Haplotypes of the monoamine oxidase genes and the risk for substance use disorders
Identifieur interne : 003862 ( Istex/Curation ); précédent : 003861; suivant : 003863Haplotypes of the monoamine oxidase genes and the risk for substance use disorders
Auteurs : Michael M. Vanyukov [États-Unis] ; Brion S. Maher [États-Unis] ; Bernie Devlin [États-Unis] ; Ralph E. Tarter [États-Unis] ; Galina P. Kirillova [États-Unis] ; Ling-Mei Yu [États-Unis] ; Robert E. Ferrell [États-Unis]Source :
- American Journal of Medical Genetics Part B: Neuropsychiatric Genetics [ 1552-4841 ] ; 2004-02-15.
Descripteurs français
- Wicri :
- topic : Génétique.
English descriptors
- KwdEn :
- Adult males, Allele, Behavioral characteristics, Best estimate procedure, Candidate genes, Clade, Clade level, Cladistic analysis, Cladogram, Cladogram structure, Clinical interview, Common liability, Different indices, Dimensional index, Dopamine system genes, Drug abuse, Drug abuse research, Drug alcohol abuse tarter, Dusi, Early onset, European ancestry, Evolutionary history, Evolutionary relationships, Frequent haplotypes, Genet, Genetic contribution, Genetics, Genetics templeton, Haplotype, Haplotype analysis, Highest levels, Human monoamine oxidase, Important role, Large proportion, Logit analyses, Maoa, Maoa exon, Maoa gene, Maoa haplotypes, Maoa polymorphisms, Monoamine, Monoamine oxidase, Monoamine oxidase locus, Monte carlo tests, Nguyen, Nucleotide position, Oxidase, Phenotypic associations, Pittsburgh school, Polymorphism, Population substructure devlin, Promoter, Promoter region, Quantitative traits, Restriction endonuclease mapping, Screening inventory, Single polymorphisms, Substance abuse, Tarter, Templeton, Unaffected sample, Vanyukov, Vntr, Vntr polymorphism, Vntr polymorphisms.
- Teeft :
- Adult males, Allele, Behavioral characteristics, Best estimate procedure, Candidate genes, Clade, Clade level, Cladistic analysis, Cladogram, Cladogram structure, Clinical interview, Common liability, Different indices, Dimensional index, Dopamine system genes, Drug abuse, Drug abuse research, Drug alcohol abuse tarter, Dusi, Early onset, European ancestry, Evolutionary history, Evolutionary relationships, Frequent haplotypes, Genet, Genetic contribution, Genetics, Genetics templeton, Haplotype, Haplotype analysis, Highest levels, Human monoamine oxidase, Important role, Large proportion, Logit analyses, Maoa, Maoa exon, Maoa gene, Maoa haplotypes, Maoa polymorphisms, Monoamine, Monoamine oxidase, Monoamine oxidase locus, Monte carlo tests, Nguyen, Nucleotide position, Oxidase, Phenotypic associations, Pittsburgh school, Polymorphism, Population substructure devlin, Promoter, Promoter region, Quantitative traits, Restriction endonuclease mapping, Screening inventory, Single polymorphisms, Substance abuse, Tarter, Templeton, Unaffected sample, Vanyukov, Vntr, Vntr polymorphism, Vntr polymorphisms.
Abstract
Monoamine oxidase A (MAOA) locus is an attractive candidate for exploring genetic contribution to the variation in the risk for substance use disorders (SUD) because of its important role in the metabolism of neurotransmitters, including dopamine and serotonin. Prior findings have suggested an association of the MAOA gene with the risk for early onset SUD. To extend this research, we genotyped four MAOA markers (two VNTR polymorphisms and two SNPs) and built a cladogram reflecting the evolutionary history of MAOA haplotypes [Nguyen et al., under review]. The cladogram served as the framework for nested ANOVA and logit analyses of association between MAOA and indices of liability to SUD (diagnosis, age of onset, and a dimensional index of substance use related problems) in a sample of adult males of European ancestry. Whereas no association was found for the categorical diagnosis, a significant relationship was detected between the dimensional liability indices and MAOA haplotypes. Overall, our results, albeit not definitive, are consistent with the hypothesis that variants in MAOA account for a small portion of the variance of SUD risk, possibly mediated by liability to early onset behavioral problems. © 2003 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/ajmg.b.20105
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<term>Dopamine system genes</term>
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<term>Highest levels</term>
<term>Human monoamine oxidase</term>
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<term>Logit analyses</term>
<term>Maoa</term>
<term>Maoa exon</term>
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<term>Restriction endonuclease mapping</term>
<term>Screening inventory</term>
<term>Single polymorphisms</term>
<term>Substance abuse</term>
<term>Tarter</term>
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<term>Behavioral characteristics</term>
<term>Best estimate procedure</term>
<term>Candidate genes</term>
<term>Clade</term>
<term>Clade level</term>
<term>Cladistic analysis</term>
<term>Cladogram</term>
<term>Cladogram structure</term>
<term>Clinical interview</term>
<term>Common liability</term>
<term>Different indices</term>
<term>Dimensional index</term>
<term>Dopamine system genes</term>
<term>Drug abuse</term>
<term>Drug abuse research</term>
<term>Drug alcohol abuse tarter</term>
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<term>Early onset</term>
<term>European ancestry</term>
<term>Evolutionary history</term>
<term>Evolutionary relationships</term>
<term>Frequent haplotypes</term>
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<term>Genetics templeton</term>
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<term>Haplotype analysis</term>
<term>Highest levels</term>
<term>Human monoamine oxidase</term>
<term>Important role</term>
<term>Large proportion</term>
<term>Logit analyses</term>
<term>Maoa</term>
<term>Maoa exon</term>
<term>Maoa gene</term>
<term>Maoa haplotypes</term>
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<term>Nucleotide position</term>
<term>Oxidase</term>
<term>Phenotypic associations</term>
<term>Pittsburgh school</term>
<term>Polymorphism</term>
<term>Population substructure devlin</term>
<term>Promoter</term>
<term>Promoter region</term>
<term>Quantitative traits</term>
<term>Restriction endonuclease mapping</term>
<term>Screening inventory</term>
<term>Single polymorphisms</term>
<term>Substance abuse</term>
<term>Tarter</term>
<term>Templeton</term>
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<front><div type="abstract" xml:lang="fr">Monoamine oxidase A (MAOA) locus is an attractive candidate for exploring genetic contribution to the variation in the risk for substance use disorders (SUD) because of its important role in the metabolism of neurotransmitters, including dopamine and serotonin. Prior findings have suggested an association of the MAOA gene with the risk for early onset SUD. To extend this research, we genotyped four MAOA markers (two VNTR polymorphisms and two SNPs) and built a cladogram reflecting the evolutionary history of MAOA haplotypes [Nguyen et al., under review]. The cladogram served as the framework for nested ANOVA and logit analyses of association between MAOA and indices of liability to SUD (diagnosis, age of onset, and a dimensional index of substance use related problems) in a sample of adult males of European ancestry. Whereas no association was found for the categorical diagnosis, a significant relationship was detected between the dimensional liability indices and MAOA haplotypes. Overall, our results, albeit not definitive, are consistent with the hypothesis that variants in MAOA account for a small portion of the variance of SUD risk, possibly mediated by liability to early onset behavioral problems. © 2003 Wiley‐Liss, Inc.</div>
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