaaren, Benjamin F J" uniqKey="Verhaaren B" first="Benjamin F. J." last="Verhaaren">Benjamin F. J. Verhaaren</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
</author>
<author><name sortKey="Jack, Clifford R Jr" sort="Jack, Clifford R Jr" uniqKey="Jack C" first="Clifford R. Jr" last="Jack">Clifford R. Jr Jack</name>
</author>
<author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stankovich, Jim" sort="Stankovich, Jim" uniqKey="Stankovich J" first="Jim" last="Stankovich">Jim Stankovich</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1>
<s2>Hobart, Tasmania</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Hobart, Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name>
<affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name>
</author>
<author><name sortKey="Heijer, Tom Den" sort="Heijer, Tom Den" uniqKey="Heijer T" first="Tom Den" last="Heijer">Tom Den Heijer</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Neurofunctional Imaging Group, University of Bordeaux, Unité Mixte de Recherche (UMR) 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="09"><s1>Neurofunctional Imaging Group, Centre National de la Recherche Scientifique (CNRS), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Neurofunctional Imaging Group, Commissariat à l'Energie Atomique (CEA), UMR 5296</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name>
</author>
<author><name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name>
</author>
<author><name sortKey="Danoy, Patrick" sort="Danoy, Patrick" uniqKey="Danoy P" first="Patrick" last="Danoy">Patrick Danoy</name>
</author>
<author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name>
<affiliation wicri:level="2"><inist:fA14 i1="23"><s1>Rush Alzheimer's Disease Center, Rush University Medical Center</s1>
<s2>Chicago, Illinois</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
<sZ>22 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Buchem, Mark A Van" sort="Buchem, Mark A Van" uniqKey="Buchem M" first="Mark A. Van" last="Buchem">Mark A. Van Buchem</name>
</author>
<author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A G." last="De Bruijn">Renée F. A G. De Bruijn</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="24"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>13 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Juebin Huang" sort="Juebin Huang" uniqKey="Juebin Huang" last="Juebin Huang">JUEBIN HUANG</name>
</author>
<author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name>
</author>
<author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name>
<affiliation wicri:level="1"><inist:fA14 i1="20"><s1>Menzies Research Institute Tasmania, University of Tasmania</s1>
<s2>Hobart, Tasmania</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>37 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Hobart, Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Medical Informatics, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Radiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>38 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name>
<affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women's Hospital</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="17"><s1>Program in Medical and Population Genetics, Broad Institute</s1>
<s2>Cambridge, Massachusetts</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>39 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gislason, Gauti K" sort="Gislason, Gauti K" uniqKey="Gislason G" first="Gauti K." last="Gislason">Gauti K. Gislason</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Icelandic Heart Association</s1>
<s2>Kopavogur</s2>
<s3>ISL</s3>
<sZ>3 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>40 aut.</sZ>
</inist:fA14>
<country>Islande</country>
<wicri:noRegion>Icelandic Heart Association</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><inist:fA14 i1="25"><s1>Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>15 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>41 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pikula, Aleksandra" sort="Pikula, Aleksandra" uniqKey="Pikula A" first="Aleksandra" last="Pikula">Aleksandra Pikula</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
</author>
<author><name sortKey="Freeman, Kevin B" sort="Freeman, Kevin B" uniqKey="Freeman K" first="Kevin B." last="Freeman">Kevin B. Freeman</name>
</author>
<author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G." last="Phan">Thanh G. Phan</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>59 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
<affiliation wicri:level="3"><inist:fA14 i1="21"><s1>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>19 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>46 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stein, Jason L" sort="Stein, Jason L" uniqKey="Stein J" first="Jason L." last="Stein">Jason L. Stein</name>
</author>
<author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name>
</author>
<author><name sortKey="Arias Vasquez, Alejandro" sort="Arias Vasquez, Alejandro" uniqKey="Arias Vasquez A" first="Alejandro" last="Arias Vasquez">Alejandro Arias Vasquez</name>
</author>
<author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name>
</author>
<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name>
</author>
<author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
</author>
<author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
</author>
<author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name>
<affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s2>Boston, Massachusetts</s2>
<s3>USA</s3>
<sZ>7 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>33 aut.</sZ>
<sZ>42 aut.</sZ>
<sZ>57 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Institut National de la Santé et de la Recherche Médicale (INSERM), U708, Neuroepidemiology</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
<sZ>34 aut.</sZ>
