Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells.
Identifieur interne : 003258 ( Ncbi/Merge ); précédent : 003257; suivant : 003259Coassembled nanostructured bioscaffold reduces the expression of proinflammatory cytokines to induce apoptosis in epithelial cancer cells.
Auteurs : Rui Li [République populaire de Chine] ; Sivapriya Pavuluri [Australie] ; Kiara Bruggeman [Australie] ; Benjamin M. Long [Australie] ; Andrew J. Parnell [Royaume-Uni] ; Anne Martel [France] ; Steven R. Parnell [États-Unis] ; Frederick M. Pfeffer [Australie] ; Andrew J C. Dennison [Allemagne] ; Kevin R. Nicholas [Australie] ; Colin J. Barrow [Australie] ; David R. Nisbet [Australie] ; Richard J. Williams [Australie]Source :
- Nanomedicine : nanotechnology, biology, and medicine [ 1549-9642 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
Abstract
The local inflammatory environment of the cell promotes the growth of epithelial cancers. Therefore, controlling inflammation locally using a material in a sustained, non-steroidal fashion can effectively kill malignant cells without significant damage to surrounding healthy cells. A promising class of materials for such applications is the nanostructured scaffolds formed by epitope presenting minimalist self-assembled peptides; these are bioactive on a cellular length scale, while presenting as an easily handled hydrogel. Here, we show that the assembly process can distribute an anti-inflammatory polysaccharide, fucoidan, localized to the nanofibers within the scaffold to create a biomaterial for cancer therapy. We show that it supports healthy cells, while inducing apoptosis in cancerous epithelial cells, as demonstrated by the significant down-regulation of gene and protein expression pathways associated with epithelial cancer progression. Our findings highlight an innovative material approach with potential applications in local epithelial cancer immunotherapy and drug delivery.
DOI: 10.1016/j.nano.2016.01.009
PubMed: 26961467
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pubmed:26961467Le document en format XML
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<term>Gene Expression Regulation</term>
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<term>Neoplasms, Glandular and Epithelial</term>
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<term>Régulation de l'expression des gènes</term>
<term>Structures d'échafaudage tissulaires</term>
<term>Systèmes de délivrance de médicaments</term>
<term>Tumeurs épithéliales épidermoïdes et glandulaires</term>
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<term>Gene Expression Regulation</term>
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<front><div type="abstract" xml:lang="en">The local inflammatory environment of the cell promotes the growth of epithelial cancers. Therefore, controlling inflammation locally using a material in a sustained, non-steroidal fashion can effectively kill malignant cells without significant damage to surrounding healthy cells. A promising class of materials for such applications is the nanostructured scaffolds formed by epitope presenting minimalist self-assembled peptides; these are bioactive on a cellular length scale, while presenting as an easily handled hydrogel. Here, we show that the assembly process can distribute an anti-inflammatory polysaccharide, fucoidan, localized to the nanofibers within the scaffold to create a biomaterial for cancer therapy. We show that it supports healthy cells, while inducing apoptosis in cancerous epithelial cells, as demonstrated by the significant down-regulation of gene and protein expression pathways associated with epithelial cancer progression. Our findings highlight an innovative material approach with potential applications in local epithelial cancer immunotherapy and drug delivery.</div>
</front>
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<Abstract><AbstractText>The local inflammatory environment of the cell promotes the growth of epithelial cancers. Therefore, controlling inflammation locally using a material in a sustained, non-steroidal fashion can effectively kill malignant cells without significant damage to surrounding healthy cells. A promising class of materials for such applications is the nanostructured scaffolds formed by epitope presenting minimalist self-assembled peptides; these are bioactive on a cellular length scale, while presenting as an easily handled hydrogel. Here, we show that the assembly process can distribute an anti-inflammatory polysaccharide, fucoidan, localized to the nanofibers within the scaffold to create a biomaterial for cancer therapy. We show that it supports healthy cells, while inducing apoptosis in cancerous epithelial cells, as demonstrated by the significant down-regulation of gene and protein expression pathways associated with epithelial cancer progression. Our findings highlight an innovative material approach with potential applications in local epithelial cancer immunotherapy and drug delivery.</AbstractText>
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