Common variants at 12q14 and 12q24 are associated with hippocampal volume
Identifieur interne : 002C63 ( Pmc/Curation ); précédent : 002C62; suivant : 002C64Common variants at 12q14 and 12q24 are associated with hippocampal volume
Auteurs : Joshua C. Bis [États-Unis] ; Charles Decarli [États-Unis] ; Albert Vernon Smith [Islande] ; Fedde Van Der Lijn [Pays-Bas] ; Fabrice Crivello [France] ; Myriam Fornage [États-Unis] ; Stephanie Debette [France, États-Unis] ; Joshua M. Shulman [États-Unis] ; Helena Schmidt [Autriche] ; Velandai Srikanth [Australie] ; Maaike Schuur [Pays-Bas] ; Lei Yu [États-Unis] ; Seung-Hoan Choi [États-Unis] ; Sigurdur Sigurdsson [Islande] ; Benjamin F. J. Verhaaren [Pays-Bas] ; Anita L. Destefano [États-Unis] ; Jean-Charles Lambert [France] ; Clifford R. Jack [États-Unis] ; Maksim Struchalin [Pays-Bas] ; Jim Stankovich [Australie] ; Carla A. Ibrahim-Verbaas [Pays-Bas] ; Debra Fleischman [États-Unis] ; Alex Zijdenbos [Canada] ; Tom Den Heijer [Pays-Bas] ; Bernard Mazoyer [France] ; Laura H. Coker [États-Unis] ; Christian Enzinger [Autriche] ; Patrick Danoy [Australie] ; Najaf Amin [Pays-Bas] ; Konstantinos Arfanakis [États-Unis] ; Mark A. Van Buchem [Pays-Bas] ; Renée F. A. G. De Bruijn [Pays-Bas] ; Alexa Beiser [États-Unis] ; Carole Dufouil [France] ; Juebin Huang [États-Unis] ; Margherita Cavalieri [Autriche] ; Russell Thomson [Australie] ; Wiro J. Niessen [Pays-Bas] ; Lori B. Chibnik [États-Unis] ; Gauti K. Gislason [Islande] ; Albert Hofman [Pays-Bas] ; Aleksandra Pikula [États-Unis] ; Philippe Amouyel [France] ; Kevin B. Freeman [États-Unis] ; Thanh G. Phan [Australie] ; Ben A. Oostra [Pays-Bas] ; Jason L. Stein [États-Unis] ; Sarah E. Medland [Australie, États-Unis] ; Alejandro Arias Vasquez [Pays-Bas] ; Derrek P. Hibar [États-Unis] ; Margaret J. Wright [Australie] ; Barbara Franke [Pays-Bas] ; Nicholas G. Martin [Australie] ; Paul M. Thompson [États-Unis] ; Michael A. Nalls [États-Unis] ; Andre G. Uitterlinden [Pays-Bas] ; Rhoda Au [États-Unis] ; Alexis Elbaz [France] ; Richard J. Beare [Australie] ; John C. Van Swieten [Pays-Bas] ; Oscar Lopez [États-Unis] ; Tamara B. Harris [États-Unis] ; Vincent Chouraki [France] ; Monique M. B. Breteler [Allemagne, États-Unis] ; Philip L. De Jager [États-Unis] ; James T. Becker [États-Unis] ; Meike W. Vernooij [Pays-Bas] ; David Knopman [États-Unis] ; Franz Fazekas [Autriche] ; Philip A. Wolf [États-Unis] ; Aad Van Der Lugt [Pays-Bas] ; Vilmundur Gudnason [Islande] ; W. T. Longstreth [États-Unis] ; Mathew A. Brown [Australie] ; David A. Bennett [États-Unis] ; Cornelia M. Van Duijn [Pays-Bas] ; Thomas H. Mosley [États-Unis] ; Reinhold Schmidt [Autriche] ; Christophe Tzourio [France] ; Lenore J. Launer [Pays-Bas] ; M. Arfan Ikram [Pays-Bas] ; Sudha Seshadri [États-Unis]Source :
- Nature genetics [ 1061-4036 ] ; 2012.
Abstract
Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer’s disease and vascular risk factors. Our genome-wide association study of dementia-free persons (n=9,232) identified 46 SNPs at four loci with p-values <4.0×10-7. Two additional samples (n=2,318) replicated associations at 12q24 within
Url:
DOI: 10.1038/ng.2237
PubMed: 22504421
PubMed Central: 3427729
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Bis</name><affiliation wicri:level="1"><nlm:aff id="A1">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Neurology and Center of Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Center of Neuroscience, University of California at Davis, Sacramento, CA</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Lijn, Fedde" sort="Van Der Lijn, Fedde" uniqKey="Van Der Lijn F" first="Fedde" last="Van Der Lijn">Fedde Van Der Lijn</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name><affiliation wicri:level="1"><nlm:aff id="A7">Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. 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Shulman</name><affiliation wicri:level="1"><nlm:aff id="A15">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A17">Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biology and Biochemistry, Medical University Graz</wicri:regionArea></affiliation></author><author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name><affiliation wicri:level="1"><nlm:aff id="A18">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A19">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea></affiliation></author><author><name sortKey="Schuur, Maaike" sort="Schuur, Maaike" uniqKey="Schuur M" first="Maaike" last="Schuur">Maaike Schuur</name><affiliation wicri:level="1"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation wicri:level="1"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name><affiliation wicri:level="1"><nlm:aff id="A23">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name><affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Verhaaren, Benjamin F J" sort="Verhaaren, Benjamin F J" uniqKey="Verhaaren B" first="Benjamin F. J." last="Verhaaren">Benjamin F. J. Verhaaren</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><affiliation wicri:level="1"><nlm:aff id="A23">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="1"><nlm:aff id="A27">INSERM Unit 744, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 744, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A28">Institut Pasteur de Lille, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Université Lille Nord de France, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R." last="Jack">Clifford R. Jack</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Radiology, Mayo Clinic, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Mayo Clinic, Rochester, MN</wicri:regionArea></affiliation></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation wicri:level="1"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Stankovich, Jim" sort="Stankovich, Jim" uniqKey="Stankovich J" first="Jim" last="Stankovich">Jim Stankovich</name><affiliation wicri:level="1"><nlm:aff id="A19">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea></affiliation></author><author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name><affiliation wicri:level="1"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name><affiliation wicri:level="1"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A31">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A32">Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name><affiliation wicri:level="1"><nlm:aff id="A33">Biospective Inc., Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Biospective Inc., Montreal</wicri:regionArea></affiliation></author><author><name sortKey="Den Heijer, Tom" sort="Den Heijer, Tom" uniqKey="Den Heijer T" first="Tom" last="Den Heijer">Tom Den Heijer</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A34">Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Sint Franciscus Gasthuis, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><affiliation wicri:level="1"><nlm:aff id="A7">Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name><affiliation wicri:level="1"><nlm:aff id="A35">Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC</wicri:regionArea></affiliation></author><author><name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea></affiliation></author><author><name sortKey="Danoy, Patrick" sort="Danoy, Patrick" uniqKey="Danoy P" first="Patrick" last="Danoy">Patrick Danoy</name><affiliation wicri:level="1"><nlm:aff id="A37">University of Queensland, Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland, Diamantina Institute, Princess Alexandra Hospital, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="1"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name><affiliation wicri:level="1"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Van Buchem, Mark A" sort="Van Buchem, Mark A" uniqKey="Van Buchem M" first="Mark A." last="Van Buchem">Mark A. Van Buchem</name><affiliation wicri:level="1"><nlm:aff id="A39">Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Radiology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A. G." last="De Bruijn">Renée F. A. G. De Bruijn</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><affiliation wicri:level="1"><nlm:aff id="A23">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation wicri:level="1"><nlm:aff id="A12">INSERM, U708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F-75013, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Juebin" sort="Huang, Juebin" uniqKey="Huang J" first="Juebin" last="Huang">Juebin Huang</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea></affiliation></author><author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea></affiliation></author><author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name><affiliation wicri:level="1"><nlm:aff id="A19">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea></affiliation></author><author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Faculty of Applied Sciences, Delft University of Technology, Delft</wicri:regionArea></affiliation></author><author><name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name><affiliation