Leptin, Adiponectin, and Heart Rate Variability Among Police Officers
Identifieur interne : 003816 ( Ncbi/Checkpoint ); précédent : 003815; suivant : 003817Leptin, Adiponectin, and Heart Rate Variability Among Police Officers
Auteurs : Luenda E. Charles [États-Unis] ; Cecil M. Burchfiel [États-Unis] ; Khachatur Sarkisian [États-Unis] ; Shengqiao Li [États-Unis] ; Diane B. Miller [États-Unis] ; Ja K. Gu [États-Unis] ; Desta Fekedulegn [États-Unis] ; John M. Violanti [États-Unis] ; Michael E. Andrew [États-Unis]Source :
- American journal of human biology : the official journal of the Human Biology Council [ 1042-0533 ] ; 2014.
Abstract
Police officers have a high prevalence of cardiovascular disease (CVD). Reduced heart rate variability (HRV) is known to increase CVD risk. Leptin and adiponectin may be related to CVD health. Therefore, our objective was to investigate the relationship between these variables and HRV.
Leptin and adiponectin levels were measured in 388 officers from the Buffalo Cardio-Metabolic Occupational Police Stress study. HRV was assessed according to methods published by the Task Force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology for measurement and analysis of HRV. Mean values of high-frequency (HF) and low-frequency (LF) HRV were compared across tertiles of leptin and adiponectin using analysis of variance and analysis of covariance; trends were assessed using linear regression models.
Leptin, but not adiponectin, was significantly and inversely associated with HRV. Body mass index (BMI) and percent body fat significantly modified the association between leptin and LF (but not HF) HRV. Among officers with BMI < 25 kg/m2, leptin was not significantly associated with HRV. However, among officers with BMI ≥ 25 kg/m2, leptin was inversely associated with HRV, after adjustment for age, gender, and race/ethnicity; HF HRV,
Leptin levels were inversely associated with LF HRV, especially among officers with increased adiposity. Increased leptin levels may be associated with CVD-related health problems.
Url:
DOI: 10.1002/ajhb.22636
PubMed: 25270126
PubMed Central: 4699294
Affiliations:
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<author><name sortKey="Gu, Ja K" sort="Gu, Ja K" uniqKey="Gu J" first="Ja K." last="Gu">Ja K. Gu</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie-Occidentale</region>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie-Occidentale</region>
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<author><name sortKey="Violanti, John M" sort="Violanti, John M" uniqKey="Violanti J" first="John M." last="Violanti">John M. Violanti</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, New York</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">État de New York</region>
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<wicri:cityArea>Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo</wicri:cityArea>
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<author><name sortKey="Andrew, Michael E" sort="Andrew, Michael E" uniqKey="Andrew M" first="Michael E." last="Andrew">Michael E. Andrew</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Virginie-Occidentale</region>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title>
<p id="P1">Police officers have a high prevalence of cardiovascular disease (CVD). Reduced heart rate variability (HRV) is known to increase CVD risk. Leptin and adiponectin may be related to CVD health. Therefore, our objective was to investigate the relationship between these variables and HRV.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Leptin and adiponectin levels were measured in 388 officers from the Buffalo Cardio-Metabolic Occupational Police Stress study. HRV was assessed according to methods published by the Task Force of the European Society of Cardiology and the North American Society of Pacing Electrophysiology for measurement and analysis of HRV. Mean values of high-frequency (HF) and low-frequency (LF) HRV were compared across tertiles of leptin and adiponectin using analysis of variance and analysis of covariance; trends were assessed using linear regression models.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Leptin, but not adiponectin, was significantly and inversely associated with HRV. Body mass index (BMI) and percent body fat significantly modified the association between leptin and LF (but not HF) HRV. Among officers with BMI < 25 kg/m<sup>2</sup>
, leptin was not significantly associated with HRV. However, among officers with BMI ≥ 25 kg/m<sup>2</sup>
, leptin was inversely associated with HRV, after adjustment for age, gender, and race/ethnicity; HF HRV, <italic>P</italic>
= 0.019 and LF HRV, <italic>P</italic>
< 0.0001. Similarly, among officers with percent body fat ≥ 25.5%, leptin and LF HRV showed significant, inverse associations (adjusted <italic>P</italic>
= 0.001).</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Leptin levels were inversely associated with LF HRV, especially among officers with increased adiposity. Increased leptin levels may be associated with CVD-related health problems.</p>
</sec>
</div>
</front>
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<affiliations><list><country><li>États-Unis</li>
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<region><li>Pennsylvanie</li>
<li>Virginie-Occidentale</li>
<li>État de New York</li>
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<tree><country name="États-Unis"><region name="Virginie-Occidentale"><name sortKey="Charles, Luenda E" sort="Charles, Luenda E" uniqKey="Charles L" first="Luenda E." last="Charles">Luenda E. Charles</name>
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<name sortKey="Burchfiel, Cecil M" sort="Burchfiel, Cecil M" uniqKey="Burchfiel C" first="Cecil M." last="Burchfiel">Cecil M. Burchfiel</name>
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<name sortKey="Gu, Ja K" sort="Gu, Ja K" uniqKey="Gu J" first="Ja K." last="Gu">Ja K. Gu</name>
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<name sortKey="Miller, Diane B" sort="Miller, Diane B" uniqKey="Miller D" first="Diane B." last="Miller">Diane B. Miller</name>
<name sortKey="Sarkisian, Khachatur" sort="Sarkisian, Khachatur" uniqKey="Sarkisian K" first="Khachatur" last="Sarkisian">Khachatur Sarkisian</name>
<name sortKey="Violanti, John M" sort="Violanti, John M" uniqKey="Violanti J" first="John M." last="Violanti">John M. Violanti</name>
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