Differing actions of β-(2-thienyl)-γ-aminobutyric acid in central and peripheral preparations
Identifieur interne : 002A68 ( Istex/Checkpoint ); précédent : 002A67; suivant : 002A69Differing actions of β-(2-thienyl)-γ-aminobutyric acid in central and peripheral preparations
Auteurs : Jennifer Ong [Australie] ; David I. B. Kerr [France] ; Pascal Berthelot [France] ; Claude Vaccher [France] ; Nathalie Flouquet [France] ; Michel Debaert [France]Source :
- European Journal of Pharmacology [ 0014-2999 ] ; 1992.
English descriptors
- KwdEn :
- Agonist, Agonist activity, Agonists wcrc, Analogue, Antagonist, Baclofen, Berthelot, Control level, Different preparations, Full agonist, Gaba, Ileum, Krebs medium, Krebs solution, Neocortical slices, Partial agonism, Partial agonist, Phenyl ring, Present study, Receptor, Receptor agonist, Receptor antagonist, Receptor antagonists, Spontaneous activity, Spontaneous discharges.
- Teeft :
- Agonist, Agonist activity, Agonists wcrc, Analogue, Antagonist, Baclofen, Berthelot, Control level, Different preparations, Full agonist, Gaba, Ileum, Krebs medium, Krebs solution, Neocortical slices, Partial agonism, Partial agonist, Phenyl ring, Present study, Receptor, Receptor agonist, Receptor antagonist, Receptor antagonists, Spontaneous activity, Spontaneous discharges.
Abstract
Abstract: In the guinea-pig isolated ileum, β-(2-thicnyI)-γ-aminobutyric acid (BTG; 100–500 μM reversibly and competitively (pA2 = 4.3 ± 0.1) antagonised the baclofen-induccd (5–100 μM) depression of cholinergic twitch contractions, but not that to adenosine or morphine. By contrast, in rat neocortical slice preparations, BTG (100–500 μM) acted as an agonist, abolishing the frequency and amplitude of spontaneous discharges, sensitive to 2-hydroxysaclofen (100–500 μM). BTG exhibits differential actions at G ABAB receptors in brain and periphery.
Url:
DOI: 10.1016/0014-2999(92)90784-2
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:C81244B2BA40632FA881487CBC18CD35AA5D6938Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Differing actions of β-(2-thienyl)-γ-aminobutyric acid in central and peripheral preparations</title><author><name sortKey="Ong, Jennifer" sort="Ong, Jennifer" uniqKey="Ong J" first="Jennifer" last="Ong">Jennifer Ong</name></author><author><name sortKey="Kerr, David I B" sort="Kerr, David I B" uniqKey="Kerr D" first="David I. B." last="Kerr">David I. B. Kerr</name></author><author><name sortKey="Berthelot, Pascal" sort="Berthelot, Pascal" uniqKey="Berthelot P" first="Pascal" last="Berthelot">Pascal Berthelot</name></author><author><name sortKey="Vaccher, Claude" sort="Vaccher, Claude" uniqKey="Vaccher C" first="Claude" last="Vaccher">Claude Vaccher</name></author><author><name sortKey="Flouquet, Nathalie" sort="Flouquet, Nathalie" uniqKey="Flouquet N" first="Nathalie" last="Flouquet">Nathalie Flouquet</name></author><author><name sortKey="Debaert, Michel" sort="Debaert, Michel" uniqKey="Debaert M" first="Michel" last="Debaert">Michel Debaert</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C81244B2BA40632FA881487CBC18CD35AA5D6938</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0014-2999(92)90784-2</idno><idno type="url">https://api.istex.fr/document/C81244B2BA40632FA881487CBC18CD35AA5D6938/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">002516</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002516</idno><idno type="wicri:Area/Istex/Curation">002516</idno><idno type="wicri:Area/Istex/Checkpoint">002A68</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">002A68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Differing actions of β-(2-thienyl)-γ-aminobutyric acid in central and peripheral preparations</title><author><name sortKey="Ong, Jennifer" sort="Ong, Jennifer" uniqKey="Ong J" first="Jennifer" last="Ong">Jennifer Ong</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Anaesthesia and Intensive Care, The University of Adelaide, Adelaide, South Australia 5000</wicri:regionArea><wicri:noRegion>South Australia 5000</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Kerr, David I B" sort="Kerr, David I B" uniqKey="Kerr D" first="David I. B." last="Kerr">David I. B. Kerr</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacie Chimique, Faculté de Pharmacie, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Berthelot, Pascal" sort="Berthelot, Pascal" uniqKey="Berthelot P" first="Pascal" last="Berthelot">Pascal Berthelot</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacie Chimique, Faculté de