wicri:level="1"><nlm:aff id="A15">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Gislason, Gauti K" sort="Gislason, Gauti K" uniqKey="Gislason G" first="Gauti K." last="Gislason">Gauti K. Gislason</name><affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Pikula, Aleksandra" sort="Pikula, Aleksandra" uniqKey="Pikula A" first="Aleksandra" last="Pikula">Aleksandra Pikula</name><affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><nlm:aff id="A27">INSERM Unit 744, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 744, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A28">Institut Pasteur de Lille, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Université Lille Nord de France, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A43">Centre Hospitalier Régional Universitaire de Lille, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Freeman, Kevin B" sort="Freeman, Kevin B" uniqKey="Freeman K" first="Kevin B." last="Freeman">Kevin B. Freeman</name><affiliation wicri:level="1"><nlm:aff id="A44">Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea></affiliation></author><author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G." last="Phan">Thanh G. Phan</name><affiliation wicri:level="1"><nlm:aff id="A18">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A45">Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Stein, Jason L" sort="Stein, Jason L" uniqKey="Stein J" first="Jason L." last="Stein">Jason L. Stein</name><affiliation wicri:level="1"><nlm:aff id="A46">Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><affiliation wicri:level="1"><nlm:aff id="A47">Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Quantitative Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Quantitative Genetics, Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A49">Broad Institute of Harvard and MIT, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute of Harvard and MIT, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Vasquez, Alejandro Arias" sort="Vasquez, Alejandro Arias" uniqKey="Vasquez A" first="Alejandro Arias" last="Vasquez">Alejandro Arias Vasquez</name><affiliation wicri:level="1"><nlm:aff id="A50">Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A51">Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name><affiliation wicri:level="1"><nlm:aff id="A46">Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name><affiliation wicri:level="1"><nlm:aff id="A47">Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><affiliation wicri:level="1"><nlm:aff id="A50">Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A51">Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="A47">Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name><affiliation wicri:level="1"><nlm:aff id="A46">Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name><affiliation wicri:level="1"><nlm:aff id="A52">Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A53">Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="1"><nlm:aff id="A12">INSERM, U708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F-75013, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">UPMC Univ Paris 06 UMR_S708, Neuroepidemiology, FY75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UPMC Univ Paris 06 UMR_S708, Neuroepidemiology, FY75005, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J." last="Beare">Richard J. Beare</name><affiliation wicri:level="1"><nlm:aff id="A18">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A55">Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Flemington Rd, Parkville, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Flemington Rd, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C." last="Van Swieten">John C. Van Swieten</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lopez, Oscar" sort="Lopez, Oscar" uniqKey="Lopez O" first="Oscar" last="Lopez">Oscar Lopez</name><affiliation wicri:level="1"><nlm:aff id="A56">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A58">Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:aff id="A59">Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation wicri:level="1"><nlm:aff id="A27">INSERM Unit 744, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 744, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A28">Institut Pasteur de Lille, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Université Lille Nord de France, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name><affiliation wicri:level="1"><nlm:aff id="A60">Population Health Sciences, German Center for Neurdegenerative Diseases (DZNE), Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Population Health Sciences, German Center for Neurdegenerative Diseases (DZNE), Bonn</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Population Health Sciences, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Population Health Sciences, University of Bonn, Bonn</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A62">Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L." last="De Jager">Philip L. De Jager</name><affiliation wicri:level="1"><nlm:aff id="A15">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A63">Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T." last="Becker">James T. Becker</name><affiliation wicri:level="1"><nlm:aff id="A56">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A58">Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea></affiliation></author><author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Knopman, David" sort="Knopman, David" uniqKey="Knopman D" first="David" last="Knopman">David Knopman</name><affiliation wicri:level="1"><nlm:aff id="A64">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea></affiliation></author><author><name sortKey="Fazekas, Franz" sort="Fazekas, Franz" uniqKey="Fazekas F" first="Franz" last="Fazekas">Franz Fazekas</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea></affiliation></author><author><name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name><affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W. T." last="Longstreth">W. T. Longstreth</name><affiliation wicri:level="1"><nlm:aff id="A65">Department of Neurology, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A66">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Brown, Mathew A" sort="Brown, Mathew A" uniqKey="Brown M" first="Mathew A." last="Brown">Mathew A. Brown</name><affiliation wicri:level="1"><nlm:aff id="A67">University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name><affiliation wicri:level="1"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A68">Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A69">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="1"><nlm:aff id="A70">Univ. Bordeaux, U708, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, U708, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A71">INSERM, Neuroepidemiology U708, F-33000, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Neuroepidemiology U708, F-33000, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation wicri:level="1"><nlm:aff id="A51">Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22504421</idno><idno type="pmc">3427729</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427729</idno><idno type="RBID">PMC:3427729</idno><idno type="doi">10.1038/ng.2237</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002E13</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002E13</idno><idno type="wicri:Area/Pmc/Curation">002C63</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002C63</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Common variants at 12q14 and 12q24 are associated with hippocampal volume</title><author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C." last="Bis">Joshua C. Bis</name><affiliation wicri:level="1"><nlm:aff id="A1">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Decarli, Charles" sort="Decarli, Charles" uniqKey="Decarli C" first="Charles" last="Decarli">Charles Decarli</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Neurology and Center of Neuroscience, University of California at Davis, Sacramento, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Center of Neuroscience, University of California at Davis, Sacramento, CA</wicri:regionArea></affiliation></author><author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name><affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Lijn, Fedde" sort="Van Der Lijn, Fedde" uniqKey="Van Der Lijn F" first="Fedde" last="Van Der Lijn">Fedde Van Der Lijn</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Crivello, Fabrice" sort="Crivello, Fabrice" uniqKey="Crivello F" first="Fabrice" last="Crivello">Fabrice Crivello</name><affiliation wicri:level="1"><nlm:aff id="A7">Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name><affiliation wicri:level="1"><nlm:aff id="A10">Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A11">Human Genetics Center School of Public Health, The University of Texas Health Sciences Center at Houston, Houston, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Human Genetics Center School of Public Health, The University of Texas Health Sciences Center at Houston, Houston, TX</wicri:regionArea></affiliation></author><author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name><affiliation wicri:level="1"><nlm:aff id="A12">INSERM, U708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F-75013, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A13">Department of Epidemiology, University of Versailles St-Quentin-en-Yvelines, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology, University of Versailles St-Quentin-en-Yvelines</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A14">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Shulman, Joshua M" sort="Shulman, Joshua M" uniqKey="Shulman J" first="Joshua M." last="Shulman">Joshua M. Shulman</name><affiliation wicri:level="1"><nlm:aff id="A15">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A17">Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Institute of Molecular Biology and Biochemistry, Medical University Graz</wicri:regionArea></affiliation></author><author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name><affiliation wicri:level="1"><nlm:aff id="A18">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A19">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea></affiliation></author><author><name sortKey="Schuur, Maaike" sort="Schuur, Maaike" uniqKey="Schuur M" first="Maaike" last="Schuur">Maaike Schuur</name><affiliation wicri:level="1"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name><affiliation wicri:level="1"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Choi, Seung Hoan" sort="Choi, Seung Hoan" uniqKey="Choi S" first="Seung-Hoan" last="Choi">Seung-Hoan Choi</name><affiliation wicri:level="1"><nlm:aff id="A23">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Sigurdsson, Sigurdur" sort="Sigurdsson, Sigurdur" uniqKey="Sigurdsson S" first="Sigurdur" last="Sigurdsson">Sigurdur Sigurdsson</name><affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Verhaaren, Benjamin F J" sort="Verhaaren, Benjamin F J" uniqKey="Verhaaren B" first="Benjamin F. J." last="Verhaaren">Benjamin F. J. Verhaaren</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Destefano, Anita L" sort="Destefano, Anita L" uniqKey="Destefano A" first="Anita L." last="Destefano">Anita L. Destefano</name><affiliation wicri:level="1"><nlm:aff id="A23">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Lambert, Jean Charles" sort="Lambert, Jean Charles" uniqKey="Lambert J" first="Jean-Charles" last="Lambert">Jean-Charles Lambert</name><affiliation wicri:level="1"><nlm:aff id="A27">INSERM Unit 744, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 744, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A28">Institut Pasteur de Lille, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Université Lille Nord de France, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R." last="Jack">Clifford R. Jack</name><affiliation wicri:level="1"><nlm:aff id="A30">Department of Radiology, Mayo Clinic, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiology, Mayo Clinic, Rochester, MN</wicri:regionArea></affiliation></author><author><name sortKey="Struchalin, Maksim" sort="Struchalin, Maksim" uniqKey="Struchalin M" first="Maksim" last="Struchalin">Maksim Struchalin</name><affiliation wicri:level="1"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Stankovich, Jim" sort="Stankovich, Jim" uniqKey="Stankovich J" first="Jim" last="Stankovich">Jim Stankovich</name><affiliation wicri:level="1"><nlm:aff id="A19">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea></affiliation></author><author><name sortKey="Ibrahim Verbaas, Carla A" sort="Ibrahim Verbaas, Carla A" uniqKey="Ibrahim Verbaas C" first="Carla A." last="Ibrahim-Verbaas">Carla A. Ibrahim-Verbaas</name><affiliation wicri:level="1"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name><affiliation wicri:level="1"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A31">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A32">Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Zijdenbos, Alex" sort="Zijdenbos, Alex" uniqKey="Zijdenbos A" first="Alex" last="Zijdenbos">Alex Zijdenbos</name><affiliation wicri:level="1"><nlm:aff id="A33">Biospective Inc., Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Biospective Inc., Montreal</wicri:regionArea></affiliation></author><author><name sortKey="Den Heijer, Tom" sort="Den Heijer, Tom" uniqKey="Den Heijer T" first="Tom" last="Den Heijer">Tom Den Heijer</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A34">Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Neurology, Sint Franciscus Gasthuis, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name><affiliation wicri:level="1"><nlm:aff id="A7">Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A8">Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A9">Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Coker, Laura H" sort="Coker, Laura H" uniqKey="Coker L" first="Laura H." last="Coker">Laura H. Coker</name><affiliation wicri:level="1"><nlm:aff id="A35">Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC</wicri:regionArea></affiliation></author><author><name sortKey="Enzinger, Christian" sort="Enzinger, Christian" uniqKey="Enzinger C" first="Christian" last="Enzinger">Christian Enzinger</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea></affiliation></author><author><name sortKey="Danoy, Patrick" sort="Danoy, Patrick" uniqKey="Danoy P" first="Patrick" last="Danoy">Patrick Danoy</name><affiliation wicri:level="1"><nlm:aff id="A37">University of Queensland, Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland, Diamantina Institute, Princess Alexandra Hospital, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Amin, Najaf" sort="Amin, Najaf" uniqKey="Amin N" first="Najaf" last="Amin">Najaf Amin</name><affiliation wicri:level="1"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name><affiliation wicri:level="1"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A38">Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Van Buchem, Mark A" sort="Van Buchem, Mark A" uniqKey="Van Buchem M" first="Mark A." last="Van Buchem">Mark A. Van Buchem</name><affiliation wicri:level="1"><nlm:aff id="A39">Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Radiology, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="De Bruijn, Renee F A G" sort="De Bruijn, Renee F A G" uniqKey="De Bruijn R" first="Renée F. A. G." last="De Bruijn">Renée F. A. G. De Bruijn</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Beiser, Alexa" sort="Beiser, Alexa" uniqKey="Beiser A" first="Alexa" last="Beiser">Alexa Beiser</name><affiliation wicri:level="1"><nlm:aff id="A23">Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Dufouil, Carole" sort="Dufouil, Carole" uniqKey="Dufouil C" first="Carole" last="Dufouil">Carole Dufouil</name><affiliation wicri:level="1"><nlm:aff id="A12">INSERM, U708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F-75013, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Huang, Juebin" sort="Huang, Juebin" uniqKey="Huang J" first="Juebin" last="Huang">Juebin Huang</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea></affiliation></author><author><name sortKey="Cavalieri, Margherita" sort="Cavalieri, Margherita" uniqKey="Cavalieri M" first="Margherita" last="Cavalieri">Margherita Cavalieri</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea></affiliation></author><author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name><affiliation wicri:level="1"><nlm:aff id="A19">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart</wicri:regionArea></affiliation></author><author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name><affiliation wicri:level="1"><nlm:aff id="A5">Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A41">Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Faculty of Applied Sciences, Delft University of Technology, Delft</wicri:regionArea></affiliation></author><author><name sortKey="Chibnik, Lori B" sort="Chibnik, Lori B" uniqKey="Chibnik L" first="Lori B." last="Chibnik">Lori B. Chibnik</name><affiliation wicri:level="1"><nlm:aff id="A15">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Gislason, Gauti K" sort="Gislason, Gauti K" uniqKey="Gislason G" first="Gauti K." last="Gislason">Gauti K. Gislason</name><affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation></author><author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name><affiliation wicri:level="1"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Pikula, Aleksandra" sort="Pikula, Aleksandra" uniqKey="Pikula A" first="Aleksandra" last="Pikula">Aleksandra Pikula</name><affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name><affiliation wicri:level="1"><nlm:aff id="A27">INSERM Unit 744, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 744, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A28">Institut Pasteur de Lille, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Université Lille Nord de France, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A43">Centre Hospitalier Régional Universitaire de Lille, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Hospitalier Régional Universitaire de Lille, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Freeman, Kevin B" sort="Freeman, Kevin B" uniqKey="Freeman K" first="Kevin B." last="Freeman">Kevin B. Freeman</name><affiliation wicri:level="1"><nlm:aff id="A44">Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea></affiliation></author><author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G." last="Phan">Thanh G. Phan</name><affiliation wicri:level="1"><nlm:aff id="A18">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne</wicri:regionArea></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation wicri:level="1"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A45">Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Stein, Jason L" sort="Stein, Jason L" uniqKey="Stein J" first="Jason L." last="Stein">Jason L. Stein</name><affiliation wicri:level="1"><nlm:aff id="A46">Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E." last="Medland">Sarah E. Medland</name><affiliation wicri:level="1"><nlm:aff id="A47">Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A48">Quantitative Genetics, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Quantitative Genetics, Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A49">Broad Institute of Harvard and MIT, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Broad Institute of Harvard and MIT, Cambridge, MA</wicri:regionArea></affiliation></author><author><name sortKey="Vasquez, Alejandro Arias" sort="Vasquez, Alejandro Arias" uniqKey="Vasquez A" first="Alejandro Arias" last="Vasquez">Alejandro Arias Vasquez</name><affiliation wicri:level="1"><nlm:aff id="A50">Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A51">Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Hibar, Derrek P" sort="Hibar, Derrek P" uniqKey="Hibar D" first="Derrek P." last="Hibar">Derrek P. Hibar</name><affiliation wicri:level="1"><nlm:aff id="A46">Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J." last="Wright">Margaret J. Wright</name><affiliation wicri:level="1"><nlm:aff id="A47">Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Franke, Barbara" sort="Franke, Barbara" uniqKey="Franke B" first="Barbara" last="Franke">Barbara Franke</name><affiliation wicri:level="1"><nlm:aff id="A50">Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A51">Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G." last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:aff id="A47">Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Thompson, Paul M" sort="Thompson, Paul M" uniqKey="Thompson P" first="Paul M." last="Thompson">Paul M. Thompson</name><affiliation wicri:level="1"><nlm:aff id="A46">Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA</wicri:regionArea></affiliation></author><author><name sortKey="Nalls, Michael A" sort="Nalls, Michael A" uniqKey="Nalls M" first="Michael A." last="Nalls">Michael A. Nalls</name><affiliation wicri:level="1"><nlm:aff id="A52">Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name><affiliation wicri:level="1"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A53">Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Au, Rhoda" sort="Au, Rhoda" uniqKey="Au R" first="Rhoda" last="Au">Rhoda Au</name><affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="1"><nlm:aff id="A12">INSERM, U708, Neuroepidemiology, F-75013, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, F-75013, Paris</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A54">UPMC Univ Paris 06 UMR_S708, Neuroepidemiology, FY75005, Paris, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>UPMC Univ Paris 06 UMR_S708, Neuroepidemiology, FY75005, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J." last="Beare">Richard J. Beare</name><affiliation wicri:level="1"><nlm:aff id="A18">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A55">Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Flemington Rd, Parkville, Victoria, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Flemington Rd, Parkville, Victoria</wicri:regionArea></affiliation></author><author><name sortKey="Van Swieten, John C" sort="Van Swieten, John C" uniqKey="Van Swieten J" first="John C." last="Van Swieten">John C. Van Swieten</name><affiliation wicri:level="1"><nlm:aff id="A21">Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Lopez, Oscar" sort="Lopez, Oscar" uniqKey="Lopez O" first="Oscar" last="Lopez">Oscar Lopez</name><affiliation wicri:level="1"><nlm:aff id="A56">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A58">Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea></affiliation></author><author><name sortKey="Harris, Tamara B" sort="Harris, Tamara B" uniqKey="Harris T" first="Tamara B." last="Harris">Tamara B. Harris</name><affiliation wicri:level="1"><nlm:aff id="A59">Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD</wicri:regionArea></affiliation></author><author><name sortKey="Chouraki, Vincent" sort="Chouraki, Vincent" uniqKey="Chouraki V" first="Vincent" last="Chouraki">Vincent Chouraki</name><affiliation wicri:level="1"><nlm:aff id="A27">INSERM Unit 744, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 744, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A28">Institut Pasteur de Lille, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Pasteur de Lille, Lille</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A29">Université Lille Nord de France, Lille, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Lille Nord de France, Lille</wicri:regionArea></affiliation></author><author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name><affiliation wicri:level="1"><nlm:aff id="A60">Population Health Sciences, German Center for Neurdegenerative Diseases (DZNE), Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Population Health Sciences, German Center for Neurdegenerative Diseases (DZNE), Bonn</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A61">Population Health Sciences, University of Bonn, Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Population Health Sciences, University of Bonn, Bonn</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A62">Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="De Jager, Philip L" sort="De Jager, Philip L" uniqKey="De Jager P" first="Philip L." last="De Jager">Philip L. De Jager</name><affiliation wicri:level="1"><nlm:aff id="A15">Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A16">Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A63">Harvard Medical School, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Harvard Medical School, Boston, MA</wicri:regionArea></affiliation></author><author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T." last="Becker">James T. Becker</name><affiliation wicri:level="1"><nlm:aff id="A56">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A57">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A58">Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA</wicri:regionArea></affiliation></author><author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Knopman, David" sort="Knopman, David" uniqKey="Knopman D" first="David" last="Knopman">David Knopman</name><affiliation wicri:level="1"><nlm:aff id="A64">Department of Neurology, Mayo Clinic, Rochester, MN, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Mayo Clinic, Rochester, MN</wicri:regionArea></affiliation></author><author><name sortKey="Fazekas, Franz" sort="Fazekas, Franz" uniqKey="Fazekas F" first="Franz" last="Fazekas">Franz Fazekas</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea></affiliation></author><author><name sortKey="Wolf, Philip A" sort="Wolf, Philip A" uniqKey="Wolf P" first="Philip A." last="Wolf">Philip A. Wolf</name><affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author><author><name sortKey="Van Der Lugt, Aad" sort="Van Der Lugt, Aad" uniqKey="Van Der Lugt A" first="Aad" last="Van Der Lugt">Aad Van Der Lugt</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Gudnason, Vilmundur" sort="Gudnason, Vilmundur" uniqKey="Gudnason V" first="Vilmundur" last="Gudnason">Vilmundur Gudnason</name><affiliation wicri:level="1"><nlm:aff id="A3">Icelandic Heart Association, Kopavogur, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>Icelandic Heart Association, Kopavogur</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">University of Iceland, Faculty of Medicine, Reykjavik, Iceland</nlm:aff><country xml:lang="fr">Islande</country><wicri:regionArea>University of Iceland, Faculty of Medicine, Reykjavik</wicri:regionArea></affiliation></author><author><name sortKey="Longstreth, W T" sort="Longstreth, W T" uniqKey="Longstreth W" first="W. T." last="Longstreth">W. T. Longstreth</name><affiliation wicri:level="1"><nlm:aff id="A65">Department of Neurology, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Washington, Seattle, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A66">Department of Epidemiology, University of Washington, Seattle, WA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Epidemiology, University of Washington, Seattle, WA</wicri:regionArea></affiliation></author><author><name sortKey="Brown, Mathew A" sort="Brown, Mathew A" uniqKey="Brown M" first="Mathew A." last="Brown">Mathew A. Brown</name><affiliation wicri:level="1"><nlm:aff id="A67">University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane</wicri:regionArea></affiliation></author><author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A." last="Bennett">David A. Bennett</name><affiliation wicri:level="1"><nlm:aff id="A22">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea></affiliation></author><author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M." last="Van Duijn">Cornelia M. Van Duijn</name><affiliation wicri:level="1"><nlm:aff id="A20">Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A68">Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H." last="Mosley">Thomas H. Mosley</name><affiliation wicri:level="1"><nlm:aff id="A40">Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Mississippi Medical Center, Jackson, MS</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A69">Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name><affiliation wicri:level="1"><nlm:aff id="A36">Department of Neurology, Medical University Graz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Neurology, Medical University Graz</wicri:regionArea></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="1"><nlm:aff id="A70">Univ. Bordeaux, U708, F-33000 Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Univ. Bordeaux, U708, F-33000 Bordeaux</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A71">INSERM, Neuroepidemiology U708, F-33000, Bordeaux, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Neuroepidemiology U708, F-33000, Bordeaux</wicri:regionArea></affiliation></author><author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J." last="Launer">Lenore J. Launer</name><affiliation wicri:level="1"><nlm:aff id="A51">Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen</wicri:regionArea></affiliation></author><author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M. Arfan" last="Ikram">M. Arfan Ikram</name><affiliation wicri:level="1"><nlm:aff id="A6">Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Radiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A24">Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A42">Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</nlm:aff><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Netherlands Consortium for Healthy Ageing, Leiden</wicri:regionArea></affiliation></author><author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name><affiliation wicri:level="1"><nlm:aff id="A25">Department of Neurology, Boston University School of Medicine, Boston, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, MA</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="A26">The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA</wicri:regionArea></affiliation></author></analytic><series><title level="j">Nature genetics</title><idno type="ISSN">1061-4036</idno><idno type="eISSN">1546-1718</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer’s disease and vascular risk factors. Our genome-wide association study of dementia-free persons (n=9,232) identified 46 SNPs at four loci with p-values <4.0×10<sup>-7</sup>. Two additional samples (n=2,318) replicated associations at 12q24 within <italic>MSRB3/WIF1</italic> (discovery + replication, rs17178006; p=5.3×10<sup>-11</sup>) and at 12q14 near <italic>HRK/FBXW8</italic> (rs7294919; p=2.9×10<sup>-11</sup>). Remaining associations included one 2q24 SNP within <italic>DPP4</italic> (rs6741949; p=2.9×10<sup>-7</sup>) and nine 9p33 SNPs within <italic>ASTN2</italic> (rs7852872; p=1.0×10<sup>-7</sup>) that were also associated with HV (p<0.05) in a third younger, more heterogeneous sample (n=7,794). The <italic>ASTN2</italic> SNP was also associated with decline in cognition in a largely independent sample (n=1,563). These associations implicate genes related to apoptosis (<italic>HRK</italic>), development (<italic>WIF1)</italic>, oxidative stress (<italic>MSR3B</italic>), ubiquitination (<italic>FBXW8</italic>), enzymes targeted by new diabetes medications (<italic>DPP4</italic>), and neuronal migration (<italic>ASTN2</italic>), indicating novel genetic influences that influence hippocampal size and possibly the risk of cognitive decline and dementia.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ridha, Bh" uniqKey="Ridha B">BH Ridha</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Small, Gw" uniqKey="Small G">GW Small</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Den Heijer, T" uniqKey="Den Heijer T">T den Heijer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seshadri, S" uniqKey="Seshadri S">S 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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9216904</journal-id><journal-id journal-id-type="pubmed-jr-id">2419</journal-id><journal-id journal-id-type="nlm-ta">Nat Genet</journal-id><journal-id journal-id-type="iso-abbrev">Nat. Genet.</journal-id><journal-title-group><journal-title>Nature genetics</journal-title></journal-title-group><issn pub-type="ppub">1061-4036</issn><issn pub-type="epub">1546-1718</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22504421</article-id><article-id pub-id-type="pmc">3427729</article-id><article-id pub-id-type="doi">10.1038/ng.2237</article-id><article-id pub-id-type="manuscript">NIHMS362237</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Common variants at 12q14 and 12q24 are associated with hippocampal volume</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bis</surname><given-names>Joshua C.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>DeCarli</surname><given-names>Charles</given-names></name><xref ref-type="aff" 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contrib-type="author"><name><surname>Freeman</surname><given-names>Kevin B.</given-names></name><xref ref-type="aff" rid="A44">44</xref></contrib><contrib contrib-type="author"><name><surname>Phan</surname><given-names>Thanh G.</given-names></name><xref ref-type="aff" rid="A18">18</xref></contrib><contrib contrib-type="author"><name><surname>Oostra</surname><given-names>Ben A.</given-names></name><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A45">45</xref></contrib><contrib contrib-type="author"><name><surname>Stein</surname><given-names>Jason L.</given-names></name><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Medland</surname><given-names>Sarah E.</given-names></name><xref ref-type="aff" rid="A47">47</xref><xref ref-type="aff" rid="A48">48</xref><xref ref-type="aff" rid="A49">49</xref></contrib><contrib contrib-type="author"><name><surname>Vasquez</surname><given-names>Alejandro Arias</given-names></name><xref ref-type="aff" rid="A50">50</xref><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Hibar</surname><given-names>Derrek P.</given-names></name><xref ref-type="aff" rid="A46">46</xref></contrib><contrib contrib-type="author"><name><surname>Wright</surname><given-names>Margaret J.</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Franke</surname><given-names>Barbara</given-names></name><xref ref-type="aff" rid="A50">50</xref><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Martin</surname><given-names>Nicholas G.</given-names></name><xref ref-type="aff" rid="A47">47</xref></contrib><contrib contrib-type="author"><name><surname>Thompson</surname><given-names>Paul M.</given-names></name><xref ref-type="aff" rid="A46">46</xref><on-behalf-of>for the ENIGMA Consortium</on-behalf-of></contrib><contrib contrib-type="author"><name><surname>Nalls</surname><given-names>Michael A.</given-names></name><xref ref-type="aff" rid="A52">52</xref></contrib><contrib contrib-type="author"><name><surname>Uitterlinden</surname><given-names>Andre G.</given-names></name><xref ref-type="aff" rid="A42">42</xref><xref ref-type="aff" rid="A53">53</xref></contrib><contrib contrib-type="author"><name><surname>Au</surname><given-names>Rhoda</given-names></name><xref ref-type="aff" rid="A25">25</xref><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>Elbaz</surname><given-names>Alexis</given-names></name><xref ref-type="aff" rid="A12">12</xref><xref ref-type="aff" rid="A54">54</xref></contrib><contrib contrib-type="author"><name><surname>Beare</surname><given-names>Richard J.</given-names></name><xref ref-type="aff" rid="A18">18</xref><xref ref-type="aff" rid="A55">55</xref></contrib><contrib contrib-type="author"><name><surname>van 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contrib-type="author"><name><surname>De Jager</surname><given-names>Philip L.