Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers
Identifieur interne : 002478 ( Istex/Curation ); précédent : 002477; suivant : 002479Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers
Auteurs : Antonis C. Antoniou [Royaume-Uni] ; Olga M. Sinilnikova ; Lesley Mcguffog [Royaume-Uni] ; Sue Healey ; Heli Nevanlinna ; Tuomas Heikkinen ; Jacques Simard ; Amanda B. Spurdle ; Jonathan Beesley ; Xiaoqing Chen ; Susan L. Neuhausen ; Yuan C. Ding ; Fergus J. Couch ; Xianshu Wang ; Zachary Fredericksen ; Paolo Peterlongo ; Bernard Peissel ; Bernardo Bonanni ; Alessandra Viel ; Loris Bernard ; Paolo Radice ; Csilla I. Szabo ; Lenka Foretova ; Michal Zikan ; Kathleen Claes ; Mark H. Greene ; Phuong L. Mai ; Gad Rennert ; Flavio Lejbkowicz ; Irene L. Andrulis [Canada] ; Hilmi Ozcelik ; Gord Glendon ; Anne-Marie Gerdes ; Mads Thomassen ; Lone Sunde ; Maria A. Caligo ; Yael Laitman ; Tair Kontorovich ; Shimrit Cohen ; Bella Kaufman ; Efrat Dagan ; Ruth Gershoni Baruch ; Eitan Friedman ; Katja Harbst ; Gisela Barbany-Bustinza ; Johanna Rantala ; Hans Ehrencrona [Suède] ; Per Karlsson ; Susan M. Domchek ; Katherine L. Nathanson ; Ana Osorio ; Ignacio Blanco ; Adriana Lasa ; Javier Benítez ; Ute Hamann ; Frans B. L. Hogervorst ; Matti A. Rookus ; J. Margriet Collee ; Peter Devilee ; Marjolijn J. Ligtenberg ; Rob B. Van Der Luijt ; Cora M. Aalfs ; Quinten Waisfisz ; Juul Wijnen ; Cornelis E. P. Van Roozendaal ; Susan Peock [Royaume-Uni] ; Margaret Cook [Royaume-Uni] ; Debra Frost [Royaume-Uni] ; Clare Oliver [Royaume-Uni] ; Radka Platte [Royaume-Uni] ; D. Gareth Evans ; Fiona Lalloo ; Rosalind Eeles ; Louise Izatt ; Rosemarie Davidson ; Carol Chu ; Diana Eccles ; Trevor Cole ; Shirley Hodgson [Royaume-Uni] ; Andrew K. Godwin ; Dominique Stoppa-Lyonnet [France] ; Bruno Buecher ; Mélanie Léoné ; Brigitte Bressac-De Paillerets ; Audrey Remenieras ; Olivier Caron ; Gilbert M. Lenoir ; Nicolas Sevenet ; Michel Longy ; Sandra Fert Ferrer ; Fabienne Prieur ; David Goldgar ; Alexander Miron ; Esther M. John ; Saundra S. Buys ; Mary B. Daly ; John L. Hopper [Australie] ; Mary Beth Terry [États-Unis] ; Yosuf Yassin ; Daphne Gschwantler-Kaulich ; Christine Staudigl ; Thomas V. O. Hansen ; Rosa Bjork Barkardottir ; Tomas Kirchhoff ; Prodipto Pal ; Kristi Kosarin ; Kenneth Offit ; Marion Piedmonte ; Gustavo C. Rodriguez ; Katie Wakeley ; John F. Boggess ; Jack Basil ; Peter E. Schwartz ; Stephanie V. Blank ; Amanda E. Toland ; Marco Montagna ; Cinzia Casella ; Evgeny N. Imyanitov ; Anna Allavena ; Rita K. Schmutzler ; Beatrix Versmold ; Christoph Engel ; Alfons Meindl ; Nina Ditsch ; Norbert Arnold ; Dieter Niederacher ; Helmut Dei Ler [Allemagne] ; Britta Fiebig ; Christian Suttner ; Ines Schönbuchner ; Dorothea Gadzicki [Allemagne] ; Trinidad Caldes [Espagne] ; Miguel De La Hoya [Espagne] ; Karen A. Pooley [Royaume-Uni] ; Douglas F. Easton [Royaume-Uni] ; Georgia Chenevix-TrenchSource :
- Human Molecular Genetics [ 0964-6906 ] ; 2009-11-15.
Abstract
Genome-wide association studies of breast cancer have identified multiple single nucleotide polymorphisms (SNPs) that are associated with increased breast cancer risks in the general population. In a previous study, we demonstrated that the minor alleles at three of these SNPs, in FGFR2, TNRC9 and MAP3K1, also confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers. Three additional SNPs rs3817198 at LSP1, rs13387042 at 2q35 and rs13281615 at 8q24 have since been reported to be associated with breast cancer in the general population, and in this study we evaluated their association with breast cancer risk in 9442 BRCA1 and 5665 BRCA2 mutation carriers from 33 study centres. The minor allele of rs3817198 was associated with increased breast cancer risk only for BRCA2 mutation carriers [hazard ratio (HR) = 1.16, 95% CI: 1.07–1.25, P-trend = 2.8 × 10−4]. The best fit for the association of SNP rs13387042 at 2q35 with breast cancer risk was a dominant model for both BRCA1 and BRCA2 mutation carriers (BRCA1: HR = 1.14, 95% CI: 1.04–1.25, P = 0.0047; BRCA2: HR = 1.18 95% CI: 1.04–1.33, P = 0.0079). SNP rs13281615 at 8q24 was not associated with breast cancer for either BRCA1 or BRCA2 mutation carriers, but the estimated association for BRCA2 mutation carriers (per-allele HR = 1.06, 95% CI: 0.98–1.14) was consistent with odds ratio estimates derived from population-based case–control studies. The LSP1 and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for BRCA2 mutation carriers. There was no evidence that the associations vary by mutation type depending on whether the mutated protein is predicted to be stable or not.
