PittsburghV1, Main, Merge, bibRecord, 00B689

Haplotypes of the monoamine oxidase genes and the risk for substance use disorders

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Haplotypes of the monoamine oxidase genes and the risk for substance use disorders

Auteurs : Michael M. Vanyukov [États-Unis] ; Brion S. Maher [États-Unis] ; Bernie Devlin [États-Unis] ; Ralph E. Tarter [États-Unis] ; Galina P. Kirillova [États-Unis] ; Ling-Mei Yu [États-Unis] ; Robert E. Ferrell [États-Unis]

Source :

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2004-02-15.

RBID : ISTEX:ED4261A58CF1BA2E6CFA5C6544F712638A147451

Descripteurs français

Wicri :
- topic : Génétique.

English descriptors

Abstract

Monoamine oxidase A (MAOA) locus is an attractive candidate for exploring genetic contribution to the variation in the risk for substance use disorders (SUD) because of its important role in the metabolism of neurotransmitters, including dopamine and serotonin. Prior findings have suggested an association of the MAOA gene with the risk for early onset SUD. To extend this research, we genotyped four MAOA markers (two VNTR polymorphisms and two SNPs) and built a cladogram reflecting the evolutionary history of MAOA haplotypes [Nguyen et al., under review]. The cladogram served as the framework for nested ANOVA and logit analyses of association between MAOA and indices of liability to SUD (diagnosis, age of onset, and a dimensional index of substance use related problems) in a sample of adult males of European ancestry. Whereas no association was found for the categorical diagnosis, a significant relationship was detected between the dimensional liability indices and MAOA haplotypes. Overall, our results, albeit not definitive, are consistent with the hypothesis that variants in MAOA account for a small portion of the variance of SUD risk, possibly mediated by liability to early onset behavioral problems. © 2003 Wiley‐Liss, Inc.

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https://api.istex.fr/document/ED4261A58CF1BA2E6CFA5C6544F712638A147451/fulltext/pdf

DOI: 10.1002/ajmg.b.20105

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<term>Behavioral characteristics</term>
<term>Best estimate procedure</term>
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<term>Clade</term>
<term>Clade level</term>
<term>Cladistic analysis</term>
<term>Cladogram</term>
<term>Cladogram structure</term>
<term>Clinical interview</term>
<term>Common liability</term>
<term>Different indices</term>
<term>Dimensional index</term>
<term>Dopamine system genes</term>
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<term>Drug alcohol abuse tarter</term>
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<term>Early onset</term>
<term>European ancestry</term>
<term>Evolutionary history</term>
<term>Evolutionary relationships</term>
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<term>Genetic contribution</term>
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<term>Genetics templeton</term>
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<term>Highest levels</term>
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<front><div type="abstract" xml:lang="fr">Monoamine oxidase A (MAOA) locus is an attractive candidate for exploring genetic contribution to the variation in the risk for substance use disorders (SUD) because of its important role in the metabolism of neurotransmitters, including dopamine and serotonin. Prior findings have suggested an association of the MAOA gene with the risk for early onset SUD. To extend this research, we genotyped four MAOA markers (two VNTR polymorphisms and two SNPs) and built a cladogram reflecting the evolutionary history of MAOA haplotypes [Nguyen et al., under review]. The cladogram served as the framework for nested ANOVA and logit analyses of association between MAOA and indices of liability to SUD (diagnosis, age of onset, and a dimensional index of substance use related problems) in a sample of adult males of European ancestry. Whereas no association was found for the categorical diagnosis, a significant relationship was detected between the dimensional liability indices and MAOA haplotypes. Overall, our results, albeit not definitive, are consistent with the hypothesis that variants in MAOA account for a small portion of the variance of SUD risk, possibly mediated by liability to early onset behavioral problems. © 2003 Wiley‐Liss, Inc.</div>
</front>
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Haplotypes of the monoamine oxidase genes and the risk for substance use disorders

Haplotypes of the monoamine oxidase genes and the risk for substance use disorders

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri