Predictors of response to tenofovir disoproxil fumarate plus peginterferon alfa-2a combination therapy for chronic hepatitis B.
Identifieur interne : 001910 ( Main/Curation ); précédent : 001909; suivant : 001911Predictors of response to tenofovir disoproxil fumarate plus peginterferon alfa-2a combination therapy for chronic hepatitis B.
Auteurs : P. Marcellin [France] ; S H Ahn [Corée du Sud] ; W-L Chuang [Taïwan] ; A J Hui [République populaire de Chine] ; F. Tabak [Turquie] ; R. Mehta [Inde] ; J. Petersen [Allemagne] ; C-M Lee [Taïwan] ; X. Ma [États-Unis] ; F A Caruntu [Roumanie] ; W Y Tak [Corée du Sud] ; M. Elkhashab [Canada] ; L. Lin [États-Unis] ; G. Wu [États-Unis] ; E B Martins [États-Unis] ; P. Charuworn [États-Unis] ; L J Yee [États-Unis] ; S G Lim ; G R Foster [Royaume-Uni] ; S. Fung [Canada] ; L. Morano [Espagne] ; D. Samuel [France] ; K. Agarwal [Royaume-Uni] ; R. Idilman [Turquie] ; S I Strasser [Australie] ; M. Buti [Espagne] ; G B Gaeta [Italie] ; G. Papatheodoridis [Grèce] ; R. Flisiak [Pologne] ; H L Y. Chan [République populaire de Chine]Source :
- Alimentary pharmacology & therapeutics [ 1365-2036 ] ; 2016.
Descripteurs français
- KwdFr :
- ADN viral (sang), Administration par voie orale, Adulte, Adulte d'âge moyen, Antigènes de surface du virus de l'hépatite B (sang), Antiviraux (administration et posologie), Association de médicaments, Femelle, Humains, Hépatite B chronique (diagnostic), Hépatite B chronique (traitement médicamenteux), Injections sous-cutanées, Interféron alpha (administration et posologie), Mâle, Polyéthylène glycols (administration et posologie), Protéines recombinantes (administration et posologie), Résultat thérapeutique, Ténofovir (administration et posologie), Valeur prédictive des tests, Virus de l'hépatite B (), Virus de l'hépatite B (génétique).
- MESH :
- administration et posologie : Antiviraux, Interféron alpha, Polyéthylène glycols, Protéines recombinantes, Ténofovir.
- diagnostic : Hépatite B chronique.
- génétique : Virus de l'hépatite B.
- sang : ADN viral, Antigènes de surface du virus de l'hépatite B.
- traitement médicamenteux : Hépatite B chronique.
- Administration par voie orale, Adulte, Adulte d'âge moyen, Association de médicaments, Femelle, Humains, Injections sous-cutanées, Mâle, Résultat thérapeutique, Valeur prédictive des tests, Virus de l'hépatite B.
English descriptors
- KwdEn :
- Administration, Oral, Adult, Antiviral Agents (administration & dosage), DNA, Viral (blood), Drug Therapy, Combination, Female, Hepatitis B Surface Antigens (blood), Hepatitis B virus (drug effects), Hepatitis B virus (genetics), Hepatitis B, Chronic (diagnosis), Hepatitis B, Chronic (drug therapy), Humans, Injections, Subcutaneous, Interferon-alpha (administration & dosage), Male, Middle Aged, Polyethylene Glycols (administration & dosage), Predictive Value of Tests, Recombinant Proteins (administration & dosage), Tenofovir (administration & dosage), Treatment Outcome.
- MESH :
- chemical , administration & dosage : Antiviral Agents, Interferon-alpha, Polyethylene Glycols, Recombinant Proteins, Tenofovir.
- chemical , blood : DNA, Viral, Hepatitis B Surface Antigens.
- diagnosis : Hepatitis B, Chronic.
- drug effects : Hepatitis B virus.
- drug therapy : Hepatitis B, Chronic.
- genetics : Hepatitis B virus.
- Administration, Oral, Adult, Drug Therapy, Combination, Female, Humans, Injections, Subcutaneous, Male, Middle Aged, Predictive Value of Tests, Treatment Outcome.
