Snake venom: From fieldwork to the clinic
Identifieur interne : 001E89 ( Istex/Corpus ); précédent : 001E88; suivant : 001E90Snake venom: From fieldwork to the clinic
Auteurs : Freek J. Vonk ; Kate Jackson ; Robin Doley ; Frank Madaras ; Peter J. Mirtschin ; Nicolas VidalSource :
- BioEssays [ 0265-9247 ] ; 2011-04.
English descriptors
- KwdEn :
- Acid oxidase, Anticoagulant, Antiparasitic effects, Australian king, Biochem, Bioessays, Biol, Biol chem, Biomedical researchers, Bitis arietans, Blood pressure, Body size, Bothrops, Bothrops asper, Bothrops atrox, Bothrops jararaca, Brazilian pitviper, Bungarus multicinctus, Cerberus rynchops, Clinical medicine, Cobra, Cobra venom factor, Colubrid, Common lancehead, Comp biochem physiol, Comparative analysis, Complement system, Conservation biologists, Crisp toxin, Crotalus, Crotalus durissus, Crystal structure, Different ages, Different species, Drug discovery, Echis carinatus, Evolutionary divergence, Exon, Functional characterization, Functional sites, Geographic origin, Gland secretion, Heart disease, Hemostatic system, High degree, Individual variation, Inhibitor, King cobra, Kini, Lectin, Mackessy, Mangrove catsnake, Many venoms, Metalloproteinases, Model organisms, Molecular biology, Molecular diversity, Molecular evolution, Molecular mechanisms, Multiple sclerosis, Myasthenia gravis, Naja, Natriuretic peptide, Nerve growth factor, Neurotoxin, Novel family, Nuclear genes, Ophiophagus hannah, Other hand, Overview, Pharmacol, Pharmacological, Pharmacological characterization, Pharmacological prospecting, Pharmacological prospector, Philodryas patagoniensis, Pla2, Platelet, Platelet aggregation, Point mutations, Prey type, Proc natl acad, Prospects overviews, Prospects overviews bioessays, Prospects overviews review essays figure, Protease, Protein families, Proteome, Pseudechis australis, Pseudonaja textilis, Rattlesnake, Rattlesnake sistrurus catenatus, Receptor, Review essays, Review essays figure, Same species, Same time, Secretory protein, Segment switch, Serine protease inhibitor, Sistrurus, Sistrurus rattlesnakes, Snake populations, Snake species, Snake systematics, Snake toxin genes, Snake venom, Snake venom evolution, Snake venom lectins, Snake venom metalloproteinases, Snake venom proteins, Snake venoms, Species level, Therapeutic agents, Toxicol pharmacol, Toxicon, Toxin, Tropical rattlesnake, Tumor growth, Venom, Venom composition, Venom gland, Venom gland transcriptome, Venom molecules, Venom proteins, Venom proteome, Venom research, Venom toxins, Viper, Vonk, Wide range, Wide variety, Wiley periodicals.
