Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses
Identifieur interne : 002218 ( Main/Curation ); précédent : 002217; suivant : 002219Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses
Auteurs : P. Cunin [France] ; C. Beauvillain [France] ; C. Miot [France] ; J-F Augusto [France] ; L. Preisser [France] ; S. Blanchard [France] ; P. Pignon [France] ; M. Scotet [France] ; E. Garo [France] ; I. Fremaux [France] ; A. Chevailler [France] ; J-F Subra [France] ; P. Blanco [France] ; M R Wilson [Australie] ; P. Jeannin [France] ; Y. Delneste [France]Source :
- Cell Death & Disease [ 2041-4889 ] ; 2016.
Descripteurs français
- KwdFr :
- Agranulocytes (cytologie), Agranulocytes (immunologie), Animaux, Anticorps antinucléaires (biosynthèse), Apoptose (immunologie), Autoantigènes (génétique), Autoantigènes (immunologie), Cellules dendritiques (cytologie), Cellules dendritiques (immunologie), Clusterine (génétique), Clusterine (immunologie), Cross-priming (génétique), Culture primaire de cellules, Expression des gènes, Humains, Macrophages (cytologie), Macrophages (immunologie), Maladies auto-immunes (anatomopathologie), Maladies auto-immunes (génétique), Maladies auto-immunes (immunologie), Phagocytose, Présentation d'antigène (génétique), Rate (anatomopathologie), Rate (immunologie), Rein (anatomopathologie), Rein (immunologie), Souris, Souris de lignée C57BL, Souris knockout, Splénomégalie (anatomopathologie), Splénomégalie (génétique), Splénomégalie (immunologie), Techniques de coculture.
- MESH :
- anatomopathologie : Maladies auto-immunes, Rate, Rein, Splénomégalie.
- biosynthèse : Anticorps antinucléaires.
- cytologie : Agranulocytes, Cellules dendritiques, Macrophages.
- génétique : Autoantigènes, Clusterine, Cross-priming, Maladies auto-immunes, Présentation d'antigène, Splénomégalie.
- immunologie : Agranulocytes, Apoptose, Autoantigènes, Cellules dendritiques, Clusterine, Macrophages, Maladies auto-immunes, Rate, Rein, Splénomégalie.
- Animaux, Culture primaire de cellules, Expression des gènes, Humains, Phagocytose, Souris, Souris de lignée C57BL, Souris knockout, Techniques de coculture.
English descriptors
- KwdEn :
- Animals, Antibodies, Antinuclear (biosynthesis), Antigen Presentation (genetics), Apoptosis (immunology), Autoantigens (genetics), Autoantigens (immunology), Autoimmune Diseases (genetics), Autoimmune Diseases (immunology), Autoimmune Diseases (pathology), Clusterin (genetics), Clusterin (immunology), Coculture Techniques, Cross-Priming (genetics), Dendritic Cells (cytology), Dendritic Cells (immunology), Gene Expression, Humans, Kidney (immunology), Kidney (pathology), Leukocytes, Mononuclear (cytology), Leukocytes, Mononuclear (immunology), Macrophages (cytology), Macrophages (immunology), Mice, Mice, Inbred C57BL, Mice, Knockout, Phagocytosis, Primary Cell Culture, Spleen (immunology), Spleen (pathology), Splenomegaly (genetics), Splenomegaly (immunology), Splenomegaly (pathology).
- MESH :
- chemical , biosynthesis : Antibodies, Antinuclear.
- cytology : Dendritic Cells, Leukocytes, Mononuclear, Macrophages.
- genetics : Antigen Presentation, Autoantigens, Autoimmune Diseases, Clusterin, Cross-Priming, Splenomegaly.
- immunology : Apoptosis, Autoantigens, Autoimmune Diseases, Clusterin, Dendritic Cells, Kidney, Leukocytes, Mononuclear, Macrophages, Spleen, Splenomegaly.
- pathology : Autoimmune Diseases, Kidney, Spleen, Splenomegaly.
- Animals, Coculture Techniques, Gene Expression, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Phagocytosis, Primary Cell Culture.
Abstract
Clusterin (Clu), an extracellular chaperone, exhibits characteristics of soluble innate immunity receptors, as assessed by its ability to bind some bacteria strains. In this study, we report that Clu also binds specifically to late apoptotic cells but not to live, early apoptotic, or necrotic cells. Histones, which accumulate on blebs during the apoptotic process, represent privileged Clu-binding motifs at the surface of late apoptotic cells. As a consequence, Clu potentiates, both
Url:
DOI: 10.1038/cddis.2016.113
PubMed: 27148688
PubMed Central: 4917652
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000714
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000713
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000A69
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001F25
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001F01
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001F01
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :003512
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :003512
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003512
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :002217
Links to Exploration step
PMC:4917652Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses</title>
<author><name sortKey="Cunin, P" sort="Cunin, P" uniqKey="Cunin P" first="P" last="Cunin">P. Cunin</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beauvillain, C" sort="Beauvillain, C" uniqKey="Beauvillain C" first="C" last="Beauvillain">C. Beauvillain</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Laboratoire d'Immunologie et d'Allergologie, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miot, C" sort="Miot, C" uniqKey="Miot C" first="C" last="Miot">C. Miot</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Augusto, J F" sort="Augusto, J F" uniqKey="Augusto J" first="J-F" last="Augusto">J-F Augusto</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Service de Néphrologie-Dialyse-Transplantation, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Preisser, L" sort="Preisser, L" uniqKey="Preisser L" first="L" last="Preisser">L. Preisser</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blanchard, S" sort="Blanchard, S" uniqKey="Blanchard S" first="S" last="Blanchard">S. Blanchard</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Laboratoire d'Immunologie et d'Allergologie, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pignon, P" sort="Pignon, P" uniqKey="Pignon P" first="P" last="Pignon">P. Pignon</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scotet, M" sort="Scotet, M" uniqKey="Scotet M" first="M" last="Scotet">M. Scotet</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garo, E" sort="Garo, E" uniqKey="Garo E" first="E" last="Garo">E. Garo</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fremaux, I" sort="Fremaux, I" uniqKey="Fremaux I" first="I" last="Fremaux">I. Fremaux</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chevailler, A" sort="Chevailler, A" uniqKey="Chevailler A" first="A" last="Chevailler">A. Chevailler</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Laboratoire d'Immunologie et d'Allergologie, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Subra, J F" sort="Subra, J F" uniqKey="Subra J" first="J-F" last="Subra">J-F Subra</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Service de Néphrologie-Dialyse-Transplantation, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blanco, P" sort="Blanco, P" uniqKey="Blanco P" first="P" last="Blanco">P. Blanco</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Université Victor Segalen</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>CNRS Unit 5164</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>CHU Bordeaux</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wilson, M R" sort="Wilson, M R" uniqKey="Wilson M" first="M R" last="Wilson">M R Wilson</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>School of Biological Sciences, Illawarra Health and Medical Research Institute, University of Wollongong</institution>
, Wollongong, New South Wales,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jeannin, P" sort="Jeannin, P" uniqKey="Jeannin P" first="P" last="Jeannin">P. Jeannin</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Laboratoire d'Immunologie et d'Allergologie, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Delneste, Y" sort="Delneste, Y" uniqKey="Delneste Y" first="Y" last="Delneste">Y. Delneste</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Laboratoire d'Immunologie et d'Allergologie, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27148688</idno>
<idno type="pmc">4917652</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4917652</idno>
<idno type="RBID">PMC:4917652</idno>
<idno type="doi">10.1038/cddis.2016.113</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000714</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000714</idno>
<idno type="wicri:Area/Pmc/Curation">000713</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000713</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000A69</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A69</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001F25</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F25</idno>