Pharmacie, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Vaccher, Claude" sort="Vaccher, Claude" uniqKey="Vaccher C" first="Claude" last="Vaccher">Claude Vaccher</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacie Chimique, Faculté de Pharmacie, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Flouquet, Nathalie" sort="Flouquet, Nathalie" uniqKey="Flouquet N" first="Nathalie" last="Flouquet">Nathalie Flouquet</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacie Chimique, Faculté de Pharmacie, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Debaert, Michel" sort="Debaert, Michel" uniqKey="Debaert M" first="Michel" last="Debaert">Michel Debaert</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Pharmacie Chimique, Faculté de Pharmacie, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">European Journal of Pharmacology</title><title level="j" type="abbrev">EJP</title><idno type="ISSN">0014-2999</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">221</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="145">145</biblScope><biblScope unit="page" to="149">149</biblScope></imprint><idno type="ISSN">0014-2999</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0014-2999</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Agonist</term><term>Agonist activity</term><term>Agonists wcrc</term><term>Analogue</term><term>Antagonist</term><term>Baclofen</term><term>Berthelot</term><term>Control level</term><term>Different preparations</term><term>Full agonist</term><term>Gaba</term><term>Ileum</term><term>Krebs medium</term><term>Krebs solution</term><term>Neocortical slices</term><term>Partial agonism</term><term>Partial agonist</term><term>Phenyl ring</term><term>Present study</term><term>Receptor</term><term>Receptor agonist</term><term>Receptor antagonist</term><term>Receptor antagonists</term><term>Spontaneous activity</term><term>Spontaneous discharges</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Agonist</term><term>Agonist activity</term><term>Agonists wcrc</term><term>Analogue</term><term>Antagonist</term><term>Baclofen</term><term>Berthelot</term><term>Control level</term><term>Different preparations</term><term>Full agonist</term><term>Gaba</term><term>Ileum</term><term>Krebs medium</term><term>Krebs solution</term><term>Neocortical slices</term><term>Partial agonism</term><term>Partial agonist</term><term>Phenyl ring</term><term>Present study</term><term>Receptor</term><term>Receptor agonist</term><term>Receptor antagonist</term><term>Receptor antagonists</term><term>Spontaneous activity</term><term>Spontaneous discharges</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: In the guinea-pig isolated ileum, β-(2-thicnyI)-γ-aminobutyric acid (BTG; 100–500 μM reversibly and competitively (pA2 = 4.3 ± 0.1) antagonised the baclofen-induccd (5–100 μM) depression of cholinergic twitch contractions, but not that to adenosine or morphine. By contrast, in rat neocortical slice preparations, BTG (100–500 μM) acted as an agonist, abolishing the frequency and amplitude of spontaneous discharges, sensitive to 2-hydroxysaclofen (100–500 μM). BTG exhibits differential actions at G ABAB receptors in brain and periphery.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li></region><settlement><li>Lille</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Ong, Jennifer" sort="Ong, Jennifer" uniqKey="Ong J" first="Jennifer" last="Ong">Jennifer Ong</name></noRegion></country><country name="France"><region name="Hauts-de-France"><name sortKey="Kerr, David I B" sort="Kerr, David I B" uniqKey="Kerr D" first="David I. B." last="Kerr">David I. B. Kerr</name></region><name sortKey="Berthelot, Pascal" sort="Berthelot, Pascal" uniqKey="Berthelot P" first="Pascal" last="Berthelot">Pascal Berthelot</name><name sortKey="Debaert, Michel" sort="Debaert, Michel" uniqKey="Debaert M" first="Michel" last="Debaert">Michel Debaert</name><name sortKey="Flouquet, Nathalie" sort="Flouquet, Nathalie" uniqKey="Flouquet N" first="Nathalie" last="Flouquet">Nathalie Flouquet</name><name sortKey="Vaccher, Claude" sort="Vaccher, Claude" uniqKey="Vaccher C" first="Claude" last="Vaccher">Claude Vaccher</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A68 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 002A68 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Istex
|étape= Checkpoint
|type= RBID
|clé= ISTEX:C81244B2BA40632FA881487CBC18CD35AA5D6938
|texte= Differing actions of β-(2-thienyl)-γ-aminobutyric acid in central and peripheral preparations
}}
| This area was generated with Dilib version V0.6.33. |  |