- Teeft :
- Acid oxidase, Anticoagulant, Antiparasitic effects, Australian king, Biochem, Bioessays, Biol, Biol chem, Biomedical researchers, Bitis arietans, Blood pressure, Body size, Bothrops, Bothrops asper, Bothrops atrox, Bothrops jararaca, Brazilian pitviper, Bungarus multicinctus, Cerberus rynchops, Clinical medicine, Cobra, Cobra venom factor, Colubrid, Common lancehead, Comp biochem physiol, Comparative analysis, Complement system, Conservation biologists, Crisp toxin, Crotalus, Crotalus durissus, Crystal structure, Different ages, Different species, Drug discovery, Echis carinatus, Evolutionary divergence, Exon, Functional characterization, Functional sites, Geographic origin, Gland secretion, Heart disease, Hemostatic system, High degree, Individual variation, Inhibitor, King cobra, Kini, Lectin, Mackessy, Mangrove catsnake, Many venoms, Metalloproteinases, Model organisms, Molecular biology, Molecular diversity, Molecular evolution, Molecular mechanisms, Multiple sclerosis, Myasthenia gravis, Naja, Natriuretic peptide, Nerve growth factor, Neurotoxin, Novel family, Nuclear genes, Ophiophagus hannah, Other hand, Overview, Pharmacol, Pharmacological, Pharmacological characterization, Pharmacological prospecting, Pharmacological prospector, Philodryas patagoniensis, Pla2, Platelet, Platelet aggregation, Point mutations, Prey type, Proc natl acad, Prospects overviews, Prospects overviews bioessays, Prospects overviews review essays figure, Protease, Protein families, Proteome, Pseudechis australis, Pseudonaja textilis, Rattlesnake, Rattlesnake sistrurus catenatus, Receptor, Review essays, Review essays figure, Same species, Same time, Secretory protein, Segment switch, Serine protease inhibitor, Sistrurus, Sistrurus rattlesnakes, Snake populations, Snake species, Snake systematics, Snake toxin genes, Snake venom, Snake venom evolution, Snake venom lectins, Snake venom metalloproteinases, Snake venom proteins, Snake venoms, Species level, Therapeutic agents, Toxicol pharmacol, Toxicon, Toxin, Tropical rattlesnake, Tumor growth, Venom, Venom composition, Venom gland, Venom gland transcriptome, Venom molecules, Venom proteins, Venom proteome, Venom research, Venom toxins, Viper, Vonk, Wide range, Wide variety, Wiley periodicals.
Abstract
Snake venoms are recognized here as a grossly under‐explored resource in pharmacological prospecting. Discoveries in snake systematics demonstrate that former taxonomic bias in research has led to the neglect of thousands of species of potential medical use. Recent discoveries reveal an unexpectedly vast degree of variation in venom composition among snakes, from different species down to litter mates. The molecular mechanisms underlying this diversity are only beginning to be understood. However, the enormous potential that this resource represents for pharmacological prospecting is clear. New high‐throughput screening systems offer greatly increased speed and efficiency in identifying and extracting therapeutically useful molecules. At the same time a global biodiversity crisis is threatening the very snake populations on which hopes for new venom‐derived medications depend. Biomedical researchers, pharmacologists, clinicians, herpetologists, and conservation biologists must combine their efforts if the full potential of snake venom‐derived medications is to be realized.
Url:
DOI: 10.1002/bies.201000117
Links to Exploration step
ISTEX:A3187BDF90DDED1F2940BF61620A234C3EBA7858Le document en format XML
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toxin</term><term>Crotalus</term><term>Crotalus durissus</term><term>Crystal structure</term><term>Different ages</term><term>Different species</term><term>Drug discovery</term><term>Echis carinatus</term><term>Evolutionary divergence</term><term>Exon</term><term>Functional characterization</term><term>Functional sites</term><term>Geographic origin</term><term>Gland secretion</term><term>Heart disease</term><term>Hemostatic system</term><term>High degree</term><term>Individual variation</term><term>Inhibitor</term><term>King cobra</term><term>Kini</term><term>Lectin</term><term>Mackessy</term><term>Mangrove catsnake</term><term>Many venoms</term><term>Metalloproteinases</term><term>Model organisms</term><term>Molecular biology</term><term>Molecular diversity</term><term>Molecular evolution</term><term>Molecular mechanisms</term><term>Multiple sclerosis</term><term>Myasthenia gravis</term><term>Naja</term><term>Natriuretic peptide</term><term>Nerve growth factor</term><term>Neurotoxin</term><term>Novel family</term><term>Nuclear genes</term><term>Ophiophagus