Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.
Identifieur interne : 001237 ( Ncbi/Curation ); précédent : 001236; suivant : 001238Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.
Auteurs : Vinicius Tragante [Pays-Bas] ; Michael R. Barnes [Royaume-Uni] ; Santhi K. Ganesh [États-Unis] ; Matthew B. Lanktree [Canada] ; Wei Guo [États-Unis] ; Nora Franceschini [États-Unis] ; Erin N. Smith [États-Unis] ; Toby Johnson [Royaume-Uni] ; Michael V. Holmes [États-Unis] ; Sandosh Padmanabhan [Royaume-Uni] ; Konrad J. Karczewski [États-Unis] ; Berta Almoguera [États-Unis] ; John Barnard [États-Unis] ; Jens Baumert [Allemagne] ; Yen-Pei Christy Chang [États-Unis] ; Clara C. Elbers [Pays-Bas] ; Martin Farrall [Royaume-Uni] ; Mary E. Fischer [États-Unis] ; Tom R. Gaunt [Royaume-Uni] ; Johannes M I H. Gho [Pays-Bas] ; Christian Gieger [Allemagne] ; Anuj Goel [Royaume-Uni] ; Yan Gong [États-Unis] ; Aaron Isaacs [Pays-Bas] ; Marcus E. Kleber [Allemagne] ; Irene Mateo Leach [Pays-Bas] ; Caitrin W. Mcdonough [États-Unis] ; Matthijs F L. Meijs [Pays-Bas] ; Olle Melander [Suède] ; Christopher P. Nelson [Royaume-Uni] ; Ilja M. Nolte [Pays-Bas] ; Nathan Pankratz [États-Unis] ; Tom S. Price [Royaume-Uni] ; Jonathan Shaffer [États-Unis] ; Sonia Shah [Royaume-Uni] ; Maciej Tomaszewski [Royaume-Uni] ; Peter J. Van Der Most [Pays-Bas] ; Erik P A. Van Iperen [Pays-Bas] ; Judith M. Vonk [Pays-Bas] ; Kate Witkowska [Royaume-Uni] ; Caroline O L. Wong [Royaume-Uni] ; Li Zhang [États-Unis] ; Amber L. Beitelshees [États-Unis] ; Gerald S. Berenson [États-Unis] ; Deepak L. Bhatt [États-Unis] ; Morris Brown [Royaume-Uni] ; Amber Burt [États-Unis] ; Rhonda M. Cooper-Dehoff [États-Unis] ; John M. Connell [Royaume-Uni] ; Karen J. Cruickshanks [États-Unis] ; Sean P. Curtis [États-Unis] ; George Davey-Smith [Royaume-Uni] ; Christian Delles [Royaume-Uni] ; Ron T. Gansevoort [Pays-Bas] ; Xiuqing Guo [États-Unis] ; Shen Haiqing [États-Unis] ; Claire E. Hastie [Royaume-Uni] ; Marten H. Hofker [Pays-Bas] ; G Kees Hovingh [Pays-Bas] ; Daniel S. Kim [États-Unis] ; Susan A. Kirkland [Canada] ; Barbara E. Klein [États-Unis] ; Ronald Klein [États-Unis] ; Yun R. Li [États-Unis] ; Steffi Maiwald [Pays-Bas] ; Christopher Newton-Cheh [États-Unis] ; Eoin T. O'Brien [Irlande (pays)] ; N Charlotte Onland-Moret [Pays-Bas] ; Walter Palmas [États-Unis] ; Afshin Parsa [États-Unis] ; Brenda W. Penninx [Pays-Bas] ; Mary Pettinger [États-Unis] ; Ramachandran S. Vasan [États-Unis] ; Jane E. Ranchalis [États-Unis] ; Paul M Ridker [États-Unis] ; Lynda M. Rose [États-Unis] ; Peter Sever ; Daichi Shimbo [États-Unis] ; Laura Steele [États-Unis] ; Ronald P. Stolk [Pays-Bas] ; Barbara Thorand [Allemagne] ; Mieke D. Trip [Pays-Bas] ; Cornelia M. Van Duijn [Pays-Bas] ; W Monique Verschuren [Pays-Bas] ; Cisca Wijmenga [Pays-Bas] ; Sharon Wyatt [États-Unis] ; J Hunter Young [États-Unis] ; Aeilko H. Zwinderman [Pays-Bas] ; Connie R. Bezzina [Pays-Bas] ; Eric Boerwinkle [États-Unis] ; Juan P. Casas [Royaume-Uni] ; Mark J. Caulfield [Royaume-Uni] ; Aravinda Chakravarti [États-Unis] ; Daniel I. Chasman [États-Unis] ; Karina W. Davidson [États-Unis] ; Pieter A. Doevendans [Pays-Bas] ; Anna F. Dominiczak [Royaume-Uni] ; Garret A. Fitzgerald [États-Unis] ; John G. Gums [États-Unis] ; Myriam Fornage [États-Unis] ; Hakon Hakonarson [États-Unis] ; Indrani Halder [États-Unis] ; Hans L. Hillege [Pays-Bas] ; Thomas Illig [Allemagne] ; Gail P. Jarvik ; Julie A. Johnson [États-Unis] ; John J P. Kastelein [Pays-Bas] ; Wolfgang Koenig [Allemagne] ; Meena Kumari [Royaume-Uni] ; Winfried M Rz [Autriche] ; Sarah S. Murray [États-Unis] ; Jeffery R. O'Connell [États-Unis] ; Albertine J. Oldehinkel [Pays-Bas] ; James S. Pankow [États-Unis] ; Daniel J. Rader [États-Unis] ; Susan Redline [États-Unis] ; Muredach P. Reilly [États-Unis] ; Eric E. Schadt [États-Unis] ; Kandice Kottke-Marchant [États-Unis] ; Harold Snieder [Pays-Bas] ; Michael Snyder [États-Unis] ; Alice V. Stanton [Irlande (pays)] ; Martin D. Tobin [Royaume-Uni] ; André G. Uitterlinden [Pays-Bas] ; Pim Van Der Harst [Pays-Bas] ; Yvonne T. Van Der Schouw [Pays-Bas] ; Nilesh J. Samani [Royaume-Uni] ; Hugh Watkins [Royaume-Uni] ; Andrew D. Johnson [États-Unis] ; Alex P. Reiner [États-Unis] ; Xiaofeng Zhu [États-Unis] ; Paul I W. De Bakker [États-Unis] ; Daniel Levy [États-Unis] ; Folkert W. Asselbergs [Royaume-Uni] ; Patricia B. Munroe [Royaume-Uni] ; Brendan J. Keating [États-Unis]Source :
- American journal of human genetics [ 1537-6605 ] ; 2014.
Descripteurs français
- KwdFr :
- Biologie informatique (), Contrôle de qualité, Diastole, Europe, Facteurs de risque, Génotype, Génétique des populations, Humains, Locus de caractère quantitatif, Locus génétiques, Phénotype, Polymorphisme de nucléotide simple, Population d'origine européenne (génétique), Pression artérielle, Pression sanguine, Systole, Étude d'association pangénomique.
- MESH :
- génétique : Population d'origine européenne.
- Biologie informatique, Contrôle de qualité, Diastole, Europe, Facteurs de risque, Génotype, Génétique des populations, Humains, Locus de caractère quantitatif, Locus génétiques, Phénotype, Polymorphisme de nucléotide simple, Pression artérielle, Pression sanguine, Systole, Étude d'association pangénomique.
English descriptors
- KwdEn :
- Arterial Pressure, Blood Pressure, Computational Biology (methods), Diastole, Europe, European Continental Ancestry Group (genetics), Genetic Loci, Genetics, Population, Genome-Wide Association Study, Genotype, Humans, Phenotype, Polymorphism, Single Nucleotide, Quality Control, Quantitative Trait Loci, Risk Factors, Systole.
- MESH :
- geographic : Europe.
- genetics : European Continental Ancestry Group.
- methods : Computational Biology.
- Arterial Pressure, Blood Pressure, Diastole, Genetic Loci, Genetics, Population, Genome-Wide Association Study, Genotype, Humans, Phenotype, Polymorphism, Single Nucleotide, Quality Control, Quantitative Trait Loci, Risk Factors, Systole.
Abstract
Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ~50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p < 6 × 10(-7)) and confirmed 27 previously reported associations. Bioinformatic analysis of the 11 loci provided support for a putative role in hypertension of several genes, such as CDK6 and NUCB2. Analysis of potential pharmacological targets in databases of small molecules showed that ten of the genes are predicted to be a target for small molecules. In summary, we identified previously unknown loci associated with BP. Our findings extend our understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification.
