No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease.
Identifieur interne : 000724 ( Main/Curation ); précédent : 000723; suivant : 000725No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease.
Auteurs : Michelle K. Lupton [Australie] ; Beben Benyamin [Australie] ; Petroula Proitsi [Royaume-Uni] ; Dale R. Nyholt [Australie] ; Manuel A. Ferreira [Australie] ; Grant W. Montgomery [Australie] ; Andrew C. Heath [États-Unis] ; Pamela A. Madden [États-Unis] ; Sarah E. Medland [Australie] ; Scott D. Gordon [Australie] ; Simon Lovestone [Royaume-Uni] ; Magda Tsolaki [Grèce] ; Iwona Kloszewska [Pologne] ; Hilkka Soininen [Finlande] ; Patrizia Mecocci [Italie] ; Bruno Vellas [France] ; John F. Powell [Royaume-Uni] ; Ashley I. Bush [Australie] ; Margaret J. Wright [Australie] ; Nicholas G. Martin [Australie] ; John B. Whitfield [Australie]Source :
- Journal of Alzheimer's disease : JAD [ 1875-8908 ] ; 2017.
Abstract
Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology.
DOI: 10.3233/JAD-170027
PubMed: 28582860
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<author><name sortKey="Tsolaki, Magda" sort="Tsolaki, Magda" uniqKey="Tsolaki M" first="Magda" last="Tsolaki">Magda Tsolaki</name>
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<author><name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name>
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<author><name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name>
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<author><name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Psychiatry Psychology and Neuroscience, Kings College London, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Psychiatry Psychology and Neuroscience, Kings College London</wicri:regionArea>
<wicri:noRegion>Kings College London</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bush, Ashley I" sort="Bush, Ashley I" uniqKey="Bush A" first="Ashley I" last="Bush">Ashley I. Bush</name>
<affiliation wicri:level="4"><nlm:affiliation>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J" last="Wright">Margaret J. Wright</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Whitfield, John B" sort="Whitfield, John B" uniqKey="Whitfield J" first="John B" last="Whitfield">John B. Whitfield</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Brisbane</wicri:regionArea>
<wicri:noRegion>Brisbane</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Alzheimer's disease : JAD</title>
<idno type="eISSN">1875-8908</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology.</div>
</front>
</TEI>
</record>
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