Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses.
Identifieur interne : 001F25 ( PubMed/Corpus ); précédent : 001F24; suivant : 001F26Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses.
Auteurs : P. Cunin ; C. Beauvillain ; C. Miot ; J-F Augusto ; L. Preisser ; S. Blanchard ; P. Pignon ; M. Scotet ; E. Garo ; I. Fremaux ; A. Chevailler ; J-F Subra ; P. Blanco ; M R Wilson ; P. Jeannin ; Y. DelnesteSource :
- Cell death & disease [ 2041-4889 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Antibodies, Antinuclear (biosynthesis), Antigen Presentation (genetics), Apoptosis (immunology), Autoantigens (genetics), Autoantigens (immunology), Autoimmune Diseases (genetics), Autoimmune Diseases (immunology), Autoimmune Diseases (pathology), Clusterin (genetics), Clusterin (immunology), Coculture Techniques, Cross-Priming (genetics), Dendritic Cells (cytology), Dendritic Cells (immunology), Gene Expression, Humans, Kidney (immunology), Kidney (pathology), Leukocytes, Mononuclear (cytology), Leukocytes, Mononuclear (immunology), Macrophages (cytology), Macrophages (immunology), Mice, Mice, Inbred C57BL, Mice, Knockout, Phagocytosis, Primary Cell Culture, Spleen (immunology), Spleen (pathology), Splenomegaly (genetics), Splenomegaly (immunology), Splenomegaly (pathology).
- MESH :
- chemical , biosynthesis : Antibodies, Antinuclear.
- cytology : Dendritic Cells, Leukocytes, Mononuclear, Macrophages.
- genetics : Antigen Presentation, Autoantigens, Autoimmune Diseases, Clusterin, Cross-Priming, Splenomegaly.
- immunology : Apoptosis, Autoantigens, Autoimmune Diseases, Clusterin, Dendritic Cells, Kidney, Leukocytes, Mononuclear, Macrophages, Spleen, Splenomegaly.
- pathology : Autoimmune Diseases, Kidney, Spleen, Splenomegaly.
- Animals, Coculture Techniques, Gene Expression, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Phagocytosis, Primary Cell Culture.
Abstract
Clusterin (Clu), an extracellular chaperone, exhibits characteristics of soluble innate immunity receptors, as assessed by its ability to bind some bacteria strains. In this study, we report that Clu also binds specifically to late apoptotic cells but not to live, early apoptotic, or necrotic cells. Histones, which accumulate on blebs during the apoptotic process, represent privileged Clu-binding motifs at the surface of late apoptotic cells. As a consequence, Clu potentiates, both in vitro and in vivo, the phagocytosis of late apoptotic cells by macrophages. Moreover, the increased phagocytosis of late apoptotic cells induced by Clu favors the presentation and cross-presentation of apoptotic cell-associated antigens. Finally, we observed that, in a model of apoptotic cell-induced autoimmunity, and relative to control mice, Clu(-/-) mice develop symptoms of autoimmunity, including the generation of anti-dsDNA antibodies, deposition of immunoglobulins and complement components within kidneys, and splenomegaly. These results identify Clu as a new molecule partner involved in apoptotic cell efferocytosis and suggest a protective role for Clu in inflammation and autoimmune diseases.
DOI: 10.1038/cddis.2016.113
PubMed: 27148688
Links to Exploration step
pubmed:27148688Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses.</title><author><name sortKey="Cunin, P" sort="Cunin, P" uniqKey="Cunin P" first="P" last="Cunin">P. Cunin</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Beauvillain, C" sort="Beauvillain, C" uniqKey="Beauvillain C" first="C" last="Beauvillain">C. Beauvillain</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Miot, C" sort="Miot, C" uniqKey="Miot C" first="C" last="Miot">C. Miot</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Augusto, J F" sort="Augusto, J F" uniqKey="Augusto J" first="J-F" last="Augusto">J-F Augusto</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Preisser, L" sort="Preisser, L" uniqKey="Preisser L" first="L" last="Preisser">L. Preisser</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blanchard, S" sort="Blanchard, S" uniqKey="Blanchard S" first="S" last="Blanchard">S. Blanchard</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pignon, P" sort="Pignon, P" uniqKey="Pignon P" first="P" last="Pignon">P. Pignon</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Scotet, M" sort="Scotet, M" uniqKey="Scotet M" first="M" last="Scotet">M. Scotet</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Garo, E" sort="Garo, E" uniqKey="Garo E" first="E" last="Garo">E. Garo</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fremaux, I" sort="Fremaux, I" uniqKey="Fremaux I" first="I" last="Fremaux">I. Fremaux</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chevailler, A" sort="Chevailler, A" uniqKey="Chevailler A" first="A" last="Chevailler">A. Chevailler</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Subra, J F" sort="Subra, J F" uniqKey="Subra J" first="J-F" last="Subra">J-F Subra</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blanco, P" sort="Blanco, P" uniqKey="Blanco P" first="P" last="Blanco">P. Blanco</name><affiliation><nlm:affiliation>Université Victor Segalen, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, M R" sort="Wilson, M R" uniqKey="Wilson M" first="M R" last="Wilson">M R Wilson</name><affiliation><nlm:affiliation>School of Biological Sciences, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Jeannin, P" sort="Jeannin, P" uniqKey="Jeannin P" first="P" last="Jeannin">P. Jeannin</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Delneste, Y" sort="Delneste, Y" uniqKey="Delneste Y" first="Y" last="Delneste">Y. Delneste</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27148688</idno><idno type="pmid">27148688</idno><idno type="doi">10.1038/cddis.2016.113</idno><idno type="wicri:Area/PubMed/Corpus">001F25</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses.</title><author><name sortKey="Cunin, P" sort="Cunin, P" uniqKey="Cunin P" first="P" last="Cunin">P. Cunin</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Beauvillain, C" sort="Beauvillain, C" uniqKey="Beauvillain C" first="C" last="Beauvillain">C. Beauvillain</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Miot, C" sort="Miot, C" uniqKey="Miot C" first="C" last="Miot">C. Miot</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Augusto, J F" sort="Augusto, J F" uniqKey="Augusto J" first="J-F" last="Augusto">J-F Augusto</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Preisser, L" sort="Preisser, L" uniqKey="Preisser L" first="L" last="Preisser">L. Preisser</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blanchard, S" sort="Blanchard, S" uniqKey="Blanchard S" first="S" last="Blanchard">S. Blanchard</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Pignon, P" sort="Pignon, P" uniqKey="Pignon P" first="P" last="Pignon">P. Pignon</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Scotet, M" sort="Scotet, M" uniqKey="Scotet M" first="M" last="Scotet">M. Scotet</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Garo, E" sort="Garo, E" uniqKey="Garo E" first="E" last="Garo">E. Garo</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Fremaux, I" sort="Fremaux, I" uniqKey="Fremaux I" first="I" last="Fremaux">I. Fremaux</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Chevailler, A" sort="Chevailler, A" uniqKey="Chevailler A" first="A" last="Chevailler">A. Chevailler</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Subra, J F" sort="Subra, J F" uniqKey="Subra J" first="J-F" last="Subra">J-F Subra</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Blanco, P" sort="Blanco, P" uniqKey="Blanco P" first="P" last="Blanco">P. Blanco</name><affiliation><nlm:affiliation>Université Victor Segalen, Bordeaux, France.</nlm:affiliation></affiliation></author><author><name sortKey="Wilson, M R" sort="Wilson, M R" uniqKey="Wilson M" first="M R" last="Wilson">M R Wilson</name><affiliation><nlm:affiliation>School of Biological Sciences, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales, Australia.</nlm:affiliation></affiliation></author><author><name sortKey="Jeannin, P" sort="Jeannin, P" uniqKey="Jeannin P" first="P" last="Jeannin">P. Jeannin</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author><author><name sortKey="Delneste, Y" sort="Delneste, Y" uniqKey="Delneste Y" first="Y" last="Delneste">Y. Delneste</name><affiliation><nlm:affiliation>Université d'Angers, Angers, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Cell death & disease</title><idno type="eISSN">2041-4889</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Antinuclear (biosynthesis)</term><term>Antigen Presentation (genetics)</term><term>Apoptosis (immunology)</term><term>Autoantigens (genetics)</term><term>Autoantigens (immunology)</term><term>Autoimmune Diseases (genetics)</term><term>Autoimmune Diseases (immunology)</term><term>Autoimmune Diseases (pathology)</term><term>Clusterin (genetics)</term><term>Clusterin (immunology)</term><term>Coculture Techniques</term><term>Cross-Priming (genetics)</term><term>Dendritic Cells (cytology)</term><term>Dendritic Cells (immunology)</term><term>Gene Expression</term><term>Humans</term><term>Kidney (immunology)</term><term>Kidney (pathology)</term><term>Leukocytes, Mononuclear (cytology)</term><term>Leukocytes, Mononuclear (immunology)</term><term>Macrophages (cytology)</term><term>Macrophages (immunology)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Phagocytosis</term><term>Primary Cell Culture</term><term>Spleen (immunology)</term><term>Spleen (pathology)</term><term>Splenomegaly (genetics)</term><term>Splenomegaly (immunology)</term><term>Splenomegaly (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Antibodies, Antinuclear</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Dendritic Cells</term><term>Leukocytes, Mononuclear</term><term>Macrophages</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Antigen Presentation</term><term>Autoantigens</term><term>Autoimmune Diseases</term><term>Clusterin</term><term>Cross-Priming</term><term>Splenomegaly</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Apoptosis</term><term>Autoantigens</term><term>Autoimmune Diseases</term><term>Clusterin</term><term>Dendritic Cells</term><term>Kidney</term><term>Leukocytes, Mononuclear</term><term>Macrophages</term><term>Spleen</term><term>Splenomegaly</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Autoimmune Diseases</term><term>Kidney</term><term>Spleen</term><term>Splenomegaly</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Coculture Techniques</term><term>Gene Expression</term><term>Humans</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mice, Knockout</term><term>Phagocytosis</term><term>Primary Cell Culture</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Clusterin (Clu), an extracellular chaperone, exhibits characteristics of soluble innate immunity receptors, as assessed by its ability to bind some bacteria strains. In this study, we report that Clu also binds specifically to late apoptotic cells but not to live, early apoptotic, or necrotic cells. Histones, which accumulate on blebs during the apoptotic process, represent privileged Clu-binding motifs at the surface of late apoptotic cells. As a consequence, Clu potentiates, both in vitro and in vivo, the phagocytosis of late apoptotic cells by macrophages. Moreover, the increased phagocytosis of late apoptotic cells induced by Clu favors the presentation and cross-presentation of apoptotic cell-associated antigens. Finally, we observed that, in a model of apoptotic cell-induced autoimmunity, and relative to control mice, Clu(-/-) mice develop symptoms of autoimmunity, including the generation of anti-dsDNA antibodies, deposition of immunoglobulins and complement components within kidneys, and splenomegaly. These results identify Clu as a new molecule partner involved in apoptotic cell efferocytosis and suggest a protective role for Clu in inflammation and autoimmune diseases.