Snake venom: From fieldwork to the clinic
Identifieur interne : 001E89 ( Istex/Curation ); précédent : 001E88; suivant : 001E90Snake venom: From fieldwork to the clinic
Auteurs : Freek J. Vonk [Pays-Bas, États-Unis] ; Kate Jackson [États-Unis] ; Robin Doley [Inde] ; Frank Madaras [Australie] ; Peter J. Mirtschin [Australie] ; Nicolas Vidal [France]Source :
- BioEssays [ 0265-9247 ] ; 2011-04.
Descripteurs français
- Wicri :
- topic : Analyse comparative.
English descriptors
- KwdEn :
- Acid oxidase, Anticoagulant, Antiparasitic effects, Australian king, Biochem, Bioessays, Biol, Biol chem, Biomedical researchers, Bitis arietans, Blood pressure, Body size, Bothrops, Bothrops asper, Bothrops atrox, Bothrops jararaca, Brazilian pitviper, Bungarus multicinctus, Cerberus rynchops, Clinical medicine, Cobra, Cobra venom factor, Colubrid, Common lancehead, Comp biochem physiol, Comparative analysis, Complement system, Conservation biologists, Crisp toxin, Crotalus, Crotalus durissus, Crystal structure, Different ages, Different species, Drug discovery, Echis carinatus, Evolutionary divergence, Exon, Functional characterization, Functional sites, Geographic origin, Gland secretion, Heart disease, Hemostatic system, High degree, Individual variation, Inhibitor, King cobra, Kini, Lectin, Mackessy, Mangrove catsnake, Many venoms, Metalloproteinases, Model organisms, Molecular biology, Molecular diversity, Molecular evolution, Molecular mechanisms, Multiple sclerosis, Myasthenia gravis, Naja, Natriuretic peptide, Nerve growth factor, Neurotoxin, Novel family, Nuclear genes, Ophiophagus hannah, Other hand, Overview, Pharmacol, Pharmacological, Pharmacological characterization, Pharmacological prospecting, Pharmacological prospector, Philodryas patagoniensis, Pla2, Platelet, Platelet aggregation, Point mutations, Prey type, Proc natl acad, Prospects overviews, Prospects overviews bioessays, Prospects overviews review essays figure, Protease, Protein families, Proteome, Pseudechis australis, Pseudonaja textilis, Rattlesnake, Rattlesnake sistrurus catenatus, Receptor, Review essays, Review essays figure, Same species, Same time, Secretory protein, Segment switch, Serine protease inhibitor, Sistrurus, Sistrurus rattlesnakes, Snake populations, Snake species, Snake systematics, Snake toxin genes, Snake venom, Snake venom evolution, Snake venom lectins, Snake venom metalloproteinases, Snake venom proteins, Snake venoms, Species level, Therapeutic agents, Toxicol pharmacol, Toxicon, Toxin, Tropical rattlesnake, Tumor growth, Venom, Venom composition, Venom gland, Venom gland transcriptome, Venom molecules, Venom proteins, Venom proteome, Venom research, Venom toxins, Viper, Vonk, Wide range, Wide variety, Wiley periodicals.
- Teeft :
- Acid oxidase, Anticoagulant, Antiparasitic effects, Australian king, Biochem, Bioessays, Biol, Biol chem, Biomedical researchers, Bitis arietans, Blood pressure, Body size, Bothrops, Bothrops asper, Bothrops atrox, Bothrops jararaca, Brazilian pitviper, Bungarus multicinctus, Cerberus rynchops, Clinical medicine, Cobra, Cobra venom factor, Colubrid, Common lancehead, Comp biochem physiol, Comparative analysis, Complement system, Conservation biologists, Crisp toxin, Crotalus, Crotalus durissus, Crystal structure, Different ages, Different species, Drug discovery, Echis carinatus, Evolutionary divergence, Exon, Functional characterization, Functional sites, Geographic origin, Gland secretion, Heart disease, Hemostatic system, High degree, Individual variation, Inhibitor, King cobra, Kini, Lectin, Mackessy, Mangrove catsnake, Many venoms, Metalloproteinases, Model organisms, Molecular biology, Molecular diversity, Molecular evolution, Molecular mechanisms, Multiple sclerosis, Myasthenia gravis, Naja, Natriuretic peptide, Nerve growth factor, Neurotoxin, Novel family, Nuclear genes, Ophiophagus hannah, Other hand, Overview, Pharmacol, Pharmacological, Pharmacological characterization, Pharmacological prospecting, Pharmacological prospector, Philodryas patagoniensis, Pla2, Platelet, Platelet aggregation, Point mutations, Prey type, Proc natl acad, Prospects overviews, Prospects overviews bioessays, Prospects overviews review essays figure, Protease, Protein families, Proteome, Pseudechis australis, Pseudonaja textilis, Rattlesnake, Rattlesnake sistrurus catenatus, Receptor, Review essays, Review essays figure, Same species, Same time, Secretory protein, Segment switch, Serine protease inhibitor, Sistrurus, Sistrurus rattlesnakes, Snake populations, Snake species, Snake systematics, Snake toxin genes, Snake venom, Snake venom evolution, Snake venom lectins, Snake venom metalloproteinases, Snake venom proteins, Snake venoms, Species level, Therapeutic agents, Toxicol pharmacol, Toxicon, Toxin, Tropical rattlesnake, Tumor growth, Venom, Venom composition, Venom gland, Venom gland transcriptome, Venom molecules, Venom proteins, Venom proteome, Venom research, Venom toxins, Viper, Vonk, Wide range, Wide variety, Wiley periodicals.