<idno type="wicri:Area/PubMed/Curation">001F01</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F01</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001F01</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F01</idno>
<idno type="wicri:Area/Ncbi/Merge">003512</idno>
<idno type="wicri:Area/Ncbi/Curation">003512</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003512</idno>
<idno type="wicri:Area/Main/Merge">002217</idno>
<idno type="wicri:Area/Main/Curation">002218</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses</title>
<author><name sortKey="Cunin, P" sort="Cunin, P" uniqKey="Cunin P" first="P" last="Cunin">P. Cunin</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Beauvillain, C" sort="Beauvillain, C" uniqKey="Beauvillain C" first="C" last="Beauvillain">C. Beauvillain</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Laboratoire d'Immunologie et d'Allergologie, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Miot, C" sort="Miot, C" uniqKey="Miot C" first="C" last="Miot">C. Miot</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Augusto, J F" sort="Augusto, J F" uniqKey="Augusto J" first="J-F" last="Augusto">J-F Augusto</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Service de Néphrologie-Dialyse-Transplantation, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Preisser, L" sort="Preisser, L" uniqKey="Preisser L" first="L" last="Preisser">L. Preisser</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blanchard, S" sort="Blanchard, S" uniqKey="Blanchard S" first="S" last="Blanchard">S. Blanchard</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Laboratoire d'Immunologie et d'Allergologie, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pignon, P" sort="Pignon, P" uniqKey="Pignon P" first="P" last="Pignon">P. Pignon</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Scotet, M" sort="Scotet, M" uniqKey="Scotet M" first="M" last="Scotet">M. Scotet</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Garo, E" sort="Garo, E" uniqKey="Garo E" first="E" last="Garo">E. Garo</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fremaux, I" sort="Fremaux, I" uniqKey="Fremaux I" first="I" last="Fremaux">I. Fremaux</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chevailler, A" sort="Chevailler, A" uniqKey="Chevailler A" first="A" last="Chevailler">A. Chevailler</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Laboratoire d'Immunologie et d'Allergologie, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Subra, J F" sort="Subra, J F" uniqKey="Subra J" first="J-F" last="Subra">J-F Subra</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Service de Néphrologie-Dialyse-Transplantation, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Blanco, P" sort="Blanco, P" uniqKey="Blanco P" first="P" last="Blanco">P. Blanco</name>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Université Victor Segalen</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>CNRS Unit 5164</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>CHU Bordeaux</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wilson, M R" sort="Wilson, M R" uniqKey="Wilson M" first="M R" last="Wilson">M R Wilson</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>School of Biological Sciences, Illawarra Health and Medical Research Institute, University of Wollongong</institution>
, Wollongong, New South Wales,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Jeannin, P" sort="Jeannin, P" uniqKey="Jeannin P" first="P" last="Jeannin">P. Jeannin</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Laboratoire d'Immunologie et d'Allergologie, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Delneste, Y" sort="Delneste, Y" uniqKey="Delneste Y" first="Y" last="Delneste">Y. Delneste</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Université d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Unit 892, Inserm, CHU d'Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, Unit 6299</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>LabEx IGO "Immuno-Graft-Onco"</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Laboratoire d'Immunologie et d'Allergologie, CHU Angers</institution>
, Angers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell Death & Disease</title>
<idno type="eISSN">2041-4889</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Antibodies, Antinuclear (biosynthesis)</term>
<term>Antigen Presentation (genetics)</term>
<term>Apoptosis (immunology)</term>
<term>Autoantigens (genetics)</term>
<term>Autoantigens (immunology)</term>
<term>Autoimmune Diseases (genetics)</term>
<term>Autoimmune Diseases (immunology)</term>
<term>Autoimmune Diseases (pathology)</term>
<term>Clusterin (genetics)</term>
<term>Clusterin (immunology)</term>
<term>Coculture Techniques</term>
<term>Cross-Priming (genetics)</term>
<term>Dendritic Cells (cytology)</term>
<term>Dendritic Cells (immunology)</term>
<term>Gene Expression</term>
<term>Humans</term>
<term>Kidney (immunology)</term>
<term>Kidney (pathology)</term>
<term>Leukocytes, Mononuclear (cytology)</term>
<term>Leukocytes, Mononuclear (immunology)</term>
<term>Macrophages (cytology)</term>
<term>Macrophages (immunology)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Phagocytosis</term>
