Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants
Identifieur interne : 002186 ( Istex/Corpus ); précédent : 002185; suivant : 002187Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants
Auteurs : Stephen V. Gordon ; Daria Bottai ; Roxane Simeone ; Timothy P. Stinear ; Roland BroschSource :
- BioEssays [ 0265-9247 ] ; 2009-04.
English descriptors
- KwdEn :
- Acad, Amino acids, Available vaccine, Bacillus, Bioessays, Biol chem, Bovis, Brosch, Buruli ulcer, Clin microbiol, Colony morphology, Comparative genomics, Complete genome sequence, Drug discovery, Etiological agent, Gene, Genes encoding proteins, Genes percent, Genetic differences, Genome, Genomic, Genomic information, Genomics, Global scale, Harmless saprophytes, Immune responses, Institut pasteur, Lipid, Locus, Marinum, Microbiol, Microti, Mycobacteria, Mycobacterial, Mycobacterial pathogenicity, Mycobacterial species, Mycobacterium, Mycobacterium abscessus, Mycobacterium bovis, Mycobacterium marinum, Mycobacterium microti, Mycobacterium pinnipedii, Mycobacterium tuberculosis, Natl, Other members, Other mycobacteria, Pathogen, Pathogenicity, Phenolic glycolipids, Phthiocerol dimycocerosates, Plos pathog, Primary infection, Proc, Proc natl acad, Pulmonary disease, Recent years, Review article, Robert koch, Secretion, Secretion system, Smooth colony type, Smooth strains, Smooth tubercle bacilli, Transcription factor, Transposon mutagenesis, Trends microbiol, Tubercle, Tubercle bacilli, Tuberculosis, Tuberculosis strains, University college dublin, Vaccine, Various members, Virulence, Virulence factors, Wiley periodicals.
- Teeft :
- Acad, Amino acids, Available vaccine, Bacillus, Bioessays, Biol chem, Bovis, Brosch, Buruli ulcer, Clin microbiol, Colony morphology, Comparative genomics, Complete genome sequence, Drug discovery, Etiological agent, Gene, Genes encoding proteins, Genes percent, Genetic differences, Genome, Genomic, Genomic information, Genomics, Global scale, Harmless saprophytes, Immune responses, Institut pasteur, Lipid, Locus, Marinum, Microbiol, Microti, Mycobacteria, Mycobacterial, Mycobacterial pathogenicity, Mycobacterial species, Mycobacterium, Mycobacterium abscessus, Mycobacterium bovis, Mycobacterium marinum, Mycobacterium microti, Mycobacterium pinnipedii, Mycobacterium tuberculosis, Natl, Other members, Other mycobacteria, Pathogen, Pathogenicity, Phenolic glycolipids, Phthiocerol dimycocerosates, Plos pathog, Primary infection, Proc, Proc natl acad, Pulmonary disease, Recent years, Review article, Robert koch, Secretion, Secretion system, Smooth colony type, Smooth strains, Smooth tubercle bacilli, Transcription factor, Transposon mutagenesis, Trends microbiol, Tubercle, Tubercle bacilli, Tuberculosis, Tuberculosis strains, University college dublin, Vaccine, Various members, Virulence, Virulence factors, Wiley periodicals.
Abstract
In contrast to the great majority of mycobacterial species that are harmless saprophytes, Mycobacterium tuberculosis and other closely related tubercle bacilli have evolved to be among the most important human and animal pathogens. The need to develop new strategies in the fight against tuberculosis (TB) and related diseases has fuelled research into the evolutionary success of the M. tuberculosis complex members. Amongst the various disciplines, genomics and functional genomics have been instrumental in improving our understanding of these organisms. In this review we will present some of the recent key findings on molecular determinants of mycobacterial pathogenicity and attenuation, the evolution of M. tuberculosis, genome dynamics, antigen mining for improved diagnostic and subunit antigens, and finally the identification of novel drug targets. The genomics revolution has changed the landscape of TB research, and now underpins our renewed efforts to defeat this deadly pathogen.
Url:
DOI: 10.1002/bies.200800191
Links to Exploration step
ISTEX:B2493F4B7DC43FFBCF9D39DED28839FCB070B403Le document en format XML
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pathogenicity</term><term>Mycobacterial species</term><term>Mycobacterium</term><term>Mycobacterium abscessus</term><term>Mycobacterium bovis</term><term>Mycobacterium marinum</term><term>Mycobacterium microti</term><term>Mycobacterium pinnipedii</term><term>Mycobacterium tuberculosis</term><term>Natl</term><term>Other members</term><term>Other mycobacteria</term><term>Pathogen</term><term>Pathogenicity</term><term>Phenolic glycolipids</term><term>Phthiocerol dimycocerosates</term><term>Plos pathog</term><term>Primary infection</term><term>Proc</term><term>Proc natl acad</term><term>Pulmonary disease</term><term>Recent years</term><term>Review article</term><term>Robert koch</term><term>Secretion</term><term>Secretion system</term><term>Smooth colony type</term><term>Smooth strains</term><term>Smooth tubercle bacilli</term><term>Transcription factor</term><term>Transposon mutagenesis</term><term>Trends microbiol</term><term>Tubercle</term><term>Tubercle bacilli</term><term>Tuberculosis</term><term>Tuberculosis strains</term><term>University college dublin</term><term>Vaccine</term><term>Various members</term><term>Virulence</term><term>Virulence factors</term><term>Wiley periodicals</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In contrast to the great majority of mycobacterial species that are harmless saprophytes, Mycobacterium tuberculosis and other closely related tubercle bacilli have evolved to be among the most important human and animal pathogens. The need to develop new strategies in the fight against tuberculosis (TB) and related diseases has fuelled research into the evolutionary success of the M. tuberculosis complex members. Amongst the various disciplines, genomics and functional genomics have been instrumental in improving our understanding of these organisms. In this review we will present some of the recent key findings on molecular determinants of mycobacterial pathogenicity and attenuation, the evolution of M. tuberculosis, genome dynamics, antigen mining for improved diagnostic and subunit antigens, and finally the identification of novel drug targets. The genomics revolution has changed the landscape of TB research, and now underpins our renewed efforts to defeat this deadly pathogen.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>mycobacterium</json:string><json:string>mycobacterium tuberculosis</json:string><json:string>genome</json:string><json:string>microbiol</json:string><json:string>bovis</json:string><json:string>mycobacterial</json:string><json:string>tubercle</json:string><json:string>pathogen</json:string><json:string>genomics</json:string><json:string>marinum</json:string><json:string>brosch</json:string><json:string>proc</json:string><json:string>natl</json:string><json:string>acad</json:string><json:string>genomic</json:string><json:string>wiley periodicals</json:string><json:string>bioessays</json:string><json:string>tuberculosis</json:string><json:string>proc natl acad</json:string><json:string>tuberculosis strains</json:string><json:string>tubercle bacilli</json:string><json:string>vaccine</json:string><json:string>review article</json:string><json:string>lipid</json:string><json:string>microti</json:string><json:string>pathogenicity</json:string><json:string>mycobacteria</json:string><json:string>mycobacterium bovis</json:string><json:string>comparative genomics</json:string><json:string>bacillus</json:string><json:string>plos pathog</json:string><json:string>clin microbiol</json:string><json:string>locus</json:string><json:string>immune responses</json:string><json:string>smooth strains</json:string><json:string>various members</json:string><json:string>other mycobacteria</json:string><json:string>smooth tubercle bacilli</json:string><json:string>university college dublin</json:string><json:string>phenolic glycolipids</json:string><json:string>institut pasteur</json:string><json:string>complete genome sequence</json:string><json:string>phthiocerol dimycocerosates</json:string><json:string>virulence</json:string><json:string>gene</json:string><json:string>available vaccine</json:string><json:string>recent years</json:string><json:string>genomic information</json:string><json:string>other members</json:string><json:string>primary infection</json:string><json:string>mycobacterial pathogenicity</json:string><json:string>mycobacterium marinum</json:string><json:string>colony morphology</json:string><json:string>amino acids</json:string><json:string>transcription factor</json:string><json:string>secretion system</json:string><json:string>genes percent</json:string><json:string>smooth colony type</json:string><json:string>mycobacterium pinnipedii</json:string><json:string>virulence factors</json:string><json:string>genes encoding proteins</json:string><json:string>genetic differences</json:string><json:string>drug discovery</json:string><json:string>harmless saprophytes</json:string><json:string>mycobacterium microti</json:string><json:string>mycobacterium abscessus</json:string><json:string>buruli ulcer</json:string><json:string>mycobacterial species</json:string><json:string>robert koch</json:string><json:string>etiological agent</json:string><json:string>transposon mutagenesis</json:string><json:string>global scale</json:string><json:string>biol chem</json:string><json:string>trends microbiol</json:string><json:string>pulmonary disease</json:string><json:string>secretion</json:string></teeft></keywords><author><json:item><name>Stephen V. Gordon</name><affiliations><json:string>UCD College of Life Sciences, University College Dublin, Ireland</json:string><json:string>UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland</json:string><json:string>E-mail: stephen.gordon@ucd.ie</json:string><json:string>Stephen V. Gordon, University College Dublin, Dublin, Ireland.Roland Brosch, Institut Pasteur, Paris, France.</json:string></affiliations></json:item><json:item><name>Daria Bottai</name><affiliations><json:string>Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy</json:string></affiliations></json:item><json:item><name>Roxane Simeone</name><affiliations><json:string>Institut Pasteur, UP Pathogenomique Mycobacterienne Integree, Paris, France</json:string></affiliations></json:item><json:item><name>Timothy P. Stinear</name><affiliations><json:string>Department of Microbiology, Monash University, Clayton 3800, Australia</json:string></affiliations></json:item><json:item><name>Roland Brosch</name><affiliations><json:string>Institut Pasteur, UP Pathogenomique Mycobacterienne Integree, Paris, France</json:string><json:string>E-mail: roland.brosch@pasteur.fr</json:string><json:string>Stephen V. Gordon, University College Dublin, Dublin, Ireland.Roland Brosch, Institut Pasteur, Paris, France.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>BCG</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>evolution</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mycobacteria</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>pathogenesis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>tuberculosis</value></json:item></subject><articleId><json:string>BIES200800191</json:string></articleId><arkIstex>ark:/67375/WNG-4TTNHJDH-6</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>reviewArticle</json:string></originalGenre><abstract>In contrast to the great majority of mycobacterial species that are harmless saprophytes, Mycobacterium tuberculosis and other closely related tubercle bacilli have evolved to be among the most important human and animal pathogens. 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Gordon et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-4TTNHJDH-6</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - biology</json:string><json:string>2 - biochemistry & molecular biology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - biomedical research</json:string><json:string>3 - developmental biology</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - General Biochemistry, Genetics and Molecular Biology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string></inist></categories><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/bies.200800191</json:string></doi><id>B2493F4B7DC43FFBCF9D39DED28839FCB070B403</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/B2493F4B7DC43FFBCF9D39DED28839FCB070B403/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/B2493F4B7DC43FFBCF9D39DED28839FCB070B403/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/B2493F4B7DC43FFBCF9D39DED28839FCB070B403/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><availability><licence>Copyright © 2009 Wiley Periodicals, Inc.</licence></availability><date type="published" when="2009-04"></date></publicationStmt><notesStmt><note type="content-type" subtype="review-article" source="reviewArticle" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="review-article"><analytic><title level="a" type="main" xml:lang="en">Pathogenicity in the tubercle bacillus: molecular and evolutionary determinants</title><title level="a" type="short" xml:lang="en">Review articles</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">Stephen V.</forename><surname>Gordon</surname></persName><email>stephen.gordon@ucd.ie</email><affiliation>UCD College of Life Sciences, University College Dublin, Ireland<address><country key="IE"></country></address></affiliation><affiliation>UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland<address><country key="IE"></country></address></affiliation><affiliation>Stephen V. Gordon, University College Dublin, Dublin, Ireland. Roland Brosch, Institut Pasteur, Paris, France.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Daria</forename><surname>Bottai</surname></persName><affiliation>Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy<address><country key="IT"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Roxane</forename><surname>Simeone</surname></persName><affiliation>Institut Pasteur, UP Pathogenomique Mycobacterienne Integree, Paris, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Timothy P.</forename><surname>Stinear</surname></persName><affiliation>Department of Microbiology, Monash University, Clayton 3800, Australia<address><country key="AU"></country></address></affiliation></author><author xml:id="author-0004" role="corresp"><persName><forename type="first">Roland</forename><surname>Brosch</surname></persName><email>roland.brosch@pasteur.fr</email><affiliation>Institut Pasteur, UP Pathogenomique Mycobacterienne Integree, Paris, France<address><country key="FR"></country></address></affiliation><affiliation>Stephen V. Gordon, University College Dublin, Dublin, Ireland. Roland Brosch, Institut Pasteur, Paris, France.</affiliation></author><idno type="istex">B2493F4B7DC43FFBCF9D39DED28839FCB070B403</idno><idno type="ark">ark:/67375/WNG-4TTNHJDH-6</idno><idno type="DOI">10.1002/bies.200800191</idno><idno type="unit">BIES200800191</idno><idno type="toTypesetVersion">file:BIES.BIES200800191.pdf</idno></analytic><monogr><title level="j" type="main">BioEssays</title><title level="j" type="alt">BIOESSAYS</title><idno type="pISSN">0265-9247</idno><idno type="eISSN">1521-1878</idno><idno type="book-DOI">10.1002/(ISSN)1521-1878</idno><idno type="book-part-DOI">10.1002/bies.v31:4</idno><idno type="product">BIES</idno><imprint><biblScope unit="vol">31</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="378">378</biblScope><biblScope unit="page" to="388">388</biblScope><biblScope unit="page-count">11</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2009-04"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>In contrast to the great majority of mycobacterial species that are harmless saprophytes, <hi rend="italic">Mycobacterium tuberculosis</hi> and other closely related tubercle bacilli have evolved to be among the most important human and animal pathogens. 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