Mammographic density and risk of breast cancer by mode of detection and tumor size: a case-control study
Identifieur interne : 001B55 ( Main/Curation ); précédent : 001B54; suivant : 001B56Mammographic density and risk of breast cancer by mode of detection and tumor size: a case-control study
Auteurs : Kavitha Krishnan [Australie] ; Laura Baglietto [Australie, France] ; Carmel Apicella [Australie] ; Jennifer Stone [Australie] ; Melissa C. Southey [Australie] ; Dallas R. English [Australie] ; Graham G. Giles [Australie] ; John L. Hopper [Australie, Corée du Sud]Source :
- Breast Cancer Research : BCR [ 1465-5411 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Tumeurs du sein.
- épidémiologie : Tumeurs du sein.
- Adulte, Adulte d'âge moyen, Charge tumorale, Densité mammaire, Détection précoce de cancer, Facteurs de risque, Femelle, Humains, Incidence, Indice de masse corporelle, Mammographie, Risque, Sujet âgé, Études cas-témoins.
English descriptors
- KwdEn :
- MESH :
- epidemiology : Breast Neoplasms.
- methods : Mammography.
- pathology : Breast Neoplasms.
- Adult, Aged, Body Mass Index, Breast Density, Case-Control Studies, Early Detection of Cancer, Female, Humans, Incidence, Middle Aged, Risk, Risk Factors, Tumor Burden.
Abstract
Risk of screen-detected breast cancer mostly reflects inherent risk, while risk of interval cancer reflects inherent risk and risk of masking (risk of the tumor not being detected due to increased dense tissue). Therefore the predictors of whether a breast cancer is interval or screen-detected include those that predict masking. Our aim was to investigate the associations between mammographic measures and (1) inherent risk, and (2) masking.
We conducted a case-control study nested within the Melbourne collaborative cohort study of 244 screen-detected cases (192 small tumors (<2 cm)) matched to 700 controls and 148 interval cases (76 small tumors) matched to 446 controls. Dense area (DA), percent dense area (PDA), and non-dense area (NDA) were measured using the Cumulus software. Conditional and unconditional logistic regression were applied as appropriate to estimate the odds per adjusted standard deviation (OPERA) adjusted for age and body mass index (BMI), allowing for the association with BMI to be a function of age at diagnosis. Tests of fit were performed using the Bayesian information criterion (BIC) and the area under the receiver operating characteristic curve.
For screen-detected cancer, the association with BMI had a marginally significant dependence on age at diagnosis, and after adjustment both DA and PDA were associated with risk (OPERA approximately 1.2) and gave a similar fit. NDA was not associated with risk. For interval cancer, the BMI risk association was not dependent on age at diagnosis and the best fitting model was PDA alone (OPERA = 2.24, 95 % confidence interval 1.75, 2.86). Prediction of interval versus screen-detected cancer was best achieved by PDA alone (OPERA = 1.76, 95 % confidence interval 1.39, 2.22) with no association with BMI. When the analysis was restricted to small tumors to reduce the influence of tumor growth, we obtained similar results.
Inherent breast cancer risk is predicted by BMI and DA or PDA, but not NDA. Masking is predicted by PDA, and not by BMI. Understanding risk and masking could help tailor mammographic screening.
The online version of this article (doi:10.1186/s13058-016-0722-4) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13058-016-0722-4
PubMed: 27316945
PubMed Central: 4912759
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000B42
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000B19
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000793
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001D78
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001D54
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001D54
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :003726
- to stream Ncbi, to step Curation: Pour aller vers cette notice dans l'étape Curation :003726
- to stream Ncbi, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :003726
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :001B51
Links to Exploration step
PMC:4912759Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mammographic density and risk of breast cancer by mode of detection and tumor size: a case-control study</title>
<author><name sortKey="Krishnan, Kavitha" sort="Krishnan, Kavitha" uniqKey="Krishnan K" first="Kavitha" last="Krishnan">Kavitha Krishnan</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff5">Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff6">Gustave Roussy, F-94805 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Gustave Roussy, F-94805 Villejuif</wicri:regionArea>
<wicri:noRegion>94805 Villejuif</wicri:noRegion>
<wicri:noRegion>94805 Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Crawley, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Crawley</wicri:regionArea>
<wicri:noRegion>Crawley</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="4"><nlm:aff id="Aff7">Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R." last="English">Dallas R. English</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff4">Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="Aff8">Seoul Department of Epidemiology, School of Public Health, Seoul National University, Seoul, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Seoul Department of Epidemiology, School of Public Health, Seoul National University, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
<settlement type="city">Séoul</settlement>
</placeName>
<orgName type="university">Université nationale de Séoul</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="Aff9">Institute of Health and Environment, Seoul National University, Seoul, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Institute of Health and Environment, Seoul National University, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
<settlement type="city">Séoul</settlement>
</placeName>
<orgName type="university">Université nationale de Séoul</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27316945</idno>
<idno type="pmc">4912759</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4912759</idno>
<idno type="RBID">PMC:4912759</idno>
<idno type="doi">10.1186/s13058-016-0722-4</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000B42</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B42</idno>
<idno type="wicri:Area/Pmc/Curation">000B19</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B19</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000793</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000793</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="wicri:Area/PubMed/Corpus">001D78</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001D78</idno>
<idno type="wicri:Area/PubMed/Curation">001D54</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001D54</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001D54</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001D54</idno>
<idno type="wicri:Area/Ncbi/Merge">003726</idno>
<idno type="wicri:Area/Ncbi/Curation">003726</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">003726</idno>
<idno type="wicri:doubleKey">1465-5411:2016:Krishnan K:mammographic:density:and</idno>
<idno type="wicri:Area/Main/Merge">001B51</idno>
<idno type="wicri:Area/Main/Curation">001B55</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mammographic density and risk of breast cancer by mode of detection and tumor size: a case-control study</title>
<author><name sortKey="Krishnan, Kavitha" sort="Krishnan, Kavitha" uniqKey="Krishnan K" first="Kavitha" last="Krishnan">Kavitha Krishnan</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff5">Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM, Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Paris-Saclay, Univ. Paris-Sud, UVSQ, CESP, INSERM, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff6">Gustave Roussy, F-94805 Villejuif, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Gustave Roussy, F-94805 Villejuif</wicri:regionArea>
<wicri:noRegion>94805 Villejuif</wicri:noRegion>
<wicri:noRegion>94805 Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Apicella, Carmel" sort="Apicella, Carmel" uniqKey="Apicella C" first="Carmel" last="Apicella">Carmel Apicella</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stone, Jennifer" sort="Stone, Jennifer" uniqKey="Stone J" first="Jennifer" last="Stone">Jennifer Stone</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff3">Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Crawley, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Centre for Genetic Origins of Health and Disease, Curtin University and University of Western Australia, Crawley</wicri:regionArea>
<wicri:noRegion>Crawley</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="4"><nlm:aff id="Aff7">Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Genetic Epidemiology Laboratory, Department of Pathology, University of Melbourne, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
<settlement type="city">Melbourne</settlement>
</placeName>
<orgName type="university">Université de Melbourne</orgName>
</affiliation>
</author>
<author><name sortKey="English, Dallas R" sort="English, Dallas R" uniqKey="English D" first="Dallas R." last="English">Dallas R. English</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Giles, Graham G" sort="Giles, Graham G" uniqKey="Giles G" first="Graham G." last="Giles">Graham G. Giles</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff2">Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="Aff4">Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Department of Epidemiology and Preventive Medicine, Monash University, Melbourne</wicri:regionArea>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation wicri:level="4"><nlm:aff id="Aff1">Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Level 3, 207 Bouverie Street, Carlton, VIC 3053 Australia</nlm:aff>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="Aff8">Seoul Department of Epidemiology, School of Public Health, Seoul National University, Seoul, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Seoul Department of Epidemiology, School of Public Health, Seoul National University, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
<settlement type="city">Séoul</settlement>
</placeName>
<orgName type="university">Université nationale de Séoul</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="Aff9">Institute of Health and Environment, Seoul National University, Seoul, Korea</nlm:aff>
<country xml:lang="fr">Corée du Sud</country>
<wicri:regionArea>Institute of Health and Environment, Seoul National University, Seoul</wicri:regionArea>
<placeName><settlement type="city">Séoul</settlement>
<region type="capital">Région capitale de Séoul</region>
<settlement type="city">Séoul</settlement>
</placeName>
<orgName type="university">Université nationale de Séoul</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">Breast Cancer Research : BCR</title>
<idno type="ISSN">1465-5411</idno>
<idno type="eISSN">1465-542X</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Body Mass Index</term>
<term>Breast Density</term>
<term>Breast Neoplasms (epidemiology)</term>
<term>Breast Neoplasms (pathology)</term>
<term>Case-Control Studies</term>
<term>Early Detection of Cancer</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Mammography (methods)</term>
<term>Middle Aged</term>
<term>Risk</term>
<term>Risk Factors</term>
<term>Tumor Burden</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Charge tumorale</term>
<term>Densité mammaire</term>
<term>Détection précoce de cancer</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Indice de masse corporelle</term>
<term>Mammographie ()</term>
<term>Risque</term>
<term>Sujet âgé</term>
<term>Tumeurs du sein (anatomopathologie)</term>
<term>Tumeurs du sein (épidémiologie)</term>
<term>Études cas-témoins</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Mammography</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Breast Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Body Mass Index</term>
<term>Breast Density</term>
<term>Case-Control Studies</term>
<term>Early Detection of Cancer</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Middle Aged</term>
<term>Risk</term>
<term>Risk Factors</term>
<term>Tumor Burden</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Charge tumorale</term>
<term>Densité mammaire</term>
<term>Détection précoce de cancer</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Indice de masse corporelle</term>
<term>Mammographie</term>
<term>Risque</term>
<term>Sujet âgé</term>
<term>Études cas-témoins</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Risk of screen-detected breast cancer mostly reflects inherent risk, while risk of interval cancer reflects inherent risk and risk of masking (risk of the tumor not being detected due to increased dense tissue). Therefore the predictors of whether a breast cancer is interval or screen-detected include those that predict masking. Our aim was to investigate the associations between mammographic measures and (1) inherent risk, and (2) masking.</p>
</sec>
<sec><title>Methods</title>
<p>We conducted a case-control study nested within the Melbourne collaborative cohort study of 244 screen-detected cases (192 small tumors (<2 cm)) matched to 700 controls and 148 interval cases (76 small tumors) matched to 446 controls. Dense area (DA), percent dense area (PDA), and non-dense area (NDA) were measured using the Cumulus software. Conditional and unconditional logistic regression were applied as appropriate to estimate the odds per adjusted standard deviation (OPERA) adjusted for age and body mass index (BMI), allowing for the association with BMI to be a function of age at diagnosis. Tests of fit were performed using the Bayesian information criterion (BIC) and the area under the receiver operating characteristic curve.</p>
</sec>
<sec><title>Results</title>
<p>For screen-detected cancer, the association with BMI had a marginally significant dependence on age at diagnosis, and after adjustment both DA and PDA were associated with risk (OPERA approximately 1.2) and gave a similar fit. NDA was not associated with risk. For interval cancer, the BMI risk association was not dependent on age at diagnosis and the best fitting model was PDA alone (OPERA = 2.24, 95 % confidence interval 1.75, 2.86). Prediction of interval versus screen-detected cancer was best achieved by PDA alone (OPERA = 1.76, 95 % confidence interval 1.39, 2.22) with no association with BMI. When the analysis was restricted to small tumors to reduce the influence of tumor growth, we obtained similar results.</p>
</sec>
<sec><title>Conclusions</title>
<p>Inherent breast cancer risk is predicted by BMI and DA or PDA, but not NDA. Masking is predicted by PDA, and not by BMI. Understanding risk and masking could help tailor mammographic screening.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s13058-016-0722-4) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wang, At" uniqKey="Wang A">AT Wang</name>
</author>
<author><name sortKey="Vachon, Cm" uniqKey="Vachon C">CM Vachon</name>
</author>
<author><name sortKey="Brandt, Kr" uniqKey="Brandt K">KR Brandt</name>
</author>
<author><name sortKey="Ghosh, K" uniqKey="Ghosh K">K Ghosh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mccormack, Va" uniqKey="Mccormack V">VA McCormack</name>
</author>
<author><name sortKey="Dos Santos Silva, I" uniqKey="Dos Santos Silva I">I dos Santos Silva</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Huo, Cw" uniqKey="Huo C">CW Huo</name>
</author>
<author><name sortKey="Chew, Gl" uniqKey="Chew G">GL Chew</name>
</author>
<author><name sortKey="Britt, Kl" uniqKey="Britt K">KL Britt</name>
</author>
<author><name sortKey="Ingman, Wv" uniqKey="Ingman W">WV Ingman</name>
</author>
<author><name sortKey="Henderson, Ma" uniqKey="Henderson M">MA Henderson</name>
</author>
<author><name sortKey="Hopper, Jl" uniqKey="Hopper J">JL Hopper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Price, Er" uniqKey="Price E">ER Price</name>
</author>
<author><name sortKey="Hargreaves, J" uniqKey="Hargreaves J">J Hargreaves</name>
</author>
<author><name sortKey="Lipson, Ja" uniqKey="Lipson J">JA Lipson</name>
</author>
<author><name sortKey="Sickles, Ea" uniqKey="Sickles E">EA Sickles</name>
</author>
<author><name sortKey="Brenner, Rj" uniqKey="Brenner R">RJ Brenner</name>
</author>
<author><name sortKey="Lindfors, Kk" uniqKey="Lindfors K">KK Lindfors</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brekelmans, Ct" uniqKey="Brekelmans C">CT Brekelmans</name>
</author>
<author><name sortKey="Van Gorp, Jm" uniqKey="Van Gorp J">JM van Gorp</name>
</author>
<author><name sortKey="Peeters, Ph" uniqKey="Peeters P">PH Peeters</name>
</author>
<author><name sortKey="Collette, Hj" uniqKey="Collette H">HJ Collette</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baglietto, L" uniqKey="Baglietto L">L Baglietto</name>
</author>
<author><name sortKey="Krishnan, K" uniqKey="Krishnan K">K Krishnan</name>
</author>
<author><name sortKey="Stone, J" uniqKey="Stone J">J Stone</name>
</author>
<author><name sortKey="Apicella, C" uniqKey="Apicella C">C Apicella</name>
</author>
<author><name sortKey="Southey, Mc" uniqKey="Southey M">MC Southey</name>
</author>
<author><name sortKey="English, Dr" uniqKey="English D">DR English</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bulun, Se" uniqKey="Bulun S">SE Bulun</name>
</author>
<author><name sortKey="Chen, D" uniqKey="Chen D">D Chen</name>
</author>
<author><name sortKey="Moy, I" uniqKey="Moy I">I Moy</name>
</author>
<author><name sortKey="Brooks, Dc" uniqKey="Brooks D">DC Brooks</name>
</author>
<author><name sortKey="Zhao, H" uniqKey="Zhao H">H Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Giles, Gg" uniqKey="Giles G">GG Giles</name>
</author>
<author><name sortKey="English, Dr" uniqKey="English D">DR English</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hopper, Jl" uniqKey="Hopper J">JL Hopper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nguyen, Tl" uniqKey="Nguyen T">TL Nguyen</name>
</author>
<author><name sortKey="Aung, Yk" uniqKey="Aung Y">YK Aung</name>
</author>
<author><name sortKey="Evans, Cf" uniqKey="Evans C">CF Evans</name>
</author>
<author><name sortKey="Yoon Ho, C" uniqKey="Yoon Ho C">C Yoon-Ho</name>
</author>
<author><name sortKey="Jenkins, Ma" uniqKey="Jenkins M">MA Jenkins</name>
</author>
<author><name sortKey="Sung, J" uniqKey="Sung J">J Sung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Bk" uniqKey="Kim B">BK Kim</name>
</author>
<author><name sortKey="Choi, Yh" uniqKey="Choi Y">YH Choi</name>
</author>
<author><name sortKey="Nguyen, Tl" uniqKey="Nguyen T">TL Nguyen</name>
</author>
<author><name sortKey="Nam, Sj" uniqKey="Nam S">SJ Nam</name>
</author>
<author><name sortKey="Lee, Je" uniqKey="Lee J">JE Lee</name>
</author>
<author><name sortKey="Hopper, Jl" uniqKey="Hopper J">JL Hopper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pepe, M" uniqKey="Pepe M">M Pepe</name>
</author>
<author><name sortKey="Longton, G" uniqKey="Longton G">G Longton</name>
</author>
<author><name sortKey="Janes, H" uniqKey="Janes H">H Janes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Houssami, N" uniqKey="Houssami N">N Houssami</name>
</author>
<author><name sortKey="Irwig, L" uniqKey="Irwig L">L Irwig</name>
</author>
<author><name sortKey="Ciatto, S" uniqKey="Ciatto S">S Ciatto</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Macinnis, Rj" uniqKey="Macinnis R">RJ Macinnis</name>
</author>
<author><name sortKey="English, Dr" uniqKey="English D">DR English</name>
</author>
<author><name sortKey="Gertig, Dm" uniqKey="Gertig D">DM Gertig</name>
</author>
<author><name sortKey="Hopper, Jl" uniqKey="Hopper J">JL Hopper</name>
</author>
<author><name sortKey="Giles, Gg" uniqKey="Giles G">GG Giles</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pollan, M" uniqKey="Pollan M">M Pollan</name>
</author>
<author><name sortKey="Ascunce, N" uniqKey="Ascunce N">N Ascunce</name>
</author>
<author><name sortKey="Ederra, M" uniqKey="Ederra M">M Ederra</name>
</author>
<author><name sortKey="Murillo, A" uniqKey="Murillo A">A Murillo</name>
</author>
<author><name sortKey="Erdozain, N" uniqKey="Erdozain N">N Erdozain</name>
</author>
<author><name sortKey="Ales Martinez, Je" uniqKey="Ales Martinez J">JE Ales-Martinez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, J" uniqKey="Ding J">J Ding</name>
</author>
<author><name sortKey="Warren, R" uniqKey="Warren R">R Warren</name>
</author>
<author><name sortKey="Girling, A" uniqKey="Girling A">A Girling</name>
</author>
<author><name sortKey="Thompson, D" uniqKey="Thompson D">D Thompson</name>
</author>
<author><name sortKey="Easton, D" uniqKey="Easton D">D Easton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boyd, Nf" uniqKey="Boyd N">NF Boyd</name>
</author>
<author><name sortKey="Guo, H" uniqKey="Guo H">H Guo</name>
</author>
<author><name sortKey="Martin, Lj" uniqKey="Martin L">LJ Martin</name>
</author>
<author><name sortKey="Sun, L" uniqKey="Sun L">L Sun</name>
</author>
<author><name sortKey="Stone, J" uniqKey="Stone J">J Stone</name>
</author>
<author><name sortKey="Fishell, E" uniqKey="Fishell E">E Fishell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pettersson, A" uniqKey="Pettersson A">A Pettersson</name>
</author>
<author><name sortKey="Tamimi, Rm" uniqKey="Tamimi R">RM Tamimi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stone, J" uniqKey="Stone J">J Stone</name>
</author>
<author><name sortKey="Thompson, Dj" uniqKey="Thompson D">DJ Thompson</name>
</author>
<author><name sortKey="Dos Santos, Si" uniqKey="Dos Santos S">SI Dos Santos</name>
</author>
<author><name sortKey="Scott, C" uniqKey="Scott C">C Scott</name>
</author>
<author><name sortKey="Tamimi, Rm" uniqKey="Tamimi R">RM Tamimi</name>
</author>
<author><name sortKey="Lindstrom, S" uniqKey="Lindstrom S">S Lindstrom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perry, N" uniqKey="Perry N">N Perry</name>
</author>
<author><name sortKey="Broeders, M" uniqKey="Broeders M">M Broeders</name>
</author>
<author><name sortKey="De Wolf, C" uniqKey="De Wolf C">C de Wolf</name>
</author>
<author><name sortKey="Tornberg, C" uniqKey="Tornberg C">C Tornberg</name>
</author>
<author><name sortKey="Holland, R" uniqKey="Holland R">R Holland</name>
</author>
<author><name sortKey="Von Karsa, L" uniqKey="Von Karsa L">L von Karsa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boyd, Nf" uniqKey="Boyd N">NF Boyd</name>
</author>
<author><name sortKey="Huszti, E" uniqKey="Huszti E">E Huszti</name>
</author>
<author><name sortKey="Melnichouk, O" uniqKey="Melnichouk O">O Melnichouk</name>
</author>
<author><name sortKey="Martin, Lj" uniqKey="Martin L">LJ Martin</name>
</author>
<author><name sortKey="Hislop, G" uniqKey="Hislop G">G Hislop</name>
</author>
<author><name sortKey="Chiarelli, A" uniqKey="Chiarelli A">A Chiarelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mandelson, Mt" uniqKey="Mandelson M">MT Mandelson</name>
</author>
<author><name sortKey="Oestreicher, N" uniqKey="Oestreicher N">N Oestreicher</name>
</author>
<author><name sortKey="Porter, Pl" uniqKey="Porter P">PL Porter</name>
</author>
<author><name sortKey="White, D" uniqKey="White D">D White</name>
</author>
<author><name sortKey="Finder, Ca" uniqKey="Finder C">CA Finder</name>
</author>
<author><name sortKey="Taplin, Sh" uniqKey="Taplin S">SH Taplin</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Domingo, L" uniqKey="Domingo L">L Domingo</name>
</author>
<author><name sortKey="Salas, D" uniqKey="Salas D">D Salas</name>
</author>
<author><name sortKey="Zubizarreta, R" uniqKey="Zubizarreta R">R Zubizarreta</name>
</author>
<author><name sortKey="Bare, M" uniqKey="Bare M">M Bare</name>
</author>
<author><name sortKey="Sarriugarte, G" uniqKey="Sarriugarte G">G Sarriugarte</name>
</author>
<author><name sortKey="Barata, T" uniqKey="Barata T">T Barata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nickson, C" uniqKey="Nickson C">C Nickson</name>
</author>
<author><name sortKey="Arzhaeva, Y" uniqKey="Arzhaeva Y">Y Arzhaeva</name>
</author>
<author><name sortKey="Aitken, Z" uniqKey="Aitken Z">Z Aitken</name>
</author>
<author><name sortKey="Elgindy, T" uniqKey="Elgindy T">T Elgindy</name>
</author>
<author><name sortKey="Buckley, M" uniqKey="Buckley M">M Buckley</name>
</author>
<author><name sortKey="Li, M" uniqKey="Li M">M Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kavanagh, Am" uniqKey="Kavanagh A">AM Kavanagh</name>
</author>
<author><name sortKey="Byrnes, Gb" uniqKey="Byrnes G">GB Byrnes</name>
</author>
<author><name sortKey="Nickson, C" uniqKey="Nickson C">C Nickson</name>
</author>
<author><name sortKey="Cawson, Jn" uniqKey="Cawson J">JN Cawson</name>
</author>
<author><name sortKey="Giles, Gg" uniqKey="Giles G">GG Giles</name>
</author>
<author><name sortKey="Hopper, Jl" uniqKey="Hopper J">JL Hopper</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B55 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 001B55 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Asie |area= AustralieFrV1 |flux= Main |étape= Curation |type= RBID |clé= PMC:4912759 |texte= Mammographic density and risk of breast cancer by mode of detection and tumor size: a case-control study }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Curation/RBID.i -Sk "pubmed:27316945" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Curation/biblio.hfd \ | NlmPubMed2Wicri -a AustralieFrV1
This area was generated with Dilib version V0.6.33. |