Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants
Identifieur interne : 002186 ( Istex/Curation ); précédent : 002185; suivant : 002187Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants
Auteurs : Stephen V. Gordon [Irlande (pays), France] ; Daria Bottai [Italie] ; Roxane Simeone [France] ; Timothy P. Stinear [Australie] ; Roland Brosch [France]Source :
- BioEssays [ 0265-9247 ] ; 2009-04.
Descripteurs français
- Wicri :
- topic : Vaccin.
English descriptors
- KwdEn :
- Acad, Amino acids, Available vaccine, Bacillus, Bioessays, Biol chem, Bovis, Brosch, Buruli ulcer, Clin microbiol, Colony morphology, Comparative genomics, Complete genome sequence, Drug discovery, Etiological agent, Gene, Genes encoding proteins, Genes percent, Genetic differences, Genome, Genomic, Genomic information, Genomics, Global scale, Harmless saprophytes, Immune responses, Institut pasteur, Lipid, Locus, Marinum, Microbiol, Microti, Mycobacteria, Mycobacterial, Mycobacterial pathogenicity, Mycobacterial species, Mycobacterium, Mycobacterium abscessus, Mycobacterium bovis, Mycobacterium marinum, Mycobacterium microti, Mycobacterium pinnipedii, Mycobacterium tuberculosis, Natl, Other members, Other mycobacteria, Pathogen, Pathogenicity, Phenolic glycolipids, Phthiocerol dimycocerosates, Plos pathog, Primary infection, Proc, Proc natl acad, Pulmonary disease, Recent years, Review article, Robert koch, Secretion, Secretion system, Smooth colony type, Smooth strains, Smooth tubercle bacilli, Transcription factor, Transposon mutagenesis, Trends microbiol, Tubercle, Tubercle bacilli, Tuberculosis, Tuberculosis strains, University college dublin, Vaccine, Various members, Virulence, Virulence factors, Wiley periodicals.
- Teeft :
- Acad, Amino acids, Available vaccine, Bacillus, Bioessays, Biol chem, Bovis, Brosch, Buruli ulcer, Clin microbiol, Colony morphology, Comparative genomics, Complete genome sequence, Drug discovery, Etiological agent, Gene, Genes encoding proteins, Genes percent, Genetic differences, Genome, Genomic, Genomic information, Genomics, Global scale, Harmless saprophytes, Immune responses, Institut pasteur, Lipid, Locus, Marinum, Microbiol, Microti, Mycobacteria, Mycobacterial, Mycobacterial pathogenicity, Mycobacterial species, Mycobacterium, Mycobacterium abscessus, Mycobacterium bovis, Mycobacterium marinum, Mycobacterium microti, Mycobacterium pinnipedii, Mycobacterium tuberculosis, Natl, Other members, Other mycobacteria, Pathogen, Pathogenicity, Phenolic glycolipids, Phthiocerol dimycocerosates, Plos pathog, Primary infection, Proc, Proc natl acad, Pulmonary disease, Recent years, Review article, Robert koch, Secretion, Secretion system, Smooth colony type, Smooth strains, Smooth tubercle bacilli, Transcription factor, Transposon mutagenesis, Trends microbiol, Tubercle, Tubercle bacilli, Tuberculosis, Tuberculosis strains, University college dublin, Vaccine, Various members, Virulence, Virulence factors, Wiley periodicals.
Abstract
In contrast to the great majority of mycobacterial species that are harmless saprophytes, Mycobacterium tuberculosis and other closely related tubercle bacilli have evolved to be among the most important human and animal pathogens. The need to develop new strategies in the fight against tuberculosis (TB) and related diseases has fuelled research into the evolutionary success of the M. tuberculosis complex members. Amongst the various disciplines, genomics and functional genomics have been instrumental in improving our understanding of these organisms. In this review we will present some of the recent key findings on molecular determinants of mycobacterial pathogenicity and attenuation, the evolution of M. tuberculosis, genome dynamics, antigen mining for improved diagnostic and subunit antigens, and finally the identification of novel drug targets. The genomics revolution has changed the landscape of TB research, and now underpins our renewed efforts to defeat this deadly pathogen.
Url:
DOI: 10.1002/bies.200800191
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Gordon</name><affiliation wicri:level="1"><mods:affiliation>UCD College of Life Sciences, University College Dublin, Ireland</mods:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>UCD College of Life Sciences, University College Dublin</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland</mods:affiliation><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: stephen.gordon@ucd.ie</mods:affiliation><country wicri:rule="url">Irlande (pays)</country></affiliation><affiliation wicri:level="1"><mods:affiliation>Stephen V. 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Gordon, University College Dublin, Dublin, Ireland.Roland Brosch, Institut Pasteur, Paris, France.</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Stephen V. Gordon, University College Dublin, Dublin, Ireland.Roland Brosch, Institut Pasteur, Paris</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">BioEssays</title><title level="j" type="alt">BIOESSAYS</title><idno type="ISSN">0265-9247</idno><idno type="eISSN">1521-1878</idno><imprint><biblScope unit="vol">31</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="378">378</biblScope><biblScope unit="page" to="388">388</biblScope><biblScope unit="page-count">11</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2009-04">2009-04</date></imprint><idno type="ISSN">0265-9247</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0265-9247</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acad</term><term>Amino acids</term><term>Available 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marinum</term><term>Mycobacterium microti</term><term>Mycobacterium pinnipedii</term><term>Mycobacterium tuberculosis</term><term>Natl</term><term>Other members</term><term>Other mycobacteria</term><term>Pathogen</term><term>Pathogenicity</term><term>Phenolic glycolipids</term><term>Phthiocerol dimycocerosates</term><term>Plos pathog</term><term>Primary infection</term><term>Proc</term><term>Proc natl acad</term><term>Pulmonary disease</term><term>Recent years</term><term>Review article</term><term>Robert koch</term><term>Secretion</term><term>Secretion system</term><term>Smooth colony type</term><term>Smooth strains</term><term>Smooth tubercle bacilli</term><term>Transcription factor</term><term>Transposon mutagenesis</term><term>Trends microbiol</term><term>Tubercle</term><term>Tubercle bacilli</term><term>Tuberculosis</term><term>Tuberculosis strains</term><term>University college dublin</term><term>Vaccine</term><term>Various members</term><term>Virulence</term><term>Virulence factors</term><term>Wiley periodicals</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acad</term><term>Amino acids</term><term>Available vaccine</term><term>Bacillus</term><term>Bioessays</term><term>Biol chem</term><term>Bovis</term><term>Brosch</term><term>Buruli ulcer</term><term>Clin microbiol</term><term>Colony morphology</term><term>Comparative genomics</term><term>Complete genome sequence</term><term>Drug discovery</term><term>Etiological agent</term><term>Gene</term><term>Genes encoding proteins</term><term>Genes percent</term><term>Genetic differences</term><term>Genome</term><term>Genomic</term><term>Genomic information</term><term>Genomics</term><term>Global scale</term><term>Harmless saprophytes</term><term>Immune responses</term><term>Institut pasteur</term><term>Lipid</term><term>Locus</term><term>Marinum</term><term>Microbiol</term><term>Microti</term><term>Mycobacteria</term><term>Mycobacterial</term><term>Mycobacterial pathogenicity</term><term>Mycobacterial species</term><term>Mycobacterium</term><term>Mycobacterium abscessus</term><term>Mycobacterium bovis</term><term>Mycobacterium marinum</term><term>Mycobacterium microti</term><term>Mycobacterium pinnipedii</term><term>Mycobacterium tuberculosis</term><term>Natl</term><term>Other members</term><term>Other mycobacteria</term><term>Pathogen</term><term>Pathogenicity</term><term>Phenolic glycolipids</term><term>Phthiocerol dimycocerosates</term><term>Plos pathog</term><term>Primary infection</term><term>Proc</term><term>Proc natl acad</term><term>Pulmonary disease</term><term>Recent years</term><term>Review article</term><term>Robert koch</term><term>Secretion</term><term>Secretion system</term><term>Smooth colony type</term><term>Smooth strains</term><term>Smooth tubercle bacilli</term><term>Transcription factor</term><term>Transposon mutagenesis</term><term>Trends microbiol</term><term>Tubercle</term><term>Tubercle bacilli</term><term>Tuberculosis</term><term>Tuberculosis strains</term><term>University college dublin</term><term>Vaccine</term><term>Various members</term><term>Virulence</term><term>Virulence factors</term><term>Wiley periodicals</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In contrast to the great majority of mycobacterial species that are harmless saprophytes, Mycobacterium tuberculosis and other closely related tubercle bacilli have evolved to be among the most important human and animal pathogens. The need to develop new strategies in the fight against tuberculosis (TB) and related diseases has fuelled research into the evolutionary success of the M. tuberculosis complex members. Amongst the various disciplines, genomics and functional genomics have been instrumental in improving our understanding of these organisms. In this review we will present some of the recent key findings on molecular determinants of mycobacterial pathogenicity and attenuation, the evolution of M. tuberculosis, genome dynamics, antigen mining for improved diagnostic and subunit antigens, and finally the identification of novel drug targets. The genomics revolution has changed the landscape of TB research, and now underpins our renewed efforts to defeat this deadly pathogen.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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