hannah</term><term>Other hand</term><term>Overview</term><term>Pharmacol</term><term>Pharmacological</term><term>Pharmacological characterization</term><term>Pharmacological prospecting</term><term>Pharmacological prospector</term><term>Philodryas patagoniensis</term><term>Pla2</term><term>Platelet</term><term>Platelet aggregation</term><term>Point mutations</term><term>Prey type</term><term>Proc natl acad</term><term>Prospects overviews</term><term>Prospects overviews bioessays</term><term>Prospects overviews review essays figure</term><term>Protease</term><term>Protein families</term><term>Proteome</term><term>Pseudechis australis</term><term>Pseudonaja textilis</term><term>Rattlesnake</term><term>Rattlesnake sistrurus catenatus</term><term>Receptor</term><term>Review essays</term><term>Review essays figure</term><term>Same species</term><term>Same time</term><term>Secretory protein</term><term>Segment switch</term><term>Serine protease inhibitor</term><term>Sistrurus</term><term>Sistrurus rattlesnakes</term><term>Snake populations</term><term>Snake species</term><term>Snake systematics</term><term>Snake toxin genes</term><term>Snake venom</term><term>Snake venom evolution</term><term>Snake venom lectins</term><term>Snake venom metalloproteinases</term><term>Snake venom proteins</term><term>Snake venoms</term><term>Species level</term><term>Therapeutic agents</term><term>Toxicol pharmacol</term><term>Toxicon</term><term>Toxin</term><term>Tropical rattlesnake</term><term>Tumor growth</term><term>Venom</term><term>Venom composition</term><term>Venom gland</term><term>Venom gland transcriptome</term><term>Venom molecules</term><term>Venom proteins</term><term>Venom proteome</term><term>Venom research</term><term>Venom toxins</term><term>Viper</term><term>Vonk</term><term>Wide range</term><term>Wide variety</term><term>Wiley periodicals</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acid oxidase</term><term>Anticoagulant</term><term>Antiparasitic effects</term><term>Australian king</term><term>Biochem</term><term>Bioessays</term><term>Biol</term><term>Biol chem</term><term>Biomedical researchers</term><term>Bitis arietans</term><term>Blood pressure</term><term>Body size</term><term>Bothrops</term><term>Bothrops asper</term><term>Bothrops atrox</term><term>Bothrops jararaca</term><term>Brazilian pitviper</term><term>Bungarus multicinctus</term><term>Cerberus rynchops</term><term>Clinical medicine</term><term>Cobra</term><term>Cobra venom factor</term><term>Colubrid</term><term>Common lancehead</term><term>Comp biochem physiol</term><term>Comparative analysis</term><term>Complement system</term><term>Conservation biologists</term><term>Crisp toxin</term><term>Crotalus</term><term>Crotalus durissus</term><term>Crystal structure</term><term>Different ages</term><term>Different species</term><term>Drug discovery</term><term>Echis carinatus</term><term>Evolutionary divergence</term><term>Exon</term><term>Functional characterization</term><term>Functional sites</term><term>Geographic origin</term><term>Gland secretion</term><term>Heart disease</term><term>Hemostatic system</term><term>High degree</term><term>Individual variation</term><term>Inhibitor</term><term>King cobra</term><term>Kini</term><term>Lectin</term><term>Mackessy</term><term>Mangrove catsnake</term><term>Many venoms</term><term>Metalloproteinases</term><term>Model organisms</term><term>Molecular biology</term><term>Molecular diversity</term><term>Molecular evolution</term><term>Molecular mechanisms</term><term>Multiple sclerosis</term><term>Myasthenia gravis</term><term>Naja</term><term>Natriuretic peptide</term><term>Nerve growth factor</term><term>Neurotoxin</term><term>Novel family</term><term>Nuclear genes</term><term>Ophiophagus hannah</term><term>Other hand</term><term>Overview</term><term>Pharmacol</term><term>Pharmacological</term><term>Pharmacological characterization</term><term>Pharmacological prospecting</term><term>Pharmacological prospector</term><term>Philodryas patagoniensis</term><term>Pla2</term><term>Platelet</term><term>Platelet aggregation</term><term>Point mutations</term><term>Prey type</term><term>Proc natl acad</term><term>Prospects overviews</term><term>Prospects overviews bioessays</term><term>Prospects overviews review essays figure</term><term>Protease</term><term>Protein families</term><term>Proteome</term><term>Pseudechis australis</term><term>Pseudonaja textilis</term><term>Rattlesnake</term><term>Rattlesnake sistrurus catenatus</term><term>Receptor</term><term>Review essays</term><term>Review essays figure</term><term>Same species</term><term>Same