<sZ>58 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J." last="Beare">Richard J. Beare</name>
<affiliation wicri:level="1"><inist:fA14 i1="19"><s1>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University</s1>
<s2>Melbourne, Victoria</s2>
<s3>AUS</s3>
<sZ>10 aut.</sZ>
<sZ>45 aut.</sZ>
<sZ>59 aut.</sZ>
</inist:fA14>
<country>Australie</country>
<wicri:noRegion>Melbourne, Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Swieten, John C Van" sort="Swieten, John C Van" uniqKey="Swieten J" first="John C. Van" last="Swieten">John C. Van Swieten</name>
<affiliation wicri:level="3"><inist:fA14 i1="22"><s1>Department of Neurology, Erasmus Medical Center University Medical Center</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>11 aut.</sZ>
<sZ>21 aut.</sZ>
<sZ>24 aut.</sZ>
<sZ>32 aut.</sZ>
<sZ>60 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Nature genetics</title>
<title level="j" type="abbreviated">Nat. genet.</title>
<idno type="ISSN">1061-4036</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Variant</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Variant</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Aging is associated with reductions in hippocampal volume that are accelerated by Alzheimer's disease and vascular risk factors. Our genome-wide association study (GWAS) of dementia-free persons (n = 9,232) identified 46 SNPs at four loci with P values of <4.0 x 10<sup>-7</sup>
. In two additional samples (n = 2,318), associations were replicated at 12q14 within MSR83-WIF1 (discovery and replication; rs17178006; P = 5.3 × 10<sup>-11</sup>
) and at 12q24 near HRK-FBXW8 (rs7294919; P = 2.9 x 10<sup>-11</sup>
). Remaining associations included one SNP at 2q24 within DPP4 (rs6741949; P = 2.9 × 10<sup>-7</sup>
) and nine SNPs at 9p33 within ASTN2 (rs7852872; P = 1.0 × 10<sup>-7</sup>
); along with the chromosome 12 associations, these loci were also associated with hippocampal volume (P < 0.05) in a third younger, more heterogeneous sample (n = 7,794). The SNP in ASTN2 also showed suggestive association with decline in cognition in a largely independent sample (n =1,563). These associations implicate genes related to apoptosis (HRK), development (WIF1), oxidative stress (MSR3B), ubiquitination (FBXWB) and neuronal migration (ASTN2), as well as enzymes targeted by new diabetes medications (DPP4), indicating new genetic influences on hippocampal size and possibly the risk of cognitive decline and dementia.</div>
</front>
</TEI>
</INIST>
<PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Common variants at 12q14 and 12q24 are associated with hippocampal volume</title>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology and Center of Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Center of Neuroscience, University of California at Davis, Sacramento, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Lijn, Fedde" sort="Van Der Lijn, Fedde" uniqKey="Van Der Lijn F" first="Fedde" last="Van Der Lijn">Fedde Van Der Lijn</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A8">Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A9">Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A11">Human Genetics Center School of Public Health, The University of Texas Health Sciences Center at Houston, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Human Genetics Center School of Public Health, The University of Texas Health Sciences Center at Houston, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation wicri:level="3"><nlm:aff id="A12">INSERM, U708, Neuroepidemiology, F-75013, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U708, Neuroepidemiology, F-75013, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A13">Department of Epidemiology, University of Versailles St-Quentin-en-Yvelines, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Epidemiology, University of Versailles St-Quentin-en-Yvelines</wicri:regionArea>
<wicri:noRegion>University of Versailles St-Quentin-en-Yvelines</wicri:noRegion>
<wicri:noRegion>University of Versailles St-Quentin-en-Yvelines</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A16">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Institute of Molecular Biology and Biochemistry, Medical University Graz</wicri:regionArea>
<wicri:noRegion>Medical University Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name>
<affiliation wicri:level="3"><nlm:aff id="A18">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A19">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea>
<wicri:noRegion>Hobart</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schuur, Maaike" sort="Schuur, Maaike" uniqKey="Schuur M" first="Maaike" last="Schuur">Maaike Schuur</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Verhaaren, Benjamin F J" sort="Verhaaren, Benjamin F J" uniqKey="Verhaaren B" first="Benjamin F. J." last="Verhaaren">Benjamin F. J. Verhaaren</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<affiliation wicri:level="3"><nlm:aff id="A27">INSERM Unit 744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM Unit 744, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A28">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A29">Université Lille Nord de France, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R." last="Jack">Clifford R. Jack</name>
<affiliation wicri:level="2"><nlm:aff id="A30">Department of Radiology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stankovich, Jim" sort="Stankovich, Jim" uniqKey="Stankovich J" first="Jim" last="Stankovich">Jim Stankovich</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea>
<wicri:noRegion>Hobart</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A31">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A32">Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name>