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DOI: 10.1093/hmg/ddp372
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Olga M. Sinilnikova<affiliation><mods:affiliation>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS, Université de Lyon, Lyon, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Epidemiology, University of California Irvine, Irvine, CA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Epidemiology, University of California Irvine, Irvine, CA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Mayo Clinic, Rochester, MN, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Mayo Clinic, Rochester, MN, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Mayo Clinic, Rochester, MN, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Istituto Europeo di Oncologia, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Centro di Riferimento Oncologico, IRCCS, Aviano, PN, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Cogentech, Consortium for Genomic Technologies, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Clinical Genetics Branch, US National Cancer Institute, Rockville, MD, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Clinical Genetics Branch, US National Cancer Institute, Rockville, MD, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Ontario Cancer Genetics Network, Cancer Care Ontario, Ontario, Canada,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, Pisa, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Genetics Institute Rambam Medical Center, Haifa, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Genetics Institute Rambam Medical Center, Haifa, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department Oncology, Lund University, Sweden,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Oncology, Sahlgrenska University, Gothenburg, Sweden,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>University of Pennsylvania, Philadelphia, PA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>University of Pennsylvania, Philadelphia, PA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Group of Human Genetics, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERERER), Instituto de Salud Carlos III, Madrid, Spain,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Cancer Genetics Counseling Program, Catalan Institute of Oncology (ICO), Barcelona, Spain,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Genetics Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Group of Human Genetics, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERERER), Instituto de Salud Carlos III, Madrid, Spain,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580 69120, Heidelberg, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Family Cancer Clinic, Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Genetic Epidemiology and</mods:affiliation><wicri:noCountry code="no comma">Department of Genetic Epidemiology and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Clinical Molecular Genetics, Utrecht University Medical Center, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Clinical Genetics, University Medical Center, Maastricht, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Translational Cancer Genetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Clinical Genetics, Guy's Hospital, London, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Ferguson-Smith Centre for Clinical Genetics, Glasgow, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Yorkshire Regional Genetics Service, Leeds, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Fox Chase Cancer Center, Philadelphia, PA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Département de Génétique, Institut Curie, Paris, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS, Université de Lyon, Lyon, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>INSERM U946, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>CNRS FRE2939, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Laboratoire de Génétique Constitutionnelle, Institut Bergonié, Bordeaux, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>INSERM U916, Institut Bergonié, Bordeaux, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Service de Génétique Clinique Chromosomique et Moléculaire, CHU de St Etienne, St Etienne, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Dermatology, University of Utah, Utah, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Northern California Cancer Center, Fremont and Stanford University School of Medicine, Stanford, CA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Fox Chase Cancer Center, Philadelphia, PA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna, Vienna, Austria,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna, Vienna, Austria,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Pathology, Landspitali-University Hospital, Reykjavik, Iceland,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>GOG Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY 14263, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>NorthShore University Health System, Evanston Northwestern Healthcare, Evanston IL 60201, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>New England Medical Center, Tufts University, Boston, MA 02111, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>University of North Carolina, Chapel Hill, NC 27599, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>St Elizabeth Medical Center, Edgewood, KY 41017, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Yale University School of Medicine, New Haven, CT 06510, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>New York University School of Medicine, New York, NY 10016, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Istituto Oncologico Veneto, IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Istituto Oncologico Veneto, IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>N.N. Petrov Institute of Oncology, St Petersburg, Russia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Cologne, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Cologne, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Obstetrics and Gynaecology, Technical University Munich, Munich, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Ludwig-Maximilian University Munich, Munich, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Molecular Genetics Laboratory, Department of Obstetrics and Gynaecology, University of Duesseldorf, Duesseldorf, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Molecular Genetics Laboratory, Department of Obstetrics and Gynaecology, University of Duesseldorf, Duesseldorf, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Institute of Human Genetics, University of Regensburg, Regensburg, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Institute of Human Genetics, University of Würzburg, Würzburg, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers</title><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: antonis@srl.cam.ac.uk</mods:affiliation><country wicri:rule="url">Royaume-Uni</country></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><mods:affiliation>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS, Université de Lyon, Lyon, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><mods:affiliation>Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><mods:affiliation>Department of Epidemiology, University of California Irvine, Irvine, CA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Ding, Yuan C" sort="Ding, Yuan C" uniqKey="Ding Y" first="Yuan C." last="Ding">Yuan C. Ding</name><affiliation><mods:affiliation>Department of Epidemiology, University of California Irvine, Irvine, CA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><mods:affiliation>Mayo Clinic, Rochester, MN, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><mods:affiliation>Mayo Clinic, Rochester, MN, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name><affiliation><mods:affiliation>Mayo Clinic, Rochester, MN, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><mods:affiliation>Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><mods:affiliation>Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><mods:affiliation>Istituto Europeo di Oncologia, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name><affiliation><mods:affiliation>Centro di Riferimento Oncologico, IRCCS, Aviano, PN, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name><affiliation><mods:affiliation>Istituto Europeo di Oncologia, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Cogentech, Consortium for Genomic Technologies, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><mods:affiliation>Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation><mods:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation><mods:affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Zikan, Michal" sort="Zikan, Michal" uniqKey="Zikan M" first="Michal" last="Zikan">Michal Zikan</name><affiliation><mods:affiliation>Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Claes, Kathleen" sort="Claes, Kathleen" uniqKey="Claes K" first="Kathleen" last="Claes">Kathleen Claes</name><affiliation><mods:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><mods:affiliation>Clinical Genetics Branch, US National Cancer Institute, Rockville, MD, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation><mods:affiliation>Clinical Genetics Branch, US National Cancer Institute, Rockville, MD, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><mods:affiliation>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Lejbkowicz, Flavio" sort="Lejbkowicz, Flavio" uniqKey="Lejbkowicz F" first="Flavio" last="Lejbkowicz">Flavio Lejbkowicz</name><affiliation><mods:affiliation>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><mods:affiliation>Ontario Cancer Genetics Network, Cancer Care Ontario, Ontario, Canada,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation wicri:level="4"><mods:affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada,</mods:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name><affiliation><mods:affiliation>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><mods:affiliation>Ontario Cancer Genetics Network, Cancer Care Ontario, Ontario, Canada,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><mods:affiliation>Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><mods:affiliation>Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Sunde, Lone" sort="Sunde, Lone" uniqKey="Sunde L" first="Lone" last="Sunde">Lone Sunde</name><affiliation><mods:affiliation>Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation><mods:affiliation>Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, Pisa, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><mods:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Kontorovich, Tair" sort="Kontorovich, Tair" uniqKey="Kontorovich T" first="Tair" last="Kontorovich">Tair Kontorovich</name><affiliation><mods:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Cohen, Shimrit" sort="Cohen, Shimrit" uniqKey="Cohen S" first="Shimrit" last="Cohen">Shimrit Cohen</name><affiliation><mods:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name><affiliation><mods:affiliation>The Oncology Institute Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Dagan, Efrat" sort="Dagan, Efrat" uniqKey="Dagan E" first="Efrat" last="Dagan">Efrat Dagan</name><affiliation><mods:affiliation>Genetics Institute Rambam Medical Center, Haifa, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Baruch, Ruth Gershoni" sort="Baruch, Ruth Gershoni" uniqKey="Baruch R" first="Ruth Gershoni" last="Baruch">Ruth Gershoni Baruch</name><affiliation><mods:affiliation>Genetics Institute Rambam Medical Center, Haifa, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><mods:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Harbst, Katja" sort="Harbst, Katja" uniqKey="Harbst K" first="Katja" last="Harbst">Katja Harbst</name><affiliation><mods:affiliation>Department Oncology, Lund University, Sweden,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Barbany Bustinza, Gisela" sort="Barbany Bustinza, Gisela" uniqKey="Barbany Bustinza G" first="Gisela" last="Barbany-Bustinza">Gisela Barbany-Bustinza</name><affiliation><mods:affiliation>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name><affiliation><mods:affiliation>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation wicri:level="4"><mods:affiliation>Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden,</mods:affiliation><orgName type="university">Université d'Uppsala</orgName><country>Suède</country><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Karlsson, Per" sort="Karlsson, Per" uniqKey="Karlsson P" first="Per" last="Karlsson">Per Karlsson</name><affiliation><mods:affiliation>Department of Oncology, Sahlgrenska University, Gothenburg, Sweden,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><mods:affiliation>University of Pennsylvania, Philadelphia, PA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><mods:affiliation>University of Pennsylvania, Philadelphia, PA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><mods:affiliation>Group of Human Genetics, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERERER), Instituto de Salud Carlos III, Madrid, Spain,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><mods:affiliation>Cancer Genetics Counseling Program, Catalan Institute of Oncology (ICO), Barcelona, Spain,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Lasa, Adriana" sort="Lasa, Adriana" uniqKey="Lasa A" first="Adriana" last="Lasa">Adriana Lasa</name><affiliation><mods:affiliation>Genetics Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><mods:affiliation>Group of Human Genetics, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERERER), Instituto de Salud Carlos III, Madrid, Spain,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><mods:affiliation>Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580 69120, Heidelberg, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><mods:affiliation>Family Cancer Clinic, Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A." last="Rookus">Matti A. Rookus</name><affiliation><mods:affiliation>Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collee">J. Margriet Collee</name><affiliation><mods:affiliation>Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><mods:affiliation>Department of Genetic Epidemiology and</mods:affiliation><wicri:noCountry code="no comma">Department of Genetic Epidemiology and</wicri:noCountry></affiliation></author><author><name sortKey="Ligtenberg, Marjolijn J" sort="Ligtenberg, Marjolijn J" uniqKey="Ligtenberg M" first="Marjolijn J." last="Ligtenberg">Marjolijn J. Ligtenberg</name><affiliation><mods:affiliation>Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B." last="Van Der Luijt">Rob B. Van Der Luijt</name><affiliation><mods:affiliation>Department of Clinical Molecular Genetics, Utrecht University Medical Center, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Aalfs, Cora M" sort="Aalfs, Cora M" uniqKey="Aalfs C" first="Cora M." last="Aalfs">Cora M. Aalfs</name><affiliation><mods:affiliation>Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name><affiliation><mods:affiliation>Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Wijnen, Juul" sort="Wijnen, Juul" uniqKey="Wijnen J" first="Juul" last="Wijnen">Juul Wijnen</name><affiliation><mods:affiliation>Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Van Roozendaal, Cornelis E P" sort="Van Roozendaal, Cornelis E P" uniqKey="Van Roozendaal C" first="Cornelis E. P." last="Van Roozendaal">Cornelis E. P. Van Roozendaal</name><affiliation><mods:affiliation>Department of Clinical Genetics, University Medical Center, Maastricht, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Oliver, Clare" sort="Oliver, Clare" uniqKey="Oliver C" first="Clare" last="Oliver">Clare Oliver</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation><mods:affiliation>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Lalloo, Fiona" sort="Lalloo, Fiona" uniqKey="Lalloo F" first="Fiona" last="Lalloo">Fiona Lalloo</name><affiliation><mods:affiliation>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name><affiliation><mods:affiliation>Translational Cancer Genetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation><mods:affiliation>Clinical Genetics, Guy's Hospital, London, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name><affiliation><mods:affiliation>Ferguson-Smith Centre for Clinical Genetics, Glasgow, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Chu, Carol" sort="Chu, Carol" uniqKey="Chu C" first="Carol" last="Chu">Carol Chu</name><affiliation><mods:affiliation>Yorkshire Regional Genetics Service, Leeds, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><mods:affiliation>Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Cole, Trevor" sort="Cole, Trevor" uniqKey="Cole T" first="Trevor" last="Cole">Trevor Cole</name><affiliation><mods:affiliation>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name><affiliation wicri:level="4"><mods:affiliation>Department of Cancer Genetics, St Georges Hospital, University of London, London, UK,</mods:affiliation><orgName type="university">Université de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><mods:affiliation>Fox Chase Cancer Center, Philadelphia, PA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation wicri:level="4"><mods:affiliation>INSERM U509, Service de Génétique Oncologique, Institut Curie, and Université Paris-Descartes, Paris, France,</mods:affiliation><orgName type="university">Université Paris-Descartes</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Buecher, Bruno" sort="Buecher, Bruno" uniqKey="Buecher B" first="Bruno" last="Buecher">Bruno Buecher</name><affiliation><mods:affiliation>Département de Génétique, Institut Curie, Paris, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Leone, Melanie" sort="Leone, Melanie" uniqKey="Leone M" first="Mélanie" last="Léoné">Mélanie Léoné</name><affiliation><mods:affiliation>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS, Université de Lyon, Lyon, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name><affiliation><mods:affiliation>Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>INSERM U946, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Remenieras, Audrey" sort="Remenieras, Audrey" uniqKey="Remenieras A" first="Audrey" last="Remenieras">Audrey Remenieras</name><affiliation><mods:affiliation>Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name><affiliation><mods:affiliation>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Lenoir, Gilbert M" sort="Lenoir, Gilbert M" uniqKey="Lenoir G" first="Gilbert M." last="Lenoir">Gilbert M. Lenoir</name><affiliation><mods:affiliation>Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>CNRS FRE2939, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Sevenet, Nicolas" sort="Sevenet, Nicolas" uniqKey="Sevenet N" first="Nicolas" last="Sevenet">Nicolas Sevenet</name><affiliation><mods:affiliation>Laboratoire de Génétique Constitutionnelle, Institut Bergonié, Bordeaux, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Longy, Michel" sort="Longy, Michel" uniqKey="Longy M" first="Michel" last="Longy">Michel Longy</name><affiliation><mods:affiliation>Laboratoire de Génétique Constitutionnelle, Institut Bergonié, Bordeaux, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>INSERM U916, Institut Bergonié, Bordeaux, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Ferrer, Sandra Fert" sort="Ferrer, Sandra Fert" uniqKey="Ferrer S" first="Sandra Fert" last="Ferrer">Sandra Fert Ferrer</name><affiliation><mods:affiliation>Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Prieur, Fabienne" sort="Prieur, Fabienne" uniqKey="Prieur F" first="Fabienne" last="Prieur">Fabienne Prieur</name><affiliation><mods:affiliation>Service de Génétique Clinique Chromosomique et Moléculaire, CHU de St Etienne, St Etienne, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Goldgar, David" sort="Goldgar, David" uniqKey="Goldgar D" first="David" last="Goldgar">David Goldgar</name><affiliation><mods:affiliation>Department of Dermatology, University of Utah, Utah, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><mods:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><mods:affiliation>Northern California Cancer Center, Fremont and Stanford University School of Medicine, Stanford, CA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation><mods:affiliation>Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation><mods:affiliation>Fox Chase Cancer Center, Philadelphia, PA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><mods:affiliation>The University of Melbourne, Melbourne, Australia,</mods:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name><affiliation wicri:level="4"><mods:affiliation>Columbia University, New York, NY, USA,</mods:affiliation><orgName type="university">Université Columbia</orgName><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Yassin, Yosuf" sort="Yassin, Yosuf" uniqKey="Yassin Y" first="Yosuf" last="Yassin">Yosuf Yassin</name><affiliation><mods:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Gschwantler Kaulich, Daphne" sort="Gschwantler Kaulich, Daphne" uniqKey="Gschwantler Kaulich D" first="Daphne" last="Gschwantler-Kaulich">Daphne Gschwantler-Kaulich</name><affiliation><mods:affiliation>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna, Vienna, Austria,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Staudigl, Christine" sort="Staudigl, Christine" uniqKey="Staudigl C" first="Christine" last="Staudigl">Christine Staudigl</name><affiliation><mods:affiliation>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna, Vienna, Austria,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation><mods:affiliation>Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Barkardottir, Rosa Bjork" sort="Barkardottir, Rosa Bjork" uniqKey="Barkardottir R" first="Rosa Bjork" last="Barkardottir">Rosa Bjork Barkardottir</name><affiliation><mods:affiliation>Department of Pathology, Landspitali-University Hospital, Reykjavik, Iceland,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name><affiliation><mods:affiliation>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Pal, Prodipto" sort="Pal, Prodipto" uniqKey="Pal P" first="Prodipto" last="Pal">Prodipto Pal</name><affiliation><mods:affiliation>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Kosarin, Kristi" sort="Kosarin, Kristi" uniqKey="Kosarin K" first="Kristi" last="Kosarin">Kristi Kosarin</name><affiliation><mods:affiliation>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><mods:affiliation>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><mods:affiliation>GOG Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY 14263, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C." last="Rodriguez">Gustavo C. Rodriguez</name><affiliation><mods:affiliation>NorthShore University Health System, Evanston Northwestern Healthcare, Evanston IL 60201, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Wakeley, Katie" sort="Wakeley, Katie" uniqKey="Wakeley K" first="Katie" last="Wakeley">Katie Wakeley</name><affiliation><mods:affiliation>New England Medical Center, Tufts University, Boston, MA 02111, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Boggess, John F" sort="Boggess, John F" uniqKey="Boggess J" first="John F." last="Boggess">John F. Boggess</name><affiliation><mods:affiliation>University of North Carolina, Chapel Hill, NC 27599, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Basil, Jack" sort="Basil, Jack" uniqKey="Basil J" first="Jack" last="Basil">Jack Basil</name><affiliation><mods:affiliation>St Elizabeth Medical Center, Edgewood, KY 41017, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Schwartz, Peter E" sort="Schwartz, Peter E" uniqKey="Schwartz P" first="Peter E." last="Schwartz">Peter E. Schwartz</name><affiliation><mods:affiliation>Yale University School of Medicine, New Haven, CT 06510, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Blank, Stephanie V" sort="Blank, Stephanie V" uniqKey="Blank S" first="Stephanie V." last="Blank">Stephanie V. Blank</name><affiliation><mods:affiliation>New York University School of Medicine, New York, NY 10016, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><mods:affiliation>Department of Internal Medicine and</mods:affiliation><wicri:noCountry code="no comma">Department of Internal Medicine and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><mods:affiliation>Istituto Oncologico Veneto, IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Casella, Cinzia" sort="Casella, Cinzia" uniqKey="Casella C" first="Cinzia" last="Casella">Cinzia Casella</name><affiliation><mods:affiliation>Istituto Oncologico Veneto, IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N." last="Imyanitov">Evgeny N. Imyanitov</name><affiliation><mods:affiliation>N.N. Petrov Institute of Oncology, St Petersburg, Russia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Allavena, Anna" sort="Allavena, Anna" uniqKey="Allavena A" first="Anna" last="Allavena">Anna Allavena</name><affiliation><mods:affiliation>Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><mods:affiliation>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Cologne, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name><affiliation><mods:affiliation>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Cologne, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><mods:affiliation>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><mods:affiliation>Department of Obstetrics and Gynaecology, Technical University Munich, Munich, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Ditsch, Nina" sort="Ditsch, Nina" uniqKey="Ditsch N" first="Nina" last="Ditsch">Nina Ditsch</name><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Ludwig-Maximilian University Munich, Munich, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><mods:affiliation>Molecular Genetics Laboratory, Department of Obstetrics and Gynaecology, University of Duesseldorf, Duesseldorf, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><mods:affiliation>Molecular Genetics Laboratory, Department of Obstetrics and Gynaecology, University of Duesseldorf, Duesseldorf, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Dei Ler, Helmut" sort="Dei Ler, Helmut" uniqKey="Dei Ler H" first="Helmut" last="Dei Ler">Helmut Dei Ler</name><affiliation wicri:level="4"><mods:affiliation>Department of Obstetrics and Gynaecology, University of Ulm, Ulm, Germany,</mods:affiliation><orgName type="university">Université d'Ulm</orgName><country>Allemagne</country><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName></affiliation></author><author><name sortKey="Fiebig, Britta" sort="Fiebig, Britta" uniqKey="Fiebig B" first="Britta" last="Fiebig">Britta Fiebig</name><affiliation><mods:affiliation>Institute of Human Genetics, University of Regensburg, Regensburg, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Suttner, Christian" sort="Suttner, Christian" uniqKey="Suttner C" first="Christian" last="Suttner">Christian Suttner</name><affiliation><mods:affiliation>Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Schonbuchner, Ines" sort="Schonbuchner, Ines" uniqKey="Schonbuchner I" first="Ines" last="Schönbuchner">Ines Schönbuchner</name><affiliation><mods:affiliation>Institute of Human Genetics, University of Würzburg, Würzburg, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Gadzicki, Dorothea" sort="Gadzicki, Dorothea" uniqKey="Gadzicki D" first="Dorothea" last="Gadzicki">Dorothea Gadzicki</name><affiliation wicri:level="1"><mods:affiliation>Institute of Cellular and Molecular Pathology, Medical University, Hannover, Germany and</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Cellular and Molecular Pathology, Medical University, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation wicri:level="1"><mods:affiliation>Hospital Clinico San Carlos 28040, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinico San Carlos 28040, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation wicri:level="1"><mods:affiliation>Hospital Clinico San Carlos 28040, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinico San Carlos 28040, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C65392F6F6B47F4DCA91ADB2D9862ADC24116036</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1093/hmg/ddp372</idno><idno type="url">https://api.istex.fr/document/C65392F6F6B47F4DCA91ADB2D9862ADC24116036/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002478</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002478</idno><idno type="wicri:Area/Istex/Curation">002478</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers</title><author><name sortKey="Antoniou, Antonis C" sort="Antoniou, Antonis C" uniqKey="Antoniou A" first="Antonis C." last="Antoniou">Antonis C. Antoniou</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: antonis@srl.cam.ac.uk</mods:affiliation><country wicri:rule="url">Royaume-Uni</country></affiliation></author><author><name sortKey="Sinilnikova, Olga M" sort="Sinilnikova, Olga M" uniqKey="Sinilnikova O" first="Olga M." last="Sinilnikova">Olga M. Sinilnikova</name><affiliation><mods:affiliation>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS, Université de Lyon, Lyon, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Mcguffog, Lesley" sort="Mcguffog, Lesley" uniqKey="Mcguffog L" first="Lesley" last="Mcguffog">Lesley Mcguffog</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Healey, Sue" sort="Healey, Sue" uniqKey="Healey S" first="Sue" last="Healey">Sue Healey</name><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Heikkinen, Tuomas" sort="Heikkinen, Tuomas" uniqKey="Heikkinen T" first="Tuomas" last="Heikkinen">Tuomas Heikkinen</name><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Simard, Jacques" sort="Simard, Jacques" uniqKey="Simard J" first="Jacques" last="Simard">Jacques Simard</name><affiliation><mods:affiliation>Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Québec and Laval University, Quebec, Canada,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Beesley, Jonathan" sort="Beesley, Jonathan" uniqKey="Beesley J" first="Jonathan" last="Beesley">Jonathan Beesley</name><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Chen, Xiaoqing" sort="Chen, Xiaoqing" uniqKey="Chen X" first="Xiaoqing" last="Chen">Xiaoqing Chen</name><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Neuhausen, Susan L" sort="Neuhausen, Susan L" uniqKey="Neuhausen S" first="Susan L." last="Neuhausen">Susan L. Neuhausen</name><affiliation><mods:affiliation>Department of Epidemiology, University of California Irvine, Irvine, CA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Ding, Yuan C" sort="Ding, Yuan C" uniqKey="Ding Y" first="Yuan C." last="Ding">Yuan C. Ding</name><affiliation><mods:affiliation>Department of Epidemiology, University of California Irvine, Irvine, CA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Couch, Fergus J" sort="Couch, Fergus J" uniqKey="Couch F" first="Fergus J." last="Couch">Fergus J. Couch</name><affiliation><mods:affiliation>Mayo Clinic, Rochester, MN, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Wang, Xianshu" sort="Wang, Xianshu" uniqKey="Wang X" first="Xianshu" last="Wang">Xianshu Wang</name><affiliation><mods:affiliation>Mayo Clinic, Rochester, MN, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Fredericksen, Zachary" sort="Fredericksen, Zachary" uniqKey="Fredericksen Z" first="Zachary" last="Fredericksen">Zachary Fredericksen</name><affiliation><mods:affiliation>Mayo Clinic, Rochester, MN, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Peterlongo, Paolo" sort="Peterlongo, Paolo" uniqKey="Peterlongo P" first="Paolo" last="Peterlongo">Paolo Peterlongo</name><affiliation><mods:affiliation>Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy,</mods:affiliation></affiliation><affiliation><mods:affiliation>Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Peissel, Bernard" sort="Peissel, Bernard" uniqKey="Peissel B" first="Bernard" last="Peissel">Bernard Peissel</name><affiliation><mods:affiliation>Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Bonanni, Bernardo" sort="Bonanni, Bernardo" uniqKey="Bonanni B" first="Bernardo" last="Bonanni">Bernardo Bonanni</name><affiliation><mods:affiliation>Istituto Europeo di Oncologia, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Viel, Alessandra" sort="Viel, Alessandra" uniqKey="Viel A" first="Alessandra" last="Viel">Alessandra Viel</name><affiliation><mods:affiliation>Centro di Riferimento Oncologico, IRCCS, Aviano, PN, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Bernard, Loris" sort="Bernard, Loris" uniqKey="Bernard L" first="Loris" last="Bernard">Loris Bernard</name><affiliation><mods:affiliation>Istituto Europeo di Oncologia, Milan, Italy,</mods:affiliation></affiliation><affiliation><mods:affiliation>Cogentech, Consortium for Genomic Technologies, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Radice, Paolo" sort="Radice, Paolo" uniqKey="Radice P" first="Paolo" last="Radice">Paolo Radice</name><affiliation><mods:affiliation>Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy,</mods:affiliation></affiliation><affiliation><mods:affiliation>Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Szabo, Csilla I" sort="Szabo, Csilla I" uniqKey="Szabo C" first="Csilla I." last="Szabo">Csilla I. Szabo</name><affiliation><mods:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Foretova, Lenka" sort="Foretova, Lenka" uniqKey="Foretova L" first="Lenka" last="Foretova">Lenka Foretova</name><affiliation><mods:affiliation>Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Zikan, Michal" sort="Zikan, Michal" uniqKey="Zikan M" first="Michal" last="Zikan">Michal Zikan</name><affiliation><mods:affiliation>Department of Biochemistry and Experimental Oncology, First Faculty of Medicine, Charles University, Prague, Czech Republic,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Claes, Kathleen" sort="Claes, Kathleen" uniqKey="Claes K" first="Kathleen" last="Claes">Kathleen Claes</name><affiliation><mods:affiliation>Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Greene, Mark H" sort="Greene, Mark H" uniqKey="Greene M" first="Mark H." last="Greene">Mark H. Greene</name><affiliation><mods:affiliation>Clinical Genetics Branch, US National Cancer Institute, Rockville, MD, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Mai, Phuong L" sort="Mai, Phuong L" uniqKey="Mai P" first="Phuong L." last="Mai">Phuong L. Mai</name><affiliation><mods:affiliation>Clinical Genetics Branch, US National Cancer Institute, Rockville, MD, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Rennert, Gad" sort="Rennert, Gad" uniqKey="Rennert G" first="Gad" last="Rennert">Gad Rennert</name><affiliation><mods:affiliation>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Lejbkowicz, Flavio" sort="Lejbkowicz, Flavio" uniqKey="Lejbkowicz F" first="Flavio" last="Lejbkowicz">Flavio Lejbkowicz</name><affiliation><mods:affiliation>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and B. Rappaport Faculty of Medicine, Technion, Haifa, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Andrulis, Irene L" sort="Andrulis, Irene L" uniqKey="Andrulis I" first="Irene L." last="Andrulis">Irene L. Andrulis</name><affiliation><mods:affiliation>Ontario Cancer Genetics Network, Cancer Care Ontario, Ontario, Canada,</mods:affiliation></affiliation><affiliation><mods:affiliation>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada,</mods:affiliation></affiliation><affiliation wicri:level="4"><mods:affiliation>Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada,</mods:affiliation><orgName type="university">Université de Toronto</orgName><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Ozcelik, Hilmi" sort="Ozcelik, Hilmi" uniqKey="Ozcelik H" first="Hilmi" last="Ozcelik">Hilmi Ozcelik</name><affiliation><mods:affiliation>Fred A. Litwin Center for Cancer Genetics, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Glendon, Gord" sort="Glendon, Gord" uniqKey="Glendon G" first="Gord" last="Glendon">Gord Glendon</name><affiliation><mods:affiliation>Ontario Cancer Genetics Network, Cancer Care Ontario, Ontario, Canada,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Gerdes, Anne Marie" sort="Gerdes, Anne Marie" uniqKey="Gerdes A" first="Anne-Marie" last="Gerdes">Anne-Marie Gerdes</name><affiliation><mods:affiliation>Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Thomassen, Mads" sort="Thomassen, Mads" uniqKey="Thomassen M" first="Mads" last="Thomassen">Mads Thomassen</name><affiliation><mods:affiliation>Department of Biochemistry, Pharmacology and Genetics, Odense University Hospital, Odense, Denmark,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Sunde, Lone" sort="Sunde, Lone" uniqKey="Sunde L" first="Lone" last="Sunde">Lone Sunde</name><affiliation><mods:affiliation>Department of Clinical Genetics, Aarhus University Hospital, Aarhus, Denmark,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Caligo, Maria A" sort="Caligo, Maria A" uniqKey="Caligo M" first="Maria A." last="Caligo">Maria A. Caligo</name><affiliation><mods:affiliation>Division of Surgical, Molecular and Ultrastructural Pathology, Department of Oncology, University of Pisa