DOI: 10.1016/j.ajhg.2013.12.016
PubMed: 24560520
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Peter Sever<affiliation><nlm:affiliation>International Centre for Circulatory Health, Imperial College London, W2 1LA UK.</nlm:affiliation>
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<affiliation><nlm:affiliation>International Centre for Circulatory Health, Imperial College London, W2 1LA UK.</nlm:affiliation>
<wicri:noCountry code="subField">W2 1LA UK</wicri:noCountry>
</affiliation>
Le document en format XML
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<author><name sortKey="Gaunt, Tom R" sort="Gaunt, Tom R" uniqKey="Gaunt T" first="Tom R" last="Gaunt">Tom R. Gaunt</name>
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<author><name sortKey="Gho, Johannes M I H" sort="Gho, Johannes M I H" uniqKey="Gho J" first="Johannes M I H" last="Gho">Johannes M I H. Gho</name>
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<author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name>
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<author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name>
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<country xml:lang="fr">Royaume-Uni</country>
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<author><name sortKey="Gong, Yan" sort="Gong, Yan" uniqKey="Gong Y" first="Yan" last="Gong">Yan Gong</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610</wicri:regionArea>
<placeName><region type="state">Floride</region>
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</author>
<author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name>
<affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3015 GE Rotterdam</wicri:regionArea>
<wicri:noRegion>3015 GE Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E" last="Kleber">Marcus E. Kleber</name>
<affiliation wicri:level="3"><nlm:affiliation>Medical Clinic V, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Medical Clinic V, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mateo Leach, Irene" sort="Mateo Leach, Irene" uniqKey="Mateo Leach I" first="Irene" last="Mateo Leach">Irene Mateo Leach</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcdonough, Caitrin W" sort="Mcdonough, Caitrin W" uniqKey="Mcdonough C" first="Caitrin W" last="Mcdonough">Caitrin W. Mcdonough</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meijs, Matthijs F L" sort="Meijs, Matthijs F L" uniqKey="Meijs M" first="Matthijs F L" last="Meijs">Matthijs F L. Meijs</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name>
<affiliation wicri:level="1"><nlm:affiliation>Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö 20502, Sweden; Centre of Emergency Medicine, Skåne University Hospital, Malmö 20502, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö 20502, Sweden; Centre of Emergency Medicine, Skåne University Hospital, Malmö 20502</wicri:regionArea>
<wicri:noRegion>Malmö 20502</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P" last="Nelson">Christopher P. Nelson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP</wicri:regionArea>
<wicri:noRegion>Leicester LE3 9QP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M" last="Nolte">Ilja M. Nolte</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pankratz, Nathan" sort="Pankratz, Nathan" uniqKey="Pankratz N" first="Nathan" last="Pankratz">Nathan Pankratz</name>
<affiliation wicri:level="2"><nlm:affiliation>Institute of Human Genetics, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute of Human Genetics, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Price, Tom S" sort="Price, Tom S" uniqKey="Price T" first="Tom S" last="Price">Tom S. Price</name>
<affiliation wicri:level="1"><nlm:affiliation>MRC SGDP Centre, Institute of Psychiatry, London SE5 8AF, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC SGDP Centre, Institute of Psychiatry, London SE5 8AF</wicri:regionArea>
<wicri:noRegion>London SE5 8AF</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shaffer, Jonathan" sort="Shaffer, Jonathan" uniqKey="Shaffer J" first="Jonathan" last="Shaffer">Jonathan Shaffer</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Columbia University, New York, NY 10032, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Columbia University, New York, NY 10032</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Shah, Sonia" sort="Shah, Sonia" uniqKey="Shah S" first="Sonia" last="Shah">Sonia Shah</name>
<affiliation wicri:level="4"><nlm:affiliation>UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Kathleen Lonsdale Building, Gower Place, London WC1E 6BT, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Kathleen Lonsdale Building, Gower Place, London WC1E 6BT</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tomaszewski, Maciej" sort="Tomaszewski, Maciej" uniqKey="Tomaszewski M" first="Maciej" last="Tomaszewski">Maciej Tomaszewski</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP</wicri:regionArea>
<wicri:noRegion>Leicester LE3 9QP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Most, Peter J" sort="Van Der Most, Peter J" uniqKey="Van Der Most P" first="Peter J" last="Van Der Most">Peter J. Van Der Most</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Iperen, Erik P A" sort="Van Iperen, Erik P A" uniqKey="Van Iperen E" first="Erik P A" last="Van Iperen">Erik P A. Van Iperen</name>
<affiliation wicri:level="1"><nlm:affiliation>Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vonk, Judith M" sort="Vonk, Judith M" uniqKey="Vonk J" first="Judith M" last="Vonk">Judith M. Vonk</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witkowska, Kate" sort="Witkowska, Kate" uniqKey="Witkowska K" first="Kate" last="Witkowska">Kate Witkowska</name>
<affiliation wicri:level="4"><nlm:affiliation>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wong, Caroline O L" sort="Wong, Caroline O L" uniqKey="Wong C" first="Caroline O L" last="Wong">Caroline O L. Wong</name>
<affiliation wicri:level="4"><nlm:affiliation>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beitelshees, Amber L" sort="Beitelshees, Amber L" uniqKey="Beitelshees A" first="Amber L" last="Beitelshees">Amber L. Beitelshees</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Berenson, Gerald S" sort="Berenson, Gerald S" uniqKey="Berenson G" first="Gerald S" last="Berenson">Gerald S. Berenson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA 70118, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA 70118</wicri:regionArea>
<placeName><region type="state">Louisiane</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhatt, Deepak L" sort="Bhatt, Deepak L" uniqKey="Bhatt D" first="Deepak L" last="Bhatt">Deepak L. Bhatt</name>
<affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brown, Morris" sort="Brown, Morris" uniqKey="Brown M" first="Morris" last="Brown">Morris Brown</name>
<affiliation wicri:level="4"><nlm:affiliation>Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Burt, Amber" sort="Burt, Amber" uniqKey="Burt A" first="Amber" last="Burt">Amber Burt</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine (Medical Genetics), University of Washington, Seattle, WA 98195, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Medical Genetics), University of Washington, Seattle, WA 98195</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Cooper Dehoff, Rhonda M" sort="Cooper Dehoff, Rhonda M" uniqKey="Cooper Dehoff R" first="Rhonda M" last="Cooper-Dehoff">Rhonda M. Cooper-Dehoff</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Connell, John M" sort="Connell, John M" uniqKey="Connell J" first="John M" last="Connell">John M. Connell</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Dundee, Ninewells Hospital &Medical School, Dundee DD1 9SY, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Dundee, Ninewells Hospital &Medical School, Dundee DD1 9SY</wicri:regionArea>
<wicri:noRegion>Dundee DD1 9SY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cruickshanks, Karen J" sort="Cruickshanks, Karen J" uniqKey="Cruickshanks K" first="Karen J" last="Cruickshanks">Karen J. Cruickshanks</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA; Department of Population Health Sciences, University of Wisconsin, Madison, WI 53726, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA; Department of Population Health Sciences, University of Wisconsin, Madison, WI 53726</wicri:regionArea>
<placeName><region type="state">Wisconsin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Curtis, Sean P" sort="Curtis, Sean P" uniqKey="Curtis S" first="Sean P" last="Curtis">Sean P. Curtis</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey-Smith">George Davey-Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN</wicri:regionArea>
<wicri:noRegion>Bristol BS8 2BN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Delles, Christian" sort="Delles, Christian" uniqKey="Delles C" first="Christian" last="Delles">Christian Delles</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gansevoort, Ron T" sort="Gansevoort, Ron T" uniqKey="Gansevoort R" first="Ron T" last="Gansevoort">Ron T. Gansevoort</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Nephrology, Department of Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Division of Nephrology, Department of Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guo, Xiuqing" sort="Guo, Xiuqing" uniqKey="Guo X" first="Xiuqing" last="Guo">Xiuqing Guo</name>
<affiliation wicri:level="2"><nlm:affiliation>Cedars-Sinai Med Ctr-PEDS, Los Angeles, CA 90048, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cedars-Sinai Med Ctr-PEDS, Los Angeles, CA 90048</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haiqing, Shen" sort="Haiqing, Shen" uniqKey="Haiqing S" first="Shen" last="Haiqing">Shen Haiqing</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hastie, Claire E" sort="Hastie, Claire E" uniqKey="Hastie C" first="Claire E" last="Hastie">Claire E. Hastie</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hofker, Marten H" sort="Hofker, Marten H" uniqKey="Hofker M" first="Marten H" last="Hofker">Marten H. Hofker</name>
<affiliation wicri:level="1"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Department Pathology and Medical Biology, Medical Biology Division, Molecular Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Department Pathology and Medical Biology, Medical Biology Division, Molecular Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<wicri:noRegion>9700 RB Groningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hovingh, G Kees" sort="Hovingh, G Kees" uniqKey="Hovingh G" first="G Kees" last="Hovingh">G Kees Hovingh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Daniel S" sort="Kim, Daniel S" uniqKey="Kim D" first="Daniel S" last="Kim">Daniel S. Kim</name>
<affiliation wicri:level="4"><nlm:affiliation>Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA 98195</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Kirkland, Susan A" sort="Kirkland, Susan A" uniqKey="Kirkland S" first="Susan A" last="Kirkland">Susan A. Kirkland</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS B3H 1V7, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS B3H 1V7</wicri:regionArea>
<wicri:noRegion>NS B3H 1V7</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klein, Barbara E" sort="Klein, Barbara E" uniqKey="Klein B" first="Barbara E" last="Klein">Barbara E. Klein</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726</wicri:regionArea>
<placeName><region type="state">Wisconsin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klein, Ronald" sort="Klein, Ronald" uniqKey="Klein R" first="Ronald" last="Klein">Ronald Klein</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726</wicri:regionArea>
<placeName><region type="state">Wisconsin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Yun R" sort="Li, Yun R" uniqKey="Li Y" first="Yun R" last="Li">Yun R. Li</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maiwald, Steffi" sort="Maiwald, Steffi" uniqKey="Maiwald S" first="Steffi" last="Maiwald">Steffi Maiwald</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Newton Cheh, Christopher" sort="Newton Cheh, Christopher" uniqKey="Newton Cheh C" first="Christopher" last="Newton-Cheh">Christopher Newton-Cheh</name>
<affiliation wicri:level="2"><nlm:affiliation>Broad Institute of Harvard and MIT, Massachusetts General Hospital, Boston, MA 02142, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Broad Institute of Harvard and MIT, Massachusetts General Hospital, Boston, MA 02142</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Brien, Eoin T" sort="O Brien, Eoin T" uniqKey="O Brien E" first="Eoin T" last="O'Brien">Eoin T. O'Brien</name>
<affiliation wicri:level="1"><nlm:affiliation>Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.</nlm:affiliation>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4</wicri:regionArea>
<wicri:noRegion>Dublin 4</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palmas, Walter" sort="Palmas, Walter" uniqKey="Palmas W" first="Walter" last="Palmas">Walter Palmas</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Columbia University, New York, NY 10032, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Columbia University, New York, NY 10032</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W" last="Penninx">Brenda W. Penninx</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry/EMGO Institute, VU University Medical Centre, 1081 BT Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry/EMGO Institute, VU University Medical Centre, 1081 BT Amsterdam</wicri:regionArea>
<wicri:noRegion>1081 BT Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pettinger, Mary" sort="Pettinger, Mary" uniqKey="Pettinger M" first="Mary" last="Pettinger">Mary Pettinger</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran S" last="Vasan">Ramachandran S. Vasan</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Boston University School of Medicine, Framingham, MA 02118, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Boston University School of Medicine, Framingham, MA 02118</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ranchalis, Jane E" sort="Ranchalis, Jane E" uniqKey="Ranchalis J" first="Jane E" last="Ranchalis">Jane E. Ranchalis</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine (Medical Genetics), University of Washington, Seattle, WA 98195, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Medical Genetics), University of Washington, Seattle, WA 98195</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="M Ridker, Paul" sort="M Ridker, Paul" uniqKey="M Ridker P" first="Paul" last="M Ridker">Paul M Ridker</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M" last="Rose">Lynda M. Rose</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sever, Peter" sort="Sever, Peter" uniqKey="Sever P" first="Peter" last="Sever">Peter Sever</name>
<affiliation><nlm:affiliation>International Centre for Circulatory Health, Imperial College London, W2 1LA UK.</nlm:affiliation>
<wicri:noCountry code="subField">W2 1LA UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shimbo, Daichi" sort="Shimbo, Daichi" uniqKey="Shimbo D" first="Daichi" last="Shimbo">Daichi Shimbo</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Columbia University, New York, NY 10032, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Columbia University, New York, NY 10032</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Steele, Laura" sort="Steele, Laura" uniqKey="Steele L" first="Laura" last="Steele">Laura Steele</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thorand, Barbara" sort="Thorand, Barbara" uniqKey="Thorand B" first="Barbara" last="Thorand">Barbara Thorand</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764</wicri:regionArea>
<wicri:noRegion>85764</wicri:noRegion>
<wicri:noRegion>85764</wicri:noRegion>
<wicri:noRegion>Neuherberg 85764</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trip, Mieke D" sort="Trip, Mieke D" uniqKey="Trip M" first="Mieke D" last="Trip">Mieke D. Trip</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3015 GE Rotterdam</wicri:regionArea>
<wicri:noRegion>3015 GE Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Verschuren, W Monique" sort="Verschuren, W Monique" uniqKey="Verschuren W" first="W Monique" last="Verschuren">W Monique Verschuren</name>
<affiliation wicri:level="1"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven</wicri:regionArea>
<wicri:noRegion>3720 BA Bilthoven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wyatt, Sharon" sort="Wyatt, Sharon" uniqKey="Wyatt S" first="Sharon" last="Wyatt">Sharon Wyatt</name>
<affiliation wicri:level="2"><nlm:affiliation>Schools of Nursing and Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Schools of Nursing and Medicine, University of Mississippi Medical Center, Jackson, MS 39216</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Young, J Hunter" sort="Young, J Hunter" uniqKey="Young J" first="J Hunter" last="Young">J Hunter Young</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zwinderman, Aeilko H" sort="Zwinderman, Aeilko H" uniqKey="Zwinderman A" first="Aeilko H" last="Zwinderman">Aeilko H. Zwinderman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bezzina, Connie R" sort="Bezzina, Connie R" uniqKey="Bezzina C" first="Connie R" last="Bezzina">Connie R. Bezzina</name>
<affiliation wicri:level="1"><nlm:affiliation>Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands; Molecular and Experimental Cardiology Group, Academic Medical Centre, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands; Molecular and Experimental Cardiology Group, Academic Medical Centre, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<affiliation wicri:level="2"><nlm:affiliation>Human Genetics Center and Institute of Molecular Medicine and Division of Epidemiology, University of Texas Health Science Center, Houston, TX 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Human Genetics Center and Institute of Molecular Medicine and Division of Epidemiology, University of Texas Health Science Center, Houston, TX 77030</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Casas, Juan P" sort="Casas, Juan P" uniqKey="Casas J" first="Juan P" last="Casas">Juan P. Casas</name>
<affiliation wicri:level="4"><nlm:affiliation>Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK; Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK; Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London WC1E 6BT</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J" last="Caulfield">Mark J. Caulfield</name>
<affiliation wicri:level="4"><nlm:affiliation>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chakravarti, Aravinda" sort="Chakravarti, Aravinda" uniqKey="Chakravarti A" first="Aravinda" last="Chakravarti">Aravinda Chakravarti</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davidson, Karina W" sort="Davidson, Karina W" uniqKey="Davidson K" first="Karina W" last="Davidson">Karina W. Davidson</name>
<affiliation wicri:level="4"><nlm:affiliation>Departments of Medicine & Psychiatry, Columbia University, New York, NY 10032, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Medicine & Psychiatry, Columbia University, New York, NY 10032</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Doevendans, Pieter A" sort="Doevendans, Pieter A" uniqKey="Doevendans P" first="Pieter A" last="Doevendans">Pieter A. Doevendans</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F" last="Dominiczak">Anna F. Dominiczak</name>
<affiliation wicri:level="4"><nlm:affiliation>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fitzgerald, Garret A" sort="Fitzgerald, Garret A" uniqKey="Fitzgerald G" first="Garret A" last="Fitzgerald">Garret A. Fitzgerald</name>
<affiliation wicri:level="2"><nlm:affiliation>The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gums, John G" sort="Gums, John G" uniqKey="Gums J" first="John G" last="Gums">John G. Gums</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Pharmacotherapy and Translational Research and Community Health and Family Medicine, University of Florida, Gainesville, FL 32610, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pharmacotherapy and Translational Research and Community Health and Family Medicine, University of Florida, Gainesville, FL 32610</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><nlm:affiliation>Institute of Molecular Medicine and School of Public Health Division of Epidemiology Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute of Molecular Medicine and School of Public Health Division of Epidemiology Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Halder, Indrani" sort="Halder, Indrani" uniqKey="Halder I" first="Indrani" last="Halder">Indrani Halder</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Medicine, University of Pittsburgh, PA 15261, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Medicine, University of Pittsburgh, PA 15261</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L" last="Hillege">Hans L. Hillege</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name>
<affiliation wicri:level="3"><nlm:affiliation>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover 30625</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jarvik, Gail P" sort="Jarvik, Gail P" uniqKey="Jarvik G" first="Gail P" last="Jarvik">Gail P. Jarvik</name>
<affiliation><nlm:affiliation>International Centre for Circulatory Health, Imperial College London, W2 1LA UK.</nlm:affiliation>
<wicri:noCountry code="subField">W2 1LA UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Johnson, Julie A" sort="Johnson, Julie A" uniqKey="Johnson J" first="Julie A" last="Johnson">Julie A. Johnson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J P" last="Kastelein">John J P. Kastelein</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm 89081, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm 89081</wicri:regionArea>
<wicri:noRegion>89081</wicri:noRegion>
<wicri:noRegion>89081</wicri:noRegion>
<wicri:noRegion>Ulm 89081</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, Division of Population Health, University College London, Torrington Place, London WC1E 7HB, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Public Health, Division of Population Health, University College London, Torrington Place, London WC1E 7HB</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical Clinic V, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany; Synlab Academy, Synlab Services GmbH, Mannheim 69214, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Medical Clinic V, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany; Synlab Academy, Synlab Services GmbH, Mannheim 69214, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036</wicri:regionArea>
<wicri:noRegion>Graz 8036</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Murray, Sarah S" sort="Murray, Sarah S" uniqKey="Murray S" first="Sarah S" last="Murray">Sarah S. Murray</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of California San Diego, La Jolla, CA 92037, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of California San Diego, La Jolla, CA 92037</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Connell, Jeffery R" sort="O Connell, Jeffery R" uniqKey="O Connell J" first="Jeffery R" last="O'Connell">Jeffery R. O'Connell</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oldehinkel, Albertine J" sort="Oldehinkel, Albertine J" uniqKey="Oldehinkel A" first="Albertine J" last="Oldehinkel">Albertine J. Oldehinkel</name>
<affiliation wicri:level="4"><nlm:affiliation>Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pankow, James S" sort="Pankow, James S" uniqKey="Pankow J" first="James S" last="Pankow">James S. Pankow</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rader, Daniel J" sort="Rader, Daniel J" uniqKey="Rader D" first="Daniel J" last="Rader">Daniel J. Rader</name>
<affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reilly, Muredach P" sort="Reilly, Muredach P" uniqKey="Reilly M" first="Muredach P" last="Reilly">Muredach P. Reilly</name>
<affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schadt, Eric E" sort="Schadt, Eric E" uniqKey="Schadt E" first="Eric E" last="Schadt">Eric E. Schadt</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kottke Marchant, Kandice" sort="Kottke Marchant, Kandice" uniqKey="Kottke Marchant K" first="Kandice" last="Kottke-Marchant">Kandice Kottke-Marchant</name>
<affiliation wicri:level="2"><nlm:affiliation>Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Snyder, Michael" sort="Snyder, Michael" uniqKey="Snyder M" first="Michael" last="Snyder">Michael Snyder</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stanton, Alice V" sort="Stanton, Alice V" uniqKey="Stanton A" first="Alice V" last="Stanton">Alice V. Stanton</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland.</nlm:affiliation>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2</wicri:regionArea>
<wicri:noRegion>Dublin 2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D" last="Tobin">Martin D. Tobin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Health Sciences, University of Leicester, Leicester LE1 7RH</wicri:regionArea>
<wicri:noRegion>Leicester LE1 7RH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Epidemiology and Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Departments of Epidemiology and Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam</wicri:regionArea>
<wicri:noRegion>3015 GE Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name>
<affiliation wicri:level="1"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP</wicri:regionArea>
<wicri:noRegion>Leicester LE3 9QP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name>
<affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D" last="Johnson">Andrew D. Johnson</name>
<affiliation wicri:level="2"><nlm:affiliation>National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA 01702, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA 01702</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhu, Xiaofeng" sort="Zhu, Xiaofeng" uniqKey="Zhu X" first="Xiaofeng" last="Zhu">Xiaofeng Zhu</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I W" last="De Bakker">Paul I W. De Bakker</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA and Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA and Broad Institute of MIT and Harvard, Cambridge, MA 02142</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London WC1E 6BT, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London WC1E 6BT</wicri:regionArea>
<wicri:noRegion>London WC1E 6BT</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B" last="Munroe">Patricia B. Munroe</name>
<affiliation wicri:level="4"><nlm:affiliation>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. Electronic address: p.b.munroe@qmul.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keating, Brendan J" sort="Keating, Brendan J" uniqKey="Keating B" first="Brendan J" last="Keating">Brendan J. Keating</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bkeating@mail.med.upenn.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.</title>
<author><name sortKey="Tragante, Vinicius" sort="Tragante, Vinicius" uniqKey="Tragante V" first="Vinicius" last="Tragante">Vinicius Tragante</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Barnes, Michael R" sort="Barnes, Michael R" uniqKey="Barnes M" first="Michael R" last="Barnes">Michael R. Barnes</name>
<affiliation wicri:level="4"><nlm:affiliation>William Harvey Research Institute National Institute for Health Biomedical Research Unit, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>William Harvey Research Institute National Institute for Health Biomedical Research Unit, Barts and the London School of Medicine, Queen Mary University of London, London EC1M 6BQ</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ganesh, Santhi K" sort="Ganesh, Santhi K" uniqKey="Ganesh S" first="Santhi K" last="Ganesh">Santhi K. Ganesh</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Cardiovascular Medicine, Departments of Internal Medicine and Human Genetics, University of Michigan Health System, Ann Arbor, MI 48109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Cardiovascular Medicine, Departments of Internal Medicine and Human Genetics, University of Michigan Health System, Ann Arbor, MI 48109</wicri:regionArea>
<placeName><region type="state">Michigan</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lanktree, Matthew B" sort="Lanktree, Matthew B" uniqKey="Lanktree M" first="Matthew B" last="Lanktree">Matthew B. Lanktree</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, McMaster University, Hamilton, ON L8S 4L8, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, McMaster University, Hamilton, ON L8S 4L8</wicri:regionArea>
<orgName type="university">Université McMaster</orgName>
<placeName><settlement type="city">Hamilton (Ontario)</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guo, Wei" sort="Guo, Wei" uniqKey="Guo W" first="Wei" last="Guo">Wei Guo</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Franceschini, Nora" sort="Franceschini, Nora" uniqKey="Franceschini N" first="Nora" last="Franceschini">Nora Franceschini</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smith, Erin N" sort="Smith, Erin N" uniqKey="Smith E" first="Erin N" last="Smith">Erin N. Smith</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics and Rady's Children's Hospital, University of California at San Diego, School of Medicine, La Jolla, CA 92093, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pediatrics and Rady's Children's Hospital, University of California at San Diego, School of Medicine, La Jolla, CA 92093</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnson, Toby" sort="Johnson, Toby" uniqKey="Johnson T" first="Toby" last="Johnson">Toby Johnson</name>
<affiliation wicri:level="4"><nlm:affiliation>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Holmes, Michael V" sort="Holmes, Michael V" uniqKey="Holmes M" first="Michael V" last="Holmes">Michael V. Holmes</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name>