<affiliation wicri:level="3"><nlm:aff id="A33">Biospective Inc., Montreal, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Biospective Inc., Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Den Heijer, Tom" sort="Den Heijer, Tom" uniqKey="Den Heijer T" first="Tom" last="Den Heijer">Tom Den Heijer</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A34">Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Sint Franciscus Gasthuis, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A8">Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A9">Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name>
<affiliation wicri:level="2"><nlm:aff id="A35">Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea>
<wicri:noRegion>Medical University Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Danoy, Patrick" sort="Danoy, Patrick" uniqKey="Danoy P" first="Patrick" last="Danoy">Patrick Danoy</name>
<affiliation wicri:level="1"><nlm:aff id="A37">University of Queensland, Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland, Diamantina Institute, Princess Alexandra Hospital, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A38">Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Buchem, Mark A" sort="Van Buchem, Mark A" uniqKey="Van Buchem M" first="Mark A." last="Van Buchem">Mark A. Van Buchem</name>
<affiliation wicri:level="3"><nlm:aff id="A39">Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A. G." last="De Bruijn">Renée F. A. G. De Bruijn</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="3"><nlm:aff id="A12">INSERM, U708, Neuroepidemiology, F-75013, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U708, Neuroepidemiology, F-75013, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Juebin" sort="Huang, Juebin" uniqKey="Huang J" first="Juebin" last="Huang">Juebin Huang</name>
<affiliation wicri:level="2"><nlm:aff id="A40">Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea>
<wicri:noRegion>Medical University Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea>
<wicri:noRegion>Hobart</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A41">Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Faculty of Applied Sciences, Delft University of Technology, Delft</wicri:regionArea>
<wicri:noRegion>Delft</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A16">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gislason, Gauti K" sort="Gislason, Gauti K" uniqKey="Gislason G" first="Gauti K." last="Gislason">Gauti K. Gislason</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pikula, Aleksandra" sort="Pikula, Aleksandra" uniqKey="Pikula A" first="Aleksandra" last="Pikula">Aleksandra Pikula</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation wicri:level="3"><nlm:aff id="A27">INSERM Unit 744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM Unit 744, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A28">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A29">Université Lille Nord de France, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A43">Centre Hospitalier Régional Universitaire de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Freeman, Kevin B" sort="Freeman, Kevin B" uniqKey="Freeman K" first="Kevin B." last="Freeman">Kevin B. Freeman</name>
<affiliation wicri:level="2"><nlm:aff id="A44">Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G." last="Phan">Thanh G. Phan</name>
<affiliation wicri:level="3"><nlm:aff id="A18">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A45">Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stein, Jason L" sort="Stein, Jason L" uniqKey="Stein J" first="Jason L." last="Stein">Jason L. Stein</name>
<affiliation wicri:level="2"><nlm:aff id="A46">Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name>
<affiliation wicri:level="1"><nlm:aff id="A47">Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A48">Quantitative Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Quantitative Genetics, Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A49">Broad Institute of Harvard and MIT, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Broad Institute of Harvard and MIT, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vasquez, Alejandro Arias" sort="Vasquez, Alejandro Arias" uniqKey="Vasquez A" first="Alejandro Arias" last="Vasquez">Alejandro Arias Vasquez</name>
<affiliation wicri:level="3"><nlm:aff id="A50">Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A51">Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name>
<affiliation wicri:level="2"><nlm:aff id="A46">Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name>
<affiliation wicri:level="1"><nlm:aff id="A47">Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name>
<affiliation wicri:level="3"><nlm:aff id="A50">Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A51">Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><nlm:aff id="A47">Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
<affiliation wicri:level="2"><nlm:aff id="A46">Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
<affiliation wicri:level="2"><nlm:aff id="A52">Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A53">Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation wicri:level="3"><nlm:aff id="A12">INSERM, U708, Neuroepidemiology, F-75013, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U708, Neuroepidemiology, F-75013, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A54">UPMC Univ Paris 06 UMR_S708, Neuroepidemiology, FY75005, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UPMC Univ Paris 06 UMR_S708, Neuroepidemiology, FY75005, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J." last="Beare">Richard J. Beare</name>
<affiliation wicri:level="3"><nlm:aff id="A18">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A55">Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Flemington Rd, Parkville, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Flemington Rd, Parkville, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C." last="Van Swieten">John C. Van Swieten</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lopez, Oscar" sort="Lopez, Oscar" uniqKey="Lopez O" first="Oscar" last="Lopez">Oscar Lopez</name>
