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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Familiality of Addiction and Its Developmental Mechanisms in Girls</title><author><name sortKey="Kirillova, Galina" sort="Kirillova, Galina" uniqKey="Kirillova G" first="Galina" last="Kirillova">Galina Kirillova</name></author><author><name sortKey="Reynolds, Maureen" sort="Reynolds, Maureen" uniqKey="Reynolds M" first="Maureen" last="Reynolds">Maureen Reynolds</name></author><author><name sortKey="Kirisci, Levent" sort="Kirisci, Levent" uniqKey="Kirisci L" first="Levent" last="Kirisci">Levent Kirisci</name></author><author><name sortKey="Mosovsky, Sherri" sort="Mosovsky, Sherri" uniqKey="Mosovsky S" first="Sherri" last="Mosovsky">Sherri Mosovsky</name></author><author><name sortKey="Ridenour, Ty" sort="Ridenour, Ty" uniqKey="Ridenour T" first="Ty" last="Ridenour">Ty Ridenour</name></author><author><name sortKey="Tarter, Ralph" sort="Tarter, Ralph" uniqKey="Tarter R" first="Ralph" last="Tarter">Ralph Tarter</name></author><author><name sortKey="Vanyukov, Michael" sort="Vanyukov, Michael" uniqKey="Vanyukov M" first="Michael" last="Vanyukov">Michael Vanyukov</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25156223</idno><idno type="pmc">4199288</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199288</idno><idno type="RBID">PMC:4199288</idno><idno type="doi">10.1016/j.drugalcdep.2014.07.032</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">001343</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001343</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Familiality of Addiction and Its Developmental Mechanisms in Girls</title><author><name sortKey="Kirillova, Galina" sort="Kirillova, Galina" uniqKey="Kirillova G" first="Galina" last="Kirillova">Galina Kirillova</name></author><author><name sortKey="Reynolds, Maureen" sort="Reynolds, Maureen" uniqKey="Reynolds M" first="Maureen" last="Reynolds">Maureen Reynolds</name></author><author><name sortKey="Kirisci, Levent" sort="Kirisci, Levent" uniqKey="Kirisci L" first="Levent" last="Kirisci">Levent Kirisci</name></author><author><name sortKey="Mosovsky, Sherri" sort="Mosovsky, Sherri" uniqKey="Mosovsky S" first="Sherri" last="Mosovsky">Sherri Mosovsky</name></author><author><name sortKey="Ridenour, Ty" sort="Ridenour, Ty" uniqKey="Ridenour T" first="Ty" last="Ridenour">Ty Ridenour</name></author><author><name sortKey="Tarter, Ralph" sort="Tarter, Ralph" uniqKey="Tarter R" first="Ralph" last="Tarter">Ralph Tarter</name></author><author><name sortKey="Vanyukov, Michael" sort="Vanyukov, Michael" uniqKey="Vanyukov M" first="Michael" last="Vanyukov">Michael Vanyukov</name></author></analytic><series><title level="j">Drug and alcohol dependence</title><idno type="ISSN">0376-8716</idno><idno type="eISSN">1879-0046</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P2">Drug use disorders (DUD) have been theorized to share sources of risk variation with other consummatory behaviors. We hypothesized that common mechanisms exist for familial risk for DUD, physiological maturation and nutritional status in girls. Whereas body fat content must exceed a threshold to enable adrenarche and gonadarche, nutritional status may also be a behavior risk indicator. Impaired psychological self-regulation associated with DUD risk may manifest in early overeating, which could in turn accelerate reproductive maturation, resulting in a greater likelihood of affiliation with deviant/older peers and drug use.</p></sec><sec id="S2"><title>Method</title><p id="P3">The sample consisted of families ascertained through the father who either had (N=95) or did not have (N=130) a DUD, and who had a 10–12 year old daughter and her mother available for study. Correlation, survival and path analyses of three consecutive assessments evaluated the relationships between parental DUD (number of affected parents, NAP), nutritional status (NS, subscapular skinfold measurements and body mass index), sexual maturation (Tanner stage), peer delinquency, and the daughter’s lifetime DUD diagnosis.</p></sec><sec id="S3"><title>Results</title><p id="P4">NAP was positively related to the girls’ nutritional status. Longitudinal path analysis indicated mediation of the relationship between NAP and peer delinquency by sexual maturation. The relationship between NAP and sexual maturation is mediated by NS. The effect of sexual maturation at age ~11 on the girls’ DUD risk is mediated by peer delinquency.</p></sec><sec id="S4"><title>Conclusion</title><p id="P5">The data are consistent with mediation of intergenerational transmission of DUD risk in females by elevated nutrition, leading to accelerated maturation, and affiliation with deviant peers.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7513587</journal-id><journal-id journal-id-type="pubmed-jr-id">3445</journal-id><journal-id journal-id-type="nlm-ta">Drug Alcohol Depend</journal-id><journal-id journal-id-type="iso-abbrev">Drug Alcohol Depend</journal-id><journal-title-group><journal-title>Drug and alcohol dependence</journal-title></journal-title-group><issn pub-type="ppub">0376-8716</issn><issn pub-type="epub">1879-0046</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25156223</article-id><article-id pub-id-type="pmc">4199288</article-id><article-id pub-id-type="doi">10.1016/j.drugalcdep.2014.07.032</article-id><article-id pub-id-type="manuscript">NIHMS625059</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Familiality of Addiction and Its Developmental Mechanisms in Girls</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kirillova</surname><given-names>Galina</given-names></name></contrib><contrib contrib-type="author"><name><surname>Reynolds</surname><given-names>Maureen</given-names></name></contrib><contrib contrib-type="author"><name><surname>Kirisci</surname><given-names>Levent</given-names></name></contrib><contrib contrib-type="author"><name><surname>Mosovsky</surname><given-names>Sherri</given-names></name></contrib><contrib contrib-type="author"><name><surname>Ridenour</surname><given-names>Ty</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tarter</surname><given-names>Ralph</given-names></name></contrib><contrib contrib-type="author"><name><surname>Vanyukov</surname><given-names>Michael</given-names></name></contrib><aff id="A1">The University of Pittsburgh</aff></contrib-group><author-notes><corresp id="FN1">Corresponding Author: Galina Kirillova, Pharmacology Science, 3520 Forbes Avenue, Suite 203, Pittsburgh, PA 15213, +14126489909, <email>galinag@pitt.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>8</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>12</day><month>8</month><year>2014</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>10</month><year>2014</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>10</month><year>2015</year></pub-date><volume>143</volume><fpage>213</fpage><lpage>218</lpage><pmc-comment>elocation-id from pubmed: 10.1016/j.drugalcdep.2014.07.032</pmc-comment>
<permissions><copyright-statement>© 2014 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year></permissions><abstract><sec id="S1"><title>Background</title><p id="P2">Drug use disorders (DUD) have been theorized to share sources of risk variation with other consummatory behaviors. We hypothesized that common mechanisms exist for familial risk for DUD, physiological maturation and nutritional status in girls. Whereas body fat content must exceed a threshold to enable adrenarche and gonadarche, nutritional status may also be a behavior risk indicator. Impaired psychological self-regulation associated with DUD risk may manifest in early overeating, which could in turn accelerate reproductive maturation, resulting in a greater likelihood of affiliation with deviant/older peers and drug use.</p></sec><sec id="S2"><title>Method</title><p id="P3">The sample consisted of families ascertained through the father who either had (N=95) or did not have (N=130) a DUD, and who had a 10–12 year old daughter and her mother available for study. Correlation, survival and path analyses of three consecutive assessments evaluated the relationships between parental DUD (number of affected parents, NAP), nutritional status (NS, subscapular skinfold measurements and body mass index), sexual maturation (Tanner stage), peer delinquency, and the daughter’s lifetime DUD diagnosis.</p></sec><sec id="S3"><title>Results</title><p id="P4">NAP was positively related to the girls’ nutritional status. Longitudinal path analysis indicated mediation of the relationship between NAP and peer delinquency by sexual maturation. The relationship between NAP and sexual maturation is mediated by NS. The effect of sexual maturation at age ~11 on the girls’ DUD risk is mediated by peer delinquency.</p></sec><sec id="S4"><title>Conclusion</title><p id="P5">The data are consistent with mediation of intergenerational transmission of DUD risk in females by elevated nutrition, leading to accelerated maturation, and affiliation with deviant peers.</p></sec></abstract><kwd-group><kwd>Drug dependence</kwd><kwd>Gender</kwd><kwd>Females</kwd><kwd>Genetics</kwd><kwd>Eating behavior</kwd><kwd>Obesity</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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