Abstract
Snake venoms are recognized here as a grossly under‐explored resource in pharmacological prospecting. Discoveries in snake systematics demonstrate that former taxonomic bias in research has led to the neglect of thousands of species of potential medical use. Recent discoveries reveal an unexpectedly vast degree of variation in venom composition among snakes, from different species down to litter mates. The molecular mechanisms underlying this diversity are only beginning to be understood. However, the enormous potential that this resource represents for pharmacological prospecting is clear. New high‐throughput screening systems offer greatly increased speed and efficiency in identifying and extracting therapeutically useful molecules. At the same time a global biodiversity crisis is threatening the very snake populations on which hopes for new venom‐derived medications depend. Biomedical researchers, pharmacologists, clinicians, herpetologists, and conservation biologists must combine their efforts if the full potential of snake venom‐derived medications is to be realized.
Url:
DOI: 10.1002/bies.201000117
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Vonk</name><affiliation wicri:level="1"><mods:affiliation>Leiden University, Institute of Biology, Sylvius Laboratory, Leiden, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Leiden University, Institute of Biology, Sylvius Laboratory, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Netherlands Centre for Biodiversity Naturalis, Leiden, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Netherlands Centre for Biodiversity Naturalis, Leiden</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: f.j.vonk@biology.leidenuniv.nl</mods:affiliation><country wicri:rule="url">Pays-Bas</country></affiliation><affiliation wicri:level="1"><mods:affiliation>Correspondence address: Department of Biology, Whitman College, 345 Boyer Avenue, Walla Walla, WA 99362, USA.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Correspondence address: Department of Biology, Whitman College, 345 Boyer Avenue, Walla Walla, WA 99362</wicri:regionArea></affiliation></author><author><name sortKey="Jackson, Kate" sort="Jackson, Kate" uniqKey="Jackson K" first="Kate" last="Jackson">Kate Jackson</name><affiliation wicri:level="1"><mods:affiliation>Department of Biology, Whitman College, Walla Walla, WA, USA</mods:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biology, Whitman College, Walla Walla, WA</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: jacksok@whitman.edu</mods:affiliation><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="1"><mods:affiliation>Correspondence address: Department of Biology, Whitman College, 345 Boyer Avenue, Walla Walla, WA 99362, USA.</mods:affiliation><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Correspondence address: Department of Biology, Whitman College, 345 Boyer Avenue, Walla Walla, WA 99362</wicri:regionArea></affiliation></author><author><name sortKey="Doley, Robin" sort="Doley, Robin" uniqKey="Doley R" first="Robin" last="Doley">Robin Doley</name><affiliation wicri:level="1"><mods:affiliation>Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, India</mods:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur</wicri:regionArea></affiliation></author><author><name sortKey="Madaras, Frank" sort="Madaras, Frank" uniqKey="Madaras F" first="Frank" last="Madaras">Frank Madaras</name><affiliation wicri:level="1"><mods:affiliation>Venom Science Pty Ltd., Tanunda, SA, Australia</mods:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Venom Science Pty Ltd., Tanunda, SA</wicri:regionArea></affiliation></author><author><name sortKey="Mirtschin, Peter J" sort="Mirtschin, Peter J" uniqKey="Mirtschin P" first="Peter J." last="Mirtschin">Peter J. 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unit="vol">33</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="269">269</biblScope><biblScope unit="page" to="279">279</biblScope><biblScope unit="page-count">11</biblScope><publisher>WILEY‐VCH Verlag</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="2011-04">2011-04</date></imprint><idno type="ISSN">0265-9247</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0265-9247</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acid oxidase</term><term>Anticoagulant</term><term>Antiparasitic effects</term><term>Australian king</term><term>Biochem</term><term>Bioessays</term><term>Biol</term><term>Biol chem</term><term>Biomedical researchers</term><term>Bitis arietans</term><term>Blood pressure</term><term>Body size</term><term>Bothrops</term><term>Bothrops asper</term><term>Bothrops atrox</term><term>Bothrops jararaca</term><term>Brazilian pitviper</term><term>Bungarus multicinctus</term><term>Cerberus rynchops</term><term>Clinical medicine</term><term>Cobra</term><term>Cobra venom factor</term><term>Colubrid</term><term>Common lancehead</term><term>Comp biochem physiol</term><term>Comparative analysis</term><term>Complement system</term><term>Conservation biologists</term><term>Crisp toxin</term><term>Crotalus</term><term>Crotalus durissus</term><term>Crystal structure</term><term>Different ages</term><term>Different species</term><term>Drug discovery</term><term>Echis carinatus</term><term>Evolutionary divergence</term><term>Exon</term><term>Functional characterization</term><term>Functional sites</term><term>Geographic origin</term><term>Gland secretion</term><term>Heart disease</term><term>Hemostatic system</term><term>High degree</term><term>Individual variation</term><term>Inhibitor</term><term>King cobra</term><term>Kini</term><term>Lectin</term><term>Mackessy</term><term>Mangrove catsnake</term><term>Many venoms</term><term>Metalloproteinases</term><term>Model organisms</term><term>Molecular biology</term><term>Molecular diversity</term><term>Molecular evolution</term><term>Molecular mechanisms</term><term>Multiple sclerosis</term><term>Myasthenia gravis</term><term>Naja</term><term>Natriuretic peptide</term><term>Nerve growth factor</term><term>Neurotoxin</term><term>Novel family</term><term>Nuclear genes</term><term>Ophiophagus hannah</term><term>Other hand</term><term>Overview</term><term>Pharmacol</term><term>Pharmacological</term><term>Pharmacological characterization</term><term>Pharmacological prospecting</term><term>Pharmacological prospector</term><term>Philodryas patagoniensis</term><term>Pla2</term><term>Platelet</term><term>Platelet aggregation</term><term>Point mutations</term><term>Prey type</term><term>Proc natl acad</term><term>Prospects overviews</term><term>Prospects overviews bioessays</term><term>Prospects overviews review essays figure</term><term>Protease</term><term>Protein families</term><term>Proteome</term><term>Pseudechis australis</term><term>Pseudonaja textilis</term><term>Rattlesnake</term><term>Rattlesnake sistrurus catenatus</term><term>Receptor</term><term>Review essays</term><term>Review essays figure</term><term>Same species</term><term>Same time</term><term>Secretory protein</term><term>Segment switch</term><term>Serine protease inhibitor</term><term>Sistrurus</term><term>Sistrurus rattlesnakes</term><term>Snake populations</term><term>Snake species</term><term>Snake systematics</term><term>Snake toxin genes</term><term>Snake venom</term><term>Snake venom evolution</term><term>Snake venom lectins</term><term>Snake venom metalloproteinases</term><term>Snake venom proteins</term><term>Snake venoms</term><term>Species level</term><term>Therapeutic agents</term><term>Toxicol pharmacol</term><term>Toxicon</term><term>Toxin</term><term>Tropical rattlesnake</term><term>Tumor growth</term><term>Venom</term><term>Venom composition</term><term>Venom gland</term><term>Venom gland transcriptome</term><term>Venom molecules</term><term>Venom proteins</term><term>Venom proteome</term><term>Venom research</term><term>Venom toxins</term><term>Viper</term><term>Vonk</term><term>Wide range</term><term>Wide variety</term><term>Wiley periodicals</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acid oxidase</term><term>Anticoagulant</term><term>Antiparasitic effects</term><term>Australian king</term><term>Biochem</term><term>Bioessays</term><term>Biol</term><term>Biol chem</term><term>Biomedical researchers</term><term>Bitis arietans</term><term>Blood pressure</term><term>Body size</term><term>Bothrops</term><term>Bothrops asper</term><term>Bothrops atrox</term><term>Bothrops jararaca</term><term>Brazilian pitviper</term><term>Bungarus multicinctus</term><term>Cerberus rynchops</term><term>Clinical medicine</term><term>Cobra</term><term>Cobra venom factor</term><term>Colubrid</term><term>Common lancehead</term><term>Comp biochem physiol</term><term>Comparative analysis</term><term>Complement system</term><term>Conservation biologists</term><term>Crisp toxin</term><term>Crotalus</term><term>Crotalus durissus</term><term>Crystal structure</term><term>Different ages</term><term>Different species</term><term>Drug discovery</term><term>Echis carinatus</term><term>Evolutionary divergence</term><term>Exon</term><term>Functional characterization</term><term>Functional sites</term><term>Geographic origin</term><term>Gland secretion</term><term>Heart disease</term><term>Hemostatic system</term><term>High degree</term><term>Individual variation</term><term>Inhibitor</term><term>King cobra</term><term>Kini</term><term>Lectin</term><term>Mackessy</term><term>Mangrove catsnake</term><term>Many venoms</term><term>Metalloproteinases</term><term>Model organisms</term><term>Molecular biology</term><term>Molecular diversity</term><term>Molecular evolution</term><term>Molecular mechanisms</term><term>Multiple sclerosis</term><term>Myasthenia gravis</term><term>Naja</term><term>Natriuretic peptide</term><term>Nerve growth factor</term><term>Neurotoxin</term><term>Novel family</term><term>Nuclear genes</term><term>Ophiophagus hannah</term><term>Other hand</term><term>Overview</term><term>Pharmacol</term><term>Pharmacological</term><term>Pharmacological characterization</term><term>Pharmacological prospecting</term><term>Pharmacological prospector</term><term>Philodryas patagoniensis</term><term>Pla2</term><term>Platelet</term><term>Platelet aggregation</term><term>Point mutations</term><term>Prey type</term><term>Proc natl acad</term><term>Prospects overviews</term><term>Prospects overviews bioessays</term><term>Prospects overviews review essays figure</term><term>Protease</term><term>Protein families</term><term>Proteome</term><term>Pseudechis australis</term><term>Pseudonaja textilis</term><term>Rattlesnake</term><term>Rattlesnake sistrurus catenatus</term><term>Receptor</term><term>Review essays</term><term>Review essays figure</term><term>Same species</term><term>Same time</term><term>Secretory protein</term><term>Segment switch</term><term>Serine protease inhibitor</term><term>Sistrurus</term><term>Sistrurus rattlesnakes</term><term>Snake populations</term><term>Snake species</term><term>Snake systematics</term><term>Snake toxin genes</term><term>Snake venom</term><term>Snake venom evolution</term><term>Snake venom lectins</term><term>Snake venom metalloproteinases</term><term>Snake venom proteins</term><term>Snake venoms</term><term>Species level</term><term>Therapeutic agents</term><term>Toxicol pharmacol</term><term>Toxicon</term><term>Toxin</term><term>Tropical rattlesnake</term><term>Tumor growth</term><term>Venom</term><term>Venom composition</term><term>Venom gland</term><term>Venom gland transcriptome</term><term>Venom molecules</term><term>Venom proteins</term><term>Venom proteome</term><term>Venom research</term><term>Venom toxins</term><term>Viper</term><term>Vonk</term><term>Wide range</term><term>Wide variety</term><term>Wiley periodicals</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Analyse comparative</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Snake venoms are recognized here as a grossly under‐explored resource in pharmacological prospecting. Discoveries in snake systematics demonstrate that former taxonomic bias in research has led to the neglect of thousands of species of potential medical use. Recent discoveries reveal an unexpectedly vast degree of variation in venom composition among snakes, from different species down to litter mates. The molecular mechanisms underlying this diversity are only beginning to be understood. However, the enormous potential that this resource represents for pharmacological prospecting is clear. New high‐throughput screening systems offer greatly increased speed and efficiency in identifying and extracting therapeutically useful molecules. At the same time a global biodiversity crisis is threatening the very snake populations on which hopes for new venom‐derived medications depend. Biomedical researchers, pharmacologists, clinicians, herpetologists, and conservation biologists must combine their efforts if the full potential of snake venom‐derived medications is to be realized.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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