<affiliation wicri:level="2"><nlm:aff id="A56">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A57">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A58">Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<affiliation wicri:level="2"><nlm:aff id="A59">Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name>
<affiliation wicri:level="3"><nlm:aff id="A27">INSERM Unit 744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM Unit 744, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A28">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A29">Université Lille Nord de France, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name>
<affiliation wicri:level="3"><nlm:aff id="A60">Population Health Sciences, German Center for Neurdegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Population Health Sciences, German Center for Neurdegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A61">Population Health Sciences, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Population Health Sciences, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A62">Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
<settlement type="city">Cambridge (Massachusetts)</settlement>
</placeName>
<orgName type="university">Université Harvard</orgName>
</affiliation>
</author>
<author><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L." last="De Jager">Philip L. De Jager</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A16">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A63">Harvard Medical School, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T." last="Becker">James T. Becker</name>
<affiliation wicri:level="2"><nlm:aff id="A56">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A57">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A58">Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Knopman, David" sort="Knopman, David" uniqKey="Knopman D" first="David" last="Knopman">David Knopman</name>
<affiliation wicri:level="2"><nlm:aff id="A64">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fazekas, Franz" sort="Fazekas, Franz" uniqKey="Fazekas F" first="Franz" last="Fazekas">Franz Fazekas</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea>
<wicri:noRegion>Medical University Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W. T." last="Longstreth">W. T. Longstreth</name>
<affiliation wicri:level="4"><nlm:aff id="A65">Department of Neurology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A66">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Brown, Mathew A" sort="Brown, Mathew A" uniqKey="Brown M" first="Mathew A." last="Brown">Mathew A. Brown</name>
<affiliation wicri:level="1"><nlm:aff id="A67">University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A68">Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="2"><nlm:aff id="A40">Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A69">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea>
<wicri:noRegion>Medical University Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation wicri:level="1"><nlm:aff id="A70">Univ. Bordeaux, U708, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Bordeaux, U708, F-33000 Bordeaux</wicri:regionArea>
<wicri:noRegion>33000 Bordeaux</wicri:noRegion>
<wicri:noRegion>33000 Bordeaux</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A71">INSERM, Neuroepidemiology U708, F-33000, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, Neuroepidemiology U708, F-33000, Bordeaux</wicri:regionArea>
<wicri:noRegion>33000, Bordeaux</wicri:noRegion>
<wicri:noRegion>33000, Bordeaux</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="3"><nlm:aff id="A51">Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22504421</idno>
<idno type="pmc">3427729</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427729</idno>
<idno type="RBID">PMC:3427729</idno>
<idno type="doi">10.1038/ng.2237</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">002E13</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E13</idno>
<idno type="wicri:Area/Pmc/Curation">002C63</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C63</idno>
<idno type="wicri:Area/Pmc/Checkpoint">002011</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002011</idno>
<idno type="wicri:Area/Ncbi/Merge">000D78</idno>
<idno type="wicri:Area/Ncbi/Curation">000D78</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000D78</idno>
<idno type="wicri:doubleKey">1061-4036:2012:Bis J:common:variants:at</idno>
<idno type="wicri:Area/Main/Merge">005688</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common variants at 12q14 and 12q24 are associated with hippocampal volume</title>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="4"><nlm:aff id="A1">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Neurology and Center of Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology and Center of Neuroscience, University of California at Davis, Sacramento, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Lijn, Fedde" sort="Van Der Lijn, Fedde" uniqKey="Van Der Lijn F" first="Fedde" last="Van Der Lijn">Fedde Van Der Lijn</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A8">Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A9">Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><nlm:aff id="A10">Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A11">Human Genetics Center School of Public Health, The University of Texas Health Sciences Center at Houston, Houston, TX, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Human Genetics Center School of Public Health, The University of Texas Health Sciences Center at Houston, Houston, TX</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation wicri:level="3"><nlm:aff id="A12">INSERM, U708, Neuroepidemiology, F-75013, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U708, Neuroepidemiology, F-75013, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A13">Department of Epidemiology, University of Versailles St-Quentin-en-Yvelines, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Epidemiology, University of Versailles St-Quentin-en-Yvelines</wicri:regionArea>