and Pisa University Hospital, Pisa, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Laitman, Yael" sort="Laitman, Yael" uniqKey="Laitman Y" first="Yael" last="Laitman">Yael Laitman</name><affiliation><mods:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Kontorovich, Tair" sort="Kontorovich, Tair" uniqKey="Kontorovich T" first="Tair" last="Kontorovich">Tair Kontorovich</name><affiliation><mods:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Cohen, Shimrit" sort="Cohen, Shimrit" uniqKey="Cohen S" first="Shimrit" last="Cohen">Shimrit Cohen</name><affiliation><mods:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Kaufman, Bella" sort="Kaufman, Bella" uniqKey="Kaufman B" first="Bella" last="Kaufman">Bella Kaufman</name><affiliation><mods:affiliation>The Oncology Institute Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation></affiliation><affiliation><mods:affiliation>The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Dagan, Efrat" sort="Dagan, Efrat" uniqKey="Dagan E" first="Efrat" last="Dagan">Efrat Dagan</name><affiliation><mods:affiliation>Genetics Institute Rambam Medical Center, Haifa, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Baruch, Ruth Gershoni" sort="Baruch, Ruth Gershoni" uniqKey="Baruch R" first="Ruth Gershoni" last="Baruch">Ruth Gershoni Baruch</name><affiliation><mods:affiliation>Genetics Institute Rambam Medical Center, Haifa, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Friedman, Eitan" sort="Friedman, Eitan" uniqKey="Friedman E" first="Eitan" last="Friedman">Eitan Friedman</name><affiliation><mods:affiliation>The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel,</mods:affiliation></affiliation><affiliation><mods:affiliation>The Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Harbst, Katja" sort="Harbst, Katja" uniqKey="Harbst K" first="Katja" last="Harbst">Katja Harbst</name><affiliation><mods:affiliation>Department Oncology, Lund University, Sweden,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Barbany Bustinza, Gisela" sort="Barbany Bustinza, Gisela" uniqKey="Barbany Bustinza G" first="Gisela" last="Barbany-Bustinza">Gisela Barbany-Bustinza</name><affiliation><mods:affiliation>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Rantala, Johanna" sort="Rantala, Johanna" uniqKey="Rantala J" first="Johanna" last="Rantala">Johanna Rantala</name><affiliation><mods:affiliation>Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Ehrencrona, Hans" sort="Ehrencrona, Hans" uniqKey="Ehrencrona H" first="Hans" last="Ehrencrona">Hans Ehrencrona</name><affiliation wicri:level="4"><mods:affiliation>Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden,</mods:affiliation><orgName type="university">Université d'Uppsala</orgName><country>Suède</country><placeName><settlement type="city">Uppsala</settlement><region nuts="1">Svealand</region><region nuts="1">East Middle Sweden</region></placeName></affiliation></author><author><name sortKey="Karlsson, Per" sort="Karlsson, Per" uniqKey="Karlsson P" first="Per" last="Karlsson">Per Karlsson</name><affiliation><mods:affiliation>Department of Oncology, Sahlgrenska University, Gothenburg, Sweden,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Domchek, Susan M" sort="Domchek, Susan M" uniqKey="Domchek S" first="Susan M." last="Domchek">Susan M. Domchek</name><affiliation><mods:affiliation>University of Pennsylvania, Philadelphia, PA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Nathanson, Katherine L" sort="Nathanson, Katherine L" uniqKey="Nathanson K" first="Katherine L." last="Nathanson">Katherine L. Nathanson</name><affiliation><mods:affiliation>University of Pennsylvania, Philadelphia, PA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Osorio, Ana" sort="Osorio, Ana" uniqKey="Osorio A" first="Ana" last="Osorio">Ana Osorio</name><affiliation><mods:affiliation>Group of Human Genetics, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERERER), Instituto de Salud Carlos III, Madrid, Spain,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Blanco, Ignacio" sort="Blanco, Ignacio" uniqKey="Blanco I" first="Ignacio" last="Blanco">Ignacio Blanco</name><affiliation><mods:affiliation>Cancer Genetics Counseling Program, Catalan Institute of Oncology (ICO), Barcelona, Spain,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Lasa, Adriana" sort="Lasa, Adriana" uniqKey="Lasa A" first="Adriana" last="Lasa">Adriana Lasa</name><affiliation><mods:affiliation>Genetics Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Benitez, Javier" sort="Benitez, Javier" uniqKey="Benitez J" first="Javier" last="Benítez">Javier Benítez</name><affiliation><mods:affiliation>Group of Human Genetics, Human Cancer Genetics Programme, Spanish National Cancer Centre (CNIO) and Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERERER), Instituto de Salud Carlos III, Madrid, Spain,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation><mods:affiliation>Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 580 69120, Heidelberg, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hogervorst, Frans B L" sort="Hogervorst, Frans B L" uniqKey="Hogervorst F" first="Frans B. L." last="Hogervorst">Frans B. L. Hogervorst</name><affiliation><mods:affiliation>Family Cancer Clinic, Department of Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Rookus, Matti A" sort="Rookus, Matti A" uniqKey="Rookus M" first="Matti A." last="Rookus">Matti A. Rookus</name><affiliation><mods:affiliation>Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Collee, J Margriet" sort="Collee, J Margriet" uniqKey="Collee J" first="J. Margriet" last="Collee">J. Margriet Collee</name><affiliation><mods:affiliation>Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation><mods:affiliation>Department of Genetic Epidemiology and</mods:affiliation><wicri:noCountry code="no comma">Department of Genetic Epidemiology and</wicri:noCountry></affiliation></author><author><name sortKey="Ligtenberg, Marjolijn J" sort="Ligtenberg, Marjolijn J" uniqKey="Ligtenberg M" first="Marjolijn J." last="Ligtenberg">Marjolijn J. Ligtenberg</name><affiliation><mods:affiliation>Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Van Der Luijt, Rob B" sort="Van Der Luijt, Rob B" uniqKey="Van Der Luijt R" first="Rob B." last="Van Der Luijt">Rob B. Van Der Luijt</name><affiliation><mods:affiliation>Department of Clinical Molecular Genetics, Utrecht University Medical Center, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Aalfs, Cora M" sort="Aalfs, Cora M" uniqKey="Aalfs C" first="Cora M." last="Aalfs">Cora M. Aalfs</name><affiliation><mods:affiliation>Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Waisfisz, Quinten" sort="Waisfisz, Quinten" uniqKey="Waisfisz Q" first="Quinten" last="Waisfisz">Quinten Waisfisz</name><affiliation><mods:affiliation>Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Wijnen, Juul" sort="Wijnen, Juul" uniqKey="Wijnen J" first="Juul" last="Wijnen">Juul Wijnen</name><affiliation><mods:affiliation>Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Van Roozendaal, Cornelis E P" sort="Van Roozendaal, Cornelis E P" uniqKey="Van Roozendaal C" first="Cornelis E. P." last="Van Roozendaal">Cornelis E. P. Van Roozendaal</name><affiliation><mods:affiliation>Department of Clinical Genetics, University Medical Center, Maastricht, The Netherlands,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Peock, Susan" sort="Peock, Susan" uniqKey="Peock S" first="Susan" last="Peock">Susan Peock</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Cook, Margaret" sort="Cook, Margaret" uniqKey="Cook M" first="Margaret" last="Cook">Margaret Cook</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Frost, Debra" sort="Frost, Debra" uniqKey="Frost D" first="Debra" last="Frost">Debra Frost</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Oliver, Clare" sort="Oliver, Clare" uniqKey="Oliver C" first="Clare" last="Oliver">Clare Oliver</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Platte, Radka" sort="Platte, Radka" uniqKey="Platte R" first="Radka" last="Platte">Radka Platte</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Evans, D Gareth" sort="Evans, D Gareth" uniqKey="Evans D" first="D. Gareth" last="Evans">D. Gareth Evans</name><affiliation><mods:affiliation>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Lalloo, Fiona" sort="Lalloo, Fiona" uniqKey="Lalloo F" first="Fiona" last="Lalloo">Fiona Lalloo</name><affiliation><mods:affiliation>Genetic Medicine, Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Eeles, Rosalind" sort="Eeles, Rosalind" uniqKey="Eeles R" first="Rosalind" last="Eeles">Rosalind Eeles</name><affiliation><mods:affiliation>Translational Cancer Genetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Izatt, Louise" sort="Izatt, Louise" uniqKey="Izatt L" first="Louise" last="Izatt">Louise Izatt</name><affiliation><mods:affiliation>Clinical Genetics, Guy's Hospital, London, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Davidson, Rosemarie" sort="Davidson, Rosemarie" uniqKey="Davidson R" first="Rosemarie" last="Davidson">Rosemarie Davidson</name><affiliation><mods:affiliation>Ferguson-Smith Centre for Clinical Genetics, Glasgow, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Chu, Carol" sort="Chu, Carol" uniqKey="Chu C" first="Carol" last="Chu">Carol Chu</name><affiliation><mods:affiliation>Yorkshire Regional Genetics Service, Leeds, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Eccles, Diana" sort="Eccles, Diana" uniqKey="Eccles D" first="Diana" last="Eccles">Diana Eccles</name><affiliation><mods:affiliation>Wessex Clinical Genetics Service, Princess Anne Hospital, Southampton, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Cole, Trevor" sort="Cole, Trevor" uniqKey="Cole T" first="Trevor" last="Cole">Trevor Cole</name><affiliation><mods:affiliation>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Edgbaston, Birmingham, UK,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hodgson, Shirley" sort="Hodgson, Shirley" uniqKey="Hodgson S" first="Shirley" last="Hodgson">Shirley Hodgson</name><affiliation wicri:level="4"><mods:affiliation>Department of Cancer Genetics, St Georges Hospital, University of London, London, UK,</mods:affiliation><orgName type="university">Université de Londres</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Godwin, Andrew K" sort="Godwin, Andrew K" uniqKey="Godwin A" first="Andrew K." last="Godwin">Andrew K. Godwin</name><affiliation><mods:affiliation>Fox Chase Cancer Center, Philadelphia, PA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation wicri:level="4"><mods:affiliation>INSERM U509, Service de Génétique Oncologique, Institut Curie, and Université Paris-Descartes, Paris, France,</mods:affiliation><orgName type="university">Université Paris-Descartes</orgName><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Buecher, Bruno" sort="Buecher, Bruno" uniqKey="Buecher B" first="Bruno" last="Buecher">Bruno Buecher</name><affiliation><mods:affiliation>Département de Génétique, Institut Curie, Paris, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Leone, Melanie" sort="Leone, Melanie" uniqKey="Leone M" first="Mélanie" last="Léoné">Mélanie Léoné</name><affiliation><mods:affiliation>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon/Centre Léon Bérard, UMR5201 CNRS, Université de Lyon, Lyon, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Bressac De Paillerets, Brigitte" sort="Bressac De Paillerets, Brigitte" uniqKey="Bressac De Paillerets B" first="Brigitte" last="Bressac-De Paillerets">Brigitte Bressac-De Paillerets</name><affiliation><mods:affiliation>Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM U946, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Remenieras, Audrey" sort="Remenieras, Audrey" uniqKey="Remenieras A" first="Audrey" last="Remenieras">Audrey Remenieras</name><affiliation><mods:affiliation>Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Caron, Olivier" sort="Caron, Olivier" uniqKey="Caron O" first="Olivier" last="Caron">Olivier Caron</name><affiliation><mods:affiliation>Consultation de Génétique, Département de Médecine, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Lenoir, Gilbert M" sort="Lenoir, Gilbert M" uniqKey="Lenoir G" first="Gilbert M." last="Lenoir">Gilbert M. Lenoir</name><affiliation><mods:affiliation>Genetics Department, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation></affiliation><affiliation><mods:affiliation>CNRS FRE2939, Institut de Cancérologie Gustave Roussy, Villejuif, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Sevenet, Nicolas" sort="Sevenet, Nicolas" uniqKey="Sevenet N" first="Nicolas" last="Sevenet">Nicolas Sevenet</name><affiliation><mods:affiliation>Laboratoire de Génétique Constitutionnelle, Institut Bergonié, Bordeaux, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Longy, Michel" sort="Longy, Michel" uniqKey="Longy M" first="Michel" last="Longy">Michel Longy</name><affiliation><mods:affiliation>Laboratoire de Génétique Constitutionnelle, Institut Bergonié, Bordeaux, France,</mods:affiliation></affiliation><affiliation><mods:affiliation>INSERM U916, Institut Bergonié, Bordeaux, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Ferrer, Sandra Fert" sort="Ferrer, Sandra Fert" uniqKey="Ferrer S" first="Sandra Fert" last="Ferrer">Sandra Fert Ferrer</name><affiliation><mods:affiliation>Laboratoire de Génétique Chromosomique, Hôtel Dieu Centre Hospitalier, Chambéry, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Prieur, Fabienne" sort="Prieur, Fabienne" uniqKey="Prieur F" first="Fabienne" last="Prieur">Fabienne Prieur</name><affiliation><mods:affiliation>Service de Génétique Clinique Chromosomique et Moléculaire, CHU de St Etienne, St Etienne, France,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Goldgar, David" sort="Goldgar, David" uniqKey="Goldgar D" first="David" last="Goldgar">David Goldgar</name><affiliation><mods:affiliation>Department of Dermatology, University of Utah, Utah, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Miron, Alexander" sort="Miron, Alexander" uniqKey="Miron A" first="Alexander" last="Miron">Alexander Miron</name><affiliation><mods:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="John, Esther M" sort="John, Esther M" uniqKey="John E" first="Esther M." last="John">Esther M. John</name><affiliation><mods:affiliation>Northern California Cancer Center, Fremont and Stanford University School of Medicine, Stanford, CA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Buys, Saundra S" sort="Buys, Saundra S" uniqKey="Buys S" first="Saundra S." last="Buys">Saundra S. Buys</name><affiliation><mods:affiliation>Huntsman Cancer Institute, University of Utah Health Sciences Centre, Salt Lake City, UT, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Daly, Mary B" sort="Daly, Mary B" uniqKey="Daly M" first="Mary B." last="Daly">Mary B. Daly</name><affiliation><mods:affiliation>Fox Chase Cancer Center, Philadelphia, PA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name><affiliation wicri:level="4"><mods:affiliation>The University of Melbourne, Melbourne, Australia,</mods:affiliation><orgName type="university">Université de Melbourne</orgName><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Terry, Mary Beth" sort="Terry, Mary Beth" uniqKey="Terry M" first="Mary Beth" last="Terry">Mary Beth Terry</name><affiliation wicri:level="4"><mods:affiliation>Columbia University, New York, NY, USA,</mods:affiliation><orgName type="university">Université Columbia</orgName><country>États-Unis</country><placeName><settlement type="city">New York</settlement><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Yassin, Yosuf" sort="Yassin, Yosuf" uniqKey="Yassin Y" first="Yosuf" last="Yassin">Yosuf Yassin</name><affiliation><mods:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Gschwantler Kaulich, Daphne" sort="Gschwantler Kaulich, Daphne" uniqKey="Gschwantler Kaulich D" first="Daphne" last="Gschwantler-Kaulich">Daphne Gschwantler-Kaulich</name><affiliation><mods:affiliation>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna, Vienna, Austria,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Staudigl, Christine" sort="Staudigl, Christine" uniqKey="Staudigl C" first="Christine" last="Staudigl">Christine Staudigl</name><affiliation><mods:affiliation>Division of Special Gynecology, Department of OB/GYN, Medical University of Vienna, Vienna, Austria,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Hansen, Thomas V O" sort="Hansen, Thomas V O" uniqKey="Hansen T" first="Thomas V. O." last="Hansen">Thomas V. O. Hansen</name><affiliation><mods:affiliation>Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Barkardottir, Rosa Bjork" sort="Barkardottir, Rosa Bjork" uniqKey="Barkardottir R" first="Rosa Bjork" last="Barkardottir">Rosa Bjork Barkardottir</name><affiliation><mods:affiliation>Department of Pathology, Landspitali-University Hospital, Reykjavik, Iceland,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Kirchhoff, Tomas" sort="Kirchhoff, Tomas" uniqKey="Kirchhoff T" first="Tomas" last="Kirchhoff">Tomas Kirchhoff</name><affiliation><mods:affiliation>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Pal, Prodipto" sort="Pal, Prodipto" uniqKey="Pal P" first="Prodipto" last="Pal">Prodipto Pal</name><affiliation><mods:affiliation>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Kosarin, Kristi" sort="Kosarin, Kristi" uniqKey="Kosarin K" first="Kristi" last="Kosarin">Kristi Kosarin</name><affiliation><mods:affiliation>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Offit, Kenneth" sort="Offit, Kenneth" uniqKey="Offit K" first="Kenneth" last="Offit">Kenneth Offit</name><affiliation><mods:affiliation>Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Piedmonte, Marion" sort="Piedmonte, Marion" uniqKey="Piedmonte M" first="Marion" last="Piedmonte">Marion Piedmonte</name><affiliation><mods:affiliation>GOG Statistical and Data Center, Roswell Park Cancer Institute, Buffalo, NY 14263, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Rodriguez, Gustavo C" sort="Rodriguez, Gustavo C" uniqKey="Rodriguez G" first="Gustavo C." last="Rodriguez">Gustavo C. Rodriguez</name><affiliation><mods:affiliation>NorthShore University Health System, Evanston Northwestern Healthcare, Evanston IL 60201, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Wakeley, Katie" sort="Wakeley, Katie" uniqKey="Wakeley K" first="Katie" last="Wakeley">Katie Wakeley</name><affiliation><mods:affiliation>New England Medical Center, Tufts University, Boston, MA 02111, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Boggess, John F" sort="Boggess, John F" uniqKey="Boggess J" first="John F." last="Boggess">John F. Boggess</name><affiliation><mods:affiliation>University