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">27148688</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>06</Day></DateCreated><DateCompleted><Year>2017</Year><Month>10</Month><Day>31</Day></DateCompleted><DateRevised><Year>2017</Year><Month>10</Month><Day>31</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-4889</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><PubDate><Year>2016</Year><Month>May</Month><Day>05</Day></PubDate></JournalIssue><Title>Cell death & disease</Title><ISOAbbreviation>Cell Death Dis</ISOAbbreviation></Journal><ArticleTitle>Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses.</ArticleTitle><Pagination><MedlinePgn>e2215</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/cddis.2016.113</ELocationID><Abstract><AbstractText>Clusterin (Clu), an extracellular chaperone, exhibits characteristics of soluble innate immunity receptors, as assessed by its ability to bind some bacteria strains. In this study, we report that Clu also binds specifically to late apoptotic cells but not to live, early apoptotic, or necrotic cells. Histones, which accumulate on blebs during the apoptotic process, represent privileged Clu-binding motifs at the surface of late apoptotic cells. As a consequence, Clu potentiates, both in vitro and in vivo, the phagocytosis of late apoptotic cells by macrophages. Moreover, the increased phagocytosis of late apoptotic cells induced by Clu favors the presentation and cross-presentation of apoptotic cell-associated antigens. Finally, we observed that, in a model of apoptotic cell-induced autoimmunity, and relative to control mice, Clu(-/-) mice develop symptoms of autoimmunity, including the generation of anti-dsDNA antibodies, deposition of immunoglobulins and complement components within kidneys, and splenomegaly. These results identify Clu as a new molecule partner involved in apoptotic cell efferocytosis and suggest a protective role for Clu in inflammation and autoimmune diseases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cunin</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beauvillain</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratoire d'Immunologie et d'Allergologie, CHU Angers, Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miot</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Augusto</LastName><ForeName>J-F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Néphrologie-Dialyse-Transplantation, CHU Angers, Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Preisser</LastName><ForeName>L</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blanchard</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratoire d'Immunologie et d'Allergologie, CHU Angers, Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pignon</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Scotet</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Garo</LastName><ForeName>E</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fremaux</LastName><ForeName>I</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chevailler</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratoire d'Immunologie et d'Allergologie, CHU Angers, Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Subra</LastName><ForeName>J-F</ForeName><Initials>JF</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Service de Néphrologie-Dialyse-Transplantation, CHU Angers, Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Blanco</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Université Victor Segalen, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS Unit 5164, Bordeaux, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CHU Bordeaux, Bordeaux, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wilson</LastName><ForeName>M R</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>School of Biological Sciences, Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, New South Wales, Australia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeannin</LastName><ForeName>P</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratoire d'Immunologie et d'Allergologie, CHU Angers, Angers, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delneste</LastName><ForeName>Y</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Université d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Unit 892, Inserm, CHU d'Angers, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>CNRS, Unit 6299, Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>LabEx IGO "Immuno-Graft-Onco", Angers, France.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratoire d'Immunologie et d'Allergologie, CHU Angers, Angers, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>05</Month><Day>05</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Cell Death Dis</MedlineTA><NlmUniqueID>101524092</NlmUniqueID></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000974">Antibodies, Antinuclear</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance 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