<term>Primary Cell Culture</term>
<term>Spleen (immunology)</term>
<term>Spleen (pathology)</term>
<term>Splenomegaly (genetics)</term>
<term>Splenomegaly (immunology)</term>
<term>Splenomegaly (pathology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Agranulocytes (cytologie)</term>
<term>Agranulocytes (immunologie)</term>
<term>Animaux</term>
<term>Anticorps antinucléaires (biosynthèse)</term>
<term>Apoptose (immunologie)</term>
<term>Autoantigènes (génétique)</term>
<term>Autoantigènes (immunologie)</term>
<term>Cellules dendritiques (cytologie)</term>
<term>Cellules dendritiques (immunologie)</term>
<term>Clusterine (génétique)</term>
<term>Clusterine (immunologie)</term>
<term>Cross-priming (génétique)</term>
<term>Culture primaire de cellules</term>
<term>Expression des gènes</term>
<term>Humains</term>
<term>Macrophages (cytologie)</term>
<term>Macrophages (immunologie)</term>
<term>Maladies auto-immunes (anatomopathologie)</term>
<term>Maladies auto-immunes (génétique)</term>
<term>Maladies auto-immunes (immunologie)</term>
<term>Phagocytose</term>
<term>Présentation d'antigène (génétique)</term>
<term>Rate (anatomopathologie)</term>
<term>Rate (immunologie)</term>
<term>Rein (anatomopathologie)</term>
<term>Rein (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Splénomégalie (anatomopathologie)</term>
<term>Splénomégalie (génétique)</term>
<term>Splénomégalie (immunologie)</term>
<term>Techniques de coculture</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Antinuclear</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Maladies auto-immunes</term>
<term>Rate</term>
<term>Rein</term>
<term>Splénomégalie</term>
</keywords>
<keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Anticorps antinucléaires</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Agranulocytes</term>
<term>Cellules dendritiques</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Dendritic Cells</term>
<term>Leukocytes, Mononuclear</term>
<term>Macrophages</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Antigen Presentation</term>
<term>Autoantigens</term>
<term>Autoimmune Diseases</term>
<term>Clusterin</term>
<term>Cross-Priming</term>
<term>Splenomegaly</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Autoantigènes</term>
<term>Clusterine</term>
<term>Cross-priming</term>
<term>Maladies auto-immunes</term>
<term>Présentation d'antigène</term>
<term>Splénomégalie</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Agranulocytes</term>
<term>Apoptose</term>
<term>Autoantigènes</term>
<term>Cellules dendritiques</term>
<term>Clusterine</term>
<term>Macrophages</term>
<term>Maladies auto-immunes</term>
<term>Rate</term>
<term>Rein</term>
<term>Splénomégalie</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Apoptosis</term>
<term>Autoantigens</term>
<term>Autoimmune Diseases</term>
<term>Clusterin</term>
<term>Dendritic Cells</term>
<term>Kidney</term>
<term>Leukocytes, Mononuclear</term>
<term>Macrophages</term>
<term>Spleen</term>
<term>Splenomegaly</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Autoimmune Diseases</term>
<term>Kidney</term>
<term>Spleen</term>
<term>Splenomegaly</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Coculture Techniques</term>
<term>Gene Expression</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mice, Knockout</term>
<term>Phagocytosis</term>
<term>Primary Cell Culture</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Culture primaire de cellules</term>
<term>Expression des gènes</term>
<term>Humains</term>
<term>Phagocytose</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Souris knockout</term>
<term>Techniques de coculture</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Clusterin (Clu), an extracellular chaperone, exhibits characteristics of soluble innate immunity receptors, as assessed by its ability to bind some bacteria strains. In this study, we report that Clu also binds specifically to late apoptotic cells but not to live, early apoptotic, or necrotic cells. Histones, which accumulate on blebs during the apoptotic process, represent privileged Clu-binding motifs at the surface of late apoptotic cells. As a consequence, Clu potentiates, both <italic>in vitro</italic>
and <italic>in vivo</italic>
, the phagocytosis of late apoptotic cells by macrophages. Moreover, the increased phagocytosis of late apoptotic cells induced by Clu favors the presentation and cross-presentation of apoptotic cell-associated antigens. Finally, we observed that, in a model of apoptotic cell-induced autoimmunity, and relative to control mice, Clu<sup>−/−</sup>
mice develop symptoms of autoimmunity, including the generation of anti-dsDNA antibodies, deposition of immunoglobulins and complement components within kidneys, and splenomegaly. These results identify Clu as a new molecule partner involved in apoptotic cell efferocytosis and suggest a protective role for Clu in inflammation and autoimmune diseases.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002218 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 002218 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Curation |type= RBID |clé= PMC:4917652 |texte= Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:27148688" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |