Computer‐based detection of neonatal changes to branching morphogenesis reveals different mechanisms of and predicts prostate enlargement in mice haplo‐insufficient for bone morphogenetic protein 4
Identifieur interne : 001875 ( Istex/Checkpoint ); précédent : 001874; suivant : 001876Computer‐based detection of neonatal changes to branching morphogenesis reveals different mechanisms of and predicts prostate enlargement in mice haplo‐insufficient for bone morphogenetic protein 4
Auteurs : Ghanim Almahbobi [Australie] ; Shelley Hedwards [Australie] ; Gabriel Fricout [France] ; Dominique Jeulin [France] ; John F. Bertram [Australie] ; Gail P. Risbridger [Australie]Source :
- The Journal of Pathology [ 0022-3417 ] ; 2005-05.
Descripteurs français
- Wicri :
- topic : Logiciel.
English descriptors
- KwdEn :
- Anterior prostate, Asymmetry, Binary images, Biol, Bmp4, Bmp4 mice, Branch points, Centre, Confocal, Confocal microscopy, Cunha, Current method, Different mechanisms, Duct, Ductal, Enlargement, Epithelial, Epithelial cells, Epithelial ducts, Individual lobes, Lateral, Lateral ducts, Lobe, Main ducts, Main epithelial ducts, Medial, Medial ducts, Monash, Monash university, Morphogenesis, Mouse, Mouse prostate, Neonatal, Neonatal period, Open bars, Optical frames, Pathol, Phenotype, Postnatal days, Prostate, Prostate enlargement, Prostate gland, Prostatic, Prostatic lobes, Reproducibility, Right lobes, Single lobes, Skeleton, Skeletonization, Software, Solid bars, Terminal tips, Total branch length, Total ductal length, Total length, Total volume, Ventral prostate.
- Teeft :
- Anterior prostate, Asymmetry, Binary images, Biol, Bmp4, Bmp4 mice, Branch points, Centre, Confocal, Confocal microscopy, Cunha, Current method, Different mechanisms, Duct, Ductal, Enlargement, Epithelial, Epithelial cells, Epithelial ducts, Individual lobes, Lateral, Lateral ducts, Lobe, Main ducts, Main epithelial ducts, Medial, Medial ducts, Monash, Monash university, Morphogenesis, Mouse, Mouse prostate, Neonatal, Neonatal period, Open bars, Optical frames, Pathol, Phenotype, Postnatal days, Prostate, Prostate enlargement, Prostate gland, Prostatic, Prostatic lobes, Reproducibility, Right lobes, Single lobes, Skeleton, Skeletonization, Software, Solid bars, Terminal tips, Total branch length, Total ductal length, Total length, Total volume, Ventral prostate.
Abstract
Early changes to branching morphogenesis of the prostate are believed to lead to enlargement of the gland in adult life. However, it has not been possible to demonstrate directly that alterations to branching during the developmental period have a permanent effect on adult prostate size. In order to examine branching morphogenesis in a quantitative manner in neonatal mice, a combination of imaging and computational technology was used to detect and quantify branching using bone morphogenetic protein 4 haplo‐insufficient mice that develop enlarged prostate glands in adulthood. Accurate estimates were made of six parameters of branching, including prostate ductal length and volume and number of main ducts, branches, branch points, and tips. The results show that the prostate is significantly larger on day 3, well before the emergence of the phenotype in older animals. The ventral prostate is enlarged because the number of main epithelial ducts is increased; enlargement of the anterior prostate in mutant animals occurs because there are more branches. These lobe‐specific mechanisms underlying prostate enlargement indicate the complex nature of gland pathology in mice, rather than a simple increase in weight or volume. This method provides a powerful means to investigate the aetiology of prostate disease in animal models prior to emergence of a phenotype in later life. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Url:
DOI: 10.1002/path.1753
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
ISTEX:8F75A80403C31FE060FA8BF46918F85DA70A498CLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Computer‐based detection of neonatal changes to branching morphogenesis reveals different mechanisms of and predicts prostate enlargement in mice haplo‐insufficient for bone morphogenetic protein 4</title><author><name sortKey="Almahbobi, Ghanim" sort="Almahbobi, Ghanim" uniqKey="Almahbobi G" first="Ghanim" last="Almahbobi">Ghanim Almahbobi</name></author><author><name sortKey="Hedwards, Shelley" sort="Hedwards, Shelley" uniqKey="Hedwards S" first="Shelley" last="Hedwards">Shelley Hedwards</name></author><author><name sortKey="Fricout, Gabriel" sort="Fricout, Gabriel" uniqKey="Fricout G" first="Gabriel" last="Fricout">Gabriel Fricout</name></author><author><name sortKey="Jeulin, Dominique" sort="Jeulin, Dominique" uniqKey="Jeulin D" first="Dominique" last="Jeulin">Dominique Jeulin</name></author><author><name sortKey="Bertram, John F" sort="Bertram, John F" uniqKey="Bertram J" first="John F" last="Bertram">John F. Bertram</name></author><author><name sortKey="Risbridger, Gail P" sort="Risbridger, Gail P" uniqKey="Risbridger G" first="Gail P" last="Risbridger">Gail P. Risbridger</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:8F75A80403C31FE060FA8BF46918F85DA70A498C</idno><date when="2005" year="2005">2005</date><idno type="doi">10.1002/path.1753</idno><idno type="url">https://api.istex.fr/document/8F75A80403C31FE060FA8BF46918F85DA70A498C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001B07</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001B07</idno><idno type="wicri:Area/Istex/Curation">001B07</idno><idno type="wicri:Area/Istex/Checkpoint">001875</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001875</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Computer‐based detection of neonatal changes to branching morphogenesis reveals different mechanisms of and predicts prostate enlargement in mice haplo‐insufficient for bone morphogenetic protein 4</title><author><name sortKey="Almahbobi, Ghanim" sort="Almahbobi, Ghanim" uniqKey="Almahbobi G" first="Ghanim" last="Almahbobi">Ghanim Almahbobi</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Urology Research, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria 3168</wicri:regionArea><wicri:noRegion>Victoria 3168</wicri:noRegion></affiliation></author><author><name sortKey="Hedwards, Shelley" sort="Hedwards, Shelley" uniqKey="Hedwards S" first="Shelley" last="Hedwards">Shelley Hedwards</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Urology Research, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria 3168</wicri:regionArea><wicri:noRegion>Victoria 3168</wicri:noRegion></affiliation></author><author><name sortKey="Fricout, Gabriel" sort="Fricout, Gabriel" uniqKey="Fricout G" first="Gabriel" last="Fricout">Gabriel Fricout</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Centre de Morphologie Mathématique, Ecole des Mines de Paris, 77303 Fontainebleau Cedex</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Fontainebleau</settlement></placeName></affiliation></author><author><name sortKey="Jeulin, Dominique" sort="Jeulin, Dominique" uniqKey="Jeulin D" first="Dominique" last="Jeulin">Dominique Jeulin</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Centre de Morphologie Mathématique, Ecole des Mines de Paris, 77303 Fontainebleau Cedex</wicri:regionArea><wicri:noRegion>77303 Fontainebleau Cedex</wicri:noRegion><wicri:noRegion>77303 Fontainebleau Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Bertram, John F" sort="Bertram, John F" uniqKey="Bertram J" first="John F" last="Bertram">John F. Bertram</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Anatomy and Cell Biology, Monash University, Melbourne, Victoria 3800</wicri:regionArea><wicri:noRegion>Victoria 3800</wicri:noRegion></affiliation></author><author><name sortKey="Risbridger, Gail P" sort="Risbridger, Gail P" uniqKey="Risbridger G" first="Gail P" last="Risbridger">Gail P. Risbridger</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Urology Research, Monash Institute of Reproduction and Development, Monash University, Melbourne, Victoria 3168</wicri:regionArea><wicri:noRegion>Victoria 3168</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Australie</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Correspondence address: Centre for Urology Research, Monash Institute of Reproduction and Development, 27‐31 Wright Street, Clayton, Victoria 3168</wicri:regionArea><wicri:noRegion>Victoria 3168</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Pathology</title><title level="j" type="alt">JOURNAL OF PATHOLOGY, THE</title><idno type="ISSN">0022-3417</idno><idno type="eISSN">1096-9896</idno><imprint><biblScope unit="vol">206</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="52">52</biblScope><biblScope unit="page" to="61">61</biblScope><biblScope unit="page-count">10</biblScope><publisher>John Wiley & Sons, Ltd.</publisher><pubPlace>Chichester, UK</pubPlace><date type="published" when="2005-05">2005-05</date></imprint><idno type="ISSN">0022-3417</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3417</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anterior prostate</term><term>Asymmetry</term><term>Binary images</term><term>Biol</term><term>Bmp4</term><term>Bmp4 mice</term><term>Branch points</term><term>Centre</term><term>Confocal</term><term>Confocal microscopy</term><term>Cunha</term><term>Current method</term><term>Different mechanisms</term><term>Duct</term><term>Ductal</term><term>Enlargement</term><term>Epithelial</term><term>Epithelial cells</term><term>Epithelial ducts</term><term>Individual lobes</term><term>Lateral</term><term>Lateral ducts</term><term>Lobe</term><term>Main ducts</term><term>Main epithelial ducts</term><term>Medial</term><term>Medial ducts</term><term>Monash</term><term>Monash university</term><term>Morphogenesis</term><term>Mouse</term><term>Mouse prostate</term><term>Neonatal</term><term>Neonatal period</term><term>Open bars</term><term>Optical frames</term><term>Pathol</term><term>Phenotype</term><term>Postnatal days</term><term>Prostate</term><term>Prostate enlargement</term><term>Prostate gland</term><term>Prostatic</term><term>Prostatic lobes</term><term>Reproducibility</term><term>Right lobes</term><term>Single lobes</term><term>Skeleton</term><term>Skeletonization</term><term>Software</term><term>Solid bars</term><term>Terminal tips</term><term>Total branch length</term><term>Total ductal length</term><term>Total length</term><term>Total volume</term><term>Ventral prostate</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Anterior prostate</term><term>Asymmetry</term><term>Binary images</term><term>Biol</term><term>Bmp4</term><term>Bmp4 mice</term><term>Branch points</term><term>Centre</term><term>Confocal</term><term>Confocal microscopy</term><term>Cunha</term><term>Current method</term><term>Different mechanisms</term><term>Duct</term><term>Ductal</term><term>Enlargement</term><term>Epithelial</term><term>Epithelial cells</term><term>Epithelial ducts</term><term>Individual lobes</term><term>Lateral</term><term>Lateral ducts</term><term>Lobe</term><term>Main ducts</term><term>Main epithelial ducts</term><term>Medial</term><term>Medial ducts</term><term>Monash</term><term>Monash university</term><term>Morphogenesis</term><term>Mouse</term><term>Mouse prostate</term><term>Neonatal</term><term>Neonatal period</term><term>Open bars</term><term>Optical frames</term><term>Pathol</term><term>Phenotype</term><term>Postnatal days</term><term>Prostate</term><term>Prostate enlargement</term><term>Prostate gland</term><term>Prostatic</term><term>Prostatic lobes</term><term>Reproducibility</term><term>Right lobes</term><term>Single lobes</term><term>Skeleton</term><term>Skeletonization</term><term>Software</term><term>Solid bars</term><term>Terminal tips</term><term>Total branch length</term><term>Total ductal length</term><term>Total length</term><term>Total volume</term><term>Ventral prostate</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Logiciel</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Early changes to branching morphogenesis of the prostate are believed to lead to enlargement of the gland in adult life. However, it has not been possible to demonstrate directly that alterations to branching during the developmental period have a permanent effect on adult prostate size. In order to examine branching morphogenesis in a quantitative manner in neonatal mice, a combination of imaging and computational technology was used to detect and quantify branching using bone morphogenetic protein 4 haplo‐insufficient mice that develop enlarged prostate glands in adulthood. Accurate estimates were made of six parameters of branching, including prostate ductal length and volume and number of main ducts, branches, branch points, and tips. The results show that the prostate is significantly larger on day 3, well before the emergence of the phenotype in older animals. The ventral prostate is enlarged because the number of main epithelial ducts is increased; enlargement of the anterior prostate in mutant animals occurs because there are more branches. These lobe‐specific mechanisms underlying prostate enlargement indicate the complex nature of gland pathology in mice, rather than a simple increase in weight or volume. This method provides a powerful means to investigate the aetiology of prostate disease in animal models prior to emergence of a phenotype in later life. Copyright © 2005 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Fontainebleau</li></settlement></list><tree><country name="Australie"><noRegion><name sortKey="Almahbobi, Ghanim" sort="Almahbobi, Ghanim" uniqKey="Almahbobi G" first="Ghanim" last="Almahbobi">Ghanim Almahbobi</name></noRegion><name sortKey="Bertram, John F" sort="Bertram, John F" uniqKey="Bertram J" first="John F" last="Bertram">John F. Bertram</name><name sortKey="Hedwards, Shelley" sort="Hedwards, Shelley" uniqKey="Hedwards S" first="Shelley" last="Hedwards">Shelley Hedwards</name><name sortKey="Risbridger, Gail P" sort="Risbridger, Gail P" uniqKey="Risbridger G" first="Gail P" last="Risbridger">Gail P. Risbridger</name><name sortKey="Risbridger, Gail P" sort="Risbridger, Gail P" uniqKey="Risbridger G" first="Gail P" last="Risbridger">Gail P. Risbridger</name><name sortKey="Risbridger, Gail P" sort="Risbridger, Gail P" uniqKey="Risbridger G" first="Gail P" last="Risbridger">Gail P. Risbridger</name></country><country name="France"><region name="Île-de-France"><name sortKey="Fricout, Gabriel" sort="Fricout, Gabriel" uniqKey="Fricout G" first="Gabriel" last="Fricout">Gabriel Fricout</name></region><name sortKey="Jeulin, Dominique" sort="Jeulin, Dominique" uniqKey="Jeulin D" first="Dominique" last="Jeulin">Dominique Jeulin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Istex/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001875 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Checkpoint/biblio.hfd -nk 001875 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Istex
|étape= Checkpoint
|type= RBID
|clé= ISTEX:8F75A80403C31FE060FA8BF46918F85DA70A498C
|texte= Computer‐based detection of neonatal changes to branching morphogenesis reveals different mechanisms of and predicts prostate enlargement in mice haplo‐insufficient for bone morphogenetic protein 4
}}
| This area was generated with Dilib version V0.6.33. |  |