of North Carolina, Chapel Hill, NC 27599, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Basil, Jack" sort="Basil, Jack" uniqKey="Basil J" first="Jack" last="Basil">Jack Basil</name><affiliation><mods:affiliation>St Elizabeth Medical Center, Edgewood, KY 41017, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Schwartz, Peter E" sort="Schwartz, Peter E" uniqKey="Schwartz P" first="Peter E." last="Schwartz">Peter E. Schwartz</name><affiliation><mods:affiliation>Yale University School of Medicine, New Haven, CT 06510, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Blank, Stephanie V" sort="Blank, Stephanie V" uniqKey="Blank S" first="Stephanie V." last="Blank">Stephanie V. Blank</name><affiliation><mods:affiliation>New York University School of Medicine, New York, NY 10016, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Toland, Amanda E" sort="Toland, Amanda E" uniqKey="Toland A" first="Amanda E." last="Toland">Amanda E. Toland</name><affiliation><mods:affiliation>Department of Internal Medicine and</mods:affiliation></affiliation><affiliation><mods:affiliation>Molecular Virology, Immunology and Medical Genetics, Division of Human Cancer Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Montagna, Marco" sort="Montagna, Marco" uniqKey="Montagna M" first="Marco" last="Montagna">Marco Montagna</name><affiliation><mods:affiliation>Istituto Oncologico Veneto, IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Casella, Cinzia" sort="Casella, Cinzia" uniqKey="Casella C" first="Cinzia" last="Casella">Cinzia Casella</name><affiliation><mods:affiliation>Istituto Oncologico Veneto, IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Imyanitov, Evgeny N" sort="Imyanitov, Evgeny N" uniqKey="Imyanitov E" first="Evgeny N." last="Imyanitov">Evgeny N. Imyanitov</name><affiliation><mods:affiliation>N.N. Petrov Institute of Oncology, St Petersburg, Russia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Allavena, Anna" sort="Allavena, Anna" uniqKey="Allavena A" first="Anna" last="Allavena">Anna Allavena</name><affiliation><mods:affiliation>Department of Genetics, Biology and Biochemistry, University of Turin, Turin, Italy,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name><affiliation><mods:affiliation>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Cologne, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Versmold, Beatrix" sort="Versmold, Beatrix" uniqKey="Versmold B" first="Beatrix" last="Versmold">Beatrix Versmold</name><affiliation><mods:affiliation>Department of Obstetrics and Gynaecology, Division of Molecular Gynaeco-Oncology, University of Cologne, Cologne, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Engel, Christoph" sort="Engel, Christoph" uniqKey="Engel C" first="Christoph" last="Engel">Christoph Engel</name><affiliation><mods:affiliation>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name><affiliation><mods:affiliation>Department of Obstetrics and Gynaecology, Technical University Munich, Munich, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Ditsch, Nina" sort="Ditsch, Nina" uniqKey="Ditsch N" first="Nina" last="Ditsch">Nina Ditsch</name><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Ludwig-Maximilian University Munich, Munich, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Arnold, Norbert" sort="Arnold, Norbert" uniqKey="Arnold N" first="Norbert" last="Arnold">Norbert Arnold</name><affiliation><mods:affiliation>Molecular Genetics Laboratory, Department of Obstetrics and Gynaecology, University of Duesseldorf, Duesseldorf, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Niederacher, Dieter" sort="Niederacher, Dieter" uniqKey="Niederacher D" first="Dieter" last="Niederacher">Dieter Niederacher</name><affiliation><mods:affiliation>Molecular Genetics Laboratory, Department of Obstetrics and Gynaecology, University of Duesseldorf, Duesseldorf, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Dei Ler, Helmut" sort="Dei Ler, Helmut" uniqKey="Dei Ler H" first="Helmut" last="Dei Ler">Helmut Dei Ler</name><affiliation wicri:level="4"><mods:affiliation>Department of Obstetrics and Gynaecology, University of Ulm, Ulm, Germany,</mods:affiliation><orgName type="university">Université d'Ulm</orgName><country>Allemagne</country><placeName><settlement type="city">Ulm</settlement><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region></placeName></affiliation></author><author><name sortKey="Fiebig, Britta" sort="Fiebig, Britta" uniqKey="Fiebig B" first="Britta" last="Fiebig">Britta Fiebig</name><affiliation><mods:affiliation>Institute of Human Genetics, University of Regensburg, Regensburg, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Suttner, Christian" sort="Suttner, Christian" uniqKey="Suttner C" first="Christian" last="Suttner">Christian Suttner</name><affiliation><mods:affiliation>Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Schonbuchner, Ines" sort="Schonbuchner, Ines" uniqKey="Schonbuchner I" first="Ines" last="Schönbuchner">Ines Schönbuchner</name><affiliation><mods:affiliation>Institute of Human Genetics, University of Würzburg, Würzburg, Germany,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Gadzicki, Dorothea" sort="Gadzicki, Dorothea" uniqKey="Gadzicki D" first="Dorothea" last="Gadzicki">Dorothea Gadzicki</name><affiliation wicri:level="1"><mods:affiliation>Institute of Cellular and Molecular Pathology, Medical University, Hannover, Germany and</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Cellular and Molecular Pathology, Medical University, Hannover</wicri:regionArea></affiliation></author><author><name sortKey="Caldes, Trinidad" sort="Caldes, Trinidad" uniqKey="Caldes T" first="Trinidad" last="Caldes">Trinidad Caldes</name><affiliation wicri:level="1"><mods:affiliation>Hospital Clinico San Carlos 28040, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinico San Carlos 28040, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="De La Hoya, Miguel" sort="De La Hoya, Miguel" uniqKey="De La Hoya M" first="Miguel" last="De La Hoya">Miguel De La Hoya</name><affiliation wicri:level="1"><mods:affiliation>Hospital Clinico San Carlos 28040, Madrid, Spain</mods:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Clinico San Carlos 28040, Madrid</wicri:regionArea></affiliation></author><author><name sortKey="Pooley, Karen A" sort="Pooley, Karen A" uniqKey="Pooley K" first="Karen A." last="Pooley">Karen A. Pooley</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><mods:affiliation>Department of Public Health and Primary Care, Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK,</mods:affiliation><orgName type="university">Université de Cambridge</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName></affiliation></author><author><name sortKey="Chenevix Trench, Georgia" sort="Chenevix Trench, Georgia" uniqKey="Chenevix Trench G" first="Georgia" last="Chenevix-Trench">Georgia Chenevix-Trench</name><affiliation><mods:affiliation>Queensland Institute of Medical Research, Brisbane, QLD 4029, Australia,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Human Molecular Genetics</title><idno type="ISSN">0964-6906</idno><idno type="eISSN">1460-2083</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2009-11-15">2009-11-15</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">22</biblScope><biblScope unit="page" from="4442">4442</biblScope><biblScope unit="page" to="4456">4456</biblScope></imprint><idno type="ISSN">0964-6906</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0964-6906</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Genome-wide association studies of breast cancer have identified multiple single nucleotide polymorphisms (SNPs) that are associated with increased breast cancer risks in the general population. In a previous study, we demonstrated that the minor alleles at three of these SNPs, in FGFR2, TNRC9 and MAP3K1, also confer increased risks of breast cancer for BRCA1 or BRCA2 mutation carriers. Three additional SNPs rs3817198 at LSP1, rs13387042 at 2q35 and rs13281615 at 8q24 have since been reported to be associated with breast cancer in the general population, and in this study we evaluated their association with breast cancer risk in 9442 BRCA1 and 5665 BRCA2 mutation carriers from 33 study centres. The minor allele of rs3817198 was associated with increased breast cancer risk only for BRCA2 mutation carriers [hazard ratio (HR) = 1.16, 95% CI: 1.07–1.25, P-trend = 2.8 × 10−4]. The best fit for the association of SNP rs13387042 at 2q35 with breast cancer risk was a dominant model for both BRCA1 and BRCA2 mutation carriers (BRCA1: HR = 1.14, 95% CI: 1.04–1.25, P = 0.0047; BRCA2: HR = 1.18 95% CI: 1.04–1.33, P = 0.0079). SNP rs13281615 at 8q24 was not associated with breast cancer for either BRCA1 or BRCA2 mutation carriers, but the estimated association for BRCA2 mutation carriers (per-allele HR = 1.06, 95% CI: 0.98–1.14) was consistent with odds ratio estimates derived from population-based case–control studies. The LSP1 and 2q35 SNPs appear to interact multiplicatively on breast cancer risk for BRCA2 mutation carriers. There was no evidence that the associations vary by mutation type depending on whether the mutated protein is predicted to be stable or not.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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