AustralieFrV1, Main, Curation, bibRecord, 002215

Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells.

Identifieur interne : 002215 ( Main/Curation ); précédent : 002214; suivant : 002216

Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells.

Auteurs : Rui Li [République populaire de Chine] ; Sivapriya Pavuluri [Australie] ; Kiara Bruggeman [Australie] ; Benjamin M. Long [Australie] ; Andrew J. Parnell [Royaume-Uni] ; Anne Martel [France] ; Steven R. Parnell [États-Unis] ; Frederick M. Pfeffer [Australie] ; Andrew J C. Dennison [Allemagne] ; Kevin R. Nicholas [Australie] ; Colin J. Barrow [Australie] ; David R. Nisbet [Australie] ; Richard J. Williams [Australie]

Source :

Nanomedicine : nanotechnology, biology, and medicine [ 1549-9642 ] ; 2016.

RBID : pubmed:26961467

Descripteurs français

English descriptors

KwdEn :
- Apoptosis, Biocompatible Materials, Cytokines, Drug Delivery Systems, Gene Expression Regulation, Humans, Hydrogels, Nanofibers, Neoplasms, Glandular and Epithelial, Tissue Scaffolds.
MESH :
- chemical : Biocompatible Materials, Cytokines, Hydrogels.
- Apoptosis, Drug Delivery Systems, Gene Expression Regulation, Humans, Nanofibers, Neoplasms, Glandular and Epithelial, Tissue Scaffolds.

Abstract

The local inflammatory environment of the cell promotes the growth of epithelial cancers. Therefore, controlling inflammation locally using a material in a sustained, non-steroidal fashion can effectively kill malignant cells without significant damage to surrounding healthy cells. A promising class of materials for such applications is the nanostructured scaffolds formed by epitope presenting minimalist self-assembled peptides; these are bioactive on a cellular length scale, while presenting as an easily handled hydrogel. Here, we show that the assembly process can distribute an anti-inflammatory polysaccharide, fucoidan, localized to the nanofibers within the scaffold to create a biomaterial for cancer therapy. We show that it supports healthy cells, while inducing apoptosis in cancerous epithelial cells, as demonstrated by the significant down-regulation of gene and protein expression pathways associated with epithelial cancer progression. Our findings highlight an innovative material approach with potential applications in local epithelial cancer immunotherapy and drug delivery.

DOI: 10.1016/j.nano.2016.01.009
PubMed: 26961467

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Le document en format XML

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<series><title level="j">Nanomedicine : nanotechnology, biology, and medicine</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apoptosis</term>
<term>Biocompatible Materials</term>
<term>Cytokines</term>
<term>Drug Delivery Systems</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Hydrogels</term>
<term>Nanofibers</term>
<term>Neoplasms, Glandular and Epithelial</term>
<term>Tissue Scaffolds</term>
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<term>Cytokines</term>
<term>Humains</term>
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<term>Matériaux biocompatibles</term>
<term>Nanofibres</term>
<term>Régulation de l'expression des gènes</term>
<term>Structures d'échafaudage tissulaires</term>
<term>Systèmes de délivrance de médicaments</term>
<term>Tumeurs épithéliales épidermoïdes et glandulaires</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Biocompatible Materials</term>
<term>Cytokines</term>
<term>Hydrogels</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Apoptosis</term>
<term>Drug Delivery Systems</term>
<term>Gene Expression Regulation</term>
<term>Humans</term>
<term>Nanofibers</term>
<term>Neoplasms, Glandular and Epithelial</term>
<term>Tissue Scaffolds</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term>
<term>Cytokines</term>
<term>Humains</term>
<term>Hydrogels</term>
<term>Matériaux biocompatibles</term>
<term>Nanofibres</term>
<term>Régulation de l'expression des gènes</term>
<term>Structures d'échafaudage tissulaires</term>
<term>Systèmes de délivrance de médicaments</term>
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<front><div type="abstract" xml:lang="en">The local inflammatory environment of the cell promotes the growth of epithelial cancers. Therefore, controlling inflammation locally using a material in a sustained, non-steroidal fashion can effectively kill malignant cells without significant damage to surrounding healthy cells. A promising class of materials for such applications is the nanostructured scaffolds formed by epitope presenting minimalist self-assembled peptides; these are bioactive on a cellular length scale, while presenting as an easily handled hydrogel. Here, we show that the assembly process can distribute an anti-inflammatory polysaccharide, fucoidan, localized to the nanofibers within the scaffold to create a biomaterial for cancer therapy. We show that it supports healthy cells, while inducing apoptosis in cancerous epithelial cells, as demonstrated by the significant down-regulation of gene and protein expression pathways associated with epithelial cancer progression. Our findings highlight an innovative material approach with potential applications in local epithelial cancer immunotherapy and drug delivery.</div>
</front>
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Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells.

Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells.

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