Serveur d'exploration sur les relations entre la France et l'Australie

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No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease.

Identifieur interne : 001280 ( PubMed/Curation ); précédent : 001279; suivant : 001281

No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease.

Auteurs : Michelle K. Lupton [Australie] ; Beben Benyamin [Australie] ; Petroula Proitsi [Royaume-Uni] ; Dale R. Nyholt [Australie] ; Manuel A. Ferreira [Australie] ; Grant W. Montgomery [Australie] ; Andrew C. Heath [États-Unis] ; Pamela A. Madden [États-Unis] ; Sarah E. Medland [Australie] ; Scott D. Gordon [Australie] ; Simon Lovestone [Royaume-Uni] ; Magda Tsolaki [Grèce] ; Iwona Kloszewska [Pologne] ; Hilkka Soininen [Finlande] ; Patrizia Mecocci [Italie] ; Bruno Vellas [France] ; John F. Powell [Royaume-Uni] ; Ashley I. Bush [Australie] ; Margaret J. Wright [Australie] ; Nicholas G. Martin [Australie] ; John B. Whitfield [Australie]

Source :

RBID : pubmed:28582860

Abstract

Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology.

DOI: 10.3233/JAD-170027
PubMed: 28582860

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Le document en format XML

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<name sortKey="Kloszewska, Iwona" sort="Kloszewska, Iwona" uniqKey="Kloszewska I" first="Iwona" last="Kloszewska">Iwona Kloszewska</name>
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<name sortKey="Soininen, Hilkka" sort="Soininen, Hilkka" uniqKey="Soininen H" first="Hilkka" last="Soininen">Hilkka Soininen</name>
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<nlm:affiliation>Department of Neurology, University of EasternFinland and Kuopio University Hospital, Kuopio, Finland.</nlm:affiliation>
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<name sortKey="Mecocci, Patrizia" sort="Mecocci, Patrizia" uniqKey="Mecocci P" first="Patrizia" last="Mecocci">Patrizia Mecocci</name>
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<name sortKey="Vellas, Bruno" sort="Vellas, Bruno" uniqKey="Vellas B" first="Bruno" last="Vellas">Bruno Vellas</name>
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<name sortKey="Powell, John F" sort="Powell, John F" uniqKey="Powell J" first="John F" last="Powell">John F. Powell</name>
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<nlm:affiliation>Institute of Psychiatry Psychology and Neuroscience, Kings College London, UK.</nlm:affiliation>
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<name sortKey="Bush, Ashley I" sort="Bush, Ashley I" uniqKey="Bush A" first="Ashley I" last="Bush">Ashley I. Bush</name>
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<nlm:affiliation>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.</nlm:affiliation>
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<name sortKey="Wright, Margaret J" sort="Wright, Margaret J" uniqKey="Wright M" first="Margaret J" last="Wright">Margaret J. Wright</name>
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<nlm:affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</nlm:affiliation>
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<name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name>
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<title level="j">Journal of Alzheimer's disease : JAD</title>
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<div type="abstract" xml:lang="en">Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology.</div>
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<ISOAbbreviation>J. Alzheimers Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>No Genetic Overlap Between Circulating Iron Levels and Alzheimer's Disease.</ArticleTitle>
<Pagination>
<MedlinePgn>85-99</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3233/JAD-170027</ELocationID>
<Abstract>
<AbstractText>Iron deposition in the brain is a prominent feature of Alzheimer's disease (AD). Recently, peripheral iron measures have also been shown to be associated with AD status. However, it is not known whether these associations are causal: do elevated or depleted iron levels throughout life have an effect on AD risk? We evaluate the effects of peripheral iron on AD risk using a genetic profile score approach by testing whether variants affecting iron, transferrin, or ferritin levels selected from GWAS meta-analysis of approximately 24,000 individuals are also associated with AD risk in an independent case-control cohort (n∼10,000). Conversely, we test whether AD risk variants from a GWAS meta-analysis of approximately 54,000 account for any variance in iron measures (n∼9,000). We do not identify a genetic relationship, suggesting that peripheral iron is not causal in the initiation of AD pathology.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Lupton</LastName>
<ForeName>Michelle K</ForeName>
<Initials>MK</Initials>
<AffiliationInfo>
<Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Benyamin</LastName>
<ForeName>Beben</ForeName>
<Initials>B</Initials>
<AffiliationInfo>