</given-names></name><xref ref-type="aff" rid="A15">15</xref><xref ref-type="aff" rid="A16">16</xref><xref ref-type="aff" rid="A63">63</xref></contrib><contrib contrib-type="author"><name><surname>Becker</surname><given-names>James T.</given-names></name><xref ref-type="aff" rid="A56">56</xref><xref ref-type="aff" rid="A57">57</xref><xref ref-type="aff" rid="A58">58</xref></contrib><contrib contrib-type="author"><name><surname>Vernooij</surname><given-names>Meike W.</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A24">24</xref></contrib><contrib contrib-type="author"><name><surname>Knopman</surname><given-names>David</given-names></name><xref ref-type="aff" rid="A64">64</xref></contrib><contrib contrib-type="author"><name><surname>Fazekas</surname><given-names>Franz</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Wolf</surname><given-names>Philip A.</given-names></name><xref ref-type="aff" rid="A25">25</xref><xref ref-type="aff" rid="A26">26</xref></contrib><contrib contrib-type="author"><name><surname>van der Lugt</surname><given-names>Aad</given-names></name><xref ref-type="aff" rid="A6">6</xref></contrib><contrib contrib-type="author"><name><surname>Gudnason</surname><given-names>Vilmundur</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="aff" rid="A4">4</xref></contrib><contrib contrib-type="author"><name><surname>Longstreth</surname><given-names>W.T.</given-names><suffix>Jr.</suffix></name><xref ref-type="aff" rid="A65">65</xref><xref ref-type="aff" rid="A66">66</xref></contrib><contrib contrib-type="author"><name><surname>Brown</surname><given-names>Mathew A.</given-names></name><xref ref-type="aff" rid="A67">67</xref></contrib><contrib contrib-type="author"><name><surname>Bennett</surname><given-names>David A.</given-names></name><xref ref-type="aff" rid="A22">22</xref></contrib><contrib contrib-type="author"><name><surname>van Duijn</surname><given-names>Cornelia M.</given-names></name><xref ref-type="aff" rid="A20">20</xref><xref ref-type="aff" rid="A42">42</xref><xref ref-type="aff" rid="A68">68</xref></contrib><contrib contrib-type="author"><name><surname>Mosley</surname><given-names>Thomas H.</given-names></name><xref ref-type="aff" rid="A40">40</xref><xref ref-type="aff" rid="A69">69</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Reinhold</given-names></name><xref ref-type="aff" rid="A36">36</xref></contrib><contrib contrib-type="author"><name><surname>Tzourio</surname><given-names>Christophe</given-names></name><xref ref-type="aff" rid="A70">70</xref><xref ref-type="aff" rid="A71">71</xref></contrib><contrib contrib-type="author"><name><surname>Launer</surname><given-names>Lenore J.</given-names></name><xref ref-type="aff" rid="A51">51</xref></contrib><contrib contrib-type="author"><name><surname>Ikram</surname><given-names>M. Arfan</given-names></name><xref ref-type="aff" rid="A6">6</xref><xref ref-type="aff" rid="A24">24</xref><xref ref-type="aff" rid="A42">42</xref></contrib><contrib contrib-type="author"><name><surname>Seshadri</surname><given-names>Sudha</given-names></name><xref ref-type="aff" rid="A25">25</xref><xref ref-type="aff" rid="A26">26</xref></contrib><on-behalf-of>for the CHARGE Consortium</on-behalf-of></contrib-group><aff id="A1"><label>1</label>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA</aff><aff id="A2"><label>2</label>Department of Neurology and Center of Neuroscience, University of California at Davis, Sacramento, CA, USA</aff><aff id="A3"><label>3</label>Icelandic Heart Association, Kopavogur, Iceland</aff><aff id="A4"><label>4</label>University of Iceland, Faculty of Medicine, Reykjavik, Iceland</aff><aff id="A5"><label>5</label>Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</aff><aff id="A6"><label>6</label>Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</aff><aff id="A7"><label>7</label>Univ. Bordeaux, Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</aff><aff id="A8"><label>8</label>Centre National de la Recherche Scientifique (CNRS), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</aff><aff id="A9"><label>9</label>Commissariat à l’Energie Atomique (CEA), Neurofunctional Imaging Group, UMR 5296, F-33000 Bordeaux, France</aff><aff id="A10"><label>10</label>Brown Foundation Institute of Molecular Medicine, The University of Texas Health Sciences Center at Houston, Houston, TX, USA</aff><aff id="A11"><label>11</label>Human Genetics Center School of Public Health, The University of Texas Health Sciences Center at Houston, Houston, TX, USA</aff><aff id="A12"><label>12</label>INSERM, U708, Neuroepidemiology, F-75013, Paris, France</aff><aff id="A13"><label>13</label>Department of Epidemiology, University of Versailles St-Quentin-en-Yvelines, France</aff><aff id="A14"><label>14</label>Department of Neurology, Boston University School of Medicine, Boston, MA, USA</aff><aff id="A15"><label>15</label>Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Department of Neurology, Brigham and Women’s Hospital, Boston, MA, USA</aff><aff id="A16"><label>16</label>Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA</aff><aff id="A17"><label>17</label>Institute of Molecular Biology and Biochemistry, Medical University Graz, Austria</aff><aff id="A18"><label>18</label>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Australia</aff><aff id="A19"><label>19</label>Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia</aff><aff id="A20"><label>20</label>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</aff><aff id="A21"><label>21</label>Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</aff><aff id="A22"><label>22</label>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</aff><aff id="A23"><label>23</label>Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA</aff><aff id="A24"><label>24</label>Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands</aff><aff id="A25"><label>25</label>Department of Neurology, Boston University School of Medicine, Boston, MA, USA</aff><aff id="A26"><label>26</label>The National, Heart, Lung and Blood Institute’s Framingham Heart Study, Framingham, MA, USA</aff><aff id="A27"><label>27</label>INSERM Unit 744, Lille, France</aff><aff id="A28"><label>28</label>Institut Pasteur de Lille, Lille, France</aff><aff id="A29"><label>29</label>Université Lille Nord de France, Lille, France</aff><aff id="A30"><label>30</label>Department of Radiology, Mayo Clinic, Rochester, MN, USA</aff><aff id="A31"><label>31</label>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</aff><aff id="A32"><label>32</label>Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA</aff><aff id="A33"><label>33</label>Biospective Inc., Montreal, Canada</aff><aff id="A34"><label>34</label>Department of Neurology, Sint Franciscus Gasthuis, Rotterdam, the Netherlands</aff><aff id="A35"><label>35</label>Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA</aff><aff id="A36"><label>36</label>Department of Neurology, Medical University Graz, Austria</aff><aff id="A37"><label>37</label>University of Queensland, Diamantina Institute, Princess Alexandra Hospital, Brisbane, Australia</aff><aff id="A38"><label>38</label>Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA</aff><aff id="A39"><label>39</label>Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands</aff><aff id="A40"><label>40</label>Department of Neurology, University of Mississippi Medical Center, Jackson, MS, USA</aff><aff id="A41"><label>41</label>Faculty of Applied Sciences, Delft University of Technology, Delft, the Netherlands</aff><aff id="A42"><label>42</label>Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands</aff><aff id="A43"><label>43</label>Centre Hospitalier Régional Universitaire de Lille, Lille, France</aff><aff id="A44"><label>44</label>Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, MS, USA</aff><aff id="A45"><label>45</label>Department of Clinical Genetics, Erasmus MC University Medical Center, Rotterdam, The Netherlands</aff><aff id="A46"><label>46</label>Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA</aff><aff id="A47"><label>47</label>Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia</aff><aff id="A48"><label>48</label>Quantitative Genetics, Queensland Institute of Medical Research, Brisbane, Australia</aff><aff id="A49"><label>49</label>Broad Institute of Harvard and MIT, Cambridge, MA, USA</aff><aff id="A50"><label>50</label>Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</aff><aff id="A51"><label>51</label>Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands</aff><aff id="A52"><label>52</label>Laboratory of Neurogenetics, Intramural Research Program, National Institute of Aging, NIH, Bethesda, MD, USA</aff><aff id="A53"><label>53</label>Department of Internal Medicine, Erasmus MC University Medical Center, Rotterdam, the Netherlands</aff><aff id="A54"><label>54</label>UPMC Univ Paris 06 UMR_S708, Neuroepidemiology, FY75005, Paris, France</aff><aff id="A55"><label>55</label>Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Flemington Rd, Parkville, Victoria, Australia</aff><aff id="A56"><label>56</label>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</aff><aff id="A57"><label>57</label>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</aff><aff id="A58"><label>58</label>Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA</aff><aff id="A59"><label>59</label>Laboratory of Epidemiology, Demography, and Biometry, National Institute of Health, Bethesda, MD, USA</aff><aff id="A60"><label>60</label>Population Health Sciences, German Center for Neurdegenerative Diseases (DZNE), Bonn, Germany</aff><aff id="A61"><label>61</label>Population Health Sciences, University of Bonn, Bonn, Germany</aff><aff id="A62"><label>62</label>Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA, USA</aff><aff id="A63"><label>63</label>Harvard Medical School, Boston, MA, USA</aff><aff id="A64"><label>64</label>Department of Neurology, Mayo Clinic, Rochester, MN, USA</aff><aff id="A65"><label>65</label>Department of Neurology, University of Washington, Seattle, WA, USA</aff><aff id="A66"><label>66</label>Department of Epidemiology, University of Washington, Seattle, WA, USA</aff><aff id="A67"><label>67</label>University of Queensland Diamantina Institute, Princess Alexandra Hospital, Woolloongabba, Brisbane, Australia</aff><aff id="A68"><label>68</label>Center for Medical Systems Biology, Netherlands Genomics Initiative, Leiden University Medical Center, Leiden, The Netherlands</aff><aff id="A69"><label>69</label>Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, MS, USA</aff><aff id="A70"><label>70</label>Univ. Bordeaux, U708, F-33000 Bordeaux, France</aff><aff id="A71"><label>71</label>INSERM, Neuroepidemiology U708, F-33000, Bordeaux, France</aff><author-notes><fn id="FN1" fn-type="equal"><p>Joshua C. Bis, Charles DeCarli, Albert Vernon Smith, Fedde van der Lijn, Fabrice Crivello, Myriam Fornage and Stephanie Debette contributed equally as first authors.</p><p>Cornelia M. van Duijn, Thomas H. Mosley, Reinhold Schmidt, Christophe Tzourio, Lenore J. Launer, M. Arfan Ikram and Sudha Seshadri contributed equally as last authors.</p><p>Jason L. Stein, Sarah E. Medland, Alejandro Arias Vasquez, Derrek P. Hibar, Margaret J. Wright, Barbara Franke, Nicholas G. Martin and Paul M. Thompson represent the ENIGMA consortium.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>2</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>15</day><month>4</month><year>2012</year></pub-date><pub-date pub-type="collection"><month>5</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>11</month><year>2012</year></pub-date><volume>44</volume><issue>5</issue><fpage>545</fpage><lpage>551</lpage><pmc-comment>elocation-id from pubmed: 10.1038/ng.2237</pmc-comment>
<permissions><license xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms"><license-p>Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:<ext-link ext-link-type="uri" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</ext-link></license-p></license></permissions><abstract><p id="P1">Aging is associated with reductions in hippocampal volume (HV) that are accelerated by Alzheimer’s disease and vascular risk factors. Our genome-wide association study of dementia-free persons (n=9,232) identified 46 SNPs at four loci with p-values <4.0×10<sup>-7</sup>. Two additional samples (n=2,318) replicated associations at 12q24 within <italic>MSRB3/WIF1</italic> (discovery + replication, rs17178006; p=5.3×10<sup>-11</sup>) and at 12q14 near <italic>HRK/FBXW8</italic> (rs7294919; p=2.9×10<sup>-11</sup>). Remaining associations included one 2q24 SNP within <italic>DPP4</italic> (rs6741949; p=2.9×10<sup>-7</sup>) and nine 9p33 SNPs within <italic>ASTN2</italic> (rs7852872; p=1.0×10<sup>-7</sup>) that were also associated with HV (p<0.05) in a third younger, more heterogeneous sample (n=7,794). The <italic>ASTN2</italic> SNP was also associated with decline in cognition in a largely independent sample (n=1,563). These associations implicate genes related to apoptosis (<italic>HRK</italic>), development (<italic>WIF1)</italic>, oxidative stress (<italic>MSR3B</italic>), ubiquitination (<italic>FBXW8</italic>), enzymes targeted by new diabetes medications (<italic>DPP4</italic>), and neuronal migration (<italic>ASTN2</italic>), indicating novel genetic influences that influence hippocampal size and possibly the risk of cognitive decline and dementia.</p></abstract></article-meta></front><floats-group><fig id="F1" orientation="portrait" position="float"><label>Figure 1</label><caption><title>Genome-wide Manhattan plot for hippocampal volume</title><p>The plot shows the individual p-values (based on discovery meta-analysis) against their genomic position for hippocampal volume. Within each chromosome, shown on the <italic>x</italic>-axis, the results are plotted left to right from the p-terminal end. The dashed line indicates the threshold for follow-up, p<4 ×10<sup>-7</sup> and the solid line indicates the threshold for genome-wide significance, p<5×10<sup>-8</sup>. The nearest genes are indicated above points that surpassed our significance threshold for follow-up.</p></caption><graphic xlink:href="nihms362237f1"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Figure 2</label><caption><title>Regional plots for hippocampal volume SNPs</title><p>Plots are centered on the most significant SNP at a given locus along with the meta-analysis results for SNPs in a region surrounding it (typically ± 100kb). All SNPs are plotted with their discovery meta-analysis p-values against their genomic position, with the most significant SNP in the region indicated as a diamond and other SNPs shaded according to their pairwise correlation (<italic>r<sup>2</sup></italic>) with the signal SNP. The light blue line represents the estimated recombination rates. Gene annotations are shown as dark green lines.</p></caption><graphic xlink:href="nihms362237f2"></graphic></fig><fig id="F3" orientation="portrait" position="float"><label>Figure 3</label><caption><title>Forest plots for hippocampal volume SNP associations</title><p>Plots show the study-specific association estimates (β) and 95% confidence intervals for the discovery and replication stage studies, presented as rectangles and bars. Arrowheads indicate confidence intervals that span beyond the x-axis. Study specific results are indicated by: AGES, Aging Gene-Environment Susceptibility—Reykjavik Study; ARIC, Atherosclerosis Risk in Communities Study, ASPS, Austrian Stroke Prevention Study; ERF, Erasmus Ruchphen Family study; FHS, Framingham Heart Study; RUSH, Religious Order Study & Rush Memory and Aging Project; RS I, RS II, RS III, RS R, independent phases of the Rotterdam Study; TASCOG, Tasmanian Study of Cognition and Gait; 3C, Three City Study. Estimates from the replication phase (3C, RS R) are indicated by open rectangles. The scale is mm<sup>3</sup>. The association estimate and confidence interval for the meta-analysis combining discovery and second stage results is presented as a diamond. Blank spaces indicate occasions in which a particular study was not able to provide results for a given SNP.</p></caption><graphic xlink:href="nihms362237f3"></graphic></fig><table-wrap id="T1" position="float" orientation="landscape"><label>Table 1</label><caption><p>Discovery, Replication, and Combined Meta-analysis</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1"></th><th align="left" rowspan="1" colspan="1"></th><th align="left" rowspan="1" colspan="1"></th><th align="left" rowspan="1" colspan="1"></th><th align="center" colspan="5" valign="top" rowspan="1">Discovery Meta Analysis</th><th align="center" colspan="4" valign="top" rowspan="1">Replication Meta Analysis</th><th align="center" colspan="3" valign="top" rowspan="1">Discovery + Replication</th></tr><tr><th align="left" colspan="16" valign="bottom" rowspan="1"><hr></hr></th></tr><tr><th align="left" rowspan="1" colspan="1">Locus</th><th align="left" rowspan="1" colspan="1">SNP</th><th align="left" rowspan="1" colspan="1">Gene</th><th align="left" rowspan="1" colspan="1">A1/2</th><th align="right" rowspan="1" colspan="1">AF</th><th align="right" rowspan="1" colspan="1">B</th><th align="right" rowspan="1" colspan="1">SE</th><th align="right" rowspan="1" colspan="1">P</th><th align="right" rowspan="1" colspan="1">N_Eff</th><th align="right" rowspan="1" colspan="1">B</th><th align="right" rowspan="1" colspan="1">SE</th><th align="right" rowspan="1" colspan="1">P</th><th align="right" rowspan="1" colspan="1">N_eff</th><th align="right" rowspan="1" colspan="1">B</th><th align="right" rowspan="1" colspan="1">SE</th><th align="right" rowspan="1" colspan="1">P</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">2q24</td><td align="left" rowspan="1" colspan="1">rs6741949</td><td align="left" rowspan="1" colspan="1"><bold>DPP4</bold></td><td align="left" rowspan="1" colspan="1">G/C</td><td align="right" rowspan="1" colspan="1">0.53</td><td align="right" rowspan="1" colspan="1">−61.4</td><td align="right" rowspan="1" colspan="1">11.3</td><td align="right" rowspan="1" colspan="1">5.2×10<sup>-8</sup></td><td align="right" rowspan="1" colspan="1">6,673</td><td align="right" rowspan="1" colspan="1">−10.1</td><td align="right" rowspan="1" colspan="1">25.2</td><td align="right" rowspan="1" colspan="1">0.7</td><td align="right" rowspan="1" colspan="1">1,369</td><td align="right" rowspan="1" colspan="1">−52.8</td><td align="right" rowspan="1" colspan="1">10.3</td><td align="right" rowspan="1" colspan="1">2.9×10<sup>-7</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">9q33</td><td align="left" rowspan="1" colspan="1">rs7852872</td><td align="left" rowspan="1" colspan="1"><bold>ASTN2</bold></td><td align="left" rowspan="1" colspan="1">C/G</td><td align="right" rowspan="1" colspan="1">0.62</td><td align="right" rowspan="1" colspan="1">−53.1</td><td align="right" rowspan="1" colspan="1">10.0</td><td align="right" rowspan="1" colspan="1">1.0×10<sup>-7</sup></td><td align="right" rowspan="1" colspan="1">9,187</td><td align="right" rowspan="1" colspan="1">−25.0</td><td align="right" rowspan="1" colspan="1">20.4</td><td align="right" rowspan="1" colspan="1">0.2</td><td align="right" rowspan="1" colspan="1">2,318</td><td align="right" rowspan="1" colspan="1">−47.7</td><td align="right" rowspan="1" colspan="1">9.0</td><td align="right" rowspan="1" colspan="1">1.0×10<sup>-7</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">12q14</td><td align="left" rowspan="1" colspan="1">rs17178006</td><td align="left" rowspan="1" colspan="1"><bold>MSRB3</bold></td><td align="left" rowspan="1" colspan="1">G/T</td><td align="right" rowspan="1" colspan="1">0.10</td><td align="right" rowspan="1" colspan="1">−121.0</td><td align="right" rowspan="1" colspan="1">20.7</td><td align="right" rowspan="1" colspan="1">5.5×10<sup>-9</sup></td><td align="right" rowspan="1" colspan="1">5,249</td><td align="right" rowspan="1" colspan="1">−137.9</td><td align="right" rowspan="1" colspan="1">45.5</td><td align="right" rowspan="1" colspan="1">0.002</td><td align="right" rowspan="1" colspan="1">1,003</td><td align="right" rowspan="1" colspan="1">−123.8</td><td align="right" rowspan="1" colspan="1">18.9</td><td align="right" rowspan="1" colspan="1">5.3×10<sup>-11</sup></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">rs6581612</td><td align="left" rowspan="1" colspan="1">WIF1</td><td align="left" rowspan="1" colspan="1">C/A</td><td align="right" rowspan="1" colspan="1">0.27</td><td align="right" rowspan="1" colspan="1">−60.5</td><td align="right" rowspan="1" colspan="1">10.8</td><td align="right" rowspan="1" colspan="1">2.2×10<sup>-8</sup></td><td align="right" rowspan="1" colspan="1">9,183</td><td align="right" rowspan="1" colspan="1">−75.2</td><td align="right" rowspan="1" colspan="1">22.1</td><td align="right" rowspan="1" colspan="1">0.0007</td><td align="right" rowspan="1" colspan="1">2,318</td><td align="right" rowspan="1" colspan="1">−63.3</td><td align="right" rowspan="1" colspan="1">9.7</td><td align="right" rowspan="1" colspan="1">7.1×10<sup>-11</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">12q24</td><td align="left" rowspan="1" colspan="1">rs7294919</td><td align="left" rowspan="1" colspan="1">HRK</td><td align="left" rowspan="1" colspan="1">T/C</td><td align="right" rowspan="1" colspan="1">0.91</td><td align="right" rowspan="1" colspan="1">−97.7</td><td align="right" rowspan="1" colspan="1">17.9</td><td align="right" rowspan="1" colspan="1">4.8×10<sup>-8</sup></td><td align="right" rowspan="1" colspan="1">8,089</td><td align="right" rowspan="1" colspan="1">−154.0</td><td align="right" rowspan="1" colspan="1">38.3</td><td align="right" rowspan="1" colspan="1">5.8×10<sup>-5</sup></td><td align="right" rowspan="1" colspan="1">1,573</td><td align="right" rowspan="1" colspan="1">−107.8</td><td align="right" rowspan="1" colspan="1">16.2</td><td align="right" rowspan="1" colspan="1">2.9×10<sup>-11</sup></td></tr></tbody></table><table-wrap-foot><fn id="TFN1"><p>A1/2 indicates coded (risk)/non-coded allele; B=association estimate, in mm<sup>3</sup>; SE=standard error, P=p-value, N_eff indicates effective sample size: Σ(imputation quality×N). <bold>Bolded</bold> gene names indicate that a SNP is within the gene.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" position="float" orientation="landscape"><label>Table 2</label><caption><p>Replication results in ENIGMA</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Locus</th><th align="left" rowspan="1" colspan="1">SNP</th><th align="left" rowspan="1" colspan="1">Gene</th><th align="left" rowspan="1" colspan="1">A1/2</th><th align="right" rowspan="1" colspan="1">AF</th><th align="right" rowspan="1" colspan="1">B</th><th align="right" rowspan="1" colspan="1">SE</th><th align="right" rowspan="1" colspan="1">P</th><th align="right" rowspan="1" colspan="1">N_Eff</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">2q24</td><td align="left" rowspan="1" colspan="1">rs6741949</td><td align="left" rowspan="1" colspan="1"><bold>DPP4</bold></td><td align="left" rowspan="1" colspan="1">G/C</td><td align="right" rowspan="1" colspan="1">0.58</td><td align="right" rowspan="1" colspan="1">−28.2</td><td align="right" rowspan="1" colspan="1">14.0</td><td align="right" rowspan="1" colspan="1">0.04</td><td align="right" rowspan="1" colspan="1">7,794</td></tr><tr><td align="left" colspan="9" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">9q33</td><td align="left" rowspan="1" colspan="1">rs7852872</td><td align="left" rowspan="1" colspan="1"><bold>ASTN2</bold></td><td align="left" rowspan="1" colspan="1">C/G</td><td align="right" rowspan="1" colspan="1"></td><td align="right" rowspan="1" colspan="1"></td><td align="right" rowspan="1" colspan="1"></td><td align="right" rowspan="1" colspan="1"></td><td align="right" rowspan="1" colspan="1"></td></tr><tr><td align="left" colspan="9" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>rs7040792</italic></td><td align="left" rowspan="1" colspan="1">(r<sup>2</sup>=1.0)</td><td align="left" rowspan="1" colspan="1">T/C</td><td align="right" rowspan="1" colspan="1">0.64</td><td align="right" rowspan="1" colspan="1">−29.0</td><td align="right" rowspan="1" colspan="1">12.8</td><td align="right" rowspan="1" colspan="1">0.02</td><td align="right" rowspan="1" colspan="1">7,794</td></tr><tr><td align="left" colspan="9" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">12q14</td><td align="left" rowspan="1" colspan="1">rs17178006</td><td align="left" rowspan="1" colspan="1"><bold>MSRB3</bold></td><td align="left" rowspan="1" colspan="1">G/T</td><td align="right" rowspan="1" colspan="1"></td><td align="right" rowspan="1" colspan="1"></td><td align="right" rowspan="1" colspan="1"></td><td align="right" rowspan="1" colspan="1"></td><td align="right" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>rs1370938</italic></td><td align="left" rowspan="1" colspan="1">(r<sup>2</sup>=0.30)</td><td align="left" rowspan="1" colspan="1">A/C</td><td align="right" rowspan="1" colspan="1">0.24</td><td align="right" rowspan="1" colspan="1">−32.4</td><td align="right" rowspan="1" colspan="1">14.4</td><td align="right" rowspan="1" colspan="1">0.02</td><td align="right" rowspan="1" colspan="1">7,794</td></tr><tr><td align="left" colspan="9" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1">rs6581612</td><td align="left" rowspan="1" colspan="1">WIF1</td><td align="left" rowspan="1" colspan="1">C/A</td><td align="right" rowspan="1" colspan="1"></td><td align="right" rowspan="1" colspan="1"></td><td align="right" rowspan="1" colspan="1"></td><td align="right" rowspan="1" colspan="1"></td><td align="right" rowspan="1" colspan="1"></td></tr><tr><td align="left" rowspan="1" colspan="1"></td><td align="left" rowspan="1" colspan="1"><italic>rs1498792</italic></td><td align="left" rowspan="1" colspan="1">(r<sup>2</sup>=0.96)</td><td align="left" rowspan="1" colspan="1">T/C</td><td align="right" rowspan="1" colspan="1">0.25</td><td align="right" rowspan="1" colspan="1">−25.4</td><td align="right" rowspan="1" colspan="1">14.6</td><td align="right" rowspan="1" colspan="1">0.08</td><td align="right" rowspan="1" colspan="1">7,794</td></tr><tr><td align="left" colspan="9" valign="bottom" rowspan="1"><hr></hr></td></tr><tr><td align="left" rowspan="1" colspan="1">12q24</td><td align="left" rowspan="1" colspan="1">rs7294919</td><td align="left" rowspan="1" colspan="1">HRK</td><td align="left" rowspan="1" colspan="1">T/C</td><td align="right" rowspan="1" colspan="1">0.90</td><td align="right" rowspan="1" colspan="1">−112.2</td><td align="right" rowspan="1" colspan="1">21.4</td><td align="right" rowspan="1" colspan="1">1.6×10<sup>-7</sup></td><td align="right" rowspan="1" colspan="1">7,794</td></tr></tbody></table><table-wrap-foot><fn id="TFN2"><p>A1/2 indicates coded (risk)/non-coded allele; B=association estimate, in mm<sup>3</sup>; SE=standard error, P=p-value, N_eff indicates effective sample size. <bold>Bolded</bold> gene names indicate that a SNP is within the gene. 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