Abstract
In patients with chronic hepatitis B, tenofovir disoproxil fumarate (TDF) plus pegylated interferon (PEG-IFN) for 48-weeks results in higher rates of hepatitis B surface antigen (HBsAg) loss than either monotherapy.
DOI: 10.1111/apt.13779
PubMed: 27629859
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Buti</name><affiliation wicri:level="1"><nlm:affiliation>Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Gaeta, G B" sort="Gaeta, G B" uniqKey="Gaeta G" first="G B" last="Gaeta">G B Gaeta</name><affiliation wicri:level="1"><nlm:affiliation>Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Naples</wicri:regionArea></affiliation></author><author><name sortKey="Papatheodoridis, G" sort="Papatheodoridis, G" uniqKey="Papatheodoridis G" first="G" last="Papatheodoridis">G. Papatheodoridis</name><affiliation wicri:level="1"><nlm:affiliation>Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Athens</wicri:regionArea></affiliation></author><author><name sortKey="Flisiak, R" sort="Flisiak, R" uniqKey="Flisiak R" first="R" last="Flisiak">R. Flisiak</name><affiliation wicri:level="1"><nlm:affiliation>Bialystok, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Bialystok</wicri:regionArea></affiliation></author><author><name sortKey="Chan, H L Y" sort="Chan, H L Y" uniqKey="Chan H" first="H L Y" last="Chan">H L Y. Chan</name><affiliation wicri:level="1"><nlm:affiliation>Hong Kong, China. hlychan@cuhk.edu.hk.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27629859</idno><idno type="pmid">27629859</idno><idno type="doi">10.1111/apt.13779</idno><idno type="wicri:Area/PubMed/Corpus">001689</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001689</idno><idno type="wicri:Area/PubMed/Curation">001667</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001667</idno><idno type="wicri:Area/PubMed/Checkpoint">001667</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001667</idno><idno type="wicri:Area/Ncbi/Merge">003B44</idno><idno type="wicri:Area/Ncbi/Curation">003B44</idno><idno type="wicri:Area/Ncbi/Checkpoint">003B44</idno><idno type="wicri:Area/Main/Merge">001905</idno><idno type="wicri:Area/Main/Curation">001910</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Predictors of response to tenofovir disoproxil fumarate plus peginterferon alfa-2a combination therapy for chronic hepatitis B.</title><author><name sortKey="Marcellin, P" sort="Marcellin, P" uniqKey="Marcellin P" first="P" last="Marcellin">P. Marcellin</name><affiliation wicri:level="1"><nlm:affiliation>Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Paris</wicri:regionArea></affiliation></author><author><name sortKey="Ahn, S H" sort="Ahn, S H" uniqKey="Ahn S" first="S H" last="Ahn">S H Ahn</name><affiliation wicri:level="1"><nlm:affiliation>Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Seoul</wicri:regionArea></affiliation></author><author><name sortKey="Chuang, W L" sort="Chuang, W L" uniqKey="Chuang W" first="W-L" last="Chuang">W-L Chuang</name><affiliation wicri:level="1"><nlm:affiliation>Kaohsiung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Kaohsiung</wicri:regionArea></affiliation></author><author><name sortKey="Hui, A J" sort="Hui, A J" uniqKey="Hui A" first="A J" last="Hui">A J Hui</name><affiliation wicri:level="1"><nlm:affiliation>Hong Kong, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong</wicri:regionArea></affiliation></author><author><name sortKey="Tabak, F" sort="Tabak, F" uniqKey="Tabak F" first="F" last="Tabak">F. Tabak</name><affiliation wicri:level="1"><nlm:affiliation>Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Istanbul</wicri:regionArea></affiliation></author><author><name sortKey="Mehta, R" sort="Mehta, R" uniqKey="Mehta R" first="R" last="Mehta">R. Mehta</name><affiliation wicri:level="1"><nlm:affiliation>Surat, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Surat</wicri:regionArea></affiliation></author><author><name sortKey="Petersen, J" sort="Petersen, J" uniqKey="Petersen J" first="J" last="Petersen">J. Petersen</name><affiliation wicri:level="1"><nlm:affiliation>Hamburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Lee, C M" sort="Lee, C M" uniqKey="Lee C" first="C-M" last="Lee">C-M Lee</name><affiliation wicri:level="1"><nlm:affiliation>Kaohsiung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Kaohsiung</wicri:regionArea></affiliation></author><author><name sortKey="Ma, X" sort="Ma, X" uniqKey="Ma X" first="X" last="Ma">X. Ma</name><affiliation wicri:level="1"><nlm:affiliation>Philadelphia, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Philadelphia</wicri:regionArea></affiliation></author><author><name sortKey="Caruntu, F A" sort="Caruntu, F A" uniqKey="Caruntu F" first="F A" last="Caruntu">F A Caruntu</name><affiliation wicri:level="1"><nlm:affiliation>Bucharest, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Bucharest</wicri:regionArea></affiliation></author><author><name sortKey="Tak, W Y" sort="Tak, W Y" uniqKey="Tak W" first="W Y" last="Tak">W Y Tak</name><affiliation wicri:level="1"><nlm:affiliation>Daegu, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Daegu</wicri:regionArea></affiliation></author><author><name sortKey="Elkhashab, M" sort="Elkhashab, M" uniqKey="Elkhashab M" first="M" last="Elkhashab">M. Elkhashab</name><affiliation wicri:level="1"><nlm:affiliation>Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Lin, L" sort="Lin, L" uniqKey="Lin L" first="L" last="Lin">L. Lin</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc., Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Inc., Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Wu, G" sort="Wu, G" uniqKey="Wu G" first="G" last="Wu">G. Wu</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc., Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Inc., Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Martins, E B" sort="Martins, E B" uniqKey="Martins E" first="E B" last="Martins">E B Martins</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc., Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Inc., Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Charuworn, P" sort="Charuworn, P" uniqKey="Charuworn P" first="P" last="Charuworn">P. Charuworn</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc., Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Inc., Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yee, L J" sort="Yee, L J" uniqKey="Yee L" first="L J" last="Yee">L J Yee</name><affiliation wicri:level="2"><nlm:affiliation>Gilead Sciences, Inc., Foster City, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Gilead Sciences, Inc., Foster City, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lim, S G" sort="Lim, S G" uniqKey="Lim S" first="S G" last="Lim">S G Lim</name><affiliation><nlm:affiliation>Singapore.</nlm:affiliation><wicri:noCountry code="no comma">Singapore.</wicri:noCountry></affiliation></author><author><name sortKey="Foster, G R" sort="Foster, G R" uniqKey="Foster G" first="G R" last="Foster">G R Foster</name><affiliation wicri:level="1"><nlm:affiliation>London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Fung, S" sort="Fung, S" uniqKey="Fung S" first="S" last="Fung">S. Fung</name><affiliation wicri:level="1"><nlm:affiliation>Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Morano, L" sort="Morano, L" uniqKey="Morano L" first="L" last="Morano">L. Morano</name><affiliation wicri:level="1"><nlm:affiliation>Pontevedra, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Pontevedra</wicri:regionArea></affiliation></author><author><name sortKey="Samuel, D" sort="Samuel, D" uniqKey="Samuel D" first="D" last="Samuel">D. Samuel</name><affiliation wicri:level="1"><nlm:affiliation>Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Villejuif</wicri:regionArea></affiliation></author><author><name sortKey="Agarwal, K" sort="Agarwal, K" uniqKey="Agarwal K" first="K" last="Agarwal">K. Agarwal</name><affiliation wicri:level="1"><nlm:affiliation>London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Idilman, R" sort="Idilman, R" uniqKey="Idilman R" first="R" last="Idilman">R. Idilman</name><affiliation wicri:level="1"><nlm:affiliation>Ankara, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Ankara</wicri:regionArea></affiliation></author><author><name sortKey="Strasser, S I" sort="Strasser, S I" uniqKey="Strasser S" first="S I" last="Strasser">S I Strasser</name><affiliation wicri:level="1"><nlm:affiliation>Sydney, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney</wicri:regionArea></affiliation></author><author><name sortKey="Buti, M" sort="Buti, M" uniqKey="Buti M" first="M" last="Buti">M. Buti</name><affiliation wicri:level="1"><nlm:affiliation>Barcelona, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Barcelona</wicri:regionArea></affiliation></author><author><name sortKey="Gaeta, G B" sort="Gaeta, G B" uniqKey="Gaeta G" first="G B" last="Gaeta">G B Gaeta</name><affiliation wicri:level="1"><nlm:affiliation>Naples, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Naples</wicri:regionArea></affiliation></author><author><name sortKey="Papatheodoridis, G" sort="Papatheodoridis, G" uniqKey="Papatheodoridis G" first="G" last="Papatheodoridis">G. Papatheodoridis</name><affiliation wicri:level="1"><nlm:affiliation>Athens, Greece.</nlm:affiliation><country xml:lang="fr">Grèce</country><wicri:regionArea>Athens</wicri:regionArea></affiliation></author><author><name sortKey="Flisiak, R" sort="Flisiak, R" uniqKey="Flisiak R" first="R" last="Flisiak">R. Flisiak</name><affiliation wicri:level="1"><nlm:affiliation>Bialystok, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Bialystok</wicri:regionArea></affiliation></author><author><name sortKey="Chan, H L Y" sort="Chan, H L Y" uniqKey="Chan H" first="H L Y" last="Chan">H L Y. Chan</name><affiliation wicri:level="1"><nlm:affiliation>Hong Kong, China. hlychan@cuhk.edu.hk.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Hong Kong</wicri:regionArea></affiliation></author></analytic><series><title level="j">Alimentary pharmacology & therapeutics</title><idno type="eISSN">1365-2036</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Antiviral Agents (administration & dosage)</term><term>DNA, Viral (blood)</term><term>Drug Therapy, Combination</term><term>Female</term><term>Hepatitis B Surface Antigens (blood)</term><term>Hepatitis B virus (drug effects)</term><term>Hepatitis B virus (genetics)</term><term>Hepatitis B, Chronic (diagnosis)</term><term>Hepatitis B, Chronic (drug therapy)</term><term>Humans</term><term>Injections, Subcutaneous</term><term>Interferon-alpha (administration & dosage)</term><term>Male</term><term>Middle Aged</term><term>Polyethylene Glycols (administration & dosage)</term><term>Predictive Value of Tests</term><term>Recombinant Proteins (administration & dosage)</term><term>Tenofovir (administration & dosage)</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ADN viral (sang)</term><term>Administration par voie orale</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antigènes de surface du virus de l'hépatite B (sang)</term><term>Antiviraux (administration et posologie)</term><term>Association de médicaments</term><term>Femelle</term><term>Humains</term><term>Hépatite B chronique (diagnostic)</term><term>Hépatite B chronique (traitement médicamenteux)</term><term>Injections sous-cutanées</term><term>Interféron alpha (administration et posologie)</term><term>Mâle</term><term>Polyéthylène glycols (administration et posologie)</term><term>Protéines recombinantes (administration et posologie)</term><term>Résultat thérapeutique</term><term>Ténofovir (administration et posologie)</term><term>Valeur prédictive des tests</term><term>Virus de l'hépatite B ()</term><term>Virus de l'hépatite B (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Antiviral Agents</term><term>Interferon-alpha</term><term>Polyethylene Glycols</term><term>Recombinant Proteins</term><term>Tenofovir</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>DNA, Viral</term><term>Hepatitis B Surface Antigens</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Antiviraux</term><term>Interféron alpha</term><term>Polyéthylène glycols</term><term>Protéines recombinantes</term><term>Ténofovir</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hepatitis B, Chronic</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Hépatite B chronique</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Hepatitis B virus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hepatitis B, Chronic</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Hepatitis B virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Virus de l'hépatite B</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>ADN viral</term><term>Antigènes de surface du virus de l'hépatite B</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hépatite B chronique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Drug Therapy, Combination</term><term>Female</term><term>Humans</term><term>Injections, Subcutaneous</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Association de médicaments</term><term>Femelle</term><term>Humains</term><term>Injections sous-cutanées</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Valeur prédictive des tests</term><term>Virus de l'hépatite B</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In patients with chronic hepatitis B, tenofovir disoproxil fumarate (TDF) plus pegylated interferon (PEG-IFN) for 48-weeks results in higher rates of hepatitis B surface antigen (HBsAg) loss than either monotherapy.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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