time</term><term>Secretory protein</term><term>Segment switch</term><term>Serine protease inhibitor</term><term>Sistrurus</term><term>Sistrurus rattlesnakes</term><term>Snake populations</term><term>Snake species</term><term>Snake systematics</term><term>Snake toxin genes</term><term>Snake venom</term><term>Snake venom evolution</term><term>Snake venom lectins</term><term>Snake venom metalloproteinases</term><term>Snake venom proteins</term><term>Snake venoms</term><term>Species level</term><term>Therapeutic agents</term><term>Toxicol pharmacol</term><term>Toxicon</term><term>Toxin</term><term>Tropical rattlesnake</term><term>Tumor growth</term><term>Venom</term><term>Venom composition</term><term>Venom gland</term><term>Venom gland transcriptome</term><term>Venom molecules</term><term>Venom proteins</term><term>Venom proteome</term><term>Venom research</term><term>Venom toxins</term><term>Viper</term><term>Vonk</term><term>Wide range</term><term>Wide variety</term><term>Wiley periodicals</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Snake venoms are recognized here as a grossly under‐explored resource in pharmacological prospecting. Discoveries in snake systematics demonstrate that former taxonomic bias in research has led to the neglect of thousands of species of potential medical use. Recent discoveries reveal an unexpectedly vast degree of variation in venom composition among snakes, from different species down to litter mates. The molecular mechanisms underlying this diversity are only beginning to be understood. However, the enormous potential that this resource represents for pharmacological prospecting is clear. New high‐throughput screening systems offer greatly increased speed and efficiency in identifying and extracting therapeutically useful molecules. At the same time a global biodiversity crisis is threatening the very snake populations on which hopes for new venom‐derived medications depend. Biomedical researchers, pharmacologists, clinicians, herpetologists, and conservation biologists must combine their efforts if the full potential of snake venom‐derived medications is to be realized.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>venom</json:string><json:string>toxicon</json:string><json:string>toxin</json:string><json:string>receptor</json:string><json:string>snake venom</json:string><json:string>bothrops</json:string><json:string>biol</json:string><json:string>proteome</json:string><json:string>crotalus</json:string><json:string>exon</json:string><json:string>vonk</json:string><json:string>snake venoms</json:string><json:string>bioessays</json:string><json:string>wiley periodicals</json:string><json:string>platelet</json:string><json:string>colubrid</json:string><json:string>overview</json:string><json:string>viper</json:string><json:string>venom 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lancehead</json:string><json:string>same time</json:string><json:string>geographic origin</json:string><json:string>snake populations</json:string><json:string>australian king</json:string><json:string>gland secretion</json:string><json:string>functional sites</json:string><json:string>cobra venom factor</json:string><json:string>molecular biology</json:string><json:string>evolutionary divergence</json:string><json:string>same species</json:string><json:string>different ages</json:string><json:string>functional characterization</json:string><json:string>bungarus multicinctus</json:string><json:string>species level</json:string><json:string>prospects overviews bioessays</json:string><json:string>multiple sclerosis</json:string><json:string>prey type</json:string><json:string>crisp toxin</json:string><json:string>philodryas patagoniensis</json:string><json:string>review essays figure</json:string><json:string>snake venom lectins</json:string><json:string>prospects overviews review essays figure</json:string><json:string>natriuretic peptide</json:string><json:string>pharmacological characterization</json:string><json:string>acid oxidase</json:string><json:string>hemostatic system</json:string><json:string>bothrops atrox</json:string><json:string>echis carinatus</json:string><json:string>brazilian pitviper</json:string><json:string>bothrops jararaca</json:string><json:string>heart disease</json:string><json:string>many venoms</json:string><json:string>king cobra</json:string><json:string>tropical rattlesnake</json:string><json:string>crotalus durissus</json:string><json:string>tumor growth</json:string><json:string>other hand</json:string><json:string>platelet aggregation</json:string><json:string>complement system</json:string><json:string>pseudechis australis</json:string><json:string>antiparasitic effects</json:string><json:string>cerberus rynchops</json:string><json:string>venom gland transcriptome</json:string><json:string>body size</json:string><json:string>model organisms</json:string><json:string>snake species</json:string><json:string>clinical medicine</json:string><json:string>pharmacological prospector</json:string><json:string>nuclear genes</json:string><json:string>conservation biologists</json:string><json:string>individual variation</json:string><json:string>snake toxin genes</json:string><json:string>snake venom evolution</json:string><json:string>nerve growth factor</json:string><json:string>molecular diversity</json:string><json:string>venom toxins</json:string><json:string>comp biochem physiol</json:string><json:string>mangrove catsnake</json:string><json:string>toxicol pharmacol</json:string><json:string>comparative analysis</json:string><json:string>molecular evolution</json:string><json:string>different species</json:string><json:string>snake systematics</json:string><json:string>proc natl acad</json:string><json:string>crystal structure</json:string><json:string>novel family</json:string><json:string>bothrops asper</json:string></teeft></keywords><author><json:item><name>Freek J. Vonk</name><affiliations><json:string>Leiden University, Institute of Biology, Sylvius Laboratory, Leiden, The Netherlands</json:string><json:string>Netherlands Centre for Biodiversity Naturalis, Leiden, The Netherlands</json:string><json:string>E-mail: f.j.vonk@biology.leidenuniv.nl</json:string><json:string>Correspondence address: Department of Biology, Whitman College, 345 Boyer Avenue, Walla Walla, WA 99362, USA.</json:string></affiliations></json:item><json:item><name>Kate Jackson</name><affiliations><json:string>Department of Biology, Whitman College, Walla Walla, WA, USA</json:string><json:string>E-mail: jacksok@whitman.edu</json:string><json:string>Correspondence address: Department of Biology, Whitman College, 345 Boyer Avenue, Walla Walla, WA 99362, USA.</json:string></affiliations></json:item><json:item><name>Robin Doley</name><affiliations><json:string>Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, India</json:string></affiliations></json:item><json:item><name>Frank Madaras</name><affiliations><json:string>Venom Science Pty Ltd., Tanunda, SA, Australia</json:string></affiliations></json:item><json:item><name>Peter J. 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Vonk et al.</json:string><json:string>[88]</json:string><json:string>[65, 66]</json:string><json:string>[8]</json:string><json:string>[39]</json:string><json:string>[92]</json:string><json:string>[1]</json:string><json:string>[2, 4]</json:string><json:string>[98]</json:string><json:string>[48, 86]</json:string><json:string>[38]</json:string><json:string>[101]</json:string><json:string>[91]</json:string><json:string>[4, 87]</json:string><json:string>[97]</json:string><json:string>[6, 7]</json:string><json:string>[5]</json:string><json:string>[59]</json:string><json:string>[90]</json:string><json:string>[96]</json:string><json:string>[69]</json:string><json:string>[9]</json:string><json:string>[84]</json:string><json:string>[27, 28]</json:string><json:string>[2]</json:string><json:string>[79]</json:string><json:string>[19]</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-3V6MLRZC-S</json:string></ark><categories><wos><json:string>1 - 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Biomedical researchers, pharmacologists, clinicians, herpetologists, and conservation biologists must combine their efforts if the full potential of snake venom‐derived medications is to be realized.</p></abstract><abstract type="graphical" xml:lang="en"><p><blockFixed type="graphic"><mediaResourceGroup><mediaResource alt="image" eRights="yes" copyright="WILEY-VCH" href="urn:x-wiley:02659247:media:BIES201000117:content"></mediaResource><mediaResource alt="thumbnail image" rendition="webLoRes" mimeType="image/gif" href=""></mediaResource><mediaResource alt="original image" rendition="webOriginal" mimeType="image/jpeg" href=""></mediaResource><mediaResource alt="magnified image" rendition="webHiRes" mimeType="image/jpeg" href=""></mediaResource></mediaResourceGroup></blockFixed></p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Snake venom: From fieldwork to the clinic</title><subTitle>Recent insights into snake biology, together with new technology allowing high‐throughput screening of venom, bring new hope for drug discovery</subTitle></titleInfo><titleInfo type="abbreviated" lang="en"><title>Prospects & Overviews</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Snake venom: From fieldwork to the clinic</title></titleInfo><name type="personal"><namePart type="given">Freek J.</namePart><namePart type="family">Vonk</namePart><affiliation>Leiden University, Institute of Biology, Sylvius Laboratory, Leiden, The Netherlands</affiliation><affiliation>Netherlands Centre for Biodiversity Naturalis, Leiden, The Netherlands</affiliation><affiliation>E-mail: f.j.vonk@biology.leidenuniv.nl</affiliation><affiliation>Correspondence address: Department of Biology, Whitman College, 345 Boyer Avenue, Walla Walla, WA 99362, USA.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kate</namePart><namePart type="family">Jackson</namePart><affiliation>Department of Biology, Whitman College, Walla Walla, WA, USA</affiliation><affiliation>E-mail: jacksok@whitman.edu</affiliation><affiliation>Correspondence address: Department of Biology, Whitman College, 345 Boyer Avenue, Walla Walla, WA 99362, USA.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Robin</namePart><namePart type="family">Doley</namePart><affiliation>Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, India</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Frank</namePart><namePart type="family">Madaras</namePart><affiliation>Venom Science Pty Ltd., Tanunda, SA, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Peter J.</namePart><namePart type="family">Mirtschin</namePart><affiliation>Venom Science Pty Ltd., Tanunda, SA, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nicolas</namePart><namePart type="family">Vidal</namePart><affiliation>Département Systématique et Evolution, UMR 7138, Muséum National d'Histoire Naturelle, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>WILEY‐VCH Verlag</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">2011-04</dateIssued><copyrightDate encoding="w3cdtf">2011</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">5</extent><extent unit="tables">0</extent><extent unit="references">103</extent><extent unit="words">8054</extent></physicalDescription><abstract lang="en">Snake venoms are recognized here as a grossly under‐explored resource in pharmacological prospecting. Discoveries in snake systematics demonstrate that former taxonomic bias in research has led to the neglect of thousands of species of potential medical use. Recent discoveries reveal an unexpectedly vast degree of variation in venom composition among snakes, from different species down to litter mates. The molecular mechanisms underlying this diversity are only beginning to be understood. However, the enormous potential that this resource represents for pharmacological prospecting is clear. New high‐throughput screening systems offer greatly increased speed and efficiency in identifying and extracting therapeutically useful molecules. At the same time a global biodiversity crisis is threatening the very snake populations on which hopes for new venom‐derived medications depend. Biomedical researchers, pharmacologists, clinicians, herpetologists, and conservation biologists must combine their efforts if the full potential of snake venom‐derived medications is to be realized.</abstract><abstract type="graphical" lang="en"></abstract><subject lang="en"><genre>keywords</genre><topic>drug</topic><topic>screening</topic><topic>snake</topic><topic>toxin</topic><topic>venom</topic></subject><relatedItem type="host"><titleInfo><title>BioEssays</title></titleInfo><titleInfo type="abbreviated"><title>Bioessays</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>Prospects & Overviews</topic></subject><identifier type="ISSN">0265-9247</identifier><identifier type="eISSN">1521-1878</identifier><identifier type="DOI">10.1002/(ISSN)1521-1878</identifier><identifier type="PublisherID">BIES</identifier><part><date>2011</date><detail type="volume"><caption>vol.</caption><number>33</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>269</start><end>279</end><total>11</total></extent></part></relatedItem><identifier type="istex">A3187BDF90DDED1F2940BF61620A234C3EBA7858</identifier><identifier type="ark">ark:/67375/WNG-3V6MLRZC-S</identifier><identifier type="DOI">10.1002/bies.201000117</identifier><identifier type="ArticleID">BIES201000117</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2011 WILEY Periodicals, Inc.</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>WILEY‐VCH Verlag</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/A3187BDF90DDED1F2940BF61620A234C3EBA7858/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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