AustralieFrV1, Istex, Curation, bibRecord, 000B92

Neurotensin receptor 1 gene activation by the Tcf/β-catenin pathway is an early event in human colonic adenomas

Identifieur interne : 000B92 ( Istex/Curation ); précédent : 000B91; suivant : 000B93

Neurotensin receptor 1 gene activation by the Tcf/β-catenin pathway is an early event in human colonic adenomas

Auteurs : Fre De Rique Souaze ; Ve Ronique Viardot-Foucault ; Nicolas Roullet ; Mireille Toy-Miou-Leong ; Anne Gompel ; Erik Bruyneel [Belgique] ; Eva Comperat ; Maree C. Faux [Australie] ; Marc Mareel [Belgique] ; William Roste Ne ; Jean-Franc Ois Fle Jou ; Christian Gespach ; Patricia Forgez [France]

Source :

Carcinogenesis [ 0143-3334 ] ; 2006-04.

RBID : ISTEX:3FD6A6FC30708A132EF125255DF366ECA79E71E9

English descriptors

Abstract

Alterations in the Wnt/APC (adenomatous polyposis coli) signalling pathway, resulting in β-catenin/T cell factor (Tcf)-dependent transcriptional gene activation, are frequently detected in familial and sporadic colon cancers. The neuropeptide neurotensin (NT) is widely distributed in the gastrointestinal tract. Its proliferative and survival effects are mediated by a G-protein coupled receptor, the NT1 receptor. NT1 receptor is not expressed in normal colon epithelial cells, but is over expressed in a number of cancer cells and tissues suggesting a link to the outgrowth of human colon cancer. Our results demonstrate that the upregulation of NT1 receptor occurring in colon cancer is the result of Wnt/APC signalling pathway activation. We first established the functionality of the Tcf response element within the NT1 receptor promoter. Consequently, we observed the activation of NT1 receptor gene by agents causing β-catenin cytosolic accumulation, as well as a strong decline of endogenous receptor when wt-APC was restored. At the cellular level, the re-establishment of wt-APC phenotype resulted in the impaired functionality of NT1 receptor, like the breakdown in NT-induced intracellular calcium mobilization and the loss of NT pro-invasive effect. We corroborated the Wnt/APC signalling pathway on the NT1 receptor promoter activation with human colon carcinogenesis, and showed that NT1 receptor gene activation was perfectly correlated with nuclear or cytoplasmic β-catenin localization while NT1 receptor was absent when β-catenin was localized at the cell–cell junction in early adenomas of patients with familial adenomatous polyposis, hereditary non-polyposis colorectal cancer and loss of heterozygosity tumours. In this report we establish a novel link in vitro between the Tcf/β-catenin pathway and NT1 receptor promoter activation.

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https://api.istex.fr/document/3FD6A6FC30708A132EF125255DF366ECA79E71E9/fulltext/pdf

DOI: 10.1093/carcin/bgi269

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Fre De Rique Souaze

<affiliation><mods:affiliation>INSERM U673–UPMC,</mods:affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>

Ve Ronique Viardot-Foucault

<affiliation><mods:affiliation>INSERM U673–UPMC,</mods:affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>

Nicolas Roullet

<affiliation><mods:affiliation>INSERM U673–UPMC,</mods:affiliation>
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Mireille Toy-Miou-Leong

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Anne Gompel

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Eva Comperat

<affiliation><mods:affiliation>Department of Pathology, and</mods:affiliation>
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William Roste Ne

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Jean-Franc Ois Fle Jou

<affiliation><mods:affiliation>Department of Pathology, and</mods:affiliation>
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Christian Gespach

<affiliation><mods:affiliation>INSERM U673–UPMC,</mods:affiliation>
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Le document en format XML

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<series><title level="j">Carcinogenesis</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>ANM, adjacent normal mucosa; APC, adenomatous polyposis coli</term>
<term>Activation</term>
<term>Adenoma</term>
<term>Adenomatous</term>
<term>Adenomatous polyposis coli</term>
<term>Assay</term>
<term>Binding site</term>
<term>Cellular invasion</term>
<term>Colon</term>
<term>Colon cancer</term>
<term>Colonic</term>
<term>Colonic adenomas</term>
<term>Colorectal</term>
<term>Consensus binding site</term>
<term>Cytoplasmic</term>
<term>Cytosolic</term>
<term>Early stages</term>
<term>Epithelial</term>
<term>Epithelial cells</term>
<term>FAP, familial adenomatous polyposis</term>
<term>FCS, fetal calf serum</term>
<term>Familial adenomatous polyposis</term>
<term>Focal adhesion kinase</term>
<term>GPCR, G-protein coupled receptors</term>
<term>GSK, glycogen synthase kinase</term>
<term>HBEC, human breast epithelial cells</term>
<term>HGF, hepatocyte growth factor</term>
<term>HNPCC, hereditary non-polyposis colorectal cancer</term>
<term>Hbec</term>
<term>Hereditary colorectal cancer</term>
<term>Hnpcc</term>
<term>Independent experiments</term>
<term>Intracellular</term>
<term>Invasive phenotype</term>
<term>JMV 449, H-LysΨ(CH2NH)Lys-Pro-Tyr-Ile-Leu-OH</term>
<term>Kinase</term>
<term>LEF, lymphoid enhancer factor</term>
<term>Licl</term>
<term>Localization</term>
<term>Mutation</term>
<term>NT, neurotensin</term>
<term>Neurotensin</term>
<term>Neurotensin receptor</term>
<term>Pathway</term>
<term>Polyposis</term>
<term>Positive control</term>
<term>Promoter</term>
<term>Protein content</term>
<term>Protein expression</term>
<term>Receptor</term>
<term>Receptor antagonist</term>
<term>Receptor expression</term>
<term>Receptor gene</term>
<term>Receptor labelling</term>
<term>Receptor promoter</term>
<term>Room temperature</term>
<term>Specific binding</term>
<term>Tcf, T cell factor</term>
<term>Tissue sections</term>
<term>Transfected</term>
<term>Tumour</term>
<term>Zncl2</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Activation</term>
<term>Adenoma</term>
<term>Adenomatous</term>
<term>Adenomatous polyposis coli</term>
<term>Assay</term>
<term>Binding site</term>
<term>Cellular invasion</term>
<term>Colon</term>
<term>Colon cancer</term>
<term>Colonic</term>
<term>Colonic adenomas</term>
<term>Colorectal</term>
<term>Consensus binding site</term>
<term>Cytoplasmic</term>
<term>Cytosolic</term>
<term>Early stages</term>
<term>Epithelial</term>
<term>Epithelial cells</term>
<term>Familial adenomatous polyposis</term>
<term>Focal adhesion kinase</term>
<term>Hbec</term>
<term>Hereditary colorectal cancer</term>
<term>Hnpcc</term>
<term>Independent experiments</term>
<term>Intracellular</term>
<term>Invasive phenotype</term>
<term>Kinase</term>
<term>Licl</term>
<term>Localization</term>
<term>Mutation</term>
<term>Neurotensin</term>
<term>Neurotensin receptor</term>
<term>Pathway</term>
<term>Polyposis</term>
<term>Positive control</term>
<term>Promoter</term>
<term>Protein content</term>
<term>Protein expression</term>
<term>Receptor</term>
<term>Receptor antagonist</term>
<term>Receptor expression</term>
<term>Receptor gene</term>
<term>Receptor labelling</term>
<term>Receptor promoter</term>
<term>Room temperature</term>
<term>Specific binding</term>
<term>Tissue sections</term>
<term>Transfected</term>
<term>Tumour</term>
<term>Zncl2</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
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<front><div type="abstract" xml:lang="en">Alterations in the Wnt/APC (adenomatous polyposis coli) signalling pathway, resulting in β-catenin/T cell factor (Tcf)-dependent transcriptional gene activation, are frequently detected in familial and sporadic colon cancers. The neuropeptide neurotensin (NT) is widely distributed in the gastrointestinal tract. Its proliferative and survival effects are mediated by a G-protein coupled receptor, the NT1 receptor. NT1 receptor is not expressed in normal colon epithelial cells, but is over expressed in a number of cancer cells and tissues suggesting a link to the outgrowth of human colon cancer. Our results demonstrate that the upregulation of NT1 receptor occurring in colon cancer is the result of Wnt/APC signalling pathway activation. We first established the functionality of the Tcf response element within the NT1 receptor promoter. Consequently, we observed the activation of NT1 receptor gene by agents causing β-catenin cytosolic accumulation, as well as a strong decline of endogenous receptor when wt-APC was restored. At the cellular level, the re-establishment of wt-APC phenotype resulted in the impaired functionality of NT1 receptor, like the breakdown in NT-induced intracellular calcium mobilization and the loss of NT pro-invasive effect. We corroborated the Wnt/APC signalling pathway on the NT1 receptor promoter activation with human colon carcinogenesis, and showed that NT1 receptor gene activation was perfectly correlated with nuclear or cytoplasmic β-catenin localization while NT1 receptor was absent when β-catenin was localized at the cell–cell junction in early adenomas of patients with familial adenomatous polyposis, hereditary non-polyposis colorectal cancer and loss of heterozygosity tumours. In this report we establish a novel link in vitro between the Tcf/β-catenin pathway and NT1 receptor promoter activation.</div>
</front>
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Neurotensin receptor 1 gene activation by the Tcf/β-catenin pathway is an early event in human colonic adenomas

Neurotensin receptor 1 gene activation by the Tcf/β-catenin pathway is an early event in human colonic adenomas

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