<wicri:noRegion>University of Versailles St-Quentin-en-Yvelines</wicri:noRegion>
<wicri:noRegion>University of Versailles St-Quentin-en-Yvelines</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A14">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A16">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="A17">Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Institute of Molecular Biology and Biochemistry, Medical University Graz</wicri:regionArea>
<wicri:noRegion>Medical University Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name>
<affiliation wicri:level="3"><nlm:aff id="A18">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A19">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea>
<wicri:noRegion>Hobart</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schuur, Maaike" sort="Schuur, Maaike" uniqKey="Schuur M" first="Maaike" last="Schuur">Maaike Schuur</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Verhaaren, Benjamin F J" sort="Verhaaren, Benjamin F J" uniqKey="Verhaaren B" first="Benjamin F. J." last="Verhaaren">Benjamin F. J. Verhaaren</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name>
<affiliation wicri:level="3"><nlm:aff id="A27">INSERM Unit 744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM Unit 744, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A28">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A29">Université Lille Nord de France, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R." last="Jack">Clifford R. Jack</name>
<affiliation wicri:level="2"><nlm:aff id="A30">Department of Radiology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stankovich, Jim" sort="Stankovich, Jim" uniqKey="Stankovich J" first="Jim" last="Stankovich">Jim Stankovich</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea>
<wicri:noRegion>Hobart</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A31">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A32">Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name>
<affiliation wicri:level="3"><nlm:aff id="A33">Biospective Inc., Montreal, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Biospective Inc., Montreal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Den Heijer, Tom" sort="Den Heijer, Tom" uniqKey="Den Heijer T" first="Tom" last="Den Heijer">Tom Den Heijer</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A34">Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Sint Franciscus Gasthuis, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<affiliation wicri:level="3"><nlm:aff id="A7">Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A8">Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A9">Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name>
<affiliation wicri:level="2"><nlm:aff id="A35">Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea>
<wicri:noRegion>Medical University Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Danoy, Patrick" sort="Danoy, Patrick" uniqKey="Danoy P" first="Patrick" last="Danoy">Patrick Danoy</name>
<affiliation wicri:level="1"><nlm:aff id="A37">University of Queensland, Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland, Diamantina Institute, Princess Alexandra Hospital, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A38">Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Buchem, Mark A" sort="Van Buchem, Mark A" uniqKey="Van Buchem M" first="Mark A." last="Van Buchem">Mark A. Van Buchem</name>
<affiliation wicri:level="3"><nlm:aff id="A39">Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A. G." last="De Bruijn">Renée F. A. G. De Bruijn</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name>
<affiliation wicri:level="3"><nlm:aff id="A12">INSERM, U708, Neuroepidemiology, F-75013, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U708, Neuroepidemiology, F-75013, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Juebin" sort="Huang, Juebin" uniqKey="Huang J" first="Juebin" last="Huang">Juebin Huang</name>
<affiliation wicri:level="2"><nlm:aff id="A40">Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea>
<wicri:noRegion>Medical University Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea>
<wicri:noRegion>Hobart</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name>
<affiliation wicri:level="3"><nlm:aff id="A5">Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A41">Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Faculty of Applied Sciences, Delft University of Technology, Delft</wicri:regionArea>
<wicri:noRegion>Delft</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A16">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gislason, Gauti K" sort="Gislason, Gauti K" uniqKey="Gislason G" first="Gauti K." last="Gislason">Gauti K. Gislason</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pikula, Aleksandra" sort="Pikula, Aleksandra" uniqKey="Pikula A" first="Aleksandra" last="Pikula">Aleksandra Pikula</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation wicri:level="3"><nlm:aff id="A27">INSERM Unit 744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM Unit 744, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A28">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A29">Université Lille Nord de France, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A43">Centre Hospitalier Régional Universitaire de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Freeman, Kevin B" sort="Freeman, Kevin B" uniqKey="Freeman K" first="Kevin B." last="Freeman">Kevin B. Freeman</name>
<affiliation wicri:level="2"><nlm:aff id="A44">Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G." last="Phan">Thanh G. Phan</name>
<affiliation wicri:level="3"><nlm:aff id="A18">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A45">Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stein, Jason L" sort="Stein, Jason L" uniqKey="Stein J" first="Jason L." last="Stein">Jason L. Stein</name>
<affiliation wicri:level="2"><nlm:aff id="A46">Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name>