<affiliation wicri:level="4"><nlm:affiliation>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Karczewski, Konrad J" sort="Karczewski, Konrad J" uniqKey="Karczewski K" first="Konrad J" last="Karczewski">Konrad J. Karczewski</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Almoguera, Berta" sort="Almoguera, Berta" uniqKey="Almoguera B" first="Berta" last="Almoguera">Berta Almoguera</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Barnard, John" sort="Barnard, John" uniqKey="Barnard J" first="John" last="Barnard">John Barnard</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Baumert, Jens" sort="Baumert, Jens" uniqKey="Baumert J" first="Jens" last="Baumert">Jens Baumert</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764</wicri:regionArea>
<wicri:noRegion>85764</wicri:noRegion>
<wicri:noRegion>85764</wicri:noRegion>
<wicri:noRegion>Neuherberg 85764</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chang, Yen Pei Christy" sort="Chang, Yen Pei Christy" uniqKey="Chang Y" first="Yen-Pei Christy" last="Chang">Yen-Pei Christy Chang</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD 21201, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Medicine and Epidemiology & Public Health, University of Maryland School of Medicine, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Elbers, Clara C" sort="Elbers, Clara C" uniqKey="Elbers C" first="Clara C" last="Elbers">Clara C. Elbers</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Farrall, Martin" sort="Farrall, Martin" uniqKey="Farrall M" first="Martin" last="Farrall">Martin Farrall</name>
<affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fischer, Mary E" sort="Fischer, Mary E" uniqKey="Fischer M" first="Mary E" last="Fischer">Mary E. Fischer</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726</wicri:regionArea>
<placeName><region type="state">Wisconsin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gaunt, Tom R" sort="Gaunt, Tom R" uniqKey="Gaunt T" first="Tom R" last="Gaunt">Tom R. Gaunt</name>
<affiliation wicri:level="1"><nlm:affiliation>MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN</wicri:regionArea>
<wicri:noRegion>Bristol BS8 2BN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gho, Johannes M I H" sort="Gho, Johannes M I H" uniqKey="Gho J" first="Johannes M I H" last="Gho">Johannes M I H. Gho</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gieger, Christian" sort="Gieger, Christian" uniqKey="Gieger C" first="Christian" last="Gieger">Christian Gieger</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764</wicri:regionArea>
<wicri:noRegion>85764</wicri:noRegion>
<wicri:noRegion>85764</wicri:noRegion>
<wicri:noRegion>Neuherberg 85764</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Goel, Anuj" sort="Goel, Anuj" uniqKey="Goel A" first="Anuj" last="Goel">Anuj Goel</name>
<affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gong, Yan" sort="Gong, Yan" uniqKey="Gong Y" first="Yan" last="Gong">Yan Gong</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Isaacs, Aaron" sort="Isaacs, Aaron" uniqKey="Isaacs A" first="Aaron" last="Isaacs">Aaron Isaacs</name>
<affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3015 GE Rotterdam</wicri:regionArea>
<wicri:noRegion>3015 GE Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kleber, Marcus E" sort="Kleber, Marcus E" uniqKey="Kleber M" first="Marcus E" last="Kleber">Marcus E. Kleber</name>
<affiliation wicri:level="3"><nlm:affiliation>Medical Clinic V, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Medical Clinic V, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Mannheim</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mateo Leach, Irene" sort="Mateo Leach, Irene" uniqKey="Mateo Leach I" first="Irene" last="Mateo Leach">Irene Mateo Leach</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mcdonough, Caitrin W" sort="Mcdonough, Caitrin W" uniqKey="Mcdonough C" first="Caitrin W" last="Mcdonough">Caitrin W. Mcdonough</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meijs, Matthijs F L" sort="Meijs, Matthijs F L" uniqKey="Meijs M" first="Matthijs F L" last="Meijs">Matthijs F L. Meijs</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name>
<affiliation wicri:level="1"><nlm:affiliation>Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö 20502, Sweden; Centre of Emergency Medicine, Skåne University Hospital, Malmö 20502, Sweden.</nlm:affiliation>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Hypertension and Cardiovascular Disease, Department of Clinical Sciences, Lund University, Malmö 20502, Sweden; Centre of Emergency Medicine, Skåne University Hospital, Malmö 20502</wicri:regionArea>
<wicri:noRegion>Malmö 20502</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nelson, Christopher P" sort="Nelson, Christopher P" uniqKey="Nelson C" first="Christopher P" last="Nelson">Christopher P. Nelson</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP</wicri:regionArea>
<wicri:noRegion>Leicester LE3 9QP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nolte, Ilja M" sort="Nolte, Ilja M" uniqKey="Nolte I" first="Ilja M" last="Nolte">Ilja M. Nolte</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pankratz, Nathan" sort="Pankratz, Nathan" uniqKey="Pankratz N" first="Nathan" last="Pankratz">Nathan Pankratz</name>
<affiliation wicri:level="2"><nlm:affiliation>Institute of Human Genetics, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute of Human Genetics, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Price, Tom S" sort="Price, Tom S" uniqKey="Price T" first="Tom S" last="Price">Tom S. Price</name>
<affiliation wicri:level="1"><nlm:affiliation>MRC SGDP Centre, Institute of Psychiatry, London SE5 8AF, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC SGDP Centre, Institute of Psychiatry, London SE5 8AF</wicri:regionArea>
<wicri:noRegion>London SE5 8AF</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shaffer, Jonathan" sort="Shaffer, Jonathan" uniqKey="Shaffer J" first="Jonathan" last="Shaffer">Jonathan Shaffer</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Columbia University, New York, NY 10032, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Columbia University, New York, NY 10032</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Shah, Sonia" sort="Shah, Sonia" uniqKey="Shah S" first="Sonia" last="Shah">Sonia Shah</name>
<affiliation wicri:level="4"><nlm:affiliation>UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Kathleen Lonsdale Building, Gower Place, London WC1E 6BT, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>UCL Genetics Institute, Department of Genetics, Evolution and Environment, University College London, Kathleen Lonsdale Building, Gower Place, London WC1E 6BT</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tomaszewski, Maciej" sort="Tomaszewski, Maciej" uniqKey="Tomaszewski M" first="Maciej" last="Tomaszewski">Maciej Tomaszewski</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP</wicri:regionArea>
<wicri:noRegion>Leicester LE3 9QP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Most, Peter J" sort="Van Der Most, Peter J" uniqKey="Van Der Most P" first="Peter J" last="Van Der Most">Peter J. Van Der Most</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Iperen, Erik P A" sort="Van Iperen, Erik P A" uniqKey="Van Iperen E" first="Erik P A" last="Van Iperen">Erik P A. Van Iperen</name>
<affiliation wicri:level="1"><nlm:affiliation>Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vonk, Judith M" sort="Vonk, Judith M" uniqKey="Vonk J" first="Judith M" last="Vonk">Judith M. Vonk</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Witkowska, Kate" sort="Witkowska, Kate" uniqKey="Witkowska K" first="Kate" last="Witkowska">Kate Witkowska</name>
<affiliation wicri:level="4"><nlm:affiliation>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wong, Caroline O L" sort="Wong, Caroline O L" uniqKey="Wong C" first="Caroline O L" last="Wong">Caroline O L. Wong</name>
<affiliation wicri:level="4"><nlm:affiliation>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Beitelshees, Amber L" sort="Beitelshees, Amber L" uniqKey="Beitelshees A" first="Amber L" last="Beitelshees">Amber L. Beitelshees</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Berenson, Gerald S" sort="Berenson, Gerald S" uniqKey="Berenson G" first="Gerald S" last="Berenson">Gerald S. Berenson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology, Tulane University, New Orleans, LA 70118, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Tulane University, New Orleans, LA 70118</wicri:regionArea>
<placeName><region type="state">Louisiane</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bhatt, Deepak L" sort="Bhatt, Deepak L" uniqKey="Bhatt D" first="Deepak L" last="Bhatt">Deepak L. Bhatt</name>
<affiliation wicri:level="2"><nlm:affiliation>Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brown, Morris" sort="Brown, Morris" uniqKey="Brown M" first="Morris" last="Brown">Morris Brown</name>
<affiliation wicri:level="4"><nlm:affiliation>Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Pharmacology Unit, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Burt, Amber" sort="Burt, Amber" uniqKey="Burt A" first="Amber" last="Burt">Amber Burt</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine (Medical Genetics), University of Washington, Seattle, WA 98195, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Medical Genetics), University of Washington, Seattle, WA 98195</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Cooper Dehoff, Rhonda M" sort="Cooper Dehoff, Rhonda M" uniqKey="Cooper Dehoff R" first="Rhonda M" last="Cooper-Dehoff">Rhonda M. Cooper-Dehoff</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Connell, John M" sort="Connell, John M" uniqKey="Connell J" first="John M" last="Connell">John M. Connell</name>
<affiliation wicri:level="1"><nlm:affiliation>University of Dundee, Ninewells Hospital &Medical School, Dundee DD1 9SY, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Dundee, Ninewells Hospital &Medical School, Dundee DD1 9SY</wicri:regionArea>
<wicri:noRegion>Dundee DD1 9SY</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cruickshanks, Karen J" sort="Cruickshanks, Karen J" uniqKey="Cruickshanks K" first="Karen J" last="Cruickshanks">Karen J. Cruickshanks</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA; Department of Population Health Sciences, University of Wisconsin, Madison, WI 53726, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA; Department of Population Health Sciences, University of Wisconsin, Madison, WI 53726</wicri:regionArea>
<placeName><region type="state">Wisconsin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Curtis, Sean P" sort="Curtis, Sean P" uniqKey="Curtis S" first="Sean P" last="Curtis">Sean P. Curtis</name>
<affiliation wicri:level="2"><nlm:affiliation>Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065</wicri:regionArea>
<placeName><region type="state">New Jersey</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davey Smith, George" sort="Davey Smith, George" uniqKey="Davey Smith G" first="George" last="Davey-Smith">George Davey-Smith</name>
<affiliation wicri:level="1"><nlm:affiliation>MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>MRC Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN</wicri:regionArea>
<wicri:noRegion>Bristol BS8 2BN</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Delles, Christian" sort="Delles, Christian" uniqKey="Delles C" first="Christian" last="Delles">Christian Delles</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gansevoort, Ron T" sort="Gansevoort, Ron T" uniqKey="Gansevoort R" first="Ron T" last="Gansevoort">Ron T. Gansevoort</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Nephrology, Department of Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Division of Nephrology, Department of Medicine, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Guo, Xiuqing" sort="Guo, Xiuqing" uniqKey="Guo X" first="Xiuqing" last="Guo">Xiuqing Guo</name>
<affiliation wicri:level="2"><nlm:affiliation>Cedars-Sinai Med Ctr-PEDS, Los Angeles, CA 90048, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cedars-Sinai Med Ctr-PEDS, Los Angeles, CA 90048</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Haiqing, Shen" sort="Haiqing, Shen" uniqKey="Haiqing S" first="Shen" last="Haiqing">Shen Haiqing</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hastie, Claire E" sort="Hastie, Claire E" uniqKey="Hastie C" first="Claire E" last="Hastie">Claire E. Hastie</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hofker, Marten H" sort="Hofker, Marten H" uniqKey="Hofker M" first="Marten H" last="Hofker">Marten H. Hofker</name>
<affiliation wicri:level="1"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Department Pathology and Medical Biology, Medical Biology Division, Molecular Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Department Pathology and Medical Biology, Medical Biology Division, Molecular Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<wicri:noRegion>9700 RB Groningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hovingh, G Kees" sort="Hovingh, G Kees" uniqKey="Hovingh G" first="G Kees" last="Hovingh">G Kees Hovingh</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kim, Daniel S" sort="Kim, Daniel S" uniqKey="Kim D" first="Daniel S" last="Kim">Daniel S. Kim</name>
<affiliation wicri:level="4"><nlm:affiliation>Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington, Seattle, WA 98195</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Kirkland, Susan A" sort="Kirkland, Susan A" uniqKey="Kirkland S" first="Susan A" last="Kirkland">Susan A. Kirkland</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS B3H 1V7, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Community Health and Epidemiology, Dalhousie University, Halifax, NS B3H 1V7</wicri:regionArea>
<wicri:noRegion>NS B3H 1V7</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Klein, Barbara E" sort="Klein, Barbara E" uniqKey="Klein B" first="Barbara E" last="Klein">Barbara E. Klein</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726</wicri:regionArea>
<placeName><region type="state">Wisconsin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Klein, Ronald" sort="Klein, Ronald" uniqKey="Klein R" first="Ronald" last="Klein">Ronald Klein</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI 53726</wicri:regionArea>
<placeName><region type="state">Wisconsin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Yun R" sort="Li, Yun R" uniqKey="Li Y" first="Yun R" last="Li">Yun R. Li</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Maiwald, Steffi" sort="Maiwald, Steffi" uniqKey="Maiwald S" first="Steffi" last="Maiwald">Steffi Maiwald</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Newton Cheh, Christopher" sort="Newton Cheh, Christopher" uniqKey="Newton Cheh C" first="Christopher" last="Newton-Cheh">Christopher Newton-Cheh</name>
<affiliation wicri:level="2"><nlm:affiliation>Broad Institute of Harvard and MIT, Massachusetts General Hospital, Boston, MA 02142, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Broad Institute of Harvard and MIT, Massachusetts General Hospital, Boston, MA 02142</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Brien, Eoin T" sort="O Brien, Eoin T" uniqKey="O Brien E" first="Eoin T" last="O'Brien">Eoin T. O'Brien</name>
<affiliation wicri:level="1"><nlm:affiliation>Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland.</nlm:affiliation>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4</wicri:regionArea>
<wicri:noRegion>Dublin 4</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Onland Moret, N Charlotte" sort="Onland Moret, N Charlotte" uniqKey="Onland Moret N" first="N Charlotte" last="Onland-Moret">N Charlotte Onland-Moret</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Palmas, Walter" sort="Palmas, Walter" uniqKey="Palmas W" first="Walter" last="Palmas">Walter Palmas</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Columbia University, New York, NY 10032, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Columbia University, New York, NY 10032</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Parsa, Afshin" sort="Parsa, Afshin" uniqKey="Parsa A" first="Afshin" last="Parsa">Afshin Parsa</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Penninx, Brenda W" sort="Penninx, Brenda W" uniqKey="Penninx B" first="Brenda W" last="Penninx">Brenda W. Penninx</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry/EMGO Institute, VU University Medical Centre, 1081 BT Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Psychiatry/EMGO Institute, VU University Medical Centre, 1081 BT Amsterdam</wicri:regionArea>
<wicri:noRegion>1081 BT Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pettinger, Mary" sort="Pettinger, Mary" uniqKey="Pettinger M" first="Mary" last="Pettinger">Mary Pettinger</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vasan, Ramachandran S" sort="Vasan, Ramachandran S" uniqKey="Vasan R" first="Ramachandran S" last="Vasan">Ramachandran S. Vasan</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Boston University School of Medicine, Framingham, MA 02118, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Boston University School of Medicine, Framingham, MA 02118</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ranchalis, Jane E" sort="Ranchalis, Jane E" uniqKey="Ranchalis J" first="Jane E" last="Ranchalis">Jane E. Ranchalis</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine (Medical Genetics), University of Washington, Seattle, WA 98195, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine (Medical Genetics), University of Washington, Seattle, WA 98195</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="M Ridker, Paul" sort="M Ridker, Paul" uniqKey="M Ridker P" first="Paul" last="M Ridker">Paul M Ridker</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rose, Lynda M" sort="Rose, Lynda M" uniqKey="Rose L" first="Lynda M" last="Rose">Lynda M. Rose</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Sever, Peter" sort="Sever, Peter" uniqKey="Sever P" first="Peter" last="Sever">Peter Sever</name>
<affiliation><nlm:affiliation>International Centre for Circulatory Health, Imperial College London, W2 1LA UK.</nlm:affiliation>
<wicri:noCountry code="subField">W2 1LA UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shimbo, Daichi" sort="Shimbo, Daichi" uniqKey="Shimbo D" first="Daichi" last="Shimbo">Daichi Shimbo</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, Columbia University, New York, NY 10032, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Columbia University, New York, NY 10032</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Steele, Laura" sort="Steele, Laura" uniqKey="Steele L" first="Laura" last="Steele">Laura Steele</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stolk, Ronald P" sort="Stolk, Ronald P" uniqKey="Stolk R" first="Ronald P" last="Stolk">Ronald P. Stolk</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thorand, Barbara" sort="Thorand, Barbara" uniqKey="Thorand B" first="Barbara" last="Thorand">Barbara Thorand</name>
<affiliation wicri:level="1"><nlm:affiliation>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764</wicri:regionArea>
<wicri:noRegion>85764</wicri:noRegion>
<wicri:noRegion>85764</wicri:noRegion>
<wicri:noRegion>Neuherberg 85764</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Trip, Mieke D" sort="Trip, Mieke D" uniqKey="Trip M" first="Mieke D" last="Trip">Mieke D. Trip</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, 3015 GE Rotterdam</wicri:regionArea>
<wicri:noRegion>3015 GE Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Verschuren, W Monique" sort="Verschuren, W Monique" uniqKey="Verschuren W" first="W Monique" last="Verschuren">W Monique Verschuren</name>
<affiliation wicri:level="1"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; National Institute for Public Health and the Environment (RIVM), 3720 BA Bilthoven</wicri:regionArea>
<wicri:noRegion>3720 BA Bilthoven</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wijmenga, Cisca" sort="Wijmenga, Cisca" uniqKey="Wijmenga C" first="Cisca" last="Wijmenga">Cisca Wijmenga</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wyatt, Sharon" sort="Wyatt, Sharon" uniqKey="Wyatt S" first="Sharon" last="Wyatt">Sharon Wyatt</name>
<affiliation wicri:level="2"><nlm:affiliation>Schools of Nursing and Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Schools of Nursing and Medicine, University of Mississippi Medical Center, Jackson, MS 39216</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Young, J Hunter" sort="Young, J Hunter" uniqKey="Young J" first="J Hunter" last="Young">J Hunter Young</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zwinderman, Aeilko H" sort="Zwinderman, Aeilko H" uniqKey="Zwinderman A" first="Aeilko H" last="Zwinderman">Aeilko H. Zwinderman</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bezzina, Connie R" sort="Bezzina, Connie R" uniqKey="Bezzina C" first="Connie R" last="Bezzina">Connie R. Bezzina</name>
<affiliation wicri:level="1"><nlm:affiliation>Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands; Molecular and Experimental Cardiology Group, Academic Medical Centre, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Heart Failure Research Center, Department of Clinical and Experimental Cardiology, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands; Molecular and Experimental Cardiology Group, Academic Medical Centre, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name>
<affiliation wicri:level="2"><nlm:affiliation>Human Genetics Center and Institute of Molecular Medicine and Division of Epidemiology, University of Texas Health Science Center, Houston, TX 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Human Genetics Center and Institute of Molecular Medicine and Division of Epidemiology, University of Texas Health Science Center, Houston, TX 77030</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Casas, Juan P" sort="Casas, Juan P" uniqKey="Casas J" first="Juan P" last="Casas">Juan P. Casas</name>
<affiliation wicri:level="4"><nlm:affiliation>Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK; Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK; Genetic Epidemiology Group, Department of Epidemiology and Public Health, University College London, London WC1E 6BT</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Caulfield, Mark J" sort="Caulfield, Mark J" uniqKey="Caulfield M" first="Mark J" last="Caulfield">Mark J. Caulfield</name>
<affiliation wicri:level="4"><nlm:affiliation>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chakravarti, Aravinda" sort="Chakravarti, Aravinda" uniqKey="Chakravarti A" first="Aravinda" last="Chakravarti">Aravinda Chakravarti</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chasman, Daniel I" sort="Chasman, Daniel I" uniqKey="Chasman D" first="Daniel I" last="Chasman">Daniel I. Chasman</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Davidson, Karina W" sort="Davidson, Karina W" uniqKey="Davidson K" first="Karina W" last="Davidson">Karina W. Davidson</name>
<affiliation wicri:level="4"><nlm:affiliation>Departments of Medicine & Psychiatry, Columbia University, New York, NY 10032, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Medicine & Psychiatry, Columbia University, New York, NY 10032</wicri:regionArea>
<placeName><region type="state">État de New York</region>
<settlement type="city">New York</settlement>
</placeName>
<orgName type="university">Université Columbia</orgName>
</affiliation>
</author>
<author><name sortKey="Doevendans, Pieter A" sort="Doevendans, Pieter A" uniqKey="Doevendans P" first="Pieter A" last="Doevendans">Pieter A. Doevendans</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F" last="Dominiczak">Anna F. Dominiczak</name>
<affiliation wicri:level="4"><nlm:affiliation>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA</wicri:regionArea>
<orgName type="university">Université de Glasgow</orgName>
<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fitzgerald, Garret A" sort="Fitzgerald, Garret A" uniqKey="Fitzgerald G" first="Garret A" last="Fitzgerald">Garret A. Fitzgerald</name>
<affiliation wicri:level="2"><nlm:affiliation>The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gums, John G" sort="Gums, John G" uniqKey="Gums J" first="John G" last="Gums">John G. Gums</name>
<affiliation wicri:level="2"><nlm:affiliation>Departments of Pharmacotherapy and Translational Research and Community Health and Family Medicine, University of Florida, Gainesville, FL 32610, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Pharmacotherapy and Translational Research and Community Health and Family Medicine, University of Florida, Gainesville, FL 32610</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="2"><nlm:affiliation>Institute of Molecular Medicine and School of Public Health Division of Epidemiology Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Institute of Molecular Medicine and School of Public Health Division of Epidemiology Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030</wicri:regionArea>
<placeName><region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hakonarson, Hakon" sort="Hakonarson, Hakon" uniqKey="Hakonarson H" first="Hakon" last="Hakonarson">Hakon Hakonarson</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Halder, Indrani" sort="Halder, Indrani" uniqKey="Halder I" first="Indrani" last="Halder">Indrani Halder</name>
<affiliation wicri:level="4"><nlm:affiliation>School of Medicine, University of Pittsburgh, PA 15261, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Medicine, University of Pittsburgh, PA 15261</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">Pittsburgh</settlement>
</placeName>
<orgName type="university">Université de Pittsburgh</orgName>
</affiliation>
</author>
<author><name sortKey="Hillege, Hans L" sort="Hillege, Hans L" uniqKey="Hillege H" first="Hans L" last="Hillege">Hans L. Hillege</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Illig, Thomas" sort="Illig, Thomas" uniqKey="Illig T" first="Thomas" last="Illig">Thomas Illig</name>
<affiliation wicri:level="3"><nlm:affiliation>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Hannover Unified Biobank, Hannover Medical School, Hannover 30625</wicri:regionArea>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Hanovre</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jarvik, Gail P" sort="Jarvik, Gail P" uniqKey="Jarvik G" first="Gail P" last="Jarvik">Gail P. Jarvik</name>
<affiliation><nlm:affiliation>International Centre for Circulatory Health, Imperial College London, W2 1LA UK.</nlm:affiliation>
<wicri:noCountry code="subField">W2 1LA UK</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Johnson, Julie A" sort="Johnson, Julie A" uniqKey="Johnson J" first="Julie A" last="Johnson">Julie A. Johnson</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL 32610</wicri:regionArea>
<placeName><region type="state">Floride</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kastelein, John J P" sort="Kastelein, John J P" uniqKey="Kastelein J" first="John J P" last="Kastelein">John J P. Kastelein</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Vascular Medicine, Academic Medical Center, 1105 AZ Amsterdam</wicri:regionArea>
<wicri:noRegion>1105 AZ Amsterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Koenig, Wolfgang" sort="Koenig, Wolfgang" uniqKey="Koenig W" first="Wolfgang" last="Koenig">Wolfgang Koenig</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm 89081, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm 89081</wicri:regionArea>
<wicri:noRegion>89081</wicri:noRegion>
<wicri:noRegion>89081</wicri:noRegion>
<wicri:noRegion>Ulm 89081</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kumari, Meena" sort="Kumari, Meena" uniqKey="Kumari M" first="Meena" last="Kumari">Meena Kumari</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology and Public Health, Division of Population Health, University College London, Torrington Place, London WC1E 7HB, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Epidemiology and Public Health, Division of Population Health, University College London, Torrington Place, London WC1E 7HB</wicri:regionArea>
<orgName type="university">University College de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="M Rz, Winfried" sort="M Rz, Winfried" uniqKey="M Rz W" first="Winfried" last="M Rz">Winfried M Rz</name>
<affiliation wicri:level="1"><nlm:affiliation>Medical Clinic V, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany; Synlab Academy, Synlab Services GmbH, Mannheim 69214, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Medical Clinic V, Medical Faculty Mannheim, Heidelberg University, Mannheim 68167, Germany; Synlab Academy, Synlab Services GmbH, Mannheim 69214, Germany; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz 8036</wicri:regionArea>
<wicri:noRegion>Graz 8036</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Murray, Sarah S" sort="Murray, Sarah S" uniqKey="Murray S" first="Sarah S" last="Murray">Sarah S. Murray</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of California San Diego, La Jolla, CA 92037, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Pathology, University of California San Diego, La Jolla, CA 92037</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Connell, Jeffery R" sort="O Connell, Jeffery R" uniqKey="O Connell J" first="Jeffery R" last="O'Connell">Jeffery R. O'Connell</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Oldehinkel, Albertine J" sort="Oldehinkel, Albertine J" uniqKey="Oldehinkel A" first="Albertine J" last="Oldehinkel">Albertine J. Oldehinkel</name>
<affiliation wicri:level="4"><nlm:affiliation>Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pankow, James S" sort="Pankow, James S" uniqKey="Pankow J" first="James S" last="Pankow">James S. Pankow</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Rader, Daniel J" sort="Rader, Daniel J" uniqKey="Rader D" first="Daniel J" last="Rader">Daniel J. Rader</name>
<affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Redline, Susan" sort="Redline, Susan" uniqKey="Redline S" first="Susan" last="Redline">Susan Redline</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02215</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reilly, Muredach P" sort="Reilly, Muredach P" uniqKey="Reilly M" first="Muredach P" last="Reilly">Muredach P. Reilly</name>
<affiliation wicri:level="2"><nlm:affiliation>Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Institute, the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schadt, Eric E" sort="Schadt, Eric E" uniqKey="Schadt E" first="Eric E" last="Schadt">Eric E. Schadt</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, NY 10029</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kottke Marchant, Kandice" sort="Kottke Marchant, Kandice" uniqKey="Kottke Marchant K" first="Kandice" last="Kottke-Marchant">Kandice Kottke-Marchant</name>
<affiliation wicri:level="2"><nlm:affiliation>Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Snieder, Harold" sort="Snieder, Harold" uniqKey="Snieder H" first="Harold" last="Snieder">Harold Snieder</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Snyder, Michael" sort="Snyder, Michael" uniqKey="Snyder M" first="Michael" last="Snyder">Michael Snyder</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Stanton, Alice V" sort="Stanton, Alice V" uniqKey="Stanton A" first="Alice V" last="Stanton">Alice V. Stanton</name>
<affiliation wicri:level="1"><nlm:affiliation>Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2, Ireland.</nlm:affiliation>
<country xml:lang="fr">Irlande (pays)</country>
<wicri:regionArea>Molecular & Cellular Therapeutics, Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2</wicri:regionArea>
<wicri:noRegion>Dublin 2</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tobin, Martin D" sort="Tobin, Martin D" uniqKey="Tobin M" first="Martin D" last="Tobin">Martin D. Tobin</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Health Sciences, University of Leicester, Leicester LE1 7RH, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Health Sciences, University of Leicester, Leicester LE1 7RH</wicri:regionArea>
<wicri:noRegion>Leicester LE1 7RH</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="André G" last="Uitterlinden">André G. Uitterlinden</name>
<affiliation wicri:level="1"><nlm:affiliation>Departments of Epidemiology and Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Departments of Epidemiology and Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam</wicri:regionArea>
<wicri:noRegion>3015 GE Rotterdam</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Harst, Pim" sort="Van Der Harst, Pim" uniqKey="Van Der Harst P" first="Pim" last="Van Der Harst">Pim Van Der Harst</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Department of Cardiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Department of Genetics, University of Groningen, University Medical Center Groningen, 9700 RB Groningen</wicri:regionArea>
<orgName type="university">Université de Groningue</orgName>
<placeName><settlement type="city">Groningue (ville)</settlement>
<region>Groningue (province)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Van Der Schouw, Yvonne T" sort="Van Der Schouw, Yvonne T" uniqKey="Van Der Schouw Y" first="Yvonne T" last="Van Der Schouw">Yvonne T. Van Der Schouw</name>
<affiliation wicri:level="1"><nlm:affiliation>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands.</nlm:affiliation>
<country xml:lang="fr" wicri:curation="lc">Pays-Bas</country>
<wicri:regionArea>Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht</wicri:regionArea>
<wicri:noRegion>3584 CX Utrecht</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Samani, Nilesh J" sort="Samani, Nilesh J" uniqKey="Samani N" first="Nilesh J" last="Samani">Nilesh J. Samani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester LE3 9QP</wicri:regionArea>
<wicri:noRegion>Leicester LE3 9QP</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Watkins, Hugh" sort="Watkins, Hugh" uniqKey="Watkins H" first="Hugh" last="Watkins">Hugh Watkins</name>
<affiliation wicri:level="4"><nlm:affiliation>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford OX3 9DU</wicri:regionArea>
<orgName type="university">Université d'Oxford</orgName>
<placeName><settlement type="city">Oxford</settlement>
<region type="nation">Angleterre</region>
<region type="région" nuts="1">Oxfordshire</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Johnson, Andrew D" sort="Johnson, Andrew D" uniqKey="Johnson A" first="Andrew D" last="Johnson">Andrew D. Johnson</name>
<affiliation wicri:level="2"><nlm:affiliation>National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA 01702, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA 01702</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reiner, Alex P" sort="Reiner, Alex P" uniqKey="Reiner A" first="Alex P" last="Reiner">Alex P. Reiner</name>
<affiliation wicri:level="2"><nlm:affiliation>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhu, Xiaofeng" sort="Zhu, Xiaofeng" uniqKey="Zhu X" first="Xiaofeng" last="Zhu">Xiaofeng Zhu</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106</wicri:regionArea>
<placeName><region type="state">Ohio</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="De Bakker, Paul I W" sort="De Bakker, Paul I W" uniqKey="De Bakker P" first="Paul I W" last="De Bakker">Paul I W. De Bakker</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA and Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA and Broad Institute of MIT and Harvard, Cambridge, MA 02142</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name>
<affiliation wicri:level="2"><nlm:affiliation>Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Asselbergs, Folkert W" sort="Asselbergs, Folkert W" uniqKey="Asselbergs F" first="Folkert W" last="Asselbergs">Folkert W. Asselbergs</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London WC1E 6BT, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, 3584 CX Utrecht, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, 3511 GC Utrecht, the Netherlands; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London WC1E 6BT</wicri:regionArea>
<wicri:noRegion>London WC1E 6BT</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Munroe, Patricia B" sort="Munroe, Patricia B" uniqKey="Munroe P" first="Patricia B" last="Munroe">Patricia B. Munroe</name>
<affiliation wicri:level="4"><nlm:affiliation>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK. Electronic address: p.b.munroe@qmul.ac.uk.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ</wicri:regionArea>
<orgName type="university">Université de Londres</orgName>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Keating, Brendan J" sort="Keating, Brendan J" uniqKey="Keating B" first="Brendan J" last="Keating">Brendan J. Keating</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: bkeating@mail.med.upenn.edu.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">American journal of human genetics</title>
<idno type="eISSN">1537-6605</idno>
<imprint><date when="2014" type="published">2014</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arterial Pressure</term>
<term>Blood Pressure</term>
<term>Computational Biology (methods)</term>
<term>Diastole</term>
<term>Europe</term>
<term>European Continental Ancestry Group (genetics)</term>
<term>Genetic Loci</term>
<term>Genetics, Population</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Phenotype</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Quality Control</term>
<term>Quantitative Trait Loci</term>
<term>Risk Factors</term>
<term>Systole</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Biologie informatique ()</term>
<term>Contrôle de qualité</term>
<term>Diastole</term>
<term>Europe</term>
<term>Facteurs de risque</term>
<term>Génotype</term>
<term>Génétique des populations</term>
<term>Humains</term>
<term>Locus de caractère quantitatif</term>
<term>Locus génétiques</term>
<term>Phénotype</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Population d'origine européenne (génétique)</term>
<term>Pression artérielle</term>
<term>Pression sanguine</term>
<term>Systole</term>
<term>Étude d'association pangénomique</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Europe</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>European Continental Ancestry Group</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Population d'origine européenne</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Computational Biology</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Arterial Pressure</term>
<term>Blood Pressure</term>
<term>Diastole</term>
<term>Genetic Loci</term>
<term>Genetics, Population</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Phenotype</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Quality Control</term>
<term>Quantitative Trait Loci</term>
<term>Risk Factors</term>
<term>Systole</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Biologie informatique</term>
<term>Contrôle de qualité</term>
<term>Diastole</term>
<term>Europe</term>
<term>Facteurs de risque</term>
<term>Génotype</term>
<term>Génétique des populations</term>
<term>Humains</term>
<term>Locus de caractère quantitatif</term>
<term>Locus génétiques</term>
<term>Phénotype</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Pression artérielle</term>
<term>Pression sanguine</term>
<term>Systole</term>
<term>Étude d'association pangénomique</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ~50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of European ancestry. Our analyses identified 11 previously undescribed associations in independent loci containing 31 genes including PDE1A, HLA-DQB1, CDK6, PRKAG2, VCL, H19, NUCB2, RELA, HOXC@ complex, FBN1, and NFAT5 at the Bonferroni-corrected array-wide significance threshold (p < 6 × 10(-7)) and confirmed 27 previously reported associations. Bioinformatic analysis of the 11 loci provided support for a putative role in hypertension of several genes, such as CDK6 and NUCB2. Analysis of potential pharmacological targets in databases of small molecules showed that ten of the genes are predicted to be a target for small molecules. In summary, we identified previously unknown loci associated with BP. Our findings extend our understanding of genes involved in BP regulation, which may provide new targets for therapeutic intervention or drug response stratification.</div>
</front>
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