Nicotine enhances the expression of a sucrose or cocaine conditioned place preference in adult male rats
Identifieur interne : 002707 ( Ncbi/Merge ); précédent : 002706; suivant : 002708Nicotine enhances the expression of a sucrose or cocaine conditioned place preference in adult male rats
Auteurs : Deanne M. Buffalari [États-Unis] ; Nana Yaa A. Marfo [États-Unis] ; Tracy T. Smith [États-Unis] ; Melissa E. Levin ; Matthew T. Weaver [États-Unis] ; Edda Thiels [États-Unis] ; Alan F. Sved [États-Unis] ; Eric C. Donny [États-Unis]Source :
- Pharmacology, biochemistry, and behavior [ 0091-3057 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
- administration et posologie : Cocaïne, Saccharose.
- pharmacologie : Nicotine.
- Animaux, Conditionnement classique, Mâle, Rat Sprague-Dawley, Rats.
English descriptors
- KwdEn :
- MESH :
- chemical , administration & dosage : Cocaine, Sucrose.
- chemical , pharmacology : Nicotine.
- Animals, Conditioning, Classical, Male, Rats, Rats, Sprague-Dawley.
Abstract
Nicotine has been shown to enhance the motivational properties of non-nicotine stimuli. This reinforcement-enhancing property of nicotine has the potential to promote the use of other illicit substances as well as maladaptive patterns of food intake. Therefore, the current study aimed to examine whether nicotine enhances preference for contexts paired with cocaine or sucrose utilizing a place conditioning procedure. Separate groups of adult male rats were administered sucrose or cocaine in one of two compartments of a standard CPP chamber on four consecutive days. Preference was then assessed following no injection, a single subcutaneous (s.c.) injection of nicotine, and a s.c. saline injection. Animals preferred the chamber paired with either sucrose or cocaine, as evident from an increased time spent in the paired chamber compared to baseline. Nicotine further increased the time spent in the sucrose- or cocaine-paired chamber, consistent with a reinforcement-enhancement effect. Previous results demonstrate an interaction between nicotine and intake of other drugs or food. The present findings provide an additional mechanism that may underlie these effects and which may have implications for drug dependence and obesity.
Url:
DOI: 10.1016/j.pbb.2014.06.013
PubMed: 24967870
PubMed Central: 4527043
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Buffalari</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Marfo, Nana Yaa A" sort="Marfo, Nana Yaa A" uniqKey="Marfo N" first="Nana Yaa A." last="Marfo">Nana Yaa A. 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Weaver</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Psychology, Mercyhurst University, Erie, PA 16546</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Psychology, Mercyhurst University, Erie</wicri:cityArea></affiliation></author><author><name sortKey="Thiels, Edda" sort="Thiels, Edda" uniqKey="Thiels E" first="Edda" last="Thiels">Edda Thiels</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15260</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurobiology, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Sved, Alan F" sort="Sved, Alan F" uniqKey="Sved A" first="Alan F." last="Sved">Alan F. Sved</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Donny, Eric C" sort="Donny, Eric C" uniqKey="Donny E" first="Eric C." last="Donny">Eric C. Donny</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></analytic><series><title level="j">Pharmacology, biochemistry, and behavior</title><idno type="ISSN">0091-3057</idno><idno type="eISSN">1873-5177</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cocaine (administration & dosage)</term><term>Conditioning, Classical</term><term>Male</term><term>Nicotine (pharmacology)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Sucrose (administration & dosage)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cocaïne (administration et posologie)</term><term>Conditionnement classique</term><term>Mâle</term><term>Nicotine (pharmacologie)</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Saccharose (administration et posologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cocaine</term><term>Sucrose</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Nicotine</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Cocaïne</term><term>Saccharose</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Nicotine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Conditioning, Classical</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Conditionnement classique</term><term>Mâle</term><term>Rat Sprague-Dawley</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Nicotine has been shown to enhance the motivational properties of non-nicotine stimuli. This reinforcement-enhancing property of nicotine has the potential to promote the use of other illicit substances as well as maladaptive patterns of food intake. Therefore, the current study aimed to examine whether nicotine enhances preference for contexts paired with cocaine or sucrose utilizing a place conditioning procedure. Separate groups of adult male rats were administered sucrose or cocaine in one of two compartments of a standard CPP chamber on four consecutive days. Preference was then assessed following no injection, a single subcutaneous (s.c.) injection of nicotine, and a s.c. saline injection. Animals preferred the chamber paired with either sucrose or cocaine, as evident from an increased time spent in the paired chamber compared to baseline. Nicotine further increased the time spent in the sucrose- or cocaine-paired chamber, consistent with a reinforcement-enhancement effect. Previous results demonstrate an interaction between nicotine and intake of other drugs or food. The present findings provide an additional mechanism that may underlie these effects and which may have implications for drug dependence and obesity.</p></div></front></TEI><double pmid="24967870"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nicotine enhances the expression of a sucrose or cocaine conditioned place preference in adult male rats</title><author><name sortKey="Buffalari, Deanne M" sort="Buffalari, Deanne M" uniqKey="Buffalari D" first="Deanne M." last="Buffalari">Deanne M. Buffalari</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Marfo, Nana Yaa A" sort="Marfo, Nana Yaa A" uniqKey="Marfo N" first="Nana Yaa A." last="Marfo">Nana Yaa A. Marfo</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Smith, Tracy T" sort="Smith, Tracy T" uniqKey="Smith T" first="Tracy T." last="Smith">Tracy T. Smith</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Levin, Melissa E" sort="Levin, Melissa E" uniqKey="Levin M" first="Melissa E." last="Levin">Melissa E. Levin</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Weaver, Matthew T" sort="Weaver, Matthew T" uniqKey="Weaver M" first="Matthew T." last="Weaver">Matthew T. Weaver</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Psychology, Mercyhurst University, Erie, PA 16546</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Psychology, Mercyhurst University, Erie</wicri:cityArea></affiliation></author><author><name sortKey="Thiels, Edda" sort="Thiels, Edda" uniqKey="Thiels E" first="Edda" last="Thiels">Edda Thiels</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15260</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurobiology, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Sved, Alan F" sort="Sved, Alan F" uniqKey="Sved A" first="Alan F." last="Sved">Alan F. 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Buffalari</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Marfo, Nana Yaa A" sort="Marfo, Nana Yaa A" uniqKey="Marfo N" first="Nana Yaa A." last="Marfo">Nana Yaa A. Marfo</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Smith, Tracy T" sort="Smith, Tracy T" uniqKey="Smith T" first="Tracy T." last="Smith">Tracy T. Smith</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Levin, Melissa E" sort="Levin, Melissa E" uniqKey="Levin M" first="Melissa E." last="Levin">Melissa E. Levin</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Weaver, Matthew T" sort="Weaver, Matthew T" uniqKey="Weaver M" first="Matthew T." last="Weaver">Matthew T. Weaver</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Psychology, Mercyhurst University, Erie, PA 16546</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Psychology, Mercyhurst University, Erie</wicri:cityArea></affiliation></author><author><name sortKey="Thiels, Edda" sort="Thiels, Edda" uniqKey="Thiels E" first="Edda" last="Thiels">Edda Thiels</name><affiliation wicri:level="2"><nlm:aff id="A3">Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15260</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName><wicri:cityArea>Department of Neurobiology, University of Pittsburgh, Pittsburgh</wicri:cityArea></affiliation></author><author><name sortKey="Sved, Alan F" sort="Sved, Alan F" uniqKey="Sved A" first="Alan F." last="Sved">Alan F. Sved</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Donny, Eric C" sort="Donny, Eric C" uniqKey="Donny E" first="Eric C." last="Donny">Eric C. Donny</name><affiliation wicri:level="4"><nlm:aff id="A2">Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></analytic><series><title level="j">Pharmacology, biochemistry, and behavior</title><idno type="ISSN">0091-3057</idno><idno type="eISSN">1873-5177</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P2">Nicotine has been shown to enhance the motivational properties of non-nicotine stimuli. This reinforcement-enhancing property of nicotine has the potential to promote the use of other illicit substances as well as maladaptive patterns of food intake. Therefore, the current study aimed to examine whether nicotine enhances preference for contexts paired with cocaine or sucrose utilizing a place conditioning procedure. Separate groups of adult male rats were administered sucrose or cocaine in one of two compartments of a standard CPP chamber on four consecutive days. Preference was then assessed following no injection, a single subcutaneous (s.c.) injection of nicotine, and a s.c. saline injection. Animals preferred the chamber paired with either sucrose or cocaine, as evident from an increased time spent in the paired chamber compared to baseline. Nicotine further increased the time spent in the sucrose- or cocaine-paired chamber, consistent with a reinforcement-enhancement effect. Previous results demonstrate an interaction between nicotine and intake of other drugs or food. The present findings provide an additional mechanism that may underlie these effects and which may have implications for drug dependence and obesity.</p></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nicotine enhances the expression of a sucrose or cocaine conditioned place preference in adult male rats.</title><author><name sortKey="Buffalari, Deanne M" sort="Buffalari, Deanne M" uniqKey="Buffalari D" first="Deanne M" last="Buffalari">Deanne M. Buffalari</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: deanne@pitt.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Marfo, Nana Yaa A" sort="Marfo, Nana Yaa A" uniqKey="Marfo N" first="Nana Yaa A" last="Marfo">Nana Yaa A. Marfo</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Smith, Tracy T" sort="Smith, Tracy T" uniqKey="Smith T" first="Tracy T" last="Smith">Tracy T. Smith</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Levin, Melissa E" sort="Levin, Melissa E" uniqKey="Levin M" first="Melissa E" last="Levin">Melissa E. Levin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Weaver, Matthew T" sort="Weaver, Matthew T" uniqKey="Weaver M" first="Matthew T" last="Weaver">Matthew T. Weaver</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychology, Mercyhurst University, Erie, PA 16546, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, Mercyhurst University, Erie, PA 16546</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Thiels, Edda" sort="Thiels, Edda" uniqKey="Thiels E" first="Edda" last="Thiels">Edda Thiels</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15260, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Sved, Alan F" sort="Sved, Alan F" uniqKey="Sved A" first="Alan F" last="Sved">Alan F. Sved</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Donny, Eric C" sort="Donny, Eric C" uniqKey="Donny E" first="Eric C" last="Donny">Eric C. Donny</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24967870</idno><idno type="pmid">24967870</idno><idno type="doi">10.1016/j.pbb.2014.06.013</idno><idno type="wicri:Area/PubMed/Corpus">001B70</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001B70</idno><idno type="wicri:Area/PubMed/Curation">001B62</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001B62</idno><idno type="wicri:Area/PubMed/Checkpoint">001B62</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001B62</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Nicotine enhances the expression of a sucrose or cocaine conditioned place preference in adult male rats.</title><author><name sortKey="Buffalari, Deanne M" sort="Buffalari, Deanne M" uniqKey="Buffalari D" first="Deanne M" last="Buffalari">Deanne M. Buffalari</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: deanne@pitt.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Marfo, Nana Yaa A" sort="Marfo, Nana Yaa A" uniqKey="Marfo N" first="Nana Yaa A" last="Marfo">Nana Yaa A. Marfo</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Smith, Tracy T" sort="Smith, Tracy T" uniqKey="Smith T" first="Tracy T" last="Smith">Tracy T. Smith</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Levin, Melissa E" sort="Levin, Melissa E" uniqKey="Levin M" first="Melissa E" last="Levin">Melissa E. Levin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Weaver, Matthew T" sort="Weaver, Matthew T" uniqKey="Weaver M" first="Matthew T" last="Weaver">Matthew T. Weaver</name><affiliation wicri:level="2"><nlm:affiliation>Department of Psychology, Mercyhurst University, Erie, PA 16546, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, Mercyhurst University, Erie, PA 16546</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Thiels, Edda" sort="Thiels, Edda" uniqKey="Thiels E" first="Edda" last="Thiels">Edda Thiels</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15260, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Sved, Alan F" sort="Sved, Alan F" uniqKey="Sved A" first="Alan F" last="Sved">Alan F. Sved</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Donny, Eric C" sort="Donny, Eric C" uniqKey="Donny E" first="Eric C" last="Donny">Eric C. Donny</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Psychology, 455 Langley Hall, University of Pittsburgh, Pittsburgh, PA 15260</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></analytic><series><title level="j">Pharmacology, biochemistry, and behavior</title><idno type="eISSN">1873-5177</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cocaine (administration & dosage)</term><term>Conditioning, Classical</term><term>Male</term><term>Nicotine (pharmacology)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Sucrose (administration & dosage)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cocaïne (administration et posologie)</term><term>Conditionnement classique</term><term>Mâle</term><term>Nicotine (pharmacologie)</term><term>Rat Sprague-Dawley</term><term>Rats</term><term>Saccharose (administration et posologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cocaine</term><term>Sucrose</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Nicotine</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Cocaïne</term><term>Saccharose</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Nicotine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Conditioning, Classical</term><term>Male</term><term>Rats</term><term>Rats, Sprague-Dawley</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Conditionnement classique</term><term>Mâle</term><term>Rat Sprague-Dawley</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Nicotine has been shown to enhance the motivational properties of non-nicotine stimuli. This reinforcement-enhancing property of nicotine has the potential to promote the use of other illicit substances as well as maladaptive patterns of food intake. Therefore, the current study aimed to examine whether nicotine enhances preference for contexts paired with cocaine or sucrose utilizing a place conditioning procedure. Separate groups of adult male rats were administered sucrose or cocaine in one of two compartments of a standard CPP chamber on four consecutive days. Preference was then assessed following no injection, a single subcutaneous (s.c.) injection of nicotine, and a s.c. saline injection. The animals preferred the chamber paired with either sucrose or cocaine, as evident from an increased time spent in the paired chamber compared to baseline. Nicotine further increased the time spent in the sucrose- or cocaine-paired chamber, consistent with a reinforcement-enhancement effect. Previous results demonstrate an interaction between nicotine and intake of other drugs or food. The present findings provide an additional mechanism that may underlie these effects and which may have implications for drug dependence and obesity.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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