<affiliation wicri:level="1"><nlm:aff id="A47">Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A48">Quantitative Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Quantitative Genetics, Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A49">Broad Institute of Harvard and MIT, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Broad Institute of Harvard and MIT, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vasquez, Alejandro Arias" sort="Vasquez, Alejandro Arias" uniqKey="Vasquez A" first="Alejandro Arias" last="Vasquez">Alejandro Arias Vasquez</name>
<affiliation wicri:level="3"><nlm:aff id="A50">Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A51">Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name>
<affiliation wicri:level="2"><nlm:aff id="A46">Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name>
<affiliation wicri:level="1"><nlm:aff id="A47">Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name>
<affiliation wicri:level="3"><nlm:aff id="A50">Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A51">Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><nlm:aff id="A47">Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name>
<affiliation wicri:level="2"><nlm:aff id="A46">Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name>
<affiliation wicri:level="2"><nlm:aff id="A52">Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A53">Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name>
<affiliation wicri:level="3"><nlm:aff id="A12">INSERM, U708, Neuroepidemiology, F-75013, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U708, Neuroepidemiology, F-75013, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A54">UPMC Univ Paris 06 UMR_S708, Neuroepidemiology, FY75005, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>UPMC Univ Paris 06 UMR_S708, Neuroepidemiology, FY75005, Paris</wicri:regionArea>
<placeName><region type="region" nuts="2">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J." last="Beare">Richard J. Beare</name>
<affiliation wicri:level="3"><nlm:aff id="A18">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A55">Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Flemington Rd, Parkville, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Flemington Rd, Parkville, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C." last="Van Swieten">John C. Van Swieten</name>
<affiliation wicri:level="3"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lopez, Oscar" sort="Lopez, Oscar" uniqKey="Lopez O" first="Oscar" last="Lopez">Oscar Lopez</name>
<affiliation wicri:level="2"><nlm:aff id="A56">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A57">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A58">Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name>
<affiliation wicri:level="2"><nlm:aff id="A59">Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name>
<affiliation wicri:level="3"><nlm:aff id="A27">INSERM Unit 744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM Unit 744, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A28">Institut Pasteur de Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A29">Université Lille Nord de France, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name>
<affiliation wicri:level="3"><nlm:aff id="A60">Population Health Sciences, German Center for Neurdegenerative Diseases (DZNE), Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Population Health Sciences, German Center for Neurdegenerative Diseases (DZNE), Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A61">Population Health Sciences, University of Bonn, Bonn, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Population Health Sciences, University of Bonn, Bonn</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Bonn</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A62">Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
<settlement type="city">Cambridge (Massachusetts)</settlement>
</placeName>
<orgName type="university">Université Harvard</orgName>
</affiliation>
</author>
<author><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L." last="De Jager">Philip L. De Jager</name>
<affiliation wicri:level="2"><nlm:aff id="A15">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A16">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A63">Harvard Medical School, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Harvard Medical School, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T." last="Becker">James T. Becker</name>
<affiliation wicri:level="2"><nlm:aff id="A56">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A57">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A58">Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Knopman, David" sort="Knopman, David" uniqKey="Knopman D" first="David" last="Knopman">David Knopman</name>
<affiliation wicri:level="2"><nlm:aff id="A64">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fazekas, Franz" sort="Fazekas, Franz" uniqKey="Fazekas F" first="Franz" last="Fazekas">Franz Fazekas</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea>
<wicri:noRegion>Medical University Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name>
<affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea>
<wicri:noRegion>Kopavogur</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W. T." last="Longstreth">W. T. Longstreth</name>
<affiliation wicri:level="4"><nlm:aff id="A65">Department of Neurology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A66">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Brown, Mathew A" sort="Brown, Mathew A" uniqKey="Brown M" first="Mathew A." last="Brown">Mathew A. Brown</name>
<affiliation wicri:level="1"><nlm:aff id="A67">University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name>
<affiliation wicri:level="2"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A68">Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="2"><nlm:aff id="A40">Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A69">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea>