<Affiliation>Queensland Brain Institute, University of Queensland, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Proitsi</LastName>
<ForeName>Petroula</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Institute of Psychiatry Psychology and Neuroscience, Kings College London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Nyholt</LastName>
<ForeName>Dale R</ForeName>
<Initials>DR</Initials>
<AffiliationInfo>
<Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Ferreira</LastName>
<ForeName>Manuel A</ForeName>
<Initials>MA</Initials>
<AffiliationInfo>
<Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Montgomery</LastName>
<ForeName>Grant W</ForeName>
<Initials>GW</Initials>
<AffiliationInfo>
<Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Heath</LastName>
<ForeName>Andrew C</ForeName>
<Initials>AC</Initials>
<AffiliationInfo>
<Affiliation>Washington University School of Medicine, StLouis, MO, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Madden</LastName>
<ForeName>Pamela A</ForeName>
<Initials>PA</Initials>
<AffiliationInfo>
<Affiliation>Washington University School of Medicine, StLouis, MO, USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Medland</LastName>
<ForeName>Sarah E</ForeName>
<Initials>SE</Initials>
<AffiliationInfo>
<Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Gordon</LastName>
<ForeName>Scott D</ForeName>
<Initials>SD</Initials>
<AffiliationInfo>
<Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<CollectiveName>GERAD1 Consortium</CollectiveName>
</Author>
<Author ValidYN="Y">
<CollectiveName>Alzheimer’s Disease Neuroimaging Initiative</CollectiveName>
</Author>
<Author ValidYN="Y">
<LastName>Lovestone</LastName>
<ForeName>Simon</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Tsolaki</LastName>
<ForeName>Magda</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Memory and Dementia Centre, 3rd Department of Neurology, Aristotle University of Thessaloniki, Thessaloniki, Greece.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Kloszewska</LastName>
<ForeName>Iwona</ForeName>
<Initials>I</Initials>
<AffiliationInfo>
<Affiliation>Department of Old Age Psychiatry and Psychotic Disorders, Medical University of Lodz, Lodz, Poland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Soininen</LastName>
<ForeName>Hilkka</ForeName>
<Initials>H</Initials>
<AffiliationInfo>
<Affiliation>Department of Neurology, University of EasternFinland and Kuopio University Hospital, Kuopio, Finland.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Mecocci</LastName>
<ForeName>Patrizia</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Vellas</LastName>
<ForeName>Bruno</ForeName>
<Initials>B</Initials>
<AffiliationInfo>
<Affiliation>Gerontopole, CHU, UMR INSERM 1027, University ofToulouse, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Powell</LastName>
<ForeName>John F</ForeName>
<Initials>JF</Initials>
<AffiliationInfo>
<Affiliation>Institute of Psychiatry Psychology and Neuroscience, Kings College London, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Bush</LastName>
<ForeName>Ashley I</ForeName>
<Initials>AI</Initials>
<AffiliationInfo>
<Affiliation>Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Wright</LastName>
<ForeName>Margaret J</ForeName>
<Initials>MJ</Initials>
<AffiliationInfo>
<Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Queensland Brain Institute, University of Queensland, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
<AffiliationInfo>
<Affiliation>Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Martin</LastName>
<ForeName>Nicholas G</ForeName>
<Initials>NG</Initials>
<AffiliationInfo>
<Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Whitfield</LastName>
<ForeName>John B</ForeName>
<Initials>JB</Initials>
<AffiliationInfo>
<Affiliation>QIMR Berghofer Medical Research Institute, Brisbane, Australia.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo>
<Country>Netherlands</Country>
<MedlineTA>J Alzheimers Dis</MedlineTA>
<NlmUniqueID>9814863</NlmUniqueID>
<ISSNLinking>1387-2877</ISSNLinking>
</MedlineJournalInfo>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">Alzheimer’s disease</Keyword>
<Keyword MajorTopicYN="N">apolipoproteins E</Keyword>
<Keyword MajorTopicYN="N">dementia</Keyword>
<Keyword MajorTopicYN="N">ferritin</Keyword>
<Keyword MajorTopicYN="N">genetic profile scores</Keyword>
<Keyword MajorTopicYN="N">genome-wide association study</Keyword>
<Keyword MajorTopicYN="N">iron</Keyword>
<Keyword MajorTopicYN="N">population genetics</Keyword>
<Keyword MajorTopicYN="N">transferrin</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData>
<History>
<PubMedPubDate PubStatus="pubmed">
<Year>2017</Year>
<Month>6</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2017</Year>
<Month>6</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez">
<Year>2017</Year>
<Month>6</Month>
<Day>7</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList>
<ArticleId IdType="pubmed">28582860</ArticleId>
<ArticleId IdType="pii">JAD170027</ArticleId>
<ArticleId IdType="doi">10.3233/JAD-170027</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
</record>

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