Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
Identifieur interne : 000930 ( Main/Curation ); précédent : 000929; suivant : 000931Intron retention is regulated by altered MeCP2-mediated splicing factor recruitment
Auteurs : Justin J. L. Wong [Australie] ; Dadi Gao [Australie] ; Trung V. Nguyen [Australie] ; Chau-To Kwok [Australie] ; Michelle Van Geldermalsen [Australie] ; Rob Middleton [Australie] ; Natalia Pinello [Australie] ; Annora Thoeng [Australie] ; Rajini Nagarajah [Australie] ; Jeff Holst [Australie] ; William Ritchie [Australie, France] ; John E. J. Rasko [Australie]Source :
- Nature Communications [ 2041-1723 ] ; 2017.
Abstract
While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we show that DNA methylation directly regulates IR. We also find reduced occupancy of MeCP2 near the splice junctions of retained introns, mirroring the reduced DNA methylation at these sites. Accordingly, MeCP2 depletion in tissues and cells enhances IR. By analysing the MeCP2 interactome using mass spectrometry and RNA co-precipitation, we demonstrate that decreased MeCP2 binding near splice junctions facilitates IR via reduced recruitment of splicing factors, including Tra2b, and increased RNA polymerase II stalling. These results suggest an association between IR and a slower rate of transcription elongation, which reflects inefficient splicing factor recruitment. In summary, our results reinforce the interdependency between alternative splicing involving IR and epigenetic controls of gene expression.
Url:
DOI: 10.1038/ncomms15134
PubMed: 28480880
PubMed Central: 5424149
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PMC:5424149Le document en format XML
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>
, Sydney, New South Wales 2006,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Thoeng, Annora" sort="Thoeng, Annora" uniqKey="Thoeng A" first="Annora" last="Thoeng">Annora Thoeng</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>
, Camperdown, New South Wales 2050,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>
, Sydney, New South Wales 2006,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nagarajah, Rajini" sort="Nagarajah, Rajini" uniqKey="Nagarajah R" first="Rajini" last="Nagarajah">Rajini Nagarajah</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>
, Camperdown, New South Wales 2050,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>
, Sydney, New South Wales 2006,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Holst, Jeff" sort="Holst, Jeff" uniqKey="Holst J" first="Jeff" last="Holst">Jeff Holst</name>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>
, Sydney, New South Wales 2006,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a5"><institution>Origins of Cancer Program, Centenary Institute, University of Sydney</institution>
, Camperdown, New South Wales 2050,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ritchie, William" sort="Ritchie, William" uniqKey="Ritchie W" first="William" last="Ritchie">William Ritchie</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>
, Camperdown, New South Wales 2050,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>
, Sydney, New South Wales 2006,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a4"><institution>Bioinformatics Laboratory, Centenary Institute, University of Sydney</institution>
, Camperdown, New South Wales 2050,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a6"><institution>CNRS, UMR 5203</institution>
, 34094 Montpellier,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Rasko, John E J" sort="Rasko, John E J" uniqKey="Rasko J" first="John E. J." last="Rasko">John E. J. Rasko</name>
<affiliation wicri:level="1"><nlm:aff id="a1"><institution>Gene & Stem Cell Therapy Program, Centenary Institute, University of Sydney</institution>
, Camperdown, New South Wales 2050,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a3"><institution>Sydney Medical School, University of Sydney</institution>
, Sydney, New South Wales 2006,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="a7"><institution>Cell and Molecular Therapies, Royal Prince Alfred Hospital</institution>
, Camperdown, New South Wales 2050,<country>Australia</country>
</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Nature Communications</title>
<idno type="eISSN">2041-1723</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>While intron retention (IR) is considered a widely conserved and distinct mechanism of gene expression control, its regulation is poorly understood. Here we show that DNA methylation directly regulates IR. We also find reduced occupancy of MeCP2 near the splice junctions of retained introns, mirroring the reduced DNA methylation at these sites. Accordingly, MeCP2 depletion in tissues and cells enhances IR. By analysing the MeCP2 interactome using mass spectrometry and RNA co-precipitation, we demonstrate that decreased MeCP2 binding near splice junctions facilitates IR via reduced recruitment of splicing factors, including Tra2b, and increased RNA polymerase II stalling. These results suggest an association between IR and a slower rate of transcription elongation, which reflects inefficient splicing factor recruitment. In summary, our results reinforce the interdependency between alternative splicing involving IR and epigenetic controls of gene expression.</p>
</div>
</front>
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