<wicri:noRegion>Medical University Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation wicri:level="1"><nlm:aff id="A70">Univ. Bordeaux, U708, F-33000 Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Univ. Bordeaux, U708, F-33000 Bordeaux</wicri:regionArea>
<wicri:noRegion>33000 Bordeaux</wicri:noRegion>
<wicri:noRegion>33000 Bordeaux</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A71">INSERM, Neuroepidemiology U708, F-33000, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, Neuroepidemiology U708, F-33000, Bordeaux</wicri:regionArea>
<wicri:noRegion>33000, Bordeaux</wicri:noRegion>
<wicri:noRegion>33000, Bordeaux</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="3"><nlm:aff id="A51">Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea>
<placeName><settlement type="city">Nimègue</settlement>
<region type="province" nuts="2">Gueldre</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name>
<affiliation wicri:level="3"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation wicri:level="2"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature genetics</title>
<idno type="ISSN">1061-4036</idno>
<idno type="eISSN">1546-1718</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer’s disease and vascular risk factors. Our genome-wide association study of dementia-free persons (n=9,232) identified 46 SNPs at four loci with p-values <4.0×10<sup>-7</sup>
. Two additional samples (n=2,318) replicated associations at 12q24 within <italic>MSRB3/WIF1</italic>
 (discovery + replication, rs17178006; p=5.3×10<sup>-11</sup>
) and at 12q14 near <italic>HRK/FBXW8</italic>
 (rs7294919; p=2.9×10<sup>-11</sup>
). Remaining associations included one 2q24 SNP within <italic>DPP4</italic>
 (rs6741949; p=2.9×10<sup>-7</sup>
) and nine 9p33 SNPs within <italic>ASTN2</italic>
 (rs7852872; p=1.0×10<sup>-7</sup>
) that were also associated with HV (p<0.05) in a third younger, more heterogeneous sample (n=7,794). The <italic>ASTN2</italic>
 SNP was also associated with decline in cognition in a largely independent sample (n=1,563). These associations implicate genes related to apoptosis (<italic>HRK</italic>
), development (<italic>WIF1)</italic>
, oxidative stress (<italic>MSR3B</italic>
), ubiquitination (<italic>FBXW8</italic>
), enzymes targeted by new diabetes medications (<italic>DPP4</italic>
), and neuronal migration (<italic>ASTN2</italic>
), indicating novel genetic influences that influence hippocampal size and possibly the risk of cognitive decline and dementia.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ridha, Bh" uniqKey="Ridha B">BH Ridha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Small, Gw" uniqKey="Small G">GW Small</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Den Heijer, T" uniqKey="Den Heijer T">T den Heijer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seshadri, S" uniqKey="Seshadri S">S Seshadri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sullivan, Ev" uniqKey="Sullivan E">EV Sullivan</name>
</author>
<author><name sortKey="Pfefferbaum, A" uniqKey="Pfefferbaum A">A Pfefferbaum</name>
</author>
<author><name sortKey="Swan, Ge" uniqKey="Swan G">GE Swan</name>
</author>
<author><name sortKey="Carmelli, D" uniqKey="Carmelli D">D Carmelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Psaty, Bm" uniqKey="Psaty B">BM Psaty</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zapala, Ma" uniqKey="Zapala M">MA Zapala</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sborgi, L" uniqKey="Sborgi L">L Sborgi</name>
</author>
<author><name sortKey="Barrera Vilarmau, S" uniqKey="Barrera Vilarmau S">S Barrera-Vilarmau</name>
</author>
<author><name sortKey="Obregon, P" uniqKey="Obregon P">P Obregon</name>
</author>
<author><name sortKey="De Alba, E" uniqKey="De Alba E">E de Alba</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lukiw, Wj" uniqKey="Lukiw W">WJ Lukiw</name>
</author>
<author><name sortKey="Bazan, Ng" uniqKey="Bazan N">NG Bazan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Inohara, N" uniqKey="Inohara N">N Inohara</name>
</author>
<author><name sortKey="Ding, L" uniqKey="Ding L">L Ding</name>
</author>
<author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name>
</author>
<author><name sortKey="Nunez, G" uniqKey="Nunez G">G Nunez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Imaizumi, K" uniqKey="Imaizumi K">K Imaizumi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guan, Qh" uniqKey="Guan Q">QH Guan</name>
</author>
<author><name sortKey="Pei, Ds" uniqKey="Pei D">DS Pei</name>
</author>
<author><name sortKey="Xu, Tl" uniqKey="Xu T">TL Xu</name>
</author>
<author><name sortKey="Zhang, Gy" uniqKey="Zhang G">GY Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rohn, Tt" uniqKey="Rohn T">TT Rohn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Segref, A" uniqKey="Segref A">A Segref</name>
</author>
<author><name sortKey="Hoppe, T" uniqKey="Hoppe T">T Hoppe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Riederer, Bm" uniqKey="Riederer B">BM Riederer</name>
</author>
<author><name sortKey="Leuba, G" uniqKey="Leuba G">G Leuba</name>
</author>
<author><name sortKey="Vernay, A" uniqKey="Vernay A">A Vernay</name>
</author>
<author><name sortKey="Riederer, Im" uniqKey="Riederer I">IM Riederer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liao, Eh" uniqKey="Liao E">EH Liao</name>
</author>
<author><name sortKey="Hung, W" uniqKey="Hung W">W Hung</name>
</author>
<author><name sortKey="Abrams, B" uniqKey="Abrams B">B Abrams</name>
</author>
<author><name sortKey="Zhen, M" uniqKey="Zhen M">M Zhen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Litterman, N" uniqKey="Litterman N">N Litterman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Veyrieras, Jb" uniqKey="Veyrieras J">JB Veyrieras</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schadt, Ee" uniqKey="Schadt E">EE Schadt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Myers, Aj" uniqKey="Myers A">AJ Myers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stranger, Be" uniqKey="Stranger B">BE Stranger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kalmijn, S" uniqKey="Kalmijn S">S Kalmijn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Prins, Nd" uniqKey="Prins N">ND Prins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Den Heijer, T" uniqKey="Den Heijer T">T den Heijer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gonzalez, S" uniqKey="Gonzalez S">S Gonzalez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, H" uniqKey="Kim H">H Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gogolla, N" uniqKey="Gogolla N">N Gogolla</name>
</author>
<author><name sortKey="Galimberti, I" uniqKey="Galimberti I">I Galimberti</name>
</author>
<author><name sortKey="Deguchi, Y" uniqKey="Deguchi Y">Y Deguchi</name>
</author>
<author><name sortKey="Caroni, P" uniqKey="Caroni P">P Caroni</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chibnik, Lb" uniqKey="Chibnik L">LB Chibnik</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Okamoto, Ok" uniqKey="Okamoto O">OK Okamoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Henrich Noack, P" uniqKey="Henrich Noack P">P Henrich-Noack</name>
</author>
<author><name sortKey="Prehn, Jh" uniqKey="Prehn J">JH Prehn</name>
</author>
<author><name sortKey="Krieglstein, J" uniqKey="Krieglstein J">J Krieglstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kubben, N" uniqKey="Kubben N">N Kubben</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mentlein, R" uniqKey="Mentlein R">R Mentlein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gault, Va" uniqKey="Gault V">VA Gault</name>
</author>
<author><name sortKey="Holscher, C" uniqKey="Holscher C">C Holscher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bernstein, Hg" uniqKey="Bernstein H">HG Bernstein</name>
</author>
<author><name sortKey="Schon, E" uniqKey="Schon E">E Schon</name>
</author>
<author><name sortKey="Ansorge, S" uniqKey="Ansorge S">S Ansorge</name>
</author>
<author><name sortKey="Rose, I" uniqKey="Rose I">I Rose</name>
</author>
<author><name sortKey="Dorn, A" uniqKey="Dorn A">A Dorn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lamers, D" uniqKey="Lamers D">D Lamers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jagust, W" uniqKey="Jagust W">W Jagust</name>
</author>
<author><name sortKey="Harvey, D" uniqKey="Harvey D">D Harvey</name>
</author>
<author><name sortKey="Mungas, D" uniqKey="Mungas D">D Mungas</name>
</author>
<author><name sortKey="Haan, M" uniqKey="Haan M">M Haan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hamilton, A" uniqKey="Hamilton A">A Hamilton</name>
</author>
<author><name sortKey="Patterson, S" uniqKey="Patterson S">S Patterson</name>
</author>
<author><name sortKey="Porter, D" uniqKey="Porter D">D Porter</name>
</author>
<author><name sortKey="Gault, Va" uniqKey="Gault V">VA Gault</name>
</author>
<author><name sortKey="Holscher, C" uniqKey="Holscher C">C Holscher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hamilton, A" uniqKey="Hamilton A">A Hamilton</name>
</author>
<author><name sortKey="Holscher, C" uniqKey="Holscher C">C Holscher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="During, Mj" uniqKey="During M">MJ During</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wilson, Pm" uniqKey="Wilson P">PM Wilson</name>
</author>
<author><name sortKey="Fryer, Rh" uniqKey="Fryer R">RH Fryer</name>
</author>
<author><name sortKey="Fang, Y" uniqKey="Fang Y">Y Fang</name>
</author>
<author><name sortKey="Hatten, Me" uniqKey="Hatten M">ME Hatten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gasser, Ue" uniqKey="Gasser U">UE Gasser</name>
</author>
<author><name sortKey="Hatten, Me" uniqKey="Hatten M">ME Hatten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lambert, Jc" uniqKey="Lambert J">JC Lambert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harold, D" uniqKey="Harold D">D Harold</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hollingworth, P" uniqKey="Hollingworth P">P Hollingworth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naj, Ac" uniqKey="Naj A">AC Naj</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seshadri, S" uniqKey="Seshadri S">S Seshadri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corneveaux, Jj" uniqKey="Corneveaux J">JJ Corneveaux</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Lijn, F" uniqKey="Van Der Lijn F">F van der Lijn</name>
</author>
<author><name sortKey="Den Heijer, T" uniqKey="Den Heijer T">T den Heijer</name>
</author>
<author><name sortKey="Breteler, Mm" uniqKey="Breteler M">MM Breteler</name>
</author>
<author><name sortKey="Niessen, Wj" uniqKey="Niessen W">WJ Niessen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Willer, Cj" uniqKey="Willer C">CJ Willer</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Abecasis, Gr" uniqKey="Abecasis G">GR Abecasis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnson, Ad" uniqKey="Johnson A">AD Johnson</name>
</author>
<author><name sortKey="O Onnell, Cj" uniqKey="O Onnell C">CJ O’Donnell</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</PMC>
</double>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005D83 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 005D83 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Asie
   |area=    AustralieFrV1
   |flux=    Main
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:12-0224070
   |texte=   Common variants at 12ql4 and 12q24 are associated with hippocampal volume
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Dec 5 10:43:12 2017. Site generation: Tue Mar 5 14:07:20 2024

	Serveur d'exploration sur les relations entre la France et l'Australie
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur les relations entre la France et l'Australie

Common variants at 12ql4 and 12q24 are associated with hippocampal volume

Common variants at 12ql4 and 12q24